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Protein

Ubiquitin-conjugating enzyme E2 2

Gene

UBC2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.1 Publication

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei88Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • DNA repair Source: GO_Central
  • histone H2B ubiquitination Source: TAIR
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
  • protein polyubiquitination Source: GO_Central
  • ubiquitin-dependent protein catabolic process Source: TAIR
  • vegetative to reproductive phase transition of meristem Source: TAIR

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.3.2.B5. 399.
ReactomeiR-ATH-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 2 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme 2
Ubiquitin carrier protein 2
Ubiquitin-conjugating enzyme E2-17 kDa 2
Ubiquitin-protein ligase 2
Gene namesi
Name:UBC2
Ordered Locus Names:At2g02760
ORF Names:T20F6.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G02760.
TAIRilocus:2058806. AT2G02760.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000825712 – 152Ubiquitin-conjugating enzyme E2 2Add BLAST151

Proteomic databases

PaxDbiP42745.
PRIDEiP42745.

Expressioni

Tissue specificityi

Expressed in all tissues examined. Lower levels found in leaves.1 Publication

Inductioni

Not induced by heat shock.1 Publication

Gene expression databases

ExpressionAtlasiP42745. baseline and differential.
GenevisibleiP42745. AT.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207. 2 interactors.
IntActiP42745. 2 interactors.
STRINGi3702.AT2G02760.1.

Structurei

3D structure databases

ProteinModelPortaliP42745.
SMRiP42745.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0419. Eukaryota.
COG5078. LUCA.
HOGENOMiHOG000233454.
InParanoidiP42745.
KOiK10573.
OMAiMSPANNE.
OrthoDBiEOG09360PJJ.
PhylomeDBiP42745.

Family and domain databases

CDDicd00195. UBCc. 1 hit.
Gene3Di3.10.110.10. 1 hit.
InterProiView protein in InterPro
IPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
PfamiView protein in Pfam
PF00179. UQ_con. 1 hit.
SUPFAMiSSF54495. SSF54495. 1 hit.
PROSITEiView protein in PROSITE
PS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42745-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTPARKRLM RDFKRLQQDP PAGISGAPQD NNIMLWNAVI FGPDDTPWDG
60 70 80 90 100
GTFKLSLQFS EDYPNKPPTV RFVSRMFHPN IYADGSICLD ILQNQWSPIY
110 120 130 140 150
DVAAILTSIQ SLLCDPNPNS PANSEAARMF SESKREYNRR VREVVEQSWT

AD
Length:152
Mass (Da):17,279
Last modified:November 1, 1995 - v1
Checksum:i266CD41930C38629
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19353 Genomic DNA. Translation: AAA32899.1.
Y13031 mRNA. Translation: CAA73476.1.
DQ027017 mRNA. Translation: AAY44843.1.
AC002521 Genomic DNA. Translation: AAC05346.1.
CP002685 Genomic DNA. Translation: AEC05621.1.
CP002685 Genomic DNA. Translation: ANM63049.1.
CP002685 Genomic DNA. Translation: ANM63050.1.
CP002685 Genomic DNA. Translation: ANM63051.1.
AF370558 mRNA. Translation: AAK48985.1.
AY072479 mRNA. Translation: AAL66894.1.
PIRiS43783.
RefSeqiNP_001325162.1. NM_001335136.1.
NP_001325163.1. NM_001335134.1.
NP_001325164.1. NM_001335135.1.
NP_565289.1. NM_126331.4.
UniGeneiAt.203.

Genome annotation databases

EnsemblPlantsiAT2G02760.1; AT2G02760.1; AT2G02760.
AT2G02760.2; AT2G02760.2; AT2G02760.
AT2G02760.3; AT2G02760.3; AT2G02760.
AT2G02760.4; AT2G02760.4; AT2G02760.
GeneIDi814805.
GrameneiAT2G02760.1; AT2G02760.1; AT2G02760.
AT2G02760.2; AT2G02760.2; AT2G02760.
AT2G02760.3; AT2G02760.3; AT2G02760.
AT2G02760.4; AT2G02760.4; AT2G02760.
KEGGiath:AT2G02760.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiUBC2_ARATH
AccessioniPrimary (citable) accession number: P42745
Secondary accession number(s): Q4TZ07
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 7, 2017
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families