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Protein

40S ribosomal protein S27

Gene

RPS27

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the small ribosomal subunit (PubMed:8706699). Required for proper rRNA processing and maturation of 18S rRNAs (PubMed:25424902).1 Publication1 Publication

Caution

Was originally (PubMed:8407955) thought to be a protein that could have played a role as a potentially important mediator of cellular proliferative responses to various growth factors and other environmental signals. Capable of specific binding to a cAMP response element in DNA.1 Publication

Cofactori

Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri37 – 59C4-typeSequence analysisAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-68877 Mitotic Prometaphase
R-HSA-72649 Translation initiation complex formation
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S27
Alternative name(s):
Metallopan-stimulin 1
Short name:
MPS-1
Small ribosomal subunit protein eS271 Publication
Gene namesi
Name:RPS27
Synonyms:MPS1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000177954.11
HGNCiHGNC:10416 RPS27
MIMi603702 gene
neXtProtiNX_P42677

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

Diamond-Blackfan anemia 17 (DBA17)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
See also OMIM:617409

Keywords - Diseasei

Diamond-Blackfan anemia

Organism-specific databases

DisGeNETi6232
MalaCardsiRPS27
MIMi617409 phenotype
OpenTargetsiENSG00000177954
PharmGKBiPA34820

Chemistry databases

ChEMBLiCHEMBL1932893

Polymorphism and mutation databases

BioMutaiRPS27
DMDMi1171014

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001490512 – 8440S ribosomal protein S27Add BLAST83

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP42677
PaxDbiP42677
PeptideAtlasiP42677
PRIDEiP42677
TopDownProteomicsiP42677

PTM databases

iPTMnetiP42677
PhosphoSitePlusiP42677
SwissPalmiP42677

Expressioni

Tissue specificityi

Expressed in a wide variety of actively proliferating cells and tumor tissues.

Gene expression databases

BgeeiENSG00000177954
CleanExiHS_RPS27
ExpressionAtlasiP42677 baseline and differential
GenevisibleiP42677 HS

Organism-specific databases

HPAiHPA066851

Interactioni

Subunit structurei

Component of the small ribosomal subunit.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi112146, 145 interactors
CORUMiP42677
DIPiDIP-44182N
IntActiP42677, 56 interactors
MINTiP42677
STRINGi9606.ENSP00000357555

Chemistry databases

BindingDBiP42677

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-Sb1-84[»]
4V6Xelectron microscopy5.00Ab1-84[»]
5A2Qelectron microscopy3.90b2-83[»]
5AJ0electron microscopy3.50Bb1-84[»]
5FLXelectron microscopy3.90b1-84[»]
5LKSelectron microscopy3.60Sb1-84[»]
5OA3electron microscopy4.30b2-83[»]
5T2Celectron microscopy3.60AV1-84[»]
5VYCX-ray6.00b1/b2/b3/b4/b5/b61-84[»]
6EK0electron microscopy2.90Sb1-84[»]
6FECelectron microscopy6.30Y1-84[»]
ProteinModelPortaliP42677
SMRiP42677
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri37 – 59C4-typeSequence analysisAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1779 Eukaryota
COG2051 LUCA
GeneTreeiENSGT00390000013514
HOVERGENiHBG000252
InParanoidiP42677
KOiK02978
OMAiQEGCSFR
OrthoDBiEOG091G157G
PhylomeDBiP42677
TreeFamiTF300265

Family and domain databases

HAMAPiMF_00371 Ribosomal_S27e, 1 hit
InterProiView protein in InterPro
IPR000592 Ribosomal_S27e
IPR011332 Ribosomal_zn-bd
PANTHERiPTHR11594 PTHR11594, 1 hit
PfamiView protein in Pfam
PF01667 Ribosomal_S27e, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004466 Ribosomal_S27e, 1 hit
SUPFAMiSSF57829 SSF57829, 1 hit
PROSITEiView protein in PROSITE
PS01168 RIBOSOMAL_S27E, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42677-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLAKDLLHP SPEEEKRKHK KKRLVQSPNS YFMDVKCPGC YKITTVFSHA
60 70 80
QTVVLCVGCS TVLCQPTGGK ARLTEGCSFR RKQH
Length:84
Mass (Da):9,461
Last modified:January 23, 2007 - v3
Checksum:i242C4466AC8A8900
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5K → R AA sequence (PubMed:8706699).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19739 mRNA Translation: AAA59867.1
U57847 mRNA Translation: AAB02266.1
AB061845 Genomic DNA Translation: BAB79483.1
AK312070 mRNA Translation: BAG35006.1
AL358472 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53239.1
CH471055 Genomic DNA Translation: EAW64624.1
CH471116 Genomic DNA Translation: EAW88871.1
BC002658 mRNA Translation: AAH02658.1
BC070219 mRNA Translation: AAH70219.1
AB007162 Genomic DNA Translation: BAA25825.1
CCDSiCCDS1059.1
PIRiA48045
RefSeqiNP_001021.1, NM_001030.4
UniGeneiHs.546291
Hs.654475

Genome annotation databases

EnsembliENST00000368567; ENSP00000357555; ENSG00000177954
GeneIDi6232
KEGGihsa:6232
UCSCiuc001fdv.4 human

Similar proteinsi

Entry informationi

Entry nameiRS27_HUMAN
AccessioniPrimary (citable) accession number: P42677
Secondary accession number(s): Q5T4L6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 191 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

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