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P42703

- LIFR_MOUSE

UniProt

P42703 - LIFR_MOUSE

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Protein

Leukemia inhibitory factor receptor

Gene

Lifr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.

GO - Molecular functioni

  1. leukemia inhibitory factor receptor activity Source: Ensembl
  2. oncostatin-M receptor activity Source: Ensembl

GO - Biological processi

  1. positive regulation of cell proliferation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Leukemia inhibitory factor receptor
Short name:
LIF receptor
Short name:
LIF-R
Alternative name(s):
D-factor/LIF receptor
CD_antigen: CD118
Gene namesi
Name:Lifr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:96788. Lifr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini44 – 828785ExtracellularSequence AnalysisAdd
BLAST
Transmembranei829 – 85325HelicalSequence AnalysisAdd
BLAST
Topological domaini854 – 1092239CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4343Sequence AnalysisAdd
BLAST
Chaini44 – 10921049Leukemia inhibitory factor receptorPRO_0000010903Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi53 ↔ 631 Publication
Disulfide bondi80 ↔ 881 Publication
Glycosylationi164 – 1641N-linked (GlcNAc...)1 Publication
Glycosylationi199 – 1991N-linked (GlcNAc...)1 Publication
Disulfide bondi208 ↔ 2651 Publication
Glycosylationi238 – 2381N-linked (GlcNAc...)1 Publication
Glycosylationi261 – 2611N-linked (GlcNAc...)1 Publication
Disulfide bondi336 ↔ 3461 Publication
Glycosylationi385 – 3851N-linked (GlcNAc...)4 Publications
Glycosylationi402 – 4021N-linked (GlcNAc...)2 Publications
Glycosylationi421 – 4211N-linked (GlcNAc...)1 Publication
Glycosylationi440 – 4401N-linked (GlcNAc...)1 Publication
Glycosylationi453 – 4531N-linked (GlcNAc...)1 Publication
Disulfide bondi461 ↔ 5061 Publication
Glycosylationi476 – 4761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi567 – 5671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi647 – 6471N-linked (GlcNAc...)Sequence Analysis
Glycosylationi658 – 6581N-linked (GlcNAc...)1 Publication
Glycosylationi675 – 6751N-linked (GlcNAc...)1 Publication
Glycosylationi724 – 7241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi782 – 7821N-linked (GlcNAc...)Sequence Analysis
Modified residuei922 – 9221PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP42703.
PaxDbiP42703.
PRIDEiP42703.

PTM databases

PhosphoSiteiP42703.

Expressioni

Tissue specificityi

Placenta, liver, kidney, heart, lung, brain, and embryos. The liver may be the primary site of synthesis of the secreted form.

Gene expression databases

BgeeiP42703.
CleanExiMM_LIFR.
GenevestigatoriP42703.

Interactioni

Subunit structurei

Heterodimer composed of LIFR and IL6ST. The heterodimer formed by LIFR and IL6ST interacts with the complex formed by CNTF and CNTFR (By similarity).By similarity

Protein-protein interaction databases

BioGridi201163. 3 interactions.
DIPiDIP-5772N.
IntActiP42703. 3 interactions.
MINTiMINT-4100386.

Structurei

Secondary structure

1
1092
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi54 – 6411
Beta strandi69 – 713
Beta strandi76 – 9015
Beta strandi92 – 998
Beta strandi106 – 11510
Beta strandi117 – 1226
Beta strandi136 – 1383
Turni143 – 1464
Beta strandi147 – 1526
Helixi156 – 1583
Beta strandi161 – 17010
Beta strandi174 – 1774
Beta strandi190 – 1923
Beta strandi197 – 2015
Beta strandi207 – 2093
Beta strandi212 – 2198
Beta strandi255 – 2595
Beta strandi263 – 2664
Beta strandi272 – 2776
Beta strandi288 – 2903
Beta strandi292 – 2954
Beta strandi307 – 3159
Beta strandi317 – 3259
Beta strandi335 – 34814
Beta strandi363 – 3686
Turni369 – 3713
Beta strandi374 – 3785
Beta strandi388 – 3936
Beta strandi402 – 4098
Beta strandi412 – 4198
Helixi422 – 4243
Beta strandi432 – 4387
Beta strandi444 – 45310
Beta strandi455 – 46612
Beta strandi473 – 4808
Beta strandi483 – 4919
Beta strandi504 – 5107

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Q7NX-ray4.00A/C50-529[»]
ProteinModelPortaliP42703.
SMRiP42703. Positions 50-817.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42703.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini45 – 12682Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini330 – 429100Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini430 – 529100Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini533 – 62492Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini622 – 71493Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST
Domaini719 – 828110Fibronectin type-III 6PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi514 – 5185WSXWS motif
Motifi864 – 8729Box 1 motif

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 6 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG147644.
GeneTreeiENSGT00550000074436.
HOGENOMiHOG000113324.
HOVERGENiHBG006266.
InParanoidiP42703.
KOiK05058.
OMAiFYPDIPN.
OrthoDBiEOG7V49XP.
PhylomeDBiP42703.
TreeFamiTF338122.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. Fibronectin_type3.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 5 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 4 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P42703-1) [UniParc]FASTAAdd to Basket

