ID   I12R1_HUMAN             Reviewed;         662 AA.
AC   P42701; A8K308; B2RPF1; B7ZKK3; Q8N6Q7;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   27-MAR-2024, entry version 210.
DE   RecName: Full=Interleukin-12 receptor subunit beta-1;
DE            Short=IL-12 receptor subunit beta-1;
DE            Short=IL-12R subunit beta-1;
DE            Short=IL-12R-beta-1;
DE            Short=IL-12RB1;
DE   AltName: Full=IL-12 receptor beta component;
DE   AltName: CD_antigen=CD212;
DE   Flags: Precursor;
GN   Name=IL12RB1; Synonyms=IL12R, IL12RB;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RX   PubMed=7911493;
RA   Chua A.O., Chizzonite R., Desai B.B., Truitt T.P., Nunes P., Minetti L.J.,
RA   Warrier R.R., Presky D.H., Levine J.F., Gately M.K., Gubler U.;
RT   "Expression cloning of a human IL-12 receptor component. A new member of
RT   the cytokine receptor superfamily with strong homology to gp130.";
RL   J. Immunol. 153:128-136(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Elloumi-Zghal H., Abdelhak S., Dellagi K.;
RT   "Genomic structure of IL12RB1 gene.";
RL   Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS GLN-3; SER-47; HIS-156;
RP   ARG-214; GLN-339; THR-365 AND ARG-378.
RG   SeattleSNPs variation discovery resource;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Umbilical cord blood;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), AND VARIANT
RP   ARG-214.
RC   TISSUE=Colon, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   SUBUNIT.
RX   PubMed=8943050; DOI=10.1073/pnas.93.24.14002;
RA   Presky D.H., Yang H., Minetti L.J., Chua A.O., Nabavi N., Wu C.-Y.,
RA   Gately M.K., Gubler U.;
RT   "A functional interleukin 12 receptor complex is composed of two beta-type
RT   cytokine receptor subunits.";
RL   Proc. Natl. Acad. Sci. U.S.A. 93:14002-14007(1996).
RN   [9]
RP   FUNCTION, AND INTERACTION WITH IL23R.
RX   PubMed=12023369; DOI=10.4049/jimmunol.168.11.5699;
RA   Parham C., Chirica M., Timans J., Vaisberg E., Travis M., Cheung J.,
RA   Pflanz S., Zhang R., Singh K.P., Vega F., To W., Wagner J.,
RA   O'Farrell A.-M., McClanahan T.K., Zurawski S., Hannum C., Gorman D.,
RA   Rennick D.M., Kastelein R.A., de Waal Malefyt R., Moore K.W.;
RT   "A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1
RT   and a novel cytokine receptor subunit, IL-23R.";
RL   J. Immunol. 168:5699-5708(2002).
RN   [10]
RP   VARIANT IMD30 TRP-213.
RX   PubMed=11424023; DOI=10.1086/321999;
RA   Altare F., Ensser A., Breiman A., Reichenbach J., El Baghdadi J.,
RA   Fischer A., Emile J.-F., Gaillard J.-L., Meinl E., Casanova J.-L.;
RT   "Interleukin-12 receptor beta-1 deficiency in a patient with abdominal
RT   tuberculosis.";
RL   J. Infect. Dis. 184:231-236(2001).
CC   -!- FUNCTION: Functions as an interleukin receptor which binds interleukin-
CC       12 with low affinity and is involved in IL12 transduction. Associated
CC       with IL12RB2 it forms a functional, high affinity receptor for IL12.
CC       Associates also with IL23R to form the interleukin-23 receptor which
CC       functions in IL23 signal transduction probably through activation of
CC       the Jak-Stat signaling cascade. {ECO:0000269|PubMed:12023369}.
CC   -!- SUBUNIT: Dimer or oligomer; disulfide-linked. Interacts with IL12RB2 to
CC       form the high affinity IL12 receptor. Heterodimer with IL23R; in
CC       presence of IL23. The heterodimer forms the IL23 receptor.
CC       {ECO:0000269|PubMed:12023369, ECO:0000269|PubMed:8943050}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1; Synonyms=Long;
CC         IsoId=P42701-1; Sequence=Displayed;
CC       Name=2; Synonyms=Short;
CC         IsoId=P42701-2; Sequence=VSP_001715;
CC       Name=3;
CC         IsoId=P42701-3; Sequence=VSP_037043, VSP_037044;
CC   -!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
CC       folding and thereby efficient intracellular transport and cell-surface
CC       receptor binding.
