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P42686

- SRK1_SPOLA

UniProt

P42686 - SRK1_SPOLA

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Protein
Tyrosine-protein kinase isoform SRK1
Gene
SRK1
Organism
Spongilla lacustris (Freshwater sponge)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei268 – 2681ATP By similarity
Active sitei359 – 3591Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi246 – 2549ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 5838.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase isoform SRK1 (EC:2.7.10.2)
Gene namesi
Name:SRK1
OrganismiSpongilla lacustris (Freshwater sponge)
Taxonomic identifieri6055 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPoriferaDemospongiaeHaploscleridaSpongillidaeSpongilla

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505Tyrosine-protein kinase isoform SRK1
PRO_0000088156Add
BLAST

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP42686.
SMRiP42686. Positions 231-495.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 11663SH3
Add
BLAST
Domaini122 – 21493SH2
Add
BLAST
Domaini240 – 493254Protein kinase
Add
BLAST

Sequence similaritiesi

Contains 1 SH2 domain.
Contains 1 SH3 domain.

Keywords - Domaini

SH2 domain, SH3 domain

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform SRK1 (identifier: P42686-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGSCCSSQDG DGNGKATAGS TVDSHELSQS VKGKIKQPEP KPKPPPQVPP    50
AQDVKYPIYV GKYDYDSRTD DDLSFKKGDL MYIISTDEGD WWFARSKDTA 100
GKEGYIPSNY VAEYKSLDAE EWFLGKIKRV EAEKMLNQSF NQVGSFLIRD 150
SETTPGDFSL SVKDQDRVRH YRVRRLEDGS LFVTRRSTFQ ILHELVDHYK 200
IETDGLCCKL LYPCLQAEKP QTAGLLRQAN EEWEIEKTQI KLLRRLGAGQ 250
FGEVWEGLWN GTTSVAVKTL KPGTMSVEEF LQEASIMKRL RHPKLIQLYA 300
VCTKEEPIYI VTELMKYGSL LEYLRGEDGV LKIEQLVDVA AQVASGMSYL 350
EQQNYIHRDL AARNILVGEH GICKVADFGL ARVIDEEIYE AHTGAKFPIK 400
WTAPEAAMYN RFTIKSDVWS FGVVLYEIIT YGRFPYPGMT NPEVLEKIQQ 450
NYRMPCPANC PKQFHDIMLD CWREDPASRP TFETLQWQLE EFFNSEGYRD 500
PDAIH 505
Length:505
Mass (Da):57,693
Last modified:November 1, 1995 - v1
Checksum:i6399E411C6112F91
GO
Isoform SRK4 (identifier: P42690-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry P42690.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:506
Mass (Da):57,562
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61601 mRNA. Translation: CAA43798.1.
PIRiS24550.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X61601 mRNA. Translation: CAA43798.1 .
PIRi S24550.

3D structure databases

ProteinModelPortali P42686.
SMRi P42686. Positions 231-495.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

BRENDAi 2.7.10.2. 5838.

Family and domain databases

Gene3Di 3.30.505.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Multiple src-related kinase genes, srk1-4, in the fresh water sponge Spongilla lacustris."
    Ottilie S., Raulf F., Barnekow A., Hannig G., Schartl M.
    Oncogene 7:1625-1630(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSRK1_SPOLA
AccessioniPrimary (citable) accession number: P42686
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi