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Protein

Condensin-2 complex subunit D3

Gene

NCAPD3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.1 Publication

GO - Molecular functioni

  • chromatin binding Source: GO_Central
  • methylated histone binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, DNA condensation, Mitosis

Enzyme and pathway databases

ReactomeiR-HSA-2299718 Condensation of Prophase Chromosomes

Names & Taxonomyi

Protein namesi
Recommended name:
Condensin-2 complex subunit D3
Alternative name(s):
Non-SMC condensin II complex subunit D3
Short name:
hCAP-D3
Gene namesi
Name:NCAPD3
Synonyms:CAPD3, KIAA0056
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000151503.12
HGNCiHGNC:28952 NCAPD3
MIMi609276 gene
neXtProtiNX_P42695

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23310
OpenTargetsiENSG00000151503
PharmGKBiPA162397090

Polymorphism and mutation databases

BioMutaiNCAPD3
DMDMi82654946

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000507161 – 1498Condensin-2 complex subunit D3Add BLAST1498

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei567PhosphoserineCombined sources1
Modified residuei1329PhosphoserineCombined sources1
Modified residuei1331PhosphothreonineCombined sources1
Modified residuei1348PhosphoserineCombined sources1
Modified residuei1357PhosphoserineCombined sources1
Modified residuei1372PhosphoserineCombined sources1
Modified residuei1379PhosphothreonineCombined sources1
Modified residuei1382PhosphoserineCombined sources1
Modified residuei1384PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP42695
MaxQBiP42695
PaxDbiP42695
PeptideAtlasiP42695
PRIDEiP42695

PTM databases

iPTMnetiP42695
PhosphoSitePlusiP42695

Expressioni

Gene expression databases

BgeeiENSG00000151503
CleanExiHS_NCAPD3
ExpressionAtlasiP42695 baseline and differential
GenevisibleiP42695 HS

Organism-specific databases

HPAiHPA040286

Interactioni

Subunit structurei

Component of the condensin-2 complex, which contains the SMC2 and SMC4 heterodimer, and 3 non SMC subunits that probably regulate the complex: NCAPH2, NCAPD3 and NCAPG2. Interacts with BRD4 (isoform B), leading to insulate chromatin from DNA damage response pathway.2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • methylated histone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116902, 64 interactors
CORUMiP42695
DIPiDIP-43903N
IntActiP42695, 23 interactors
MINTiP42695
STRINGi9606.ENSP00000433681

Structurei

3D structure databases

ProteinModelPortaliP42695
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati441 – 475HEAT 1Add BLAST35
Repeati537 – 572HEAT 2Add BLAST36
Repeati579 – 610HEAT 3Add BLAST32
Repeati973 – 1009HEAT 4Add BLAST37

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1219 – 1275Sequence analysisAdd BLAST57

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0413 Eukaryota
ENOG410XSGK LUCA
GeneTreeiENSGT00390000011258
HOGENOMiHOG000111840
HOVERGENiHBG061537
InParanoidiP42695
KOiK11491
OMAiRAHAIIT
OrthoDBiEOG091G00PU
PhylomeDBiP42695
TreeFamiTF101162

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR026971 CND1/NCAPD3
IPR032682 Cnd1_C
IPR012371 NCAPD3
PANTHERiPTHR14222 PTHR14222, 1 hit
PfamiView protein in Pfam
PF12717 Cnd1, 1 hit
PIRSFiPIRSF036508 Condns_HCP-6, 1 hit
SUPFAMiSSF48371 SSF48371, 4 hits

Sequencei

Sequence statusi: Complete.