CC   -!- DOMAIN: The box 1 motif is required for JAK interaction and/or
CC       activation.
CC   -!- DISEASE: Immunodeficiency 30 (IMD30) [MIM:614891]: A form of Mendelian
CC       susceptibility to mycobacterial disease, a rare condition caused by
CC       impairment of interferon-gamma mediated immunity. It is characterized
CC       by predisposition to illness caused by moderately virulent
CC       mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine,
CC       environmental non-tuberculous mycobacteria, and by the more virulent
CC       Mycobacterium tuberculosis. Other microorganisms rarely cause severe
CC       clinical disease in individuals with susceptibility to mycobacterial
CC       infections, with the exception of Salmonella which infects less than
CC       50% of these individuals. Clinical outcome severity depends on the
CC       degree of impairment of interferon-gamma mediated immunity. Some
CC       patients die of overwhelming mycobacterial disease with lepromatous-
CC       like lesions in early childhood, whereas others develop, later in life,
CC       disseminated but curable infections with tuberculoid granulomas. IMD30
CC       has low penetrance, and affected individuals have relatively mild
CC       disease and good prognosis. BCG disease and salmonellosis are the most
CC       frequent infections in IMD30 patients. {ECO:0000269|PubMed:11424023}.
CC       Note=The disease is caused by variants affecting the gene represented
CC       in this entry.
CC   -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC       subfamily. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=IL12RB1base; Note=IL12RB1 mutation db;
CC       URL="http://structure.bmc.lu.se/idbase/IL12RB1base/";
CC   -!- WEB RESOURCE: Name=SeattleSNPs;
CC       URL="http://pga.gs.washington.edu/data/il12rb1/";
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DR   EMBL; U03187; AAA21340.1; -; mRNA.
DR   EMBL; AJ297688; CAC10446.1; -; Genomic_DNA.
DR   EMBL; AJ297689; CAC10446.1; JOINED; Genomic_DNA.
DR   EMBL; AJ297690; CAC10446.1; JOINED; Genomic_DNA.
DR   EMBL; AJ297691; CAC10446.1; JOINED; Genomic_DNA.
DR   EMBL; AJ297692; CAC10446.1; JOINED; Genomic_DNA.
DR   EMBL; AJ297693; CAC10446.1; JOINED; Genomic_DNA.
DR   EMBL; AJ297694; CAC10446.1; JOINED; Genomic_DNA.
DR   EMBL; AJ297695; CAC10446.1; JOINED; Genomic_DNA.
DR   EMBL; AJ297696; CAC10446.1; JOINED; Genomic_DNA.
DR   EMBL; AJ297697; CAC10446.1; JOINED; Genomic_DNA.
DR   EMBL; AJ297698; CAC10446.1; JOINED; Genomic_DNA.
DR   EMBL; AJ297699; CAC10446.1; JOINED; Genomic_DNA.
DR   EMBL; AJ297700; CAC10446.1; JOINED; Genomic_DNA.
DR   EMBL; AJ297701; CAC10446.1; JOINED; Genomic_DNA.
DR   EMBL; AY771996; AAV28734.1; -; Genomic_DNA.
DR   EMBL; AK290423; BAF83112.1; -; mRNA.
DR   EMBL; AC020904; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471106; EAW84656.1; -; Genomic_DNA.
DR   EMBL; BC029121; AAH29121.1; -; mRNA.
DR   EMBL; BC137404; AAI37405.1; -; mRNA.
DR   EMBL; BC137406; AAI37407.1; -; mRNA.
DR   CCDS; CCDS32957.1; -. [P42701-3]
DR   CCDS; CCDS54232.1; -. [P42701-1]
DR   PIR; I37892; I37892.
DR   RefSeq; NP_001276952.1; NM_001290023.1. [P42701-2]
DR   RefSeq; NP_005526.1; NM_005535.2. [P42701-1]
DR   RefSeq; NP_714912.1; NM_153701.2. [P42701-3]
DR   PDB; 6WDP; X-ray; 2.01 A; A=27-239.
DR   PDB; 6WDQ; X-ray; 3.40 A; D=27-239.
DR   PDBsum; 6WDP; -.
