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P42681

- TXK_HUMAN

UniProt

P42681 - TXK_HUMAN

Protein

Tyrosine-protein kinase TXK

Gene

TXK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 3 (17 Oct 2006)
      Previous versions | rss
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    Functioni

    Non-receptor tyrosine kinase that plays a redundant role with ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of TXK to the cell membrane, where it is phosphorylated at Tyr-420. Phosphorylation leads to TXK full activation. Contributes also to signaling from many receptors and participates in multiple downstream pathways, including regulation of the actin cytoskeleton. Like ITK, can phosphorylate PLCG1, leading to its localization in lipid rafts and activation, followed by subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. With PARP1 and EEF1A1, TXK forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFNG to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Phosphorylates both PARP1 and EEF1A1. Phosphorylates also key sites in LCP2 leading to the up-regulation of Th1 preferred cytokine IL-2. Phosphorylates 'Tyr-201' of CTLA4 which leads to the association of PI-3 kinase with the CTLA4 receptor.5 Publications

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Enzyme regulationi

    Activated by phosphorylation by FYN.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei299 – 2991ATPPROSITE-ProRule annotation
    Active sitei390 – 3901Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi277 – 2859ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. non-membrane spanning protein tyrosine kinase activity Source: ProtInc
    3. protein binding Source: IntAct
    4. RNA polymerase II regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. activation of phospholipase C activity Source: UniProtKB
    2. adaptive immune response Source: UniProtKB
    3. cytokine production Source: UniProtKB
    4. interferon-gamma production Source: Ensembl
    5. interleukin-4 production Source: Ensembl
    6. NK T cell differentiation Source: Ensembl
    7. peptidyl-tyrosine phosphorylation Source: GOC
    8. positive regulation of interferon-gamma-mediated signaling pathway Source: UniProtKB
    9. positive regulation of interferon-gamma production Source: UniProtKB
    10. protein autophosphorylation Source: UniProtKB
    11. protein phosphorylation Source: ProtInc
    12. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    13. T cell receptor signaling pathway Source: UniProtKB
    14. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Biological processi

    Adaptive immunity, Immunity, Transcription, Transcription regulation

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 2681.
    ReactomeiREACT_163834. FCERI mediated Ca+2 mobilization.
    SignaLinkiP42681.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase TXK (EC:2.7.10.2)
    Alternative name(s):
    Protein-tyrosine kinase 4
    Resting lymphocyte kinase
    Gene namesi
    Name:TXK
    Synonyms:PTK4, RLK
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:12434. TXK.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication. Cell membrane 1 Publication; Peripheral membrane protein 1 Publication
    Note: Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. Translocates into the nucleus and enhances IFN-gamma gene transcription in T-cells.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi91 – 911Y → A: Reduces expression levels if IFN-gamma. 1 Publication
    Mutagenesisi299 – 2991K → A: Impairs kinase activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA37090.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 527527Tyrosine-protein kinase TXKPRO_0000088175Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei91 – 911Phosphotyrosine; by autocatalysis1 Publication
    Modified residuei420 – 4201Phosphotyrosine; by FYN and autocatalysis1 Publication

    Post-translational modificationi

    Phosphorylated at Tyr-420 by FYN. Autophosphorylation at Tyr-91 is critical for the activation of TXK, leading to the up-regulation of IFN-gamma gene transcription.1 Publication
    The cysteine string at the N-terminus is palmitoylated and required for the proper subcellular location.By similarity

    Keywords - PTMi

    Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PaxDbiP42681.
    PRIDEiP42681.

    PTM databases

    PhosphoSiteiP42681.

    Expressioni

    Tissue specificityi

    Expressed in T-cells and some myeloid cell lines. Expressed in Th1/Th0 cells with IFN-gamma-producing potential.2 Publications

    Gene expression databases

    ArrayExpressiP42681.
    BgeeiP42681.
    CleanExiHS_TXK.
    GenevestigatoriP42681.

    Organism-specific databases

    HPAiHPA043769.

    Interactioni

    Subunit structurei

    Interacts with PARP1 and EEF1A1. Interacts with SH2D2A By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    KITP107213EBI-7877438,EBI-1379503

    Protein-protein interaction databases

    BioGridi113145. 4 interactions.
    IntActiP42681. 4 interactions.
    MINTiMINT-1493369.
    STRINGi9606.ENSP00000264316.

