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P42702

- LIFR_HUMAN

UniProt

P42702 - LIFR_HUMAN

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Protein

Leukemia inhibitory factor receptor

Gene

LIFR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the biological activity of LIF by blocking its binding to receptors on target cells.

GO - Molecular functioni

  1. ciliary neurotrophic factor receptor binding Source: BHF-UCL
  2. growth factor binding Source: BHF-UCL
  3. leukemia inhibitory factor receptor activity Source: MGI

GO - Biological processi

  1. cell surface receptor signaling pathway Source: ProtInc
  2. ciliary neurotrophic factor-mediated signaling pathway Source: BHF-UCL
  3. cytokine-mediated signaling pathway Source: MGI
  4. leukemia inhibitory factor signaling pathway Source: BHF-UCL
  5. oncostatin-M-mediated signaling pathway Source: GOC
  6. positive regulation of cell proliferation Source: BHF-UCL
  7. response to cytokine Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

SignaLinkiP42702.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukemia inhibitory factor receptor
Short name:
LIF receptor
Short name:
LIF-R
Alternative name(s):
CD_antigen: CD118
Gene namesi
Name:LIFR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:6597. LIFR.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini45 – 833789ExtracellularSequence AnalysisAdd
BLAST
Transmembranei834 – 85825HelicalSequence AnalysisAdd
BLAST
Topological domaini859 – 1097239CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProtKB
  2. integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Involvement in diseasei

Stueve-Wiedemann syndrome (STWS) [MIM:601559]: Severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias. SWS is characterized by bowing of the lower limbs, with internal cortical thickening, wide metaphyses with abnormal trabecular pattern, and camptodactyly. Additional features include feeding and swallowing difficulties, as well as respiratory distress and hyperthermic episodes, which cause death in the first months of life. The rare survivors develop progressive scoliosis, spontaneous fractures, bowing of the lower limbs, with prominent joints and dysautonomia symptoms, including temperature instability, absent corneal and patellar reflexes, and smooth tongue.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti279 – 2791S → P in STWS. 1 Publication
VAR_025666
A chromosomal aberration involving LIFR is found in salivary gland pleiomorphic adenomas, the most common benign epithelial tumors of the salivary gland. Translocation t(5;8)(p13;q12) with PLAG1.

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi601559. phenotype.
Orphaneti3206. Stuve-Wiedemann syndrome.
PharmGKBiPA30371.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4444Sequence AnalysisAdd
BLAST
Chaini45 – 10971053Leukemia inhibitory factor receptorPRO_0000010902Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi55 ↔ 651 Publication
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi82 ↔ 901 Publication
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi131 – 1311N-linked (GlcNAc...)1 Publication
Glycosylationi143 – 1431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi191 – 1911N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi213 ↔ 2701 Publication
Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi303 – 3031N-linked (GlcNAc...)1 Publication
Disulfide bondi341 ↔ 3511 Publication
Glycosylationi390 – 3901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi407 – 4071N-linked (GlcNAc...)1 Publication
Glycosylationi426 – 4261N-linked (GlcNAc...)1 Publication
Glycosylationi445 – 4451N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi466 ↔ 5111 Publication
Glycosylationi481 – 4811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi489 – 4891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi572 – 5721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi652 – 6521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi663 – 6631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi680 – 6801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi729 – 7291N-linked (GlcNAc...)Sequence Analysis
Glycosylationi787 – 7871N-linked (GlcNAc...)Sequence Analysis
Modified residuei927 – 9271Phosphoserine1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP42702.
PaxDbiP42702.
PRIDEiP42702.

PTM databases

PhosphoSiteiP42702.

Expressioni

Gene expression databases

BgeeiP42702.
CleanExiHS_LIFR.
ExpressionAtlasiP42702. baseline and differential.
GenevestigatoriP42702.

Organism-specific databases

HPAiCAB010252.
HPA004478.

Interactioni

Subunit structurei

Heterodimer composed of LIFR and IL6ST. The heterodimer formed by LIFR and IL6ST interacts with the complex formed by CNTF and CNTFR.1 Publication

Protein-protein interaction databases

BioGridi110165. 7 interactions.
DIPiDIP-5770N.
MINTiMINT-1352123.
STRINGi9606.ENSP00000263409.

