P42689 (SRK3_SPOLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine-protein kinase SRK3
EC=2.7.10.2

Gene names

Name:

SRK3

Organism

Spongilla lacustris (Freshwater sponge)

Taxonomic identifier

6055 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Porifera › Demospongiae › Ceractinomorpha › Haplosclerida › Spongillidae › Spongilla

Protein attributes

Sequence length	334 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. Contains 1 protein kinase domain. Contains 1 SH2 domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	SH2 domain
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase Tyrosine-protein kinase
PTM	Phosphoprotein
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW non-membrane spanning protein tyrosine kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 334	›334	Tyrosine-protein kinase SRK3		PRO_0000088159
Regions
	Domain	‹1 – 42	›42	SH2
	Domain	66 – 321	256	Protein kinase
	Nucleotide binding	72 – 80	9	ATP By similarity
Sites
	Active site	186	1	Proton acceptor By similarity
	Binding site	94	1	ATP By similarity
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P42689 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 2AFEB9C409817AA2	FASTA	334	37,880
	10 20 30 40 50 60 IRTLDDGGFY MANRISFPTL QNLVSHYMMD ADGLAQRLSR PCSRANIPIT SGLSYKDEWE 70 80 90 100 110 120 IDRTTIQLQR KLGQGNFGEV WAGVWNGTTA VAVKTLKPDT MEVKDFVQEA QVMKKIHHPN 130 140 150 160 170 180 LLQLYAVCTI GEPIYIVTEL MKYGSMLEYL KHGEGKNITL HQMVDMSAQI ASGMTYLEAH 190 200 210 220 230 240 SYIHRDLAAR NILVGEGNVC KVADFGLARV IKEDIYNPRE GTKFPIKWTA PEAALYNRFT 250 260 270 280 290 300 IKSDVWSFGV LISEIVTHGR MPYPGMTNRQ VLEAVDRGYR MPCPEGCPDP LYKIMLSCWK 310 320 330 HEPDDRPTFE SLKNLLEDYY VSAAEGSYRE PAPR

References

[1]	"Multiple src-related kinase genes, srk1-4, in the fresh water sponge Spongilla lacustris." Ottilie S., Raulf F., Barnekow A., Hannig G., Schartl M. Oncogene 7:1625-1630(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X61603 mRNA. Translation: CAA43800.1.
PIR	S24552.
3D structure databases
ProteinModelPortal	P42689.
SMR	P42689. Positions 1-322.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.30.505.10. 1 hit.
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR000980. SH2. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. [Graphical view]
Pfam	PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PRINTS	PR00109. TYRKINASE.
SMART	SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS50001. SH2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SRK3_SPOLA

Accession

Primary (citable) accession number: P42689

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	April 3, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)