Reviewed, UniProtKB/Swiss-Prot P42738 (CHMU_ARATH)

Names and origin

Protein names

Recommended name:
    Chorismate mutase, chloroplastic
    EC=5.4.99.5
Alternative name(s):
    CM-1

Gene names

Name:	CM1
Ordered Locus Names:	At3g29200
ORF Names:	MXO21.4

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	Chorismate = prephenate.
Enzyme regulation	Allosterically inhibited by tyrosine and phenylalanine. Activated by tryptophan.
Pathway	Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.
Subcellular location	Plastid › chloroplast.
Sequence similarities	Contains 1 chorismate mutase domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Chloroplast Plastid
Domain	Transit peptide
Molecular function	Isomerase
Technical term	Allosteric enzyme Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chloroplast Inferred from electronic annotation. Source: UniProtKB-SubCell cytosol Traceable author statement. Source: TAIR
Molecular function	chorismate mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 60	60	Chloroplast Potential
	Chain	61 – 334	274	Chorismate mutase, chloroplastic		PRO_0000023926
Regions
	Domain	73 – 334	262	Chorismate mutase
Experimental info
	Sequence conflict	253	1	A → R in CAA81286. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P42738-1 [UniParc]. Last modified November 2, 2001. Version 2. Checksum: 4D477B08E349B08C	FASTA	334	37,594
	10 20 30 40 50 60 MRSSCCSSAI GGFFDHRREL STSTPISTLL PLPSTKSSFS VRCSLPQPSK PRSGTSSVHA 70 80 90 100 110 120 VMTLAGSLTG KKRVDESESL TLEGIRNSLI RQEDSIIFGL LERAKYCYNA DTYDPTAFDM 130 140 150 160 170 180 DGFNGSLVEY MVKGTEKLHA KVGRFKSPDE HPFFPDDLPE PMLPPLQYPK VLHFAADSIN 190 200 210 220 230 240 INKKIWNMYF RDLVPRLVKK GDDGNYGSTA VCDAICLQCL SKRIHYGKFV AEAKFQASPE 250 260 270 280 290 300 AYESAIKAQD KDALMDMLTF PTVEDAIKKR VEMKTRTYGQ EVKVGMEEKE EEEEEGNESH 310 320 330 VYKISPILVG DLYGDWIMPL TKEVQVEYLL RRLD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression in yeast of a higher plant chorismate mutase. Molecular cloning, sequencing of the cDNA and characterization of the Arabidopsis thaliana enzyme expressed in yeast." Eberhard J., Raesecke H.-R., Schmid J., Amrhein N. FEBS Lett. 334:233-236(1993) [PubMed: 8224252] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Expression analysis of Arabidopsis thaliana genes for plastidic (CM1) and cytosolic (CM2) chorismate mutases." Kuhn R., Vogt E., Schmid J., Amrhein N., Schaller A. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: cv. Landsberg erecta.
[3]	"Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence features of the regions of 4,504,864 bp covered by sixty P1 and TAC clones." Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S. DNA Res. 7:131-135(2000) [PubMed: 10819329] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Z26519 mRNA. Translation: CAA81286.1. AJ242647 Genomic DNA. Translation: CAB54518.1. AB026657 Genomic DNA. Translation: BAB01816.1.
IPI	IPI00525983.
PIR	S38958.
3D structure databases
HSSP	HSSP built from PDB template 5CSM based on UniProtKB P32178.
ModBase	Search...
Protein-protein interaction databases
STRING	P42738.
Proteomic databases
PRIDE	P42738.
Organism-specific databases
TAIR	At3g29200.
Enzyme and pathway databases
BRENDA	5.4.99.5. 302.
Gene expression databases
ArrayExpress	P42738.
Genevestigator	P42738.
GermOnline	AT3G29200. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR002701. Chorismate_mut. IPR008238. Chorismate_mutase_AroQ_euk. [Graphical view]
Gene3D	G3DSA:1.10.590.10. Chor_mut_AroQ_eu. 1 hit.
PANTHER	PTHR21145. Chor_mut_AroQ_eu. 1 hit.
Pfam	PF01817. CM_2. 1 hit. [Graphical view]
PIRSF	PIRSF017318. Chor_mut_AroQ_eu. 1 hit.
TIGRFAMs	TIGR01802. CM_pl-yst. 1 hit.
PROSITE	PS51169. CHORISMATE_MUT_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CHMU_ARATH

Accession

Primary (citable) accession number: P42738
Secondary accession number(s): Q9LS75, Q9SUJ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 2, 2001
Last modified:	October 13, 2009
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)