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P42686 (SRK1_SPOLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase isoform SRK1

EC=2.7.10.2
Gene names
Name:SRK1
OrganismSpongilla lacustris (Freshwater sponge)
Taxonomic identifier6055 [NCBI]
Taxonomic lineageEukaryotaMetazoaPoriferaDemospongiaeCeractinomorphaHaploscleridaSpongillidaeSpongilla

Protein attributes

Sequence length505 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subcellular location

Cytoplasm Probable.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.

Contains 1 protein kinase domain.

Contains 1 SH2 domain.

Contains 1 SH3 domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
   DomainSH2 domain
SH3 domain
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Tyrosine-protein kinase
   PTMPhosphoprotein
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

non-membrane spanning protein tyrosine kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform SRK1 (identifier: P42686-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform SRK4 (identifier: P42690-1)

The sequence of this isoform can be found in the external entry P42690.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 505505Tyrosine-protein kinase isoform SRK1
PRO_0000088156

Regions

Domain54 – 11663SH3
Domain122 – 21493SH2
Domain240 – 493254Protein kinase
Nucleotide binding246 – 2549ATP By similarity

Sites

Active site3591Proton acceptor By similarity
Binding site2681ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Isoform SRK1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 6399E411C6112F91

FASTA50557,693
        10         20         30         40         50         60 
MGSCCSSQDG DGNGKATAGS TVDSHELSQS VKGKIKQPEP KPKPPPQVPP AQDVKYPIYV 

        70         80         90        100        110        120 
GKYDYDSRTD DDLSFKKGDL MYIISTDEGD WWFARSKDTA GKEGYIPSNY VAEYKSLDAE 

       130        140        150        160        170        180 
EWFLGKIKRV EAEKMLNQSF NQVGSFLIRD SETTPGDFSL SVKDQDRVRH YRVRRLEDGS 

       190        200        210        220        230        240 
LFVTRRSTFQ ILHELVDHYK IETDGLCCKL LYPCLQAEKP QTAGLLRQAN EEWEIEKTQI 

       250        260        270        280        290        300 
KLLRRLGAGQ FGEVWEGLWN GTTSVAVKTL KPGTMSVEEF LQEASIMKRL RHPKLIQLYA 

       310        320        330        340        350        360 
VCTKEEPIYI VTELMKYGSL LEYLRGEDGV LKIEQLVDVA AQVASGMSYL EQQNYIHRDL 

       370        380        390        400        410        420 
AARNILVGEH GICKVADFGL ARVIDEEIYE AHTGAKFPIK WTAPEAAMYN RFTIKSDVWS 

       430        440        450        460        470        480 
FGVVLYEIIT YGRFPYPGMT NPEVLEKIQQ NYRMPCPANC PKQFHDIMLD CWREDPASRP 

       490        500 
TFETLQWQLE EFFNSEGYRD PDAIH 

« Hide

Isoform SRK4 [UniParc].

See P42690.

References

[1]"Multiple src-related kinase genes, srk1-4, in the fresh water sponge Spongilla lacustris."
Ottilie S., Raulf F., Barnekow A., Hannig G., Schartl M.
Oncogene 7:1625-1630(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X61601 mRNA. Translation: CAA43798.1.
PIRS24550.

3D structure databases

ProteinModelPortalP42686.
SMRP42686. Positions 231-495.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BRENDA2.7.10.2. 5838.

Family and domain databases

Gene3D3.30.505.10. 1 hit.
InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
PR00109. TYRKINASE.
SMARTSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSRK1_SPOLA
AccessionPrimary (citable) accession number: P42686
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families