    Structurei

    Secondary structure

    1
    527
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi148 – 1514
    Helixi157 – 16711
    Beta strandi175 – 1784
    Beta strandi181 – 1899
    Beta strandi193 – 1975
    Beta strandi200 – 2078
    Beta strandi213 – 2186
    Helixi224 – 2318
    Beta strandi237 – 2393

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2DM0NMR-A140-251[»]
    ProteinModelPortaliP42681.
    SMRiP42681. Positions 86-526.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP42681.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini82 – 14261SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini150 – 24697SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini271 – 527257Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi68 – 736Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi14 – 196Poly-Cys

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH2 domain, SH3 domain

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233859.
    HOVERGENiHBG008761.
    InParanoidiP42681.
    KOiK08016.
    OMAiPIKWSPP.
    OrthoDBiEOG7KM5SC.
    PhylomeDBiP42681.
    TreeFamiTF351634.

    Family and domain databases

    Gene3Di3.30.505.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00109. TYRKINASE.
    SMARTiSM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P42681-1 [UniParc]FASTAAdd to Basket

    « Hide

    MILSSYNTIQ SVFCCCCCCS VQKRQMRTQI SLSTDEELPE KYTQRRRPWL    50
    SQLSNKKQSN TGRVQPSKRK PLPPLPPSEV AEEKIQVKAL YDFLPREPCN 100
    LALRRAEEYL ILEKYNPHWW KARDRLGNEG LIPSNYVTEN KITNLEIYEW 150
    YHRNITRNQA EHLLRQESKE GAFIVRDSRH LGSYTISVFM GARRSTEAAI 200
    KHYQIKKNDS GQWYVAERHA FQSIPELIWY HQHNAAGLMT RLRYPVGLMG 250
    SCLPATAGFS YEKWEIDPSE LAFIKEIGSG QFGVVHLGEW RSHIQVAIKA 300
    INEGSMSEED FIEEAKVMMK LSHSKLVQLY GVCIQRKPLY IVTEFMENGC 350
    LLNYLRENKG KLRKEMLLSV CQDICEGMEY LERNGYIHRD LAARNCLVSS 400
    TCIVKISDFG MTRYVLDDEY VSSFGAKFPI KWSPPEVFLF NKYSSKSDVW 450
    SFGVLMWEVF TEGKMPFENK SNLQVVEAIS EGFRLYRPHL APMSIYEVMY 500
    SCWHEKPEGR PTFAELLRAV TEIAETW 527
    Length:527
    Mass (Da):61,258
    Last modified:October 17, 2006 - v3
    Checksum:iBCCA081F4155CAA6
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti45 – 451R → H.2 Publications
    Corresponds to variant rs7658300 [ dbSNP | Ensembl ].
    VAR_028368
    Natural varianti63 – 631R → C.1 Publication
    Corresponds to variant rs41265727 [ dbSNP | Ensembl ].
    VAR_041869
    Natural varianti336 – 3361R → Q.1 Publication
    Corresponds to variant rs11724347 [ dbSNP | Ensembl ].
    VAR_028369

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L27071 mRNA. Translation: AAA74557.1.
    U34379
    , U34367, U34368, U34369, U34370, U34371, U34372, U34373, U34374, U34375, U34376, U34377, U34378 Genomic DNA. Translation: AAB60412.1.
    CCDSiCCDS3480.1.
    PIRiI84483.
    RefSeqiNP_003319.2. NM_003328.2.
    UniGeneiHs.479669.

    Genome annotation databases

    EnsembliENST00000264316; ENSP00000264316; ENSG00000074966.
    GeneIDi7294.
    KEGGihsa:7294.
    UCSCiuc003gxx.4. human.

    Polymorphism databases

    DMDMi116242835.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L27071 mRNA. Translation: AAA74557.1 .
    U34379
    , U34367 , U34368 , U34369 , U34370 , U34371 , U34372 , U34373 , U34374 , U34375 , U34376 , U34377 , U34378 Genomic DNA. Translation: AAB60412.1 .
    CCDSi CCDS3480.1.
    PIRi I84483.
    RefSeqi NP_003319.2. NM_003328.2.
    UniGenei Hs.479669.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2DM0 NMR - A 140-251 [» ]
    ProteinModelPortali P42681.
    SMRi P42681. Positions 86-526.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113145. 4 interactions.
    IntActi P42681. 4 interactions.
    MINTi MINT-1493369.
    STRINGi 9606.ENSP00000264316.

    Chemistry

    BindingDBi P42681.
    ChEMBLi CHEMBL4367.
    GuidetoPHARMACOLOGYi 2268.

    PTM databases

    PhosphoSitei P42681.

    Polymorphism databases

    DMDMi 116242835.

    Proteomic databases

    PaxDbi P42681.
    PRIDEi P42681.

