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P42701

- I12R1_HUMAN

UniProt

P42701 - I12R1_HUMAN

Protein

Interleukin-12 receptor subunit beta-1

Gene

IL12RB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 150 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.1 Publication

    GO - Molecular functioni

    1. cytokine receptor activity Source: UniProtKB

    GO - Biological processi

    1. cellular response to interferon-gamma Source: BHF-UCL
    2. cytokine-mediated signaling pathway Source: BHF-UCL
    3. interleukin-12-mediated signaling pathway Source: GOC
    4. interleukin-23-mediated signaling pathway Source: GOC
    5. peptidyl-tyrosine phosphorylation Source: Ensembl
    6. positive regulation of activated T cell proliferation Source: BHF-UCL
    7. positive regulation of defense response to virus by host Source: BHF-UCL
    8. positive regulation of interferon-gamma production Source: BHF-UCL
    9. positive regulation of memory T cell differentiation Source: BHF-UCL
    10. positive regulation of T cell mediated cytotoxicity Source: BHF-UCL
    11. positive regulation of T-helper 17 cell lineage commitment Source: BHF-UCL
    12. positive regulation of T-helper 17 type immune response Source: BHF-UCL
    13. positive regulation of T-helper 1 type immune response Source: BHF-UCL
    14. signal transduction Source: BHF-UCL

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    SignaLinkiP42701.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-12 receptor subunit beta-1
    Short name:
    IL-12 receptor subunit beta-1
    Short name:
    IL-12R subunit beta-1
    Short name:
    IL-12R-beta-1
    Short name:
    IL-12RB1
    Alternative name(s):
    IL-12 receptor beta component
    CD_antigen: CD212
    Gene namesi
    Name:IL12RB1
    Synonyms:IL12R, IL12RB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:5971. IL12RB1.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. interleukin-12 receptor complex Source: BHF-UCL
    3. interleukin-23 receptor complex Source: BHF-UCL

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]: This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti213 – 2131R → W in MSMD. 1 Publication
    VAR_015577

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi209950. phenotype.
    Orphaneti319552. Mendelian susceptibility to mycobacterial diseases due to complete IL12RB1 deficiency.
    186. Primary biliary cirrhosis.
    PharmGKBiPA29786.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 662639Interleukin-12 receptor subunit beta-1PRO_0000010917Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi52 ↔ 62By similarity
    Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi329 – 3291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi346 – 3461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi352 – 3521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi442 – 4421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi456 – 4561N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP42701.
    PaxDbiP42701.
    PRIDEiP42701.

    PTM databases

    PhosphoSiteiP42701.

    Expressioni

    Gene expression databases

    ArrayExpressiP42701.
    BgeeiP42701.
    CleanExiHS_IL12RB1.
    GenevestigatoriP42701.

    Interactioni

    Subunit structurei

    Dimer or oligomer; disulfide-linked. Interacts with IL12RB2 to form the high affinity IL12 receptor. Heterodimer with IL23R; in presence of IL23. The heterodimer forms the IL23 receptor.2 Publications

    Protein-protein interaction databases

    BioGridi109808. 4 interactions.
    DIPiDIP-3773N.
    IntActiP42701. 3 interactions.
    STRINGi9606.ENSP00000314425.

    Structurei

    3D structure databases

    ProteinModelPortaliP42701.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini24 – 545522ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini571 – 66292CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei546 – 57025HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 13691Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini142 – 23493Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini237 – 337101Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini338 – 444107Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini448 – 54295Fibronectin type-III 5PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi222 – 2265WSXWS motif
    Motifi577 – 5859Box 1 motif

    Domaini

    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.

    Sequence similaritiesi

    Contains 5 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42645.
    HOGENOMiHOG000082476.
    HOVERGENiHBG052058.
    InParanoidiP42701.
    KOiK05063.
    OMAiCPGVLKE.
    OrthoDBiEOG79KPF9.
    PhylomeDBiP42701.
    TreeFamiTF338613.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR003529. Hematopoietin_rcpt_Gp130_CS.
    IPR013783. Ig-like_fold.
    [Graphical view]
    PfamiPF00041. fn3. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    PROSITEiPS50853. FN3. 3 hits.
    PS01353. HEMATOPO_REC_L_F2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P42701-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEPLVTWVVP LLFLFLLSRQ GAACRTSECC FQDPPYPDAD SGSASGPRDL    50
    RCYRISSDRY ECSWQYEGPT AGVSHFLRCC LSSGRCCYFA AGSATRLQFS 100
    DQAGVSVLYT VTLWVESWAR NQTEKSPEVT LQLYNSVKYE PPLGDIKVSK 150
    LAGQLRMEWE TPDNQVGAEV QFRHRTPSSP WKLGDCGPQD DDTESCLCPL 200
    EMNVAQEFQL RRRQLGSQGS SWSKWSSPVC VPPENPPQPQ VRFSVEQLGQ 250
    DGRRRLTLKE QPTQLELPEG CQGLAPGTEV TYRLQLHMLS CPCKAKATRT 300
    LHLGKMPYLS GAAYNVAVIS SNQFGPGLNQ TWHIPADTHT EPVALNISVG 350
    TNGTTMYWPA RAQSMTYCIE WQPVGQDGGL ATCSLTAPQD PDPAGMATYS 400
    WSRESGAMGQ EKCYYITIFA SAHPEKLTLW STVLSTYHFG GNASAAGTPH 450
    HVSVKNHSLD SVSVDWAPSL LSTCPGVLKE YVVRCRDEDS KQVSEHPVQP 500
    TETQVTLSGL RAGVAYTVQV RADTAWLRGV WSQPQRFSIE VQVSDWLIFF 550
    ASLGSFLSIL LVGVLGYLGL NRAARHLCPP LPTPCASSAI EFPGGKETWQ 600
    WINPVDFQEE ASLQEALVVE MSWDKGERTE PLEKTELPEG APELALDTEL 650
    SLEDGDRCKA KM 662
    Length:662
    Mass (Da):73,109
    Last modified:November 1, 1995 - v1
    Checksum:i541ADA60F62DA1EF
    GO
    Isoform 2 (identifier: P42701-2) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         659-662: KAKM → DR