Structurei

Secondary structure

1
1097
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi55 – 595Combined sources
Beta strandi62 – 665Combined sources
Beta strandi71 – 733Combined sources
Beta strandi79 – 835Combined sources
Beta strandi85 – 873Combined sources
Beta strandi89 – 979Combined sources
Beta strandi104 – 1063Combined sources
Beta strandi110 – 1134Combined sources
Beta strandi145 – 1473Combined sources
Turni148 – 1514Combined sources
Beta strandi152 – 1598Combined sources
Helixi161 – 1633Combined sources
Beta strandi169 – 18113Combined sources
Beta strandi183 – 19210Combined sources
Helixi194 – 1963Combined sources
Beta strandi199 – 2068Combined sources
Beta strandi216 – 22510Combined sources
Beta strandi231 – 2333Combined sources
Beta strandi242 – 2443Combined sources
Beta strandi254 – 2563Combined sources
Beta strandi258 – 2625Combined sources
Beta strandi267 – 2715Combined sources
Beta strandi277 – 2848Combined sources
Beta strandi293 – 2953Combined sources
Beta strandi297 – 3015Combined sources
Beta strandi312 – 3209Combined sources
Beta strandi322 – 3309Combined sources
Beta strandi337 – 3459Combined sources
Beta strandi348 – 3547Combined sources
Helixi363 – 3653Combined sources
Beta strandi368 – 3736Combined sources
Turni374 – 3763Combined sources
Beta strandi379 – 3824Combined sources
Beta strandi393 – 3986Combined sources
Beta strandi406 – 4138Combined sources
Beta strandi418 – 4258Combined sources
Helixi427 – 4304Combined sources
Beta strandi437 – 4415Combined sources
Beta strandi444 – 4485Combined sources
Beta strandi451 – 4544Combined sources
Beta strandi467 – 4715Combined sources
Beta strandi473 – 4753Combined sources
Beta strandi479 – 4813Combined sources
Beta strandi488 – 4914Combined sources
Beta strandi501 – 5044Combined sources
Beta strandi506 – 5105Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3E0GX-ray3.10A52-534[»]
ProteinModelPortaliP42702.
SMRiP42702. Positions 52-822.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42702.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini49 – 13890Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini335 – 434100Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini435 – 534100Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini538 – 62992Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini627 – 71993Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST
Domaini724 – 833110Fibronectin type-III 6PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi519 – 5235WSXWS motif
Motifi869 – 8779Box 1 motif

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 6 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG147644.
GeneTreeiENSGT00550000074436.
HOGENOMiHOG000113324.
HOVERGENiHBG006266.
InParanoidiP42702.
KOiK05058.
OMAiFYPDIPN.
OrthoDBiEOG7V49XP.
PhylomeDBiP42702.
TreeFamiTF338122.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR003961. Fibronectin_type3.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 5 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 5 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P42702-1) [UniParc]FASTAAdd to Basket