    Protocols and materials databases

    DNASUi 7294.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264316 ; ENSP00000264316 ; ENSG00000074966 .
    GeneIDi 7294.
    KEGGi hsa:7294.
    UCSCi uc003gxx.4. human.

    Organism-specific databases

    CTDi 7294.
    GeneCardsi GC04M047984.
    H-InvDB HIX0031512.
    HGNCi HGNC:12434. TXK.
    HPAi HPA043769.
    MIMi 600058. gene.
    neXtProti NX_P42681.
    PharmGKBi PA37090.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233859.
    HOVERGENi HBG008761.
    InParanoidi P42681.
    KOi K08016.
    OMAi PIKWSPP.
    OrthoDBi EOG7KM5SC.
    PhylomeDBi P42681.
    TreeFami TF351634.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 2681.
    Reactomei REACT_163834. FCERI mediated Ca+2 mobilization.
    SignaLinki P42681.

    Miscellaneous databases

    ChiTaRSi TXK. human.
    EvolutionaryTracei P42681.
    GeneWikii TXK_(gene).
    GenomeRNAii 7294.
    NextBioi 28519.
    PROi P42681.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P42681.
    Bgeei P42681.
    CleanExi HS_TXK.
    Genevestigatori P42681.

    Family and domain databases

    Gene3Di 3.30.505.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00109. TYRKINASE.
    SMARTi SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12."
      Haire R.N., Ohta Y., Lewis J.E., Fu S.M., Kroisel P.M., Litman G.W.
      Hum. Mol. Genet. 3:897-901(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-45, TISSUE SPECIFICITY.
      Tissue: Blood.
    2. "Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene."
      Ohta Y., Haire R.N., Amemiya C.T., Litman R.T., Trager T., Riess O., Litman G.W.
      Oncogene 12:937-942(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Tissue: Blood.
    3. "Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4."
      Schneider H., Schwartzberg P.L., Rudd C.E.
      Biochem. Biophys. Res. Commun. 252:14-19(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PHOSPHORYLATION OF CTLA4, MUTAGENESIS OF LYS-299.
    4. "Txk, a nonreceptor tyrosine kinase of the Tec family, is expressed in T helper type 1 cells and regulates interferon gamma production in human T lymphocytes."
      Kashiwakura J., Suzuki N., Nagafuchi H., Takeno M., Takeba Y., Shimoyama Y., Sakane T.
      J. Exp. Med. 190:1147-1154(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, FUNCTION.
    5. Cited for: FUNCTION IN PHOSPHORYLATION OF PLCG1.
    6. "Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site."
      Kashiwakura J., Suzuki N., Takeno M., Itoh S., Oku T., Sakane T., Nakajin S., Toyoshima S.
      Biol. Pharm. Bull. 25:718-721(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: AUTOPHOSPHORYLATION, PHOSPHORYLATION AT TYR-91 AND TYR-420, ENZYME REGULATION, MUTAGENESIS OF TYR-91.
    7. "Txk, a member of nonreceptor tyrosine kinase of Tec family, acts as a Th1 cell-specific transcription factor and regulates IFN-gamma gene transcription."
      Takeba Y., Nagafuchi H., Takeno M., Kashiwakura J., Suzuki N.
      J. Immunol. 168:2365-2370(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: DNA-BINDING, FUNCTION.
    8. "Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells."
      Maruyama T., Nara K., Yoshikawa H., Suzuki N.
      Clin. Exp. Immunol. 147:164-175(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PARP1 AND EEF1A1, FUNCTION IN PHOSPHORYLATION OF PARP1 AND EEF1A1, SUBCELLULAR LOCATION, FUNCTION AS A TRANSCRIPTION FACTOR.
    9. "Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk."
      Readinger J.A., Mueller K.L., Venegas A.M., Horai R., Schwartzberg P.L.
      Immunol. Rev. 228:93-114(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON FUNCTION.
    10. "Solution structure of the SH2 domain of human tyrosine-protein kinase TXK."
      RIKEN structural genomics initiative (RSGI)
      Submitted (OCT-2006) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 140-251.
    11. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-45; CYS-63 AND GLN-336.

    Entry informationi

    Entry nameiTXK_HUMAN
    AccessioniPrimary (citable) accession number: P42681
    Secondary accession number(s): Q14220
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: October 17, 2006
    Last modified: October 1, 2014
    This is version 144 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Unlike the other TEC subfamily members, TXK is activated independently of the activity of phosphatidylinositol 3-kinase, consistent with its lack of a PH domain. Membrane association is performed through palmitoylation at the N-terminus.Curated

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3