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Protein

Leukemia inhibitory factor receptor

Gene

Lifr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-6788467. IL-6-type cytokine receptor ligand interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukemia inhibitory factor receptor
Short name:
LIF receptor
Short name:
LIF-R
Alternative name(s):
D-factor/LIF receptor
CD_antigen: CD118
Gene namesi
Name:Lifr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96788. Lifr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini44 – 828ExtracellularSequence analysisAdd BLAST785
Transmembranei829 – 853HelicalSequence analysisAdd BLAST25
Topological domaini854 – 1092CytoplasmicSequence analysisAdd BLAST239

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 43Sequence analysisAdd BLAST43
ChainiPRO_000001090344 – 1092Leukemia inhibitory factor receptorAdd BLAST1049

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 631 Publication
Disulfide bondi80 ↔ 881 Publication
Glycosylationi164N-linked (GlcNAc...)1 Publication1
Glycosylationi199N-linked (GlcNAc...)1 Publication1
Disulfide bondi208 ↔ 2651 Publication
Glycosylationi238N-linked (GlcNAc...)1 Publication1
Glycosylationi261N-linked (GlcNAc...)1 Publication1
Disulfide bondi336 ↔ 3461 Publication
Glycosylationi385N-linked (GlcNAc...)4 Publications1
Glycosylationi402N-linked (GlcNAc...)2 Publications1
Glycosylationi421N-linked (GlcNAc...)1 Publication1
Glycosylationi440N-linked (GlcNAc...)1 Publication1
Glycosylationi453N-linked (GlcNAc...)1 Publication1
Disulfide bondi461 ↔ 5061 Publication
Glycosylationi476N-linked (GlcNAc...)Sequence analysis1
Glycosylationi567N-linked (GlcNAc...)Sequence analysis1
Glycosylationi647N-linked (GlcNAc...)Sequence analysis1
Glycosylationi658N-linked (GlcNAc...)1 Publication1
Glycosylationi675N-linked (GlcNAc...)1 Publication1
Glycosylationi724N-linked (GlcNAc...)Sequence analysis1
Glycosylationi782N-linked (GlcNAc...)Sequence analysis1
Modified residuei922PhosphoserineBy similarity1
Modified residuei1039PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP42703.
PaxDbiP42703.
PeptideAtlasiP42703.
PRIDEiP42703.

PTM databases

iPTMnetiP42703.
PhosphoSitePlusiP42703.

Expressioni

Tissue specificityi

Placenta, liver, kidney, heart, lung, brain, and embryos. The liver may be the primary site of synthesis of the secreted form.

Gene expression databases

BgeeiENSMUSG00000054263.
CleanExiMM_LIFR.
GenevisibleiP42703. MM.

Interactioni

Subunit structurei

Heterodimer composed of LIFR and IL6ST. The heterodimer formed by LIFR and IL6ST interacts with the complex formed by CNTF and CNTFR (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201163. 3 interactors.
DIPiDIP-5772N.
IntActiP42703. 3 interactors.
MINTiMINT-4100386.
STRINGi10090.ENSMUSP00000064551.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Q7NX-ray4.00A/C50-529[»]
ProteinModelPortaliP42703.
SMRiP42703.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42703.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 126Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST82
Domaini330 – 429Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST100
Domaini430 – 529Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST100
Domaini533 – 624Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST92
Domaini622 – 714Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST93
Domaini719 – 828Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST110

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi514 – 518WSXWS motif5
Motifi864 – 872Box 1 motif9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 6 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF1V. Eukaryota.
ENOG410ZMDF. LUCA.
GeneTreeiENSGT00550000074436.
HOGENOMiHOG000113324.
HOVERGENiHBG006266.
InParanoidiP42703.
KOiK05058.
OMAiFYPDIPN.
OrthoDBiEOG091G00RF.
PhylomeDBiP42703.
TreeFamiTF338122.

