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Protein

60 kDa SS-A/Ro ribonucleoprotein

Gene

trove2

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs. May stabilize some of these RNAs and protect them from degradation.2 Publications
May play roles in cilia formation and/or maintenance.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi378 – 3781Divalent metal cation2 Publications
Metal bindingi380 – 3801Divalent metal cation2 Publications
Metal bindingi445 – 4451Divalent metal cation2 Publications

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • misfolded RNA binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Cilium biogenesis/degradation

Keywords - Ligandi

Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa SS-A/Ro ribonucleoprotein
Short name:
60 kDa Ro protein
Short name:
60 kDa ribonucleoprotein Ro
Short name:
RoRNP
Alternative name(s):
TROVE domain family member 2
Gene namesi
Name:trove2
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-968761. trove2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 53853860 kDa SS-A/Ro ribonucleoproteinPRO_0000174171Add
BLAST

Proteomic databases

PRIDEiP42700.

Structurei

Secondary structure

1
538
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi19 – 213Combined sources
Beta strandi23 – 264Combined sources
Helixi29 – 3911Combined sources
Beta strandi46 – 483Combined sources
Helixi50 – 6617Combined sources
Turni67 – 693Combined sources
Helixi70 – 8314Combined sources
Helixi90 – 10011Combined sources
Beta strandi101 – 1033Combined sources
Helixi105 – 11814Combined sources
Helixi122 – 13413Combined sources
Helixi146 – 15712Combined sources
Helixi161 – 1688Combined sources
Beta strandi174 – 1763Combined sources
Helixi179 – 1857Combined sources
Helixi193 – 20311Combined sources
Helixi206 – 2127Combined sources
Turni213 – 2153Combined sources
Helixi220 – 23617Combined sources
Helixi241 – 25111Combined sources
Helixi255 – 2573Combined sources
Helixi262 – 2643Combined sources
Helixi266 – 2749Combined sources
Helixi278 – 29013Combined sources
Turni291 – 2944Combined sources
Helixi299 – 30810Combined sources
Helixi311 – 3166Combined sources
Helixi321 – 33313Combined sources
Helixi347 – 35913Combined sources
Beta strandi371 – 3766Combined sources
Helixi379 – 3824Combined sources
Beta strandi383 – 3853Combined sources
Helixi392 – 40615Combined sources
Beta strandi408 – 42013Combined sources
Helixi430 – 4378Combined sources
Helixi449 – 4568Combined sources
Beta strandi462 – 4687Combined sources
Beta strandi474 – 4763Combined sources
Helixi479 – 49012Combined sources
Beta strandi495 – 5006Combined sources
Beta strandi502 – 5098Combined sources
Beta strandi516 – 5205Combined sources
Helixi526 – 5349Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YVPX-ray2.20A/B1-538[»]
1YVRX-ray1.95A1-538[»]
2I91X-ray2.65A/B1-538[»]
ProteinModelPortaliP42700.
SMRiP42700. Positions 4-537.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42700.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 369354TROVEPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni120 – 284165RNA-binding2 PublicationsAdd
BLAST
Regioni361 – 538178VWFA-like domainCuratedAdd
BLAST

Domaini

The horseshoe-shaped TROVE domain is built with 7 helical HEAT-like repeats, and is closed by the VWFA-like domain giving rise to a ring-shaped monomer. Single-stranded RNA is bound in the positively charged central cavity.
The MIDAS-like motif in the VWFA-like domain binds divalent metal cations.2 Publications

Sequence similaritiesi

Belongs to the Ro 60 kDa family.Curated
Contains 1 TROVE domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG013234.
KOiK11089.

Family and domain databases

InterProiIPR008858. TROVE_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF05731. TROVE. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS50988. TROVE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42700-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEATMDQTQP LNEKQVPNSE GCYVWQVSDM NRLRRFLCFG SEGGTYYIEE
60 70 80 90 100
KKLGQENAEA LLRLIEDGKG CEVVQEIKTF SQEGRAAKQE PTLFALAVCS
110 120 130 140 150
QCSDIKTKQA AFRAVPEVCR IPTHLFTFIQ FKKDLKEGMK CGMWGRALRK
160 170 180 190 200
AVSDWYNTKD ALNLAMAVTK YKQRNGWSHK DLLRLSHIKP ANEGLTMVAK
210 220 230 240 250
YVSKGWKEVQ EAYKEKELSP ETEKVLKYLE ATERVKRTKD ELEIIHLIDE
260 270 280 290 300
YRLVREHLLT IHLKSKEIWK SLLQDMPLTA LLRNLGKMTA DSVLAPASSE
310 320 330 340 350
VSSVCERLTN EKLLKKARIH PFHILVALET YKKGHGNRGK LRWIPDTSIV
360 370 380 390 400
EALDNAFYKS FKLVEPTGKR FLLAIDVSAS MNQRVLGSIL NASVVAAAMC
410 420 430 440 450
MLVARTEKDS HMVAFSDEML PCPITVNMLL HEVVEKMSDI TMGSTDCALP
460 470 480 490 500
MLWAQKTNTA ADIFIVFTDC ETNVEDVHPA TALKQYREKM GIPAKLIVCA
510 520 530
MTSNGFSIAD PDDRGMLDIC GFDSGALDVI RNFTLDLI
Length:538
Mass (Da):60,688
Last modified:November 1, 1995 - v1
Checksum:i548C17B0AE9EBFD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15430 mRNA. Translation: AAC38001.1.
PIRiI51560.
RefSeqiNP_001079344.1. NM_001085875.1.
UniGeneiXl.303.

Genome annotation databases

GeneIDi378688.
KEGGixla:378688.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L15430 mRNA. Translation: AAC38001.1.
PIRiI51560.
RefSeqiNP_001079344.1. NM_001085875.1.
UniGeneiXl.303.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YVPX-ray2.20A/B1-538[»]
1YVRX-ray1.95A1-538[»]
2I91X-ray2.65A/B1-538[»]
ProteinModelPortaliP42700.
SMRiP42700. Positions 4-537.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP42700.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi378688.
KEGGixla:378688.

Organism-specific databases

CTDi6738.
XenbaseiXB-GENE-968761. trove2.

Phylogenomic databases

HOVERGENiHBG013234.
KOiK11089.

Miscellaneous databases

EvolutionaryTraceiP42700.

Family and domain databases

InterProiIPR008858. TROVE_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF05731. TROVE. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS50988. TROVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRO60_XENLA
AccessioniPrimary (citable) accession number: P42700
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 17, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.