P42695-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVALRGLGSG LQPWCPLDLR LEWVDTVWEL DFTETEPLDP SIEAEIIETG
60 70 80 90 100
LAAFTKLYES LLPFATGEHG SMESIWTFFI ENNVSHSTLV ALFYHFVQIV
110 120 130 140 150
HKKNVSVQYR EYGLHAAGLY FLLLEVPGSV ANQVFHPVMF DKCIQTLKKS
160 170 180 190 200
WPQESNLNRK RKKEQPKSSQ ANPGRHRKRG KPPRREDIEM DEIIEEQEDE
210 220 230 240 250
NICFSARDLS QIRNAIFHLL KNFLRLLPKF SLKEKPQCVQ NCIEVFVSLT
260 270 280 290 300
NFEPVLHECH VTQARALNQA KYIPELAYYG LYLLCSPIHG EGDKVISCVF
310 320 330 340 350
HQMLSVILML EVGEGSHRAP LAVTSQVINC RNQAVQFISA LVDELKESIF
360 370 380 390 400
PVVRILLQHI CAKVVDKSEY RTFAAQSLVQ LLSKLPCGEY AMFIAWLYKY
410 420 430 440 450
SRSSKIPHRV FTLDVVLALL ELPEREVDNT LSLEHQKFLK HKFLVQEIMF
460 470 480 490 500
DRCLDKAPTV RSKALSSFAH CLELTVTSAS ESILELLINS PTFSVIESHP
510 520 530 540 550
GTLLRNSSAF SYQRQTSNRS EPSGEINIDS SGETVGSGER CVMAMLRRRI
560 570 580 590 600
RDEKTNVRKS ALQVLVSILK HCDVSGMKED LWILQDQCRD PAVSVRKQAL
610 620 630 640 650
QSLTELLMAQ PRCVQIQKAW LRGVVPVVMD CESTVQEKAL EFLDQLLLQN
660 670 680 690 700
IRHHSHFHSG DDSQVLAWAL LTLLTTESQE LSRYLNKAFH IWSKKEKFSP
710 720 730 740 750
TFINNVISHT GTEHSAPAWM LLSKIAGSSP RLDYSRIIQS WEKISSQQNP
760 770 780 790 800
NSNTLGHILC VIGHIAKHLP KSTRDKVTDA VKCKLNGFQW SLEVISSAVD
810 820 830 840 850
ALQRLCRASA ETPAEEQELL TQVCGDVLST CEHRLSNIVL KENGTGNMDE
860 870 880 890 900
DLLVKYIFTL GDIAQLCPAR VEKRIFLLIQ SVLASSADAD HSPSSQGSSE
910 920 930 940 950
APASQPPPQV RGSVMPSVIR AHAIITLGKL CLQHEDLAKK SIPALVRELE
960 970 980 990 1000
VCEDVAVRNN VIIVMCDLCI RYTIMVDKYI PNISMCLKDS DPFIRKQTLI
1010 1020 1030 1040 1050
LLTNLLQEEF VKWKGSLFFR FVSTLIDSHP DIASFGEFCL AHLLLKRNPV
1060 1070 1080 1090 1100
MFFQHFIECI FHFNNYEKHE KYNKFPQSER EKRLFSLKGK SNKERRMKIY
1110 1120 1130 1140 1150
KFLLEHFTDE QRFNITSKIC LSILACFADG ILPLDLDASE LLSDTFEVLS
1160 1170 1180 1190 1200
SKEIKLLAMR SKPDKDLLME EDDMALANVV MQEAQKKLIS QVQKRNFIEN
1210 1220 1230 1240 1250
IIPIIISLKT VLEKNKIPAL RELMHYLREV MQDYRDELKD FFAVDKQLAS
1260 1270 1280 1290 1300
ELEYDMKKYQ EQLVQEQELA KHADVAGTAG GAEVAPVAQV ALCLETVPVP
1310 1320 1330 1340 1350
AGQENPAMSP AVSQPCTPRA SAGHVAVSSP TPETGPLQRL LPKARPMSLS
1360 1370 1380 1390 1400
TIAILNSVKK AVESKSRHRS RSLGVLPFTL NSGSPEKTCS QVSSYSLEQE
1410 1420 1430 1440 1450
SNGEIEHVTK RAISTPEKSI SDVTFGAGVS YIGTPRTPSS AKEKIEGRSQ
1460 1470 1480 1490
GNDILCLSLP DKPPPQPQQW NVRSPARNKD TPACSRRSLR KTPLKTAN
Length:1,498
Mass (Da):168,891
Last modified:November 22, 2005 - v2
Checksum:i038033DA393E4310
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053043622R → Q. Corresponds to variant dbSNP:rs12292394Ensembl.1
Natural variantiVAR_053044907P → T. Corresponds to variant dbSNP:rs34739733Ensembl.1
Natural variantiVAR_0530451034S → R. Corresponds to variant dbSNP:rs7927108Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D29954 mRNA Translation: BAA06224.1
AP001775 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67824.1
BC098398 mRNA Translation: AAH98398.1
AF070553 mRNA Translation: AAC28639.1
CCDSiCCDS31723.1
RefSeqiNP_056076.1, NM_015261.2
UniGeneiHs.438550

Genome annotation databases

EnsembliENST00000534548; ENSP00000433681; ENSG00000151503
GeneIDi23310
KEGGihsa:23310
UCSCiuc001qhd.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCNDD3_HUMAN
AccessioniPrimary (citable) accession number: P42695
Secondary accession number(s): A6NFS2, Q4KMQ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 22, 2005
Last modified: May 23, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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