Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ubiquitin-conjugating enzyme 15

Gene

UBC15

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.1 Publication

Catalytic activityi

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei99Glycyl thioester intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes
R-ATH-983168 Antigen processing: Ubiquitination & Proteasome degradation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme 15 (EC:2.3.2.23)
Alternative name(s):
E2 ubiquitin-conjugating enzyme 15
PM42
Ubiquitin carrier protein
Ubiquitin-conjugating enzyme E2-18 kDa 15
Ubiquitin-protein ligase
Gene namesi
Name:UBC15
Synonyms:UBC2-1
Ordered Locus Names:At1g45050
ORF Names:F27F5.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G45050
TAIRilocus:2028255 AT1G45050

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000825751 – 161Ubiquitin-conjugating enzyme 15Add BLAST161

Proteomic databases

PaxDbiP42743

Expressioni

Gene expression databases

ExpressionAtlasiP42743 baseline and differential
GenevisibleiP42743 AT

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi26297, 3 interactors
STRINGi3702.AT1G45050.1

Structurei

3D structure databases

ProteinModelPortaliP42743
SMRiP42743
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0427 Eukaryota
COG5078 LUCA
HOGENOMiHOG000233453
InParanoidiP42743
KOiK10688
OMAiSEWQLNP
OrthoDBiEOG09360P07
PhylomeDBiP42743

Family and domain databases

CDDicd00195 UBCc, 1 hit
Gene3Di3.10.110.10, 1 hit
InterProiView protein in InterPro
IPR000608 UBQ-conjugat_E2
IPR023313 UBQ-conjugating_AS
IPR016135 UBQ-conjugating_enzyme/RWD
PfamiView protein in Pfam
PF00179 UQ_con, 1 hit
SUPFAMiSSF54495 SSF54495, 1 hit
PROSITEiView protein in PROSITE
PS00183 UBIQUITIN_CONJUGAT_1, 1 hit
PS50127 UBIQUITIN_CONJUGAT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P42743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSSAPSRK ALSKIACNRL QKELSEWQLN PPTGFRHKVT DNLQKWTIDV
60 70 80 90 100
TGAPGTLYAN ETYQLQVEFP EHYPMEAPQV VFVSPAPSHP HIYSNGHICL
110 120 130 140 150
DILYDSWSPA MTVNSVCISI LSMLSSSPAK QRPADNDRYV KNCKNGRSPK
160
ETRWWFHDDK V
Length:161
Mass (Da):18,262
Last modified:December 6, 2002 - v2
Checksum:i60C7F34A9574FB68
GO

Sequence cautioni

The sequence AAF69157 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33T → S in CAA48378 (PubMed:8219072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X68306 mRNA Translation: CAA48378.1
AF028338 Genomic DNA Translation: AAC39324.1
DQ027029 mRNA Translation: AAY44855.1
AC007915 Genomic DNA Translation: AAF69157.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE32077.1
BT026105 mRNA Translation: ABG48461.1
AK176757 mRNA Translation: BAD44520.1
PIRiC96509
S39483
RefSeqiNP_564493.1, NM_103582.4
UniGeneiAt.204

Genome annotation databases

EnsemblPlantsiAT1G45050.1; AT1G45050.1; AT1G45050
GeneIDi841072
GrameneiAT1G45050.1; AT1G45050.1; AT1G45050
KEGGiath:AT1G45050

Similar proteinsi

Entry informationi

Entry nameiUBC15_ARATH
AccessioniPrimary (citable) accession number: P42743
Secondary accession number(s): O48952, Q67XR1, Q9MAK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 6, 2002
Last modified: May 23, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health