P42701 (I12R1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-12 receptor subunit beta-1
Short name=IL-12 receptor subunit beta-1
Short name=IL-12R subunit beta-1
Short name=IL-12R-beta-1
Short name=IL-12RB1

Alternative name(s):
IL-12 receptor beta component
CD_antigen=CD212

Gene names

Name:	IL12RB1
Synonyms:	IL12R, IL12RB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	662 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. Ref.9
Subunit structure	Dimer or oligomer; disulfide-linked. Interacts with IL12RB2 to form the high affinity IL12 receptor. Heterodimer with IL23R; in presence of IL23. The heterodimer forms the IL23 receptor. Ref.8 Ref.9
Subcellular location	Membrane; Single-pass type I membrane protein.
Domain	The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif is required for JAK interaction and/or activation.
Involvement in disease	Mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]: This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10
Sequence similarities	Belongs to the type I cytokine receptor family. Type 2 subfamily. Contains 5 fibronectin type-III domains.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to interferon-gamma Inferred from direct assay Ref.9. Source: BHF-UCL interleukin-12-mediated signaling pathway Inferred from direct assay Ref.8. Source: GOC interleukin-23-mediated signaling pathway Inferred from direct assay Ref.9. Source: GOC positive regulation of T cell mediated cytotoxicity Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of T-helper 1 type immune response Inferred from direct assay PubMed 15114670. Source: BHF-UCL positive regulation of T-helper 17 cell lineage commitment Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of T-helper 17 type immune response Inferred from sequence or structural similarity. Source: BHF-UCL positive regulation of activated T cell proliferation Inferred from direct assay PubMed 11114383. Source: BHF-UCL positive regulation of defense response to virus by host Inferred from direct assay PubMed 12421946. Source: BHF-UCL positive regulation of interferon-gamma production Inferred from direct assay PubMed 11114383. Source: BHF-UCL positive regulation of memory T cell differentiation Inferred from sequence or structural similarity. Source: BHF-UCL
Cellular_component	interleukin-12 receptor complex Inferred from direct assay Ref.9. Source: BHF-UCL interleukin-23 receptor complex Inferred from direct assay Ref.9. Source: BHF-UCL
Molecular_function	cytokine receptor activity Traceable author statement Ref.8. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P42701-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P42701-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     659-662: KAKM → DR

Isoform 3 (identifier: P42701-3)

The sequence of this isoform differs from the canonical sequence as follows:
     341-422: EPVALNISVG...CYYITIFASA → DGMISAHCNL...CHHTRLILYF
     423-662: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 662	639	Interleukin-12 receptor subunit beta-1		PRO_0000010917
Regions
	Topological domain	24 – 545	522	Extracellular Potential
	Transmembrane	546 – 570	25	Helical; Potential
	Topological domain	571 – 662	92	Cytoplasmic Potential
	Domain	43 – 133	91	Fibronectin type-III 1
	Domain	143 – 236	94	Fibronectin type-III 2
	Domain	237 – 337	101	Fibronectin type-III 3
	Domain	338 – 444	107	Fibronectin type-III 4
	Domain	445 – 539	95	Fibronectin type-III 5
	Motif	222 – 226	5	WSXWS motif
	Motif	577 – 585	9	Box 1 motif
Amino acid modifications
	Glycosylation	121	1	N-linked (GlcNAc...) Potential
	Glycosylation	329	1	N-linked (GlcNAc...) Potential
	Glycosylation	346	1	N-linked (GlcNAc...) Potential
	Glycosylation	352	1	N-linked (GlcNAc...) Potential
	Glycosylation	442	1	N-linked (GlcNAc...) Potential
	Glycosylation	456	1	N-linked (GlcNAc...) Potential
	Disulfide bond	52 ↔ 62		By similarity
Natural variations
	Alternative sequence	341 – 422	82	EPVAL…IFASA → DGMISAHCNLRLPDSRDSPA SASRVAGITGICHHTRLILY F in isoform 3.		VSP_037043
	Alternative sequence	423 – 662	240	Missing in isoform 3.		VSP_037044
	Alternative sequence	659 – 662	4	KAKM → DR in isoform 2.		VSP_001715
	Natural variant	3	1	P → Q. Ref.3 Corresponds to variant rs17884651 [ dbSNP | Ensembl ].		VAR_021281
	Natural variant	47	1	P → S. Ref.3 Corresponds to variant rs17887176 [ dbSNP | Ensembl ].		VAR_021282
	Natural variant	156	1	R → H. Ref.3 Corresponds to variant rs11575926 [ dbSNP | Ensembl ].		VAR_021283
	Natural variant	213	1	R → W in MSMD. Ref.10		VAR_015577
	Natural variant	214	1	Q → R. Ref.3 Ref.7 Corresponds to variant rs11575934 [ dbSNP | Ensembl ].		VAR_021284
	Natural variant	339	1	H → Q. Ref.3 Corresponds to variant rs17884957 [ dbSNP | Ensembl ].		VAR_021285
	Natural variant	365	1	M → T. Ref.3 Corresponds to variant rs375947 [ dbSNP | Ensembl ].		VAR_011986
	Natural variant	378	1	G → R. Ref.3 Corresponds to variant rs401502 [ dbSNP | Ensembl ].		VAR_011987

