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P42688 (SRK2_SPOLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase SRK2

EC=2.7.10.2
Gene names
Name:SRK2
OrganismSpongilla lacustris (Freshwater sponge)
Taxonomic identifier6055 [NCBI]
Taxonomic lineageEukaryotaMetazoaPoriferaDemospongiaeCeractinomorphaHaploscleridaSpongillidaeSpongilla

Protein attributes

Sequence length362 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Contains 1 protein kinase domain.

Contains 1 SH2 domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainSH2 domain
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Tyrosine-protein kinase
   PTMPhosphoprotein
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

non-membrane spanning protein tyrosine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 362›362Tyrosine-protein kinase SRK2
PRO_0000088158

Regions

Domain‹1 – 70›70SH2
Domain95 – 348254Protein kinase
Nucleotide binding101 – 1099ATP By similarity

Sites

Active site2141Proton acceptor By similarity
Binding site1231ATP By similarity

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P42688 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: D8C549E9904EB6D0

FASTA36240,937
        10         20         30         40         50         60 
TFLVRESESK PGDYSLSIQD GDNVKHYRIR KLDEGGFFIT RRAVFNTLKD LVQYYQNESD 

        70         80         90        100        110        120 
GLCVNLRQPC RPLERPQIDL SHKTKDMWEI SRDSITLIRK LGAGQFGEVY QGLWNNSTPV 

       130        140        150        160        170        180 
AVKTLKAGTM QPAAFLAEAQ IMKKLRHPKL IQLYAVCTQG EPVYIITELM SKGSLLDYLQ 

       190        200        210        220        230        240 
GEAGALKLPQ LIDMAAQVAA GMAYLELHNY IHRDLAARNI LVGDNNICKV ADFGLARLIV 

       250        260        270        280        290        300 
SDDYNATEGA KFPIKWTAPE AALFNRFSIK SDVWSFGILI TELVTYGRIP YPGMSNAEVL 

       310        320        330        340        350        360 
QNLDKGYRMP CPVTTPESLY QIMLDCWKRN PADRPTFEAL QWRLEDFFVL DAGQYQHAAD 


VL 

« Hide

References

[1]"Multiple src-related kinase genes, srk1-4, in the fresh water sponge Spongilla lacustris."
Ottilie S., Raulf F., Barnekow A., Hannig G., Schartl M.
Oncogene 7:1625-1630(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X61602 mRNA. Translation: CAA43799.1.
PIRS24551.

3D structure databases

ProteinModelPortalP42688.
SMRP42688. Positions 1-356.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTSM00252. SH2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSRK2_SPOLA
AccessionPrimary (citable) accession number: P42688
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families