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Protein

RNA-binding protein 34

Gene

RBM34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000054267-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein 34
Alternative name(s):
RNA-binding motif protein 34
Gene namesi
Name:RBM34
Synonyms:KIAA0117
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:28965. RBM34.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188739.
PharmGKBiPA142671094.

Polymorphism and mutation databases

BioMutaiRBM34.
DMDMi57013870.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817901 – 430RNA-binding protein 34Add BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1
Modified residuei28PhosphoserineCombined sources1
Modified residuei99PhosphoserineCombined sources1
Modified residuei151N6-acetyllysineBy similarity1
Modified residuei288PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP42696.
MaxQBiP42696.
PaxDbiP42696.
PeptideAtlasiP42696.
PRIDEiP42696.

2D gel databases

SWISS-2DPAGEP42696.

PTM databases

iPTMnetiP42696.
PhosphoSitePlusiP42696.

Expressioni

Gene expression databases

BgeeiENSG00000188739.
CleanExiHS_RBM34.
ExpressionAtlasiP42696. baseline and differential.
GenevisibleiP42696. HS.

Organism-specific databases

HPAiHPA028606.

Interactioni

Protein-protein interaction databases

BioGridi116668. 129 interactors.
IntActiP42696. 9 interactors.
MINTiMINT-2803244.
STRINGi9606.ENSP00000386226.

Structurei

3D structure databases

ProteinModelPortaliP42696.
SMRiP42696.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini185 – 280RRM 1PROSITE-ProRule annotationAdd BLAST96
Domaini287 – 364RRM 2PROSITE-ProRule annotationAdd BLAST78

Sequence similaritiesi

Belongs to the RRM RBM34 family.Curated
Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00390000011249.
HOGENOMiHOG000060230.
HOVERGENiHBG052167.
InParanoidiP42696.
KOiK14837.
OMAiEHFLDCG.
OrthoDBiEOG091G0GEH.
PhylomeDBiP42696.
TreeFamiTF313083.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P42696-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALEGMSKRK RKRSVQEGEN PDDGVRGSPP EDYRLGQVAS SLFRGEHHSR
60 70 80 90 100
GGTGRLASLF SSLEPQIQPV YVPVPKQTIK KTKRNEEEES TSQIERPLSQ
110 120 130 140 150
EPAKKVKAKK KHTNAEKKLA DRESALASAD LEEEIHQKQG QKRKNSQPGV
160 170 180 190 200
KVADRKILDD TEDTVVSQRK KIQINQEEER LKNERTVFVG NLPVTCNKKK
210 220 230 240 250
LKSFFKEYGQ IESVRFRSLI PAEGTLSKKL AAIKRKIHPD QKNINAYVVF
260 270 280 290 300
KEESAATQAL KRNGAQIADG FRIRVDLASE TSSRDKRSVF VGNLPYKVEE
310 320 330 340 350
SAIEKHFLDC GSIMAVRIVR DKMTGIGKGF GYVLFENTDS VHLALKLNNS
360 370 380 390 400
ELMGRKLRVM RSVNKEKFKQ QNSNPRLKNV SKPKQGLNFT SKTAEGHPKS
410 420 430
LFIGEKAVLL KTKKKGQKKS GRPKKQRKQK
Length:430
Mass (Da):48,565
Last modified:October 10, 2003 - v2
Checksum:i6BA5C901E1C7C935
GO
Isoform 2 (identifier: P42696-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     220-225: IPAEGT → VCFIPP
     226-430: Missing.

Note: May be due to an intron retention.
Show »
Length:225
Mass (Da):25,577
Checksum:iB15E8AB7214E9D68
GO

Sequence cautioni

The sequence AAH29451 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA07503 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAF85051 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti94I → V in BAF85051 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_037037220 – 225IPAEGT → VCFIPP in isoform 2. 1 Publication6
Alternative sequenceiVSP_037038226 – 430Missing in isoform 2. 1 PublicationAdd BLAST205

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38491 mRNA. Translation: BAA07503.1. Different initiation.
AK292362 mRNA. Translation: BAF85051.1. Different initiation.
AL732292, AL133418 Genomic DNA. Translation: CAI21936.1.
AL133418, AL732292 Genomic DNA. Translation: CAI22960.1.
BC029451 mRNA. Translation: AAH29451.1. Different initiation.
CCDSiCCDS41477.2. [P42696-1]
RefSeqiNP_001155005.1. NM_001161533.1. [P42696-2]
NP_055829.2. NM_015014.2. [P42696-1]
UniGeneiHs.535224.

Genome annotation databases

EnsembliENST00000408888; ENSP00000386226; ENSG00000188739. [P42696-1]
GeneIDi23029.
KEGGihsa:23029.
UCSCiuc001hwn.3. human. [P42696-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38491 mRNA. Translation: BAA07503.1. Different initiation.
AK292362 mRNA. Translation: BAF85051.1. Different initiation.
AL732292, AL133418 Genomic DNA. Translation: CAI21936.1.
AL133418, AL732292 Genomic DNA. Translation: CAI22960.1.
BC029451 mRNA. Translation: AAH29451.1. Different initiation.
CCDSiCCDS41477.2. [P42696-1]
RefSeqiNP_001155005.1. NM_001161533.1. [P42696-2]
NP_055829.2. NM_015014.2. [P42696-1]
UniGeneiHs.535224.

3D structure databases

ProteinModelPortaliP42696.
SMRiP42696.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116668. 129 interactors.
IntActiP42696. 9 interactors.
MINTiMINT-2803244.
STRINGi9606.ENSP00000386226.

PTM databases

iPTMnetiP42696.
PhosphoSitePlusiP42696.

Polymorphism and mutation databases

BioMutaiRBM34.
DMDMi57013870.

2D gel databases

SWISS-2DPAGEP42696.

Proteomic databases

EPDiP42696.
MaxQBiP42696.
PaxDbiP42696.
PeptideAtlasiP42696.
PRIDEiP42696.

Protocols and materials databases

DNASUi23029.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000408888; ENSP00000386226; ENSG00000188739. [P42696-1]
GeneIDi23029.
KEGGihsa:23029.
UCSCiuc001hwn.3. human. [P42696-1]

Organism-specific databases

CTDi23029.
GeneCardsiRBM34.
HGNCiHGNC:28965. RBM34.
HPAiHPA028606.
neXtProtiNX_P42696.
OpenTargetsiENSG00000188739.
PharmGKBiPA142671094.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0118. Eukaryota.
COG0724. LUCA.
GeneTreeiENSGT00390000011249.
HOGENOMiHOG000060230.
HOVERGENiHBG052167.
InParanoidiP42696.
KOiK14837.
OMAiEHFLDCG.
OrthoDBiEOG091G0GEH.
PhylomeDBiP42696.
TreeFamiTF313083.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000054267-MONOMER.

Miscellaneous databases

ChiTaRSiRBM34. human.
GeneWikiiRBM34.
GenomeRNAii23029.
PROiP42696.

Gene expression databases

BgeeiENSG00000188739.
CleanExiHS_RBM34.
ExpressionAtlasiP42696. baseline and differential.
GenevisibleiP42696. HS.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRBM34_HUMAN
AccessioniPrimary (citable) accession number: P42696
Secondary accession number(s): A8K8J7, Q8N2Z8, Q9H5A1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 10, 2003
Last modified: November 2, 2016
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.