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P42689

- SRK3_SPOLA

UniProt

P42689 - SRK3_SPOLA

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Protein

Tyrosine-protein kinase SRK3

Gene

SRK3

Organism
Spongilla lacustris (Freshwater sponge)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei94 – 941ATPPROSITE-ProRule annotation
Active sitei186 – 1861Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi72 – 809ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase SRK3 (EC:2.7.10.2)
Gene namesi
Name:SRK3
OrganismiSpongilla lacustris (Freshwater sponge)
Taxonomic identifieri6055 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPoriferaDemospongiaeHaploscleridaSpongillidaeSpongilla

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 334›334Tyrosine-protein kinase SRK3PRO_0000088159Add
BLAST

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP42689.
SMRiP42689. Positions 1-322.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini‹1 – 42›42SH2PROSITE-ProRule annotationAdd
BLAST
Domaini66 – 321256Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

P42689-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
IRTLDDGGFY MANRISFPTL QNLVSHYMMD ADGLAQRLSR PCSRANIPIT
60 70 80 90 100
SGLSYKDEWE IDRTTIQLQR KLGQGNFGEV WAGVWNGTTA VAVKTLKPDT
110 120 130 140 150
MEVKDFVQEA QVMKKIHHPN LLQLYAVCTI GEPIYIVTEL MKYGSMLEYL
160 170 180 190 200
KHGEGKNITL HQMVDMSAQI ASGMTYLEAH SYIHRDLAAR NILVGEGNVC
210 220 230 240 250
KVADFGLARV IKEDIYNPRE GTKFPIKWTA PEAALYNRFT IKSDVWSFGV
260 270 280 290 300
LISEIVTHGR MPYPGMTNRQ VLEAVDRGYR MPCPEGCPDP LYKIMLSCWK
310 320 330
HEPDDRPTFE SLKNLLEDYY VSAAEGSYRE PAPR
Length:334
Mass (Da):37,880
Last modified:November 1, 1995 - v1
Checksum:i2AFEB9C409817AA2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61603 mRNA. Translation: CAA43800.1.
PIRiS24552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61603 mRNA. Translation: CAA43800.1 .
PIRi S24552.

3D structure databases

ProteinModelPortali P42689.
SMRi P42689. Positions 1-322.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PRINTSi PR00109. TYRKINASE.
SMARTi SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Multiple src-related kinase genes, srk1-4, in the fresh water sponge Spongilla lacustris."
    Ottilie S., Raulf F., Barnekow A., Hannig G., Schartl M.
    Oncogene 7:1625-1630(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSRK3_SPOLA
AccessioniPrimary (citable) accession number: P42689
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3