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P42689 (SRK3_SPOLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase SRK3

EC=2.7.10.2
Gene names
Name:SRK3
OrganismSpongilla lacustris (Freshwater sponge)
Taxonomic identifier6055 [NCBI]
Taxonomic lineageEukaryotaMetazoaPoriferaDemospongiaeCeractinomorphaHaploscleridaSpongillidaeSpongilla

Protein attributes

Sequence length334 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Contains 1 protein kinase domain.

Contains 1 SH2 domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainSH2 domain
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Tyrosine-protein kinase
   PTMPhosphoprotein
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

non-membrane spanning protein tyrosine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 334›334Tyrosine-protein kinase SRK3
PRO_0000088159

Regions

Domain‹1 – 42›42SH2
Domain66 – 321256Protein kinase
Nucleotide binding72 – 809ATP By similarity

Sites

Active site1861Proton acceptor By similarity
Binding site941ATP By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P42689 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 2AFEB9C409817AA2

FASTA33437,880
        10         20         30         40         50         60 
IRTLDDGGFY MANRISFPTL QNLVSHYMMD ADGLAQRLSR PCSRANIPIT SGLSYKDEWE 

        70         80         90        100        110        120 
IDRTTIQLQR KLGQGNFGEV WAGVWNGTTA VAVKTLKPDT MEVKDFVQEA QVMKKIHHPN 

       130        140        150        160        170        180 
LLQLYAVCTI GEPIYIVTEL MKYGSMLEYL KHGEGKNITL HQMVDMSAQI ASGMTYLEAH 

       190        200        210        220        230        240 
SYIHRDLAAR NILVGEGNVC KVADFGLARV IKEDIYNPRE GTKFPIKWTA PEAALYNRFT 

       250        260        270        280        290        300 
IKSDVWSFGV LISEIVTHGR MPYPGMTNRQ VLEAVDRGYR MPCPEGCPDP LYKIMLSCWK 

       310        320        330 
HEPDDRPTFE SLKNLLEDYY VSAAEGSYRE PAPR 

« Hide

References

[1]"Multiple src-related kinase genes, srk1-4, in the fresh water sponge Spongilla lacustris."
Ottilie S., Raulf F., Barnekow A., Hannig G., Schartl M.
Oncogene 7:1625-1630(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X61603 mRNA. Translation: CAA43800.1.
PIRS24552.

3D structure databases

ProteinModelPortalP42689.
SMRP42689. Positions 1-322.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSPR00109. TYRKINASE.
SMARTSM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSRK3_SPOLA
AccessionPrimary (citable) accession number: P42689
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families