Family and domain databases

CDDicd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 5 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 4 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P42703-1) [UniParc]FASTAAdd to basket
Also known as: Membrane

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAYSWWRQP SWMVDNKRSR MTPNLPWLLS ALTLLHLTMH ANGLKRGVQD
60 70 80 90 100
LKCTTNNMRV WDCTWPAPLG VSPGTVKDIC IKDRFHSCHP LETTNVKIPA
110 120 130 140 150
LSPGDHEVTI NYLNGFQSKF TLNEKDVSLI PETPEILDLS ADFFTSSLLL
160 170 180 190 200
KWNDRGSALP HPSNATWEIK VLQNPRTEPV ALVLLNTMLS GKDTVQHWNW
210 220 230 240 250
TSDLPLQCAT HSVSIRWHID SPHFSGYKEW SDWSPLKNIS WIRNTETNVF
260 270 280 290 300
PQDKVVLAGS NMTICCMSPT KVLSGQIGNT LRPLIHLYGQ TVAIHILNIP
310 320 330 340 350
VSENSGTNII FITDDDVYGT VVFAGYPPDV PQKLSCETHD LKEIICSWNP
360 370 380 390 400
GRITGLVGPR NTEYTLFESI SGKSAVFHRI EGLTNETYRL GVQMHPGQEI
410 420 430 440 450
HNFTLTGRNP LGQAQSAVVI NVTERVAPHD PTSLKVKDIN STVVTFSWYL
460 470 480 490 500
PGNFTKINLL CQIEICKANS KKEVRNATIR GAEDSTYHVA VDKLNPYTAY
510 520 530 540 550
TFRVRCSSKT FWKWSRWSDE KRHLTTEATP SKGPDTWREW SSDGKNLIVY
560 570 580 590 600
WKPLPINEAN GKILSYNVSC SLNEETQSVL EIFDPQHRAE IQLSKNDYII
610 620 630 640 650
SVVARNSAGS SPPSKIASME IPNDDITVEQ AVGLGNRIFL TWRHDPNMTC
660 670 680 690 700
DYVIKWCNSS RSEPCLLDWR KVPSNSTETV IESDQFQPGV RYNFYLYGCT
710 720 730 740 750
NQGYQLLRSI IGYVEELAPI VAPNFTVEDT SADSILVKWD DIPVEELRGF
760 770 780 790 800
LRGYLFYFQK GERDTPKTRS LEPHHSDIKL KNITDISQKT LRIADLQGKT
810 820 830 840 850
SYHLVLRAYT HGGLGPEKSM FVVTKENSVG LIIAILIPVA VAVIVGVVTS
860 870 880 890 900
ILCYRKREWI KETFYPDIPN PENCKALQFQ KSVCEGSNAL KTLEMNPCTP
910 920 930 940 950
NNVEVLESRS IVPKIEDTEI ISPVAERPGE RSEVDPENHV VVSYCPPIIE
960 970 980 990 1000
EEITNPAADE VGGASQVVYI DVQSMYQPQA KAEEEQDVDP VVVAGYKPQM
1010 1020 1030 1040 1050
RLPISPAVED TAAEDEEGKT AGYRPQANVN TWNLVSPDSP RSTDSNNEVV
1060 1070 1080 1090
SFGSPCSINS RQFLIPPKDE DSPKSNGGGW SFTNFFQNKP ND
Length:1,092
Mass (Da):122,574
Last modified:November 1, 1995 - v1
Checksum:i6F02BBC8E154DE70
GO
Isoform 2 (identifier: P42703-2) [UniParc]FASTAAdd to basket
Also known as: Secreted

The sequence of this isoform differs from the canonical sequence as follows:
     718-719: AP → EA
     720-1092: Missing.

Show »
Length:719
Mass (Da):81,287
Checksum:i4DF1779816B06D2B
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001686718 – 719AP → EA in isoform 2. 4 Publications2
Alternative sequenceiVSP_001687720 – 1092Missing in isoform 2. 4 PublicationsAdd BLAST373

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S73496 mRNA. Translation: AAC60698.1.
S73495 mRNA. Translation: AAC60697.1.
D26177 mRNA. Translation: BAA05165.1.
D17444 mRNA. Translation: BAA04258.1.
BC031929 mRNA. Translation: AAH31929.1.
CCDSiCCDS27369.1. [P42703-1]
CCDS49577.1. [P42703-2]
PIRiJX0312.
RefSeqiNP_001106857.1. NM_001113386.1. [P42703-2]
NP_038612.1. NM_013584.2. [P42703-1]
XP_006520030.1. XM_006519967.3. [P42703-1]
XP_006520032.1. XM_006519969.3. [P42703-1]
XP_006520033.1. XM_006519970.3. [P42703-2]
XP_006520034.1. XM_006519971.2. [P42703-2]
XP_011243628.1. XM_011245326.2. [P42703-1]
UniGeneiMm.149720.