    Show »
    Length:660
    Mass (Da):72,921
    Checksum:i93B9662DA1EF27F0
    GO
    Isoform 3 (identifier: P42701-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         341-422: EPVALNISVG...CYYITIFASA → DGMISAHCNL...CHHTRLILYF
         423-662: Missing.

    Show »
    Length:381
    Mass (Da):42,366
    Checksum:i49C915FAD4B667BC
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti3 – 31P → Q.1 Publication
    Corresponds to variant rs17884651 [ dbSNP | Ensembl ].
    VAR_021281
    Natural varianti47 – 471P → S.1 Publication
    Corresponds to variant rs17887176 [ dbSNP | Ensembl ].
    VAR_021282
    Natural varianti156 – 1561R → H.1 Publication
    Corresponds to variant rs11575926 [ dbSNP | Ensembl ].
    VAR_021283
    Natural varianti213 – 2131R → W in MSMD. 1 Publication
    VAR_015577
    Natural varianti214 – 2141Q → R.2 Publications
    Corresponds to variant rs11575934 [ dbSNP | Ensembl ].
    VAR_021284
    Natural varianti339 – 3391H → Q.1 Publication
    Corresponds to variant rs17884957 [ dbSNP | Ensembl ].
    VAR_021285
    Natural varianti365 – 3651M → T.1 Publication
    Corresponds to variant rs375947 [ dbSNP | Ensembl ].
    VAR_011986
    Natural varianti378 – 3781G → R.1 Publication
    Corresponds to variant rs401502 [ dbSNP | Ensembl ].
    VAR_011987

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei341 – 42282EPVAL…IFASA → DGMISAHCNLRLPDSRDSPA SASRVAGITGICHHTRLILY F in isoform 3. 2 PublicationsVSP_037043Add
    BLAST
    Alternative sequencei423 – 662240Missing in isoform 3. 2 PublicationsVSP_037044Add
    BLAST
    Alternative sequencei659 – 6624KAKM → DR in isoform 2. 2 PublicationsVSP_001715

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03187 mRNA. Translation: AAA21340.1.
    AJ297688
    , AJ297689, AJ297690, AJ297691, AJ297692, AJ297693, AJ297694, AJ297695, AJ297696, AJ297697, AJ297698, AJ297699, AJ297700, AJ297701 Genomic DNA. Translation: CAC10446.1.
    AY771996 Genomic DNA. Translation: AAV28734.1.
    AK290423 mRNA. Translation: BAF83112.1.
    AC020904 Genomic DNA. No translation available.
    CH471106 Genomic DNA. Translation: EAW84656.1.
    BC029121 mRNA. Translation: AAH29121.1.
    BC137404 mRNA. Translation: AAI37405.1.
    BC137406 mRNA. Translation: AAI37407.1.
    CCDSiCCDS32957.1. [P42701-3]
    CCDS54232.1. [P42701-1]
    PIRiI37892.
    RefSeqiNP_001276952.1. NM_001290023.1. [P42701-2]
    NP_005526.1. NM_005535.2. [P42701-1]
    NP_714912.1. NM_153701.2. [P42701-3]
    UniGeneiHs.567294.

