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P42687 (SPK1_DUGTI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase SPK-1

EC=2.7.10.2
OrganismDugesia tigrina (Planarian) (Girardia tigrina)
Taxonomic identifier6162 [NCBI]
Taxonomic lineageEukaryotaMetazoaPlatyhelminthesRhabditophoraSeriataTricladidaContinenticolaGeoplanoideaDugesiidaeGirardia

Protein attributes

Sequence length497 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family.

Contains 1 protein kinase domain.

Contains 1 SH2 domain.

Contains 1 SH3 domain.

Caution

It is uncertain whether Met-1 is the initiator.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 497497Tyrosine-protein kinase SPK-1
PRO_0000088138

Regions

Domain33 – 9462SH3
Domain100 – 200101SH2
Domain220 – 482263Protein kinase
Nucleotide binding226 – 2349ATP By similarity

Sites

Active site3421Proton acceptor By similarity
Binding site2481ATP By similarity

Natural variations

Natural variant2121D → A.
Natural variant2351H → D.

Sequences

Sequence LengthMass (Da)Tools
P42687 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 412FD10588997524

FASTA49757,447
        10         20         30         40         50         60 
MGQKFSIKCK KQSKNKNTSK CQKIPKKAYE GPPGSYMVKA KYKYAASGDT DISFEEKEIM 

        70         80         90        100        110        120 
YVLEQFDEFW LKVVKQKDNK EGLVPSNYVS KQDGSPQSVE AWREIQRWEA EKSLMKIGLQ 

       130        140        150        160        170        180 
KGTYIIRPSR KENSYALSVR DFDEKKKICI VKHFQIKTLQ DEKGISYSVN IRNFPNILTL 

       190        200        210        220        230        240 
IQFYEKNGIG NTHIPLTDPM PDNYQPPVHF QDIEINRENI EILNEIGRGF FGSVHRAKWG 

       250        260        270        280        290        300 
RSYEVAAKML QSSKAEREKF VLEAKIMHKL RHRKIVELLG VCTEPQDMPM LIIVEYMKNG 

       310        320        330        340        350        360 
SLKEYLKTPD GKKTNLNQMV HMMAEISEGM AYLESEKVVH RDLRADNILV ANDLTRKVAD 

       370        380        390        400        410        420 
FGLTELTDGS LGDQEKKTLR FPYKWTAPEA AKSKVFTSKS DVWSYGIVMF EILTWASSPY 

       430        440        450        460        470        480 
PDIPAKEVIE KVSKGYRMPN PEKFITGVCC PDEIYKIMIW CWDANPEKRP TFLVLQEKMD 

       490 
LLIVDTLTNN AYYSHSK 

« Hide

References

[1]"Structure and expression of Spk-1, an src-related gene product found in the planarian Dugesia (G) tigrina."
Burgaya F., Garcia-Fernandez J., Riutort M., Baguna J., Salo E.
Oncogene 9:1267-1272(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X75310 mRNA. Translation: CAA53058.1.
PIRS43532.

3D structure databases

ProteinModelPortalP42687.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.7.10.2. 2016.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSPK1_DUGTI
AccessionPrimary (citable) accession number: P42687
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families