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P42690

- SRK4_SPOLA

UniProt

P42690 - SRK4_SPOLA

Protein

Tyrosine-protein kinase isoform SRK4

Gene

SRK1

Organism
Spongilla lacustris (Freshwater sponge)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei268 – 2681ATPPROSITE-ProRule annotation
    Active sitei359 – 3591Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi246 – 2549ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 5838.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase isoform SRK4 (EC:2.7.10.2)
    Gene namesi
    Name:SRK1
    OrganismiSpongilla lacustris (Freshwater sponge)
    Taxonomic identifieri6055 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaPoriferaDemospongiaeHaploscleridaSpongillidaeSpongilla

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 506506Tyrosine-protein kinase isoform SRK4PRO_0000088157Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP42690.
    SMRiP42690. Positions 58-133, 233-492.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini54 – 11663SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini122 – 21493SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini240 – 493254Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain, SH3 domain

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    PR00109. TYRKINASE.
    SMARTiSM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform SRK4 (identifier: P42690-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGSCCSSQDG DGNGKATAGS TVDSHELSQS VKGKIKQPEP KPKPPPQVPP    50
    AQDVKYPIYV GKYDYDSRTD DDLSFKKGDL MYIISTDEGD WWFARSKDTA 100
    GKEGYIPSNY VAEYKSLDAE EWFFGQVKRV DAEKQLMMPF NNLGSFLIRD 150
    SDTTPGDFSL SVRDIDRVRH YRIKKLENGT YFVTRRLTFQ SIQELVAYYT 200
    QQADGLCVNL KGPCMVMEKP QTAGLSKQAN EEWEIEKKQI KLLRGLGAGQ 250
    FGEVWEGLWN GTTSVAVKTL KPGTMSIEEF LEEASIMKQL RHPKLIQLYA 300
    VCTKEEPIYI VTELMKHGSL LEYLRGDGRS LKLPDLVDMC SQVASGMSYL 350
    EQQNYIHRDL AARNILVGEH KICKVADFGL ARVIDEEIYE AKLGAKFPIK 400
    WTAPEAAMYS RFTIKSDVWS FGIVLYEVIT YGRFPYPGMT NAQVLEQIQQ 450
    SYRMPRPMGC PEKLYAIMMD CWREDPASRP TFETLSWQLE EFFTTGDDAG 500
    YKDMER 506
    Length:506
    Mass (Da):57,562
    Last modified:November 1, 1995 - v1
    Checksum:i8ABDF4A2546C280B
    GO
    Isoform SRK1 (identifier: P42686-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry P42686.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:505
    Mass (Da):57,693
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61604 mRNA. Translation: CAA43801.1.
    PIRiS24553.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X61604 mRNA. Translation: CAA43801.1 .
    PIRi S24553.

    3D structure databases

    ProteinModelPortali P42690.
    SMRi P42690. Positions 58-133, 233-492.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 5838.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00452. SH3DOMAIN.
    PR00109. TYRKINASE.
    SMARTi SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Multiple src-related kinase genes, srk1-4, in the fresh water sponge Spongilla lacustris."
      Ottilie S., Raulf F., Barnekow A., Hannig G., Schartl M.
      Oncogene 7:1625-1630(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiSRK4_SPOLA
    AccessioniPrimary (citable) accession number: P42690
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3