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P42687

- SPK1_GIRTI

UniProt

P42687 - SPK1_GIRTI

Protein

Tyrosine-protein kinase SPK-1

Gene
N/A
Organism
Girardia tigrina (Planarian) (Dugesia tigrina)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei248 – 2481ATPPROSITE-ProRule annotation
    Active sitei342 – 3421Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi226 – 2349ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 2016.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase SPK-1 (EC:2.7.10.2)
    OrganismiGirardia tigrina (Planarian) (Dugesia tigrina)
    Taxonomic identifieri6162 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesRhabditophoraSeriataTricladidaContinenticolaGeoplanoideaDugesiidaeGirardia

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 497497Tyrosine-protein kinase SPK-1PRO_0000088138Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliP42687.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 9462SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini100 – 200101SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini220 – 482263Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain, SH3 domain

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00109. TYRKINASE.
    SMARTiSM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P42687-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGQKFSIKCK KQSKNKNTSK CQKIPKKAYE GPPGSYMVKA KYKYAASGDT    50
    DISFEEKEIM YVLEQFDEFW LKVVKQKDNK EGLVPSNYVS KQDGSPQSVE 100
    AWREIQRWEA EKSLMKIGLQ KGTYIIRPSR KENSYALSVR DFDEKKKICI 150
    VKHFQIKTLQ DEKGISYSVN IRNFPNILTL IQFYEKNGIG NTHIPLTDPM 200
    PDNYQPPVHF QDIEINRENI EILNEIGRGF FGSVHRAKWG RSYEVAAKML 250
    QSSKAEREKF VLEAKIMHKL RHRKIVELLG VCTEPQDMPM LIIVEYMKNG 300
    SLKEYLKTPD GKKTNLNQMV HMMAEISEGM AYLESEKVVH RDLRADNILV 350
    ANDLTRKVAD FGLTELTDGS LGDQEKKTLR FPYKWTAPEA AKSKVFTSKS 400
    DVWSYGIVMF EILTWASSPY PDIPAKEVIE KVSKGYRMPN PEKFITGVCC 450
    PDEIYKIMIW CWDANPEKRP TFLVLQEKMD LLIVDTLTNN AYYSHSK 497
    Length:497
    Mass (Da):57,447
    Last modified:November 1, 1995 - v1
    Checksum:i412FD10588997524
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti212 – 2121D → A.
    Natural varianti235 – 2351H → D.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75310 mRNA. Translation: CAA53058.1.
    PIRiS43532.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X75310 mRNA. Translation: CAA53058.1 .
    PIRi S43532.

    3D structure databases

    ProteinModelPortali P42687.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 2016.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00109. TYRKINASE.
    SMARTi SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and expression of Spk-1, an src-related gene product found in the planarian Dugesia (G) tigrina."
      Burgaya F., Garcia-Fernandez J., Riutort M., Baguna J., Salo E.
      Oncogene 9:1267-1272(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiSPK1_GIRTI
    AccessioniPrimary (citable) accession number: P42687
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 is the initiator.Curated

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3