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Long) [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 541ADA60F62DA1EF	FASTA	662	73,109
	10 20 30 40 50 60 MEPLVTWVVP LLFLFLLSRQ GAACRTSECC FQDPPYPDAD SGSASGPRDL RCYRISSDRY 70 80 90 100 110 120 ECSWQYEGPT AGVSHFLRCC LSSGRCCYFA AGSATRLQFS DQAGVSVLYT VTLWVESWAR 130 140 150 160 170 180 NQTEKSPEVT LQLYNSVKYE PPLGDIKVSK LAGQLRMEWE TPDNQVGAEV QFRHRTPSSP 190 200 210 220 230 240 WKLGDCGPQD DDTESCLCPL EMNVAQEFQL RRRQLGSQGS SWSKWSSPVC VPPENPPQPQ 250 260 270 280 290 300 VRFSVEQLGQ DGRRRLTLKE QPTQLELPEG CQGLAPGTEV TYRLQLHMLS CPCKAKATRT 310 320 330 340 350 360 LHLGKMPYLS GAAYNVAVIS SNQFGPGLNQ TWHIPADTHT EPVALNISVG TNGTTMYWPA 370 380 390 400 410 420 RAQSMTYCIE WQPVGQDGGL ATCSLTAPQD PDPAGMATYS WSRESGAMGQ EKCYYITIFA 430 440 450 460 470 480 SAHPEKLTLW STVLSTYHFG GNASAAGTPH HVSVKNHSLD SVSVDWAPSL LSTCPGVLKE 490 500 510 520 530 540 YVVRCRDEDS KQVSEHPVQP TETQVTLSGL RAGVAYTVQV RADTAWLRGV WSQPQRFSIE 550 560 570 580 590 600 VQVSDWLIFF ASLGSFLSIL LVGVLGYLGL NRAARHLCPP LPTPCASSAI EFPGGKETWQ 610 620 630 640 650 660 WINPVDFQEE ASLQEALVVE MSWDKGERTE PLEKTELPEG APELALDTEL SLEDGDRCKA KM
	Isoform 2 (Short) [UniParc]. Checksum: 93B9662DA1EF27F0	FASTA	660	72,921
	10 20 30 40 50 60 MEPLVTWVVP LLFLFLLSRQ GAACRTSECC FQDPPYPDAD SGSASGPRDL RCYRISSDRY 70 80 90 100 110 120 ECSWQYEGPT AGVSHFLRCC LSSGRCCYFA AGSATRLQFS DQAGVSVLYT VTLWVESWAR 130 140 150 160 170 180 NQTEKSPEVT LQLYNSVKYE PPLGDIKVSK LAGQLRMEWE TPDNQVGAEV QFRHRTPSSP 190 200 210 220 230 240 WKLGDCGPQD DDTESCLCPL EMNVAQEFQL RRRQLGSQGS SWSKWSSPVC VPPENPPQPQ 250 260 270 280 290 300 VRFSVEQLGQ DGRRRLTLKE QPTQLELPEG CQGLAPGTEV TYRLQLHMLS CPCKAKATRT 310 320 330 340 350 360 LHLGKMPYLS GAAYNVAVIS SNQFGPGLNQ TWHIPADTHT EPVALNISVG TNGTTMYWPA 370 380 390 400 410 420 RAQSMTYCIE WQPVGQDGGL ATCSLTAPQD PDPAGMATYS WSRESGAMGQ EKCYYITIFA 430 440 450 460 470 480 SAHPEKLTLW STVLSTYHFG GNASAAGTPH HVSVKNHSLD SVSVDWAPSL LSTCPGVLKE 490 500 510 520 530 540 YVVRCRDEDS KQVSEHPVQP TETQVTLSGL RAGVAYTVQV RADTAWLRGV WSQPQRFSIE 550 560 570 580 590 600 VQVSDWLIFF ASLGSFLSIL LVGVLGYLGL NRAARHLCPP LPTPCASSAI EFPGGKETWQ 610 620 630 640 650 660 WINPVDFQEE ASLQEALVVE MSWDKGERTE PLEKTELPEG APELALDTEL SLEDGDRCDR
	Isoform 3 [UniParc]. Checksum: 49C915FAD4B667BC	FASTA	381	42,366
	10 20 30 40 50 60 MEPLVTWVVP LLFLFLLSRQ GAACRTSECC FQDPPYPDAD SGSASGPRDL RCYRISSDRY 70 80 90 100 110 120 ECSWQYEGPT AGVSHFLRCC LSSGRCCYFA AGSATRLQFS DQAGVSVLYT VTLWVESWAR 130 140 150 160 170 180 NQTEKSPEVT LQLYNSVKYE PPLGDIKVSK LAGQLRMEWE TPDNQVGAEV QFRHRTPSSP 190 200 210 220 230 240 WKLGDCGPQD DDTESCLCPL EMNVAQEFQL RRRQLGSQGS SWSKWSSPVC VPPENPPQPQ 250 260 270 280 290 300 VRFSVEQLGQ DGRRRLTLKE QPTQLELPEG CQGLAPGTEV TYRLQLHMLS CPCKAKATRT 310 320 330 340 350 360 LHLGKMPYLS GAAYNVAVIS SNQFGPGLNQ TWHIPADTHT DGMISAHCNL RLPDSRDSPA 370 380 SASRVAGITG ICHHTRLILY F

