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P42709

- VDH_STRAM

UniProt

P42709 - VDH_STRAM

Protein

Valine dehydrogenase

Gene

vdh

Organism
Streptomyces ambofaciens
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Oxidative deamination of branched-chain amino acids. The catabolism of valine is the major source of fatty acid precursors for macrolide biosynthesis and a vital source of antibiotic precursors.

    Catalytic activityi

    L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei91 – 911PROSITE-ProRule annotation

    GO - Molecular functioni

    1. oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor Source: InterPro

    GO - Biological processi

    1. valine catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Branched-chain amino acid catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00362.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Valine dehydrogenase (EC:1.4.1.-)
    Short name:
    ValDH
    Gene namesi
    Name:vdh
    OrganismiStreptomyces ambofaciens
    Taxonomic identifieri1889 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – ›106›105Valine dehydrogenasePRO_0000182811Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP42709.
    SMRiP42709. Positions 23-106.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR006095. Glu/Leu/Phe/Val_DH.
    IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
    IPR016211. Glu/Phe/Leu/Val_DH_bac/arc.
    [Graphical view]
    PANTHERiPTHR11606:SF3. PTHR11606:SF3. 1 hit.
    PfamiPF02812. ELFV_dehydrog_N. 1 hit.
    [Graphical view]
    PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P42709-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDVTGAPAD VLHTLFHSDQ GGHEQVVLCQ DRASGLKAVI ALHSTALGPA    50
    LGGTRFYPIA NEAEAVADAL NLARGMSYKN AMAGLEHGGG KAVIIGDPEQ 100
    IKSEEL 106
    Length:106
    Mass (Da):10,964
    Last modified:January 23, 2007 - v2
    Checksum:i1A1116020A884ADE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei106 – 1061

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L33871 Genomic DNA. Translation: AAA62597.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L33871 Genomic DNA. Translation: AAA62597.1 .

    3D structure databases

    ProteinModelPortali P42709.
    SMRi P42709. Positions 23-106.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00362 .

    Family and domain databases

    InterProi IPR006095. Glu/Leu/Phe/Val_DH.
    IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
    IPR016211. Glu/Phe/Leu/Val_DH_bac/arc.
    [Graphical view ]
    PANTHERi PTHR11606:SF3. PTHR11606:SF3. 1 hit.
    Pfami PF02812. ELFV_dehydrog_N. 1 hit.
    [Graphical view ]
    PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Amino acid catabolism and antibiotic synthesis: valine is a source of precursors for macrolide biosynthesis in Streptomyces ambofaciens and Streptomyces fradiae."
      Tang L., Zhang Y.X., Hutchinson C.R.
      J. Bacteriol. 176:6107-6119(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 15154 / NBRC 13685 / NRRL 2420 / Isolate B3.

    Entry informationi

    Entry nameiVDH_STRAM
    AccessioniPrimary (citable) accession number: P42709
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 62 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3