Also known as: Membrane

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAYSWWRQP SWMVDNKRSR MTPNLPWLLS ALTLLHLTMH ANGLKRGVQD
60 70 80 90 100
LKCTTNNMRV WDCTWPAPLG VSPGTVKDIC IKDRFHSCHP LETTNVKIPA
110 120 130 140 150
LSPGDHEVTI NYLNGFQSKF TLNEKDVSLI PETPEILDLS ADFFTSSLLL
160 170 180 190 200
KWNDRGSALP HPSNATWEIK VLQNPRTEPV ALVLLNTMLS GKDTVQHWNW
210 220 230 240 250
TSDLPLQCAT HSVSIRWHID SPHFSGYKEW SDWSPLKNIS WIRNTETNVF
260 270 280 290 300
PQDKVVLAGS NMTICCMSPT KVLSGQIGNT LRPLIHLYGQ TVAIHILNIP
310 320 330 340 350
VSENSGTNII FITDDDVYGT VVFAGYPPDV PQKLSCETHD LKEIICSWNP
360 370 380 390 400
GRITGLVGPR NTEYTLFESI SGKSAVFHRI EGLTNETYRL GVQMHPGQEI
410 420 430 440 450
HNFTLTGRNP LGQAQSAVVI NVTERVAPHD PTSLKVKDIN STVVTFSWYL
460 470 480 490 500
PGNFTKINLL CQIEICKANS KKEVRNATIR GAEDSTYHVA VDKLNPYTAY
510 520 530 540 550
TFRVRCSSKT FWKWSRWSDE KRHLTTEATP SKGPDTWREW SSDGKNLIVY
560 570 580 590 600
WKPLPINEAN GKILSYNVSC SLNEETQSVL EIFDPQHRAE IQLSKNDYII
610 620 630 640 650
SVVARNSAGS SPPSKIASME IPNDDITVEQ AVGLGNRIFL TWRHDPNMTC
660 670 680 690 700
DYVIKWCNSS RSEPCLLDWR KVPSNSTETV IESDQFQPGV RYNFYLYGCT
710 720 730 740 750
NQGYQLLRSI IGYVEELAPI VAPNFTVEDT SADSILVKWD DIPVEELRGF
760 770 780 790 800
LRGYLFYFQK GERDTPKTRS LEPHHSDIKL KNITDISQKT LRIADLQGKT
810 820 830 840 850
SYHLVLRAYT HGGLGPEKSM FVVTKENSVG LIIAILIPVA VAVIVGVVTS
860 870 880 890 900
ILCYRKREWI KETFYPDIPN PENCKALQFQ KSVCEGSNAL KTLEMNPCTP
910 920 930 940 950
NNVEVLESRS IVPKIEDTEI ISPVAERPGE RSEVDPENHV VVSYCPPIIE
960 970 980 990 1000
EEITNPAADE VGGASQVVYI DVQSMYQPQA KAEEEQDVDP VVVAGYKPQM
1010 1020 1030 1040 1050
RLPISPAVED TAAEDEEGKT AGYRPQANVN TWNLVSPDSP RSTDSNNEVV
1060 1070 1080 1090
SFGSPCSINS RQFLIPPKDE DSPKSNGGGW SFTNFFQNKP ND
Length:1,092
Mass (Da):122,574
Last modified:November 1, 1995 - v1
Checksum:i6F02BBC8E154DE70
GO
Isoform 2 (identifier: P42703-2) [UniParc]FASTAAdd to Basket

Also known as: Secreted

The sequence of this isoform differs from the canonical sequence as follows:
     718-719: AP → EA
     720-1092: Missing.

Show »
Length:719
Mass (Da):81,287
Checksum:i4DF1779816B06D2B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei718 – 7192AP → EA in isoform 2. 4 PublicationsVSP_001686
Alternative sequencei720 – 1092373Missing in isoform 2. 4 PublicationsVSP_001687Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S73496 mRNA. Translation: AAC60698.1.
S73495 mRNA. Translation: AAC60697.1.
D26177 mRNA. Translation: BAA05165.1.
D17444 mRNA. Translation: BAA04258.1.
BC031929 mRNA. Translation: AAH31929.1.
CCDSiCCDS27369.1. [P42703-1]
CCDS49577.1. [P42703-2]
PIRiJX0312.
RefSeqiNP_001106857.1. NM_001113386.1. [P42703-2]
NP_038612.1. NM_013584.2. [P42703-1]
XP_006520030.1. XM_006519967.1. [P42703-1]
XP_006520031.1. XM_006519968.1. [P42703-1]
XP_006520032.1. XM_006519969.1. [P42703-1]
XP_006520033.1. XM_006519970.1. [P42703-2]
XP_006520034.1. XM_006519971.1. [P42703-2]
UniGeneiMm.149720.