    Genome annotation databases

    EnsembliENST00000322153; ENSP00000314425; ENSG00000096996. [P42701-3]
    ENST00000593993; ENSP00000472165; ENSG00000096996. [P42701-1]
    ENST00000600835; ENSP00000470788; ENSG00000096996. [P42701-1]
    GeneIDi3594.
    KEGGihsa:3594.
    UCSCiuc002nhw.1. human. [P42701-1]
    uc002nhy.3. human. [P42701-3]
    uc010xqb.1. human. [P42701-2]

    Polymorphism databases

    DMDMi1170462.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    IL12RB1base

    IL12RB1 mutation db

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03187 mRNA. Translation: AAA21340.1 .
    AJ297688
    , AJ297689 , AJ297690 , AJ297691 , AJ297692 , AJ297693 , AJ297694 , AJ297695 , AJ297696 , AJ297697 , AJ297698 , AJ297699 , AJ297700 , AJ297701 Genomic DNA. Translation: CAC10446.1 .
    AY771996 Genomic DNA. Translation: AAV28734.1 .
    AK290423 mRNA. Translation: BAF83112.1 .
    AC020904 Genomic DNA. No translation available.
    CH471106 Genomic DNA. Translation: EAW84656.1 .
    BC029121 mRNA. Translation: AAH29121.1 .
    BC137404 mRNA. Translation: AAI37405.1 .
    BC137406 mRNA. Translation: AAI37407.1 .
    CCDSi CCDS32957.1. [P42701-3 ]
    CCDS54232.1. [P42701-1 ]
    PIRi I37892.
    RefSeqi NP_001276952.1. NM_001290023.1. [P42701-2 ]
    NP_005526.1. NM_005535.2. [P42701-1 ]
    NP_714912.1. NM_153701.2. [P42701-3 ]
    UniGenei Hs.567294.

    3D structure databases

    ProteinModelPortali P42701.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109808. 4 interactions.
    DIPi DIP-3773N.
    IntActi P42701. 3 interactions.
    STRINGi 9606.ENSP00000314425.

    PTM databases

    PhosphoSitei P42701.

    Polymorphism databases

    DMDMi 1170462.

    Proteomic databases

    MaxQBi P42701.
    PaxDbi P42701.
    PRIDEi P42701.

    Protocols and materials databases

    DNASUi 3594.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000322153 ; ENSP00000314425 ; ENSG00000096996 . [P42701-3 ]
    ENST00000593993 ; ENSP00000472165 ; ENSG00000096996 . [P42701-1 ]
    ENST00000600835 ; ENSP00000470788 ; ENSG00000096996 . [P42701-1 ]
    GeneIDi 3594.
    KEGGi hsa:3594.
    UCSCi uc002nhw.1. human. [P42701-1 ]
    uc002nhy.3. human. [P42701-3 ]
    uc010xqb.1. human. [P42701-2 ]

    Organism-specific databases

    CTDi 3594.
    GeneCardsi GC19M018170.
    HGNCi HGNC:5971. IL12RB1.
    MIMi 209950. phenotype.
    601604. gene.
    neXtProti NX_P42701.
    Orphaneti 319552. Mendelian susceptibility to mycobacterial diseases due to complete IL12RB1 deficiency.
    186. Primary biliary cirrhosis.
    PharmGKBi PA29786.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42645.
    HOGENOMi HOG000082476.
    HOVERGENi HBG052058.
    InParanoidi P42701.
    KOi K05063.
    OMAi CPGVLKE.
    OrthoDBi EOG79KPF9.
    PhylomeDBi P42701.
    TreeFami TF338613.

    Enzyme and pathway databases

    SignaLinki P42701.

    Miscellaneous databases

    GeneWikii Interleukin_12_receptor,_beta_1_subunit.
    GenomeRNAii 3594.
    NextBioi 14043.
    PROi P42701.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P42701.
    Bgeei P42701.
    CleanExi HS_IL12RB1.
    Genevestigatori P42701.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR003529. Hematopoietin_rcpt_Gp130_CS.
    IPR013783. Ig-like_fold.
    [Graphical view ]
    Pfami PF00041. fn3. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    PROSITEi PS50853. FN3. 3 hits.
    PS01353. HEMATOPO_REC_L_F2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130."
      Chua A.O., Chizzonite R., Desai B.B., Truitt T.P., Nunes P., Minetti L.J., Warrier R.R., Presky D.H., Levine J.F., Gately M.K., Gubler U.
      J. Immunol. 153:128-136(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    2. "Genomic structure of IL12RB1 gene."
      Elloumi-Zghal H., Abdelhak S., Dellagi K.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. SeattleSNPs variation discovery resource
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLN-3; SER-47; HIS-156; ARG-214; GLN-339; THR-365 AND ARG-378.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Umbilical cord blood.
    5. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANT ARG-214.
      Tissue: Colon and Testis.
    8. "A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits."
      Presky D.H., Yang H., Minetti L.J., Chua A.O., Nabavi N., Wu C.-Y., Gately M.K., Gubler U.
      Proc. Natl. Acad. Sci. U.S.A. 93:14002-14007(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT.
    9. Cited for: FUNCTION, INTERACTION WITH IL23R.
    10. Cited for: VARIANT MSMD TRP-213.

    Entry informationi

    Entry nameiI12R1_HUMAN
    AccessioniPrimary (citable) accession number: P42701
    Secondary accession number(s): A8K308
    , B2RPF1, B7ZKK3, Q8N6Q7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 150 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3