Genome annotation databases

EnsembliENSMUST00000067190; ENSMUSP00000064551; ENSMUSG00000054263. [P42703-1]
ENSMUST00000164529; ENSMUSP00000131434; ENSMUSG00000054263. [P42703-2]
ENSMUST00000171588; ENSMUSP00000126137; ENSMUSG00000054263. [P42703-1]
GeneIDi16880.
KEGGimmu:16880.
UCSCiuc007vdw.2. mouse. [P42703-2]
uc007vdx.2. mouse. [P42703-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S73496 mRNA. Translation: AAC60698.1.
S73495 mRNA. Translation: AAC60697.1.
D26177 mRNA. Translation: BAA05165.1.
D17444 mRNA. Translation: BAA04258.1.
BC031929 mRNA. Translation: AAH31929.1.
CCDSiCCDS27369.1. [P42703-1]
CCDS49577.1. [P42703-2]
PIRiJX0312.
RefSeqiNP_001106857.1. NM_001113386.1. [P42703-2]
NP_038612.1. NM_013584.2. [P42703-1]
XP_006520030.1. XM_006519967.3. [P42703-1]
XP_006520032.1. XM_006519969.3. [P42703-1]
XP_006520033.1. XM_006519970.3. [P42703-2]
XP_006520034.1. XM_006519971.2. [P42703-2]
XP_011243628.1. XM_011245326.2. [P42703-1]
UniGeneiMm.149720.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Q7NX-ray4.00A/C50-529[»]
ProteinModelPortaliP42703.
SMRiP42703.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201163. 3 interactors.
DIPiDIP-5772N.
IntActiP42703. 3 interactors.
MINTiMINT-4100386.
STRINGi10090.ENSMUSP00000064551.

PTM databases

iPTMnetiP42703.
PhosphoSitePlusiP42703.

Proteomic databases

MaxQBiP42703.
PaxDbiP42703.
PeptideAtlasiP42703.
PRIDEiP42703.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067190; ENSMUSP00000064551; ENSMUSG00000054263. [P42703-1]
ENSMUST00000164529; ENSMUSP00000131434; ENSMUSG00000054263. [P42703-2]
ENSMUST00000171588; ENSMUSP00000126137; ENSMUSG00000054263. [P42703-1]
GeneIDi16880.
KEGGimmu:16880.
UCSCiuc007vdw.2. mouse. [P42703-2]
uc007vdx.2. mouse. [P42703-1]

Organism-specific databases

CTDi3977.
MGIiMGI:96788. Lifr.

Phylogenomic databases

eggNOGiENOG410IF1V. Eukaryota.
ENOG410ZMDF. LUCA.
GeneTreeiENSGT00550000074436.
HOGENOMiHOG000113324.
HOVERGENiHBG006266.
InParanoidiP42703.
KOiK05058.
OMAiFYPDIPN.
OrthoDBiEOG091G00RF.
PhylomeDBiP42703.
TreeFamiTF338122.

Enzyme and pathway databases

ReactomeiR-MMU-6788467. IL-6-type cytokine receptor ligand interactions.

Miscellaneous databases

EvolutionaryTraceiP42703.
PROiP42703.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054263.
CleanExiMM_LIFR.
GenevisibleiP42703. MM.

Family and domain databases

CDDicd00063. FN3. 3 hits.
Gene3Di2.60.40.10. 4 hits.
InterProiIPR003961. FN3_dom.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 5 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 4 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIFR_MOUSE
AccessioniPrimary (citable) accession number: P42703
Secondary accession number(s): Q5I0Y2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 153 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.