DR   PDBsum; 6WDQ; -.
DR   AlphaFoldDB; P42701; -.
DR   EMDB; EMD-21645; -.
DR   EMDB; EMD-21646; -.
DR   SMR; P42701; -.
DR   BioGRID; 109808; 109.
DR   ComplexPortal; CPX-382; Interleukin-12-receptor complex.
DR   ComplexPortal; CPX-383; Interleukin-23-receptor complex.
DR   CORUM; P42701; -.
DR   DIP; DIP-3773N; -.
DR   IntAct; P42701; 17.
DR   MINT; P42701; -.
DR   STRING; 9606.ENSP00000470788; -.
DR   ChEMBL; CHEMBL4523226; -.
DR   GlyCosmos; P42701; 6 sites, No reported glycans.
DR   GlyGen; P42701; 6 sites.
DR   iPTMnet; P42701; -.
DR   PhosphoSitePlus; P42701; -.
DR   BioMuta; IL12RB1; -.
DR   DMDM; 1170462; -.
DR   MassIVE; P42701; -.
DR   MaxQB; P42701; -.
DR   PaxDb; 9606-ENSP00000470788; -.
DR   PeptideAtlas; P42701; -.
DR   ProteomicsDB; 55543; -. [P42701-1]
DR   ProteomicsDB; 55544; -. [P42701-2]
DR   ABCD; P42701; 2 sequenced antibodies.
DR   Antibodypedia; 14966; 555 antibodies from 40 providers.
DR   DNASU; 3594; -.
DR   Ensembl; ENST00000322153.11; ENSP00000314425.5; ENSG00000096996.16. [P42701-3]
DR   Ensembl; ENST00000593993.7; ENSP00000472165.2; ENSG00000096996.16. [P42701-1]
DR   Ensembl; ENST00000600835.6; ENSP00000470788.1; ENSG00000096996.16. [P42701-1]
DR   GeneID; 3594; -.
DR   KEGG; hsa:3594; -.
DR   MANE-Select; ENST00000593993.7; ENSP00000472165.2; NM_005535.3; NP_005526.1.
DR   UCSC; uc002nhw.2; human. [P42701-1]
DR   AGR; HGNC:5971; -.
DR   CTD; 3594; -.
DR   DisGeNET; 3594; -.
DR   GeneCards; IL12RB1; -.
DR   HGNC; HGNC:5971; IL12RB1.
DR   HPA; ENSG00000096996; Tissue enhanced (lymphoid).
DR   MalaCards; IL12RB1; -.
DR   MIM; 601604; gene.
DR   MIM; 614891; phenotype.
DR   neXtProt; NX_P42701; -.
DR   OpenTargets; ENSG00000096996; -.
DR   Orphanet; 319552; Mendelian susceptibility to mycobacterial diseases due to complete IL12RB1 deficiency.
DR   Orphanet; 186; Primary biliary cholangitis.
DR   PharmGKB; PA29786; -.
DR   VEuPathDB; HostDB:ENSG00000096996; -.
DR   eggNOG; ENOG502S2KP; Eukaryota.
DR   GeneTree; ENSGT00390000012431; -.
DR   HOGENOM; CLU_031440_0_0_1; -.
DR   InParanoid; P42701; -.
DR   OMA; ECSWEYE; -.
DR   OrthoDB; 5302074at2759; -.
DR   PhylomeDB; P42701; -.
DR   TreeFam; TF338613; -.
DR   PathwayCommons; P42701; -.
DR   Reactome; R-HSA-9020591; Interleukin-12 signaling.
DR   Reactome; R-HSA-9020933; Interleukin-23 signaling.
DR   SignaLink; P42701; -.
DR   SIGNOR; P42701; -.
DR   BioGRID-ORCS; 3594; 24 hits in 1139 CRISPR screens.
DR   ChiTaRS; IL12RB1; human.
DR   GeneWiki; Interleukin_12_receptor,_beta_1_subunit; -.
DR   GenomeRNAi; 3594; -.
DR   Pharos; P42701; Tbio.
DR   PRO; PR:P42701; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; P42701; Protein.
DR   Bgee; ENSG00000096996; Expressed in granulocyte and 125 other cell types or tissues.
DR   ExpressionAtlas; P42701; baseline and differential.