Genome annotation databases

EnsembliENSMUST00000067190; ENSMUSP00000064551; ENSMUSG00000054263. [P42703-1]
ENSMUST00000164529; ENSMUSP00000131434; ENSMUSG00000054263. [P42703-2]
ENSMUST00000171588; ENSMUSP00000126137; ENSMUSG00000054263. [P42703-1]
GeneIDi16880.
KEGGimmu:16880.
UCSCiuc007vdw.2. mouse. [P42703-2]
uc007vdx.2. mouse. [P42703-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S73496 mRNA. Translation: AAC60698.1 .
S73495 mRNA. Translation: AAC60697.1 .
D26177 mRNA. Translation: BAA05165.1 .
D17444 mRNA. Translation: BAA04258.1 .
BC031929 mRNA. Translation: AAH31929.1 .
CCDSi CCDS27369.1. [P42703-1 ]
CCDS49577.1. [P42703-2 ]
PIRi JX0312.
RefSeqi NP_001106857.1. NM_001113386.1. [P42703-2 ]
NP_038612.1. NM_013584.2. [P42703-1 ]
XP_006520030.1. XM_006519967.1. [P42703-1 ]
XP_006520031.1. XM_006519968.1. [P42703-1 ]
XP_006520032.1. XM_006519969.1. [P42703-1 ]
XP_006520033.1. XM_006519970.1. [P42703-2 ]
XP_006520034.1. XM_006519971.1. [P42703-2 ]
UniGenei Mm.149720.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2Q7N X-ray 4.00 A/C 50-529 [» ]
ProteinModelPortali P42703.
SMRi P42703. Positions 50-817.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201163. 3 interactions.
DIPi DIP-5772N.
IntActi P42703. 3 interactions.
MINTi MINT-4100386.

PTM databases

PhosphoSitei P42703.

Proteomic databases

MaxQBi P42703.
PaxDbi P42703.
PRIDEi P42703.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000067190 ; ENSMUSP00000064551 ; ENSMUSG00000054263 . [P42703-1 ]
ENSMUST00000164529 ; ENSMUSP00000131434 ; ENSMUSG00000054263 . [P42703-2 ]
ENSMUST00000171588 ; ENSMUSP00000126137 ; ENSMUSG00000054263 . [P42703-1 ]
GeneIDi 16880.
KEGGi mmu:16880.
UCSCi uc007vdw.2. mouse. [P42703-2 ]
uc007vdx.2. mouse. [P42703-1 ]

Organism-specific databases

CTDi 3977.
MGIi MGI:96788. Lifr.

Phylogenomic databases

eggNOGi NOG147644.
GeneTreei ENSGT00550000074436.
HOGENOMi HOG000113324.
HOVERGENi HBG006266.
InParanoidi P42703.
KOi K05058.
OMAi FYPDIPN.
OrthoDBi EOG7V49XP.
PhylomeDBi P42703.
TreeFami TF338122.

Miscellaneous databases

EvolutionaryTracei P42703.
NextBioi 290878.
PROi P42703.
SOURCEi Search...

Gene expression databases

Bgeei P42703.
CleanExi MM_LIFR.
Genevestigatori P42703.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
InterProi IPR003961. Fibronectin_type3.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR013783. Ig-like_fold.
[Graphical view ]
Pfami PF00041. fn3. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 5 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 3 hits.
PROSITEi PS50853. FN3. 4 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130."
    Gearing D.P., Thut C.J., Vanden Bos T., Gimpel S.D., Delaney P.B., King J., Price V., Cosman D., Beckmann M.P.
    EMBO J. 10:2839-2848(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Pregnancy associated increase in mRNA for soluble D-factor/LIF receptor in mouse liver."
    Tomida M., Yamamoto-Yamaguchi Y., Hozumi M.
    FEBS Lett. 334:193-197(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: ICR.
    Tissue: Liver.
  3. "Three different cDNAs encoding mouse D-factor/LIF receptor."
    Tomida M., Yamamoto-Yamaguchi Y., Hozumi M.
    J. Biochem. 115:557-562(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: FVB/N.
    Tissue: Liver.
  5. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
    Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
    J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-385; ASN-402 AND ASN-675.
    Strain: C57BL/6.
    Tissue: Plasma.
  6. "Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
    Bernhard O.K., Kapp E.A., Simpson R.J.
    J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-385 AND ASN-658.
    Strain: C57BL/6.
    Tissue: Plasma.
  7. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-385.
  8. "An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor."
    Huyton T., Zhang J.G., Luo C.S., Lou M.Z., Hilton D.J., Nicola N.A., Garrett T.P.
    Proc. Natl. Acad. Sci. U.S.A. 104:12737-12742(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 49-529 IN COMPLEX WITH HUMAN LIF, DISULFIDE BOND, GLYCOSYLATION AT ASN-164; ASN-199; ASN-238; ASN-261; ASN-385; ASN-402; ASN-421; ASN-440 AND ASN-453.

Entry informationi

Entry nameiLIFR_MOUSE
AccessioniPrimary (citable) accession number: P42703
Secondary accession number(s): Q5I0Y2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3