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Protein

Tyrosine-protein kinase isoform SRK1

Gene

SRK1

Organism
Spongilla lacustris (Freshwater sponge)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei268 – 2681ATPPROSITE-ProRule annotation
Active sitei359 – 3591Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi246 – 2549ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 5838.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase isoform SRK1 (EC:2.7.10.2)
Gene namesi
Name:SRK1
OrganismiSpongilla lacustris (Freshwater sponge)
Taxonomic identifieri6055 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPoriferaDemospongiaeHaploscleridaSpongillidaeSpongilla

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505Tyrosine-protein kinase isoform SRK1PRO_0000088156Add
BLAST

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP42686.
SMRiP42686. Positions 231-495.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini54 – 11663SH3PROSITE-ProRule annotationAdd
BLAST
Domaini122 – 21493SH2PROSITE-ProRule annotationAdd
BLAST
Domaini240 – 493254Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH2 domain, SH3 domain

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform SRK1 (identifier: P42686-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSCCSSQDG DGNGKATAGS TVDSHELSQS VKGKIKQPEP KPKPPPQVPP
60 70 80 90 100
AQDVKYPIYV GKYDYDSRTD DDLSFKKGDL MYIISTDEGD WWFARSKDTA
110 120 130 140 150
GKEGYIPSNY VAEYKSLDAE EWFLGKIKRV EAEKMLNQSF NQVGSFLIRD
160 170 180 190 200
SETTPGDFSL SVKDQDRVRH YRVRRLEDGS LFVTRRSTFQ ILHELVDHYK
210 220 230 240 250
IETDGLCCKL LYPCLQAEKP QTAGLLRQAN EEWEIEKTQI KLLRRLGAGQ
260 270 280 290 300
FGEVWEGLWN GTTSVAVKTL KPGTMSVEEF LQEASIMKRL RHPKLIQLYA
310 320 330 340 350
VCTKEEPIYI VTELMKYGSL LEYLRGEDGV LKIEQLVDVA AQVASGMSYL
360 370 380 390 400
EQQNYIHRDL AARNILVGEH GICKVADFGL ARVIDEEIYE AHTGAKFPIK
410 420 430 440 450
WTAPEAAMYN RFTIKSDVWS FGVVLYEIIT YGRFPYPGMT NPEVLEKIQQ
460 470 480 490 500
NYRMPCPANC PKQFHDIMLD CWREDPASRP TFETLQWQLE EFFNSEGYRD

PDAIH
Length:505
Mass (Da):57,693
Last modified:November 1, 1995 - v1
Checksum:i6399E411C6112F91
GO
Isoform SRK4 (identifier: P42690-1) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry P42690.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:506
Mass (Da):57,562
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61601 mRNA. Translation: CAA43798.1.
PIRiS24550.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X61601 mRNA. Translation: CAA43798.1.
PIRiS24550.

3D structure databases

ProteinModelPortaliP42686.
SMRiP42686. Positions 231-495.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi2.7.10.2. 5838.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Multiple src-related kinase genes, srk1-4, in the fresh water sponge Spongilla lacustris."
    Ottilie S., Raulf F., Barnekow A., Hannig G., Schartl M.
    Oncogene 7:1625-1630(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiSRK1_SPOLA
AccessioniPrimary (citable) accession number: P42686
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 27, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.