DR   GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0042022; C:interleukin-12 receptor complex; IDA:BHF-UCL.
DR   GO; GO:0072536; C:interleukin-23 receptor complex; IDA:BHF-UCL.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR   GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
DR   GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
DR   GO; GO:0071346; P:cellular response to type II interferon; IDA:BHF-UCL.
DR   GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR   GO; GO:0035722; P:interleukin-12-mediated signaling pathway; IDA:UniProt.
DR   GO; GO:0038155; P:interleukin-23-mediated signaling pathway; IEA:GOC.
DR   GO; GO:0042104; P:positive regulation of activated T cell proliferation; IDA:BHF-UCL.
DR   GO; GO:0002230; P:positive regulation of defense response to virus by host; IDA:BHF-UCL.
DR   GO; GO:0043382; P:positive regulation of memory T cell differentiation; ISS:BHF-UCL.
DR   GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; ISS:BHF-UCL.
DR   GO; GO:0002827; P:positive regulation of T-helper 1 type immune response; IDA:BHF-UCL.
DR   GO; GO:2000330; P:positive regulation of T-helper 17 cell lineage commitment; ISS:BHF-UCL.
DR   GO; GO:2000318; P:positive regulation of T-helper 17 type immune response; ISS:BHF-UCL.
DR   GO; GO:0032729; P:positive regulation of type II interferon production; IDA:BHF-UCL.
DR   GO; GO:0007165; P:signal transduction; IC:BHF-UCL.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR   InterPro; IPR013783; Ig-like_fold.
DR   PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR   PANTHER; PTHR23036:SF51; INTERLEUKIN-12 RECEPTOR SUBUNIT BETA-1; 1.
DR   Pfam; PF00041; fn3; 1.
DR   SMART; SM00060; FN3; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 1.
DR   PROSITE; PS50853; FN3; 3.
DR   PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
DR   Genevisible; P42701; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Disease variant; Disulfide bond;
KW   Glycoprotein; Membrane; Receptor; Reference proteome; Repeat; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..662
FT                   /note="Interleukin-12 receptor subunit beta-1"
FT                   /id="PRO_0000010917"
FT   TOPO_DOM        24..545
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        546..570
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        571..662
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          46..136
FT                   /note="Fibronectin type-III 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   DOMAIN          142..234
FT                   /note="Fibronectin type-III 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   DOMAIN          237..337
FT                   /note="Fibronectin type-III 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   DOMAIN          338..444
FT                   /note="Fibronectin type-III 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   DOMAIN          448..542
FT                   /note="Fibronectin type-III 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   REGION          626..648
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           222..226
FT                   /note="WSXWS motif"
FT   MOTIF           577..585
FT                   /note="Box 1 motif"
FT   CARBOHYD        121
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        329
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        346
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        352
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        442
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        456
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        52..62
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         341..422
FT                   /note="EPVALNISVGTNGTTMYWPARAQSMTYCIEWQPVGQDGGLATCSLTAPQDPD
FT                   PAGMATYSWSRESGAMGQEKCYYITIFASA -> DGMISAHCNLRLPDSRDSPASASRV
FT                   AGITGICHHTRLILYF (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:15489334"
FT                   /id="VSP_037043"
FT   VAR_SEQ         423..662