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130." Chua A.O., Chizzonite R., Desai B.B., Truitt T.P., Nunes P., Minetti L.J., Warrier R.R., Presky D.H., Levine J.F., Gately M.K., Gubler U. J. Immunol. 153:128-136(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]	"Genomic structure of IL12RB1 gene." Elloumi-Zghal H., Abdelhak S., Dellagi K. Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	SeattleSNPs variation discovery resource Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLN-3; SER-47; HIS-156; ARG-214; GLN-339; THR-365 AND ARG-378.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Umbilical cord blood.
[5]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT ARG-214. Tissue: Colon and Testis.
[8]	"A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits." Presky D.H., Yang H., Minetti L.J., Chua A.O., Nabavi N., Wu C.-Y., Gately M.K., Gubler U. Proc. Natl. Acad. Sci. U.S.A. 93:14002-14007(1996) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT.
[9]	"A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R." Parham C., Chirica M., Timans J., Vaisberg E., Travis M., Cheung J., Pflanz S., Zhang R., Singh K.P., Vega F., To W., Wagner J., O'Farrell A.-M., McClanahan T.K., Zurawski S., Hannum C., Gorman D., Rennick D.M. , Kastelein R.A., de Waal Malefyt R., Moore K.W. J. Immunol. 168:5699-5708(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH IL23R.
[10]	"Interleukin-12 receptor beta-1 deficiency in a patient with abdominal tuberculosis." Altare F., Ensser A., Breiman A., Reichenbach J., El Baghdadi J., Fischer A., Emile J.-F., Gaillard J.-L., Meinl E., Casanova J.-L. J. Infect. Dis. 184:231-236(2001) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT MSMD TRP-213.
+	Additional computationally mapped references.