Also known as: Membrane

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMDIYVCLKR PSWMVDNKRM RTASNFQWLL STFILLYLMN QVNSQKKGAP
60 70 80 90 100
HDLKCVTNNL QVWNCSWKAP SGTGRGTDYE VCIENRSRSC YQLEKTSIKI
110 120 130 140 150
PALSHGDYEI TINSLHDFGS STSKFTLNEQ NVSLIPDTPE ILNLSADFST
160 170 180 190 200
STLYLKWNDR GSVFPHRSNV IWEIKVLRKE SMELVKLVTH NTTLNGKDTL
210 220 230 240 250
HHWSWASDMP LECAIHFVEI RCYIDNLHFS GLEEWSDWSP VKNISWIPDS
260 270 280 290 300
QTKVFPQDKV ILVGSDITFC CVSQEKVLSA LIGHTNCPLI HLDGENVAIK
310 320 330 340 350
IRNISVSASS GTNVVFTTED NIFGTVIFAG YPPDTPQQLN CETHDLKEII
360 370 380 390 400
CSWNPGRVTA LVGPRATSYT LVESFSGKYV RLKRAEAPTN ESYQLLFQML
410 420 430 440 450
PNQEIYNFTL NAHNPLGRSQ STILVNITEK VYPHTPTSFK VKDINSTAVK
460 470 480 490 500
LSWHLPGNFA KINFLCEIEI KKSNSVQEQR NVTIKGVENS SYLVALDKLN
510 520 530 540 550
PYTLYTFRIR CSTETFWKWS KWSNKKQHLT TEASPSKGPD TWREWSSDGK
560 570 580 590 600
NLIIYWKPLP INEANGKILS YNVSCSSDEE TQSLSEIPDP QHKAEIRLDK
610 620 630 640 650
NDYIISVVAK NSVGSSPPSK IASMEIPNDD LKIEQVVGMG KGILLTWHYD
660 670 680 690 700
PNMTCDYVIK WCNSSRSEPC LMDWRKVPSN STETVIESDE FRPGIRYNFF
710 720 730 740 750
LYGCRNQGYQ LLRSMIGYIE ELAPIVAPNF TVEDTSADSI LVKWEDIPVE
760 770 780 790 800
ELRGFLRGYL FYFGKGERDT SKMRVLESGR SDIKVKNITD ISQKTLRIAD
810 820 830 840 850
LQGKTSYHLV LRAYTDGGVG PEKSMYVVTK ENSVGLIIAI LIPVAVAVIV
860 870 880 890 900
GVVTSILCYR KREWIKETFY PDIPNPENCK ALQFQKSVCE GSSALKTLEM
910 920 930 940 950
NPCTPNNVEV LETRSAFPKI EDTEIISPVA ERPEDRSDAE PENHVVVSYC
960 970 980 990 1000
PPIIEEEIPN PAADEAGGTA QVIYIDVQSM YQPQAKPEEE QENDPVGGAG
1010 1020 1030 1040 1050
YKPQMHLPIN STVEDIAAEE DLDKTAGYRP QANVNTWNLV SPDSPRSIDS
1060 1070 1080 1090
NSEIVSFGSP CSINSRQFLI PPKDEDSPKS NGGGWSFTNF FQNKPND
Length:1,097
Mass (Da):123,743
Last modified:November 1, 1995 - v1
Checksum:iC8602897E359FCE5
GO
Isoform 2 (identifier: P42702-2)

Also known as: Secreted

Sequence is not available

Note: No experimental confirmation available.

Length:
Mass (Da):

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti116 – 1161H → Y.
Corresponds to variant rs3729734 [ dbSNP | Ensembl ].
VAR_029109
Natural varianti279 – 2791S → P in STWS. 1 Publication
VAR_025666
Natural varianti578 – 5781D → N.
Corresponds to variant rs3729740 [ dbSNP | Ensembl ].
VAR_029110
Natural varianti633 – 6331I → M.
Corresponds to variant rs2303743 [ dbSNP | Ensembl ].
VAR_021996
Natural varianti664 – 6641S → L.
Corresponds to variant rs3729744 [ dbSNP | Ensembl ].
VAR_038626
Natural varianti785 – 7851V → I.
Corresponds to variant rs3110234 [ dbSNP | Ensembl ].
VAR_029111
Natural varianti1068 – 10681F → L in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_036166

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61615 mRNA. Translation: CAA43805.1.
U66563 mRNA. Translation: AAB61897.1.
CCDSiCCDS3927.1. [P42702-1]
PIRiS17308.
RefSeqiNP_001121143.1. NM_001127671.1. [P42702-1]
NP_002301.1. NM_002310.5. [P42702-1]
UniGeneiHs.133421.

Genome annotation databases

EnsembliENST00000263409; ENSP00000263409; ENSG00000113594. [P42702-1]
ENST00000453190; ENSP00000398368; ENSG00000113594. [P42702-1]
GeneIDi3977.
KEGGihsa:3977.
UCSCiuc003jli.2. human. [P42702-1]

Polymorphism databases

DMDMi1170784.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61615 mRNA. Translation: CAA43805.1 .
U66563 mRNA. Translation: AAB61897.1 .
CCDSi CCDS3927.1. [P42702-1 ]
PIRi S17308.
RefSeqi NP_001121143.1. NM_001127671.1. [P42702-1 ]
NP_002301.1. NM_002310.5. [P42702-1 ]
UniGenei Hs.133421.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3E0G X-ray 3.10 A 52-534 [» ]
ProteinModelPortali P42702.
SMRi P42702. Positions 52-822.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110165. 7 interactions.
DIPi DIP-5770N.
MINTi MINT-1352123.
STRINGi 9606.ENSP00000263409.