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039,
FT                   ECO:0000303|PubMed:15489334"
FT                   /id="VSP_037044"
FT   VAR_SEQ         659..662
FT                   /note="KAKM -> DR (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334,
FT                   ECO:0000303|PubMed:7911493"
FT                   /id="VSP_001715"
FT   VARIANT         3
FT                   /note="P -> Q (in dbSNP:rs17884651)"
FT                   /evidence="ECO:0000269|Ref.3"
FT                   /id="VAR_021281"
FT   VARIANT         47
FT                   /note="P -> S (in dbSNP:rs17887176)"
FT                   /evidence="ECO:0000269|Ref.3"
FT                   /id="VAR_021282"
FT   VARIANT         156
FT                   /note="R -> H (in dbSNP:rs11575926)"
FT                   /evidence="ECO:0000269|Ref.3"
FT                   /id="VAR_021283"
FT   VARIANT         213
FT                   /note="R -> W (in IMD30; dbSNP:rs121434494)"
FT                   /evidence="ECO:0000269|PubMed:11424023"
FT                   /id="VAR_015577"
FT   VARIANT         214
FT                   /note="Q -> R (in dbSNP:rs11575934)"
FT                   /evidence="ECO:0000269|PubMed:15489334, ECO:0000269|Ref.3"
FT                   /id="VAR_021284"
FT   VARIANT         339
FT                   /note="H -> Q (in dbSNP:rs17884957)"
FT                   /evidence="ECO:0000269|Ref.3"
FT                   /id="VAR_021285"
FT   VARIANT         365
FT                   /note="M -> T (in dbSNP:rs375947)"
FT                   /evidence="ECO:0000269|Ref.3"
FT                   /id="VAR_011986"
FT   VARIANT         378
FT                   /note="G -> R (in dbSNP:rs401502)"
FT                   /evidence="ECO:0000269|Ref.3"
FT                   /id="VAR_011987"
FT   STRAND          46..54
FT                   /evidence="ECO:0007829|PDB:6WDP"
FT   STRAND          56..68
FT                   /evidence="ECO:0007829|PDB:6WDP"
FT   STRAND          74..80
FT                   /evidence="ECO:0007829|PDB:6WDP"
FT   STRAND          86..92
FT                   /evidence="ECO:0007829|PDB:6WDP"
FT   STRAND          95..100
FT                   /evidence="ECO:0007829|PDB:6WDP"
FT   STRAND          107..119
FT                   /evidence="ECO:0007829|PDB:6WDP"
FT   STRAND          122..125
FT                   /evidence="ECO:0007829|PDB:6WDP"
FT   STRAND          129..132
FT                   /evidence="ECO:0007829|PDB:6WDP"
FT   HELIX           133..135
FT                   /evidence="ECO:0007829|PDB:6WDP"
FT   STRAND          147..151
FT                   /evidence="ECO:0007829|PDB:6WDP"
FT   STRAND          154..160
FT                   /evidence="ECO:0007829|PDB:6WDP"
FT   STRAND          167..175
FT                   /evidence="ECO:0007829|PDB:6WDP"
FT   STRAND          177..179
FT                   /evidence="ECO:0007829|PDB:6WDP"
FT   STRAND          182..189
FT                   /evidence="ECO:0007829|PDB:6WDP"
FT   STRAND          191..199
FT                   /evidence="ECO:0007829|PDB:6WDP"
FT   STRAND          206..214
FT                   /evidence="ECO:0007829|PDB:6WDP"
FT   STRAND          216..218
FT                   /evidence="ECO:0007829|PDB:6WDP"
FT   STRAND          229..231
FT                   /evidence="ECO:0007829|PDB:6WDP"
SQ   SEQUENCE   662 AA;  73109 MW;  541ADA60F62DA1EF CRC64;
     MEPLVTWVVP LLFLFLLSRQ GAACRTSECC FQDPPYPDAD SGSASGPRDL RCYRISSDRY
     ECSWQYEGPT AGVSHFLRCC LSSGRCCYFA AGSATRLQFS DQAGVSVLYT VTLWVESWAR
     NQTEKSPEVT LQLYNSVKYE PPLGDIKVSK LAGQLRMEWE TPDNQVGAEV QFRHRTPSSP
     WKLGDCGPQD DDTESCLCPL EMNVAQEFQL RRRQLGSQGS SWSKWSSPVC VPPENPPQPQ
     VRFSVEQLGQ DGRRRLTLKE QPTQLELPEG CQGLAPGTEV TYRLQLHMLS CPCKAKATRT
     LHLGKMPYLS GAAYNVAVIS SNQFGPGLNQ TWHIPADTHT EPVALNISVG TNGTTMYWPA
     RAQSMTYCIE WQPVGQDGGL ATCSLTAPQD PDPAGMATYS WSRESGAMGQ EKCYYITIFA
     SAHPEKLTLW STVLSTYHFG GNASAAGTPH HVSVKNHSLD SVSVDWAPSL LSTCPGVLKE
     YVVRCRDEDS KQVSEHPVQP TETQVTLSGL RAGVAYTVQV RADTAWLRGV WSQPQRFSIE
     VQVSDWLIFF ASLGSFLSIL LVGVLGYLGL NRAARHLCPP LPTPCASSAI EFPGGKETWQ
     WINPVDFQEE ASLQEALVVE MSWDKGERTE PLEKTELPEG APELALDTEL SLEDGDRCKA
     KM
//