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P42690 (SRK4_SPOLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase isoform SRK4

EC=2.7.10.2
Gene names
Name:SRK1
OrganismSpongilla lacustris (Freshwater sponge)
Taxonomic identifier6055 [NCBI]
Taxonomic lineageEukaryotaMetazoaPoriferaDemospongiaeCeractinomorphaHaploscleridaSpongillidaeSpongilla

Protein attributes

Sequence length506 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Contains 1 protein kinase domain.

Contains 1 SH2 domain.

Contains 1 SH3 domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
   DomainSH2 domain
SH3 domain
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Tyrosine-protein kinase
   PTMPhosphoprotein
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

non-membrane spanning protein tyrosine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform SRK4 (identifier: P42690-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform SRK1 (identifier: P42686-1)

The sequence of this isoform can be found in the external entry P42686.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 506506Tyrosine-protein kinase isoform SRK4
PRO_0000088157

Regions

Domain54 – 11663SH3
Domain122 – 21493SH2
Domain240 – 493254Protein kinase
Nucleotide binding246 – 2549ATP By similarity

Sites

Active site3591Proton acceptor By similarity
Binding site2681ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Isoform SRK4 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 8ABDF4A2546C280B

FASTA50657,562
        10         20         30         40         50         60 
MGSCCSSQDG DGNGKATAGS TVDSHELSQS VKGKIKQPEP KPKPPPQVPP AQDVKYPIYV 

        70         80         90        100        110        120 
GKYDYDSRTD DDLSFKKGDL MYIISTDEGD WWFARSKDTA GKEGYIPSNY VAEYKSLDAE 

       130        140        150        160        170        180 
EWFFGQVKRV DAEKQLMMPF NNLGSFLIRD SDTTPGDFSL SVRDIDRVRH YRIKKLENGT 

       190        200        210        220        230        240 
YFVTRRLTFQ SIQELVAYYT QQADGLCVNL KGPCMVMEKP QTAGLSKQAN EEWEIEKKQI 

       250        260        270        280        290        300 
KLLRGLGAGQ FGEVWEGLWN GTTSVAVKTL KPGTMSIEEF LEEASIMKQL RHPKLIQLYA 

       310        320        330        340        350        360 
VCTKEEPIYI VTELMKHGSL LEYLRGDGRS LKLPDLVDMC SQVASGMSYL EQQNYIHRDL 

       370        380        390        400        410        420 
AARNILVGEH KICKVADFGL ARVIDEEIYE AKLGAKFPIK WTAPEAAMYS RFTIKSDVWS 

       430        440        450        460        470        480 
FGIVLYEVIT YGRFPYPGMT NAQVLEQIQQ SYRMPRPMGC PEKLYAIMMD CWREDPASRP 

       490        500 
TFETLSWQLE EFFTTGDDAG YKDMER 

« Hide

Isoform SRK1 [UniParc].

See P42686.

References

[1]"Multiple src-related kinase genes, srk1-4, in the fresh water sponge Spongilla lacustris."
Ottilie S., Raulf F., Barnekow A., Hannig G., Schartl M.
Oncogene 7:1625-1630(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X61604 mRNA. Translation: CAA43801.1.
PIRS24553.

3D structure databases

ProteinModelPortalP42690.
SMRP42690. Positions 58-133, 233-492.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.7.10.2. 5838.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSRK4_SPOLA
AccessionPrimary (citable) accession number: P42690
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families