Chemistry

ChEMBLi CHEMBL3137274.

PTM databases

PhosphoSitei P42702.

Polymorphism databases

DMDMi 1170784.

Proteomic databases

MaxQBi P42702.
PaxDbi P42702.
PRIDEi P42702.

Protocols and materials databases

DNASUi 3977.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263409 ; ENSP00000263409 ; ENSG00000113594 . [P42702-1 ]
ENST00000453190 ; ENSP00000398368 ; ENSG00000113594 . [P42702-1 ]
GeneIDi 3977.
KEGGi hsa:3977.
UCSCi uc003jli.2. human. [P42702-1 ]

Organism-specific databases

CTDi 3977.
GeneCardsi GC05M038475.
HGNCi HGNC:6597. LIFR.
HPAi CAB010252.
HPA004478.
MIMi 151443. gene.
601559. phenotype.
neXtProti NX_P42702.
Orphaneti 3206. Stuve-Wiedemann syndrome.
PharmGKBi PA30371.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG147644.
GeneTreei ENSGT00550000074436.
HOGENOMi HOG000113324.
HOVERGENi HBG006266.
InParanoidi P42702.
KOi K05058.
OMAi FYPDIPN.
OrthoDBi EOG7V49XP.
PhylomeDBi P42702.
TreeFami TF338122.

Enzyme and pathway databases

SignaLinki P42702.

Miscellaneous databases

ChiTaRSi LIFR. human.
EvolutionaryTracei P42702.
GeneWikii Leukemia_inhibitory_factor_receptor.
GenomeRNAii 3977.
NextBioi 15588.
PROi P42702.
SOURCEi Search...

Gene expression databases

Bgeei P42702.
CleanExi HS_LIFR.
ExpressionAtlasi P42702. baseline and differential.
Genevestigatori P42702.

Family and domain databases

Gene3Di 2.60.40.10. 5 hits.
InterProi IPR003961. Fibronectin_type3.
IPR003529. Hematopoietin_rcpt_Gp130_CS.
IPR013783. Ig-like_fold.
[Graphical view ]
Pfami PF00041. fn3. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 5 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 4 hits.
PROSITEi PS50853. FN3. 5 hits.
PS01353. HEMATOPO_REC_L_F2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130."
    Gearing D.P., Thut C.J., Vanden Bos T., Gimpel S.D., Delaney P.B., King J., Price V., Cosman D., Beckmann M.P.
    EMBO J. 10:2839-2848(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Placenta.
  2. "Human LIF receptor 3' non-coding region."
    Wang Z., Melmed S.
    Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 942-1097.
  3. "The recurrent translocation t(5;8)(p13;q12) in pleomorphic adenomas results in upregulation of PLAG1 gene expression under control of the LIFR promoter."
    Voz M.L., Astrom A.-K., Kas K., Mark J., Stenman G., Van de Ven W.J.M.
    Oncogene 16:1409-1416(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL TRANSLOCATION WITH PLAG1.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-927, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex."
    Skiniotis G., Lupardus P.J., Martick M., Walz T., Garcia K.C.
    Mol. Cell 31:737-748(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF 52-534, IDENTIFICATION IN A COMPLEX WITH IL6ST; CNTF AND CNTFR, GLYCOSYLATION AT ASN-131; ASN-303; ASN-407 AND ASN-426, DISULFIDE BONDS, ELECTRON MICROSCOPY, SUBUNIT.
  6. Cited for: VARIANT STWS PRO-279.
  7. Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-1068.

Entry informationi

Entry nameiLIFR_HUMAN
AccessioniPrimary (citable) accession number: P42702
Secondary accession number(s): Q6LCD9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3