Web resources

IL12RB1base

IL12RB1 mutation db

GeneReviews

SeattleSNPs

Cross-references

Sequence databases
EMBL GenBank DDBJ	U03187 mRNA. Translation: AAA21340.1. AJ297688 , AJ297689, AJ297690, AJ297691, AJ297692, AJ297693, AJ297694, AJ297695, AJ297696, AJ297697, AJ297698, AJ297699, AJ297700, AJ297701 Genomic DNA. Translation: CAC10446.1. AY771996 Genomic DNA. Translation: AAV28734.1. AK290423 mRNA. Translation: BAF83112.1. AC020904 Genomic DNA. No translation available. CH471106 Genomic DNA. Translation: EAW84656.1. BC029121 mRNA. Translation: AAH29121.1. BC137404 mRNA. Translation: AAI37405.1. BC137406 mRNA. Translation: AAI37407.1.
IPI	IPI00001400. IPI00218703. IPI00297449.
PIR	I37892.
RefSeq	NP_005526.1. NM_005535.1. NP_714912.1. NM_153701.1.
UniGene	Hs.567294.
3D structure databases
ProteinModelPortal	P42701.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3773N.
IntAct	P42701. 3 interactions.
STRING	9606.ENSP00000314425.
PTM databases
PhosphoSite	P42701.
Polymorphism databases
DMDM	1170462.
Proteomic databases
PaxDb	P42701.
PRIDE	P42701.
Protocols and materials databases
DNASU	3594.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000322153; ENSP00000314425; ENSG00000096996. ENST00000430026; ENSP00000403103; ENSG00000096996. ENST00000593993; ENSP00000472165; ENSG00000096996. ENST00000600835; ENSP00000470788; ENSG00000096996.
GeneID	3594.
KEGG	hsa:3594.
UCSC	uc002nhw.1. human. uc002nhy.3. human. uc010xqb.1. human.
Organism-specific databases
CTD	3594.
GeneCards	GC19M018170.
HGNC	HGNC:5971. IL12RB1.
MIM	209950. phenotype. 601604. gene.
neXtProt	NX_P42701.
Orphanet	748. Mendelian susceptibility to mycobacterial diseases. 186. Primary biliary cirrhosis.
PharmGKB	PA29786.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG42645.
HOGENOM	HOG000082476.
HOVERGEN	HBG052058.
InParanoid	P42701.
KO	K05063.
OMA	CPGVLKE.
OrthoDB	EOG43TZV3.
Enzyme and pathway databases
Pathway_Interaction_DB	il12_2pathway. IL12-mediated signaling events. il23pathway. IL23-mediated signaling events. il27pathway. IL27-mediated signaling events.
Gene expression databases
Bgee	P42701.
CleanEx	HS_IL12RB1.
Genevestigator	P42701.
GermOnline	ENSG00000096996. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 2 hits.
InterPro	IPR003961. Fibronectin_type3. IPR003529. Hematopoietin_rcpt_Gp130_CS. IPR013783. Ig-like_fold. [Graphical view]
Pfam	PF00041. fn3. 1 hit. [Graphical view]
SMART	SM00060. FN3. 1 hit. [Graphical view]
SUPFAM	SSF49265. FN_III-like. 1 hit.
PROSITE	PS50853. FN3. 1 hit. PS01353. HEMATOPO_REC_L_F2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	3594.
NextBio	14043.
SOURCE	Search...

Entry information

Entry name

I12R1_HUMAN

Accession

Primary (citable) accession number: P42701
Secondary accession number(s): A8K308 , B2RPF1, B7ZKK3, Q8N6Q7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 136 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.