P42677 (RS27_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 29, 2013.
Version 136.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: 40S ribosomal protein S27 Alternative name(s): Metallopan-stimulin 1 Short name=MPS-1 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Reference proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 84 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Cofactor | Binds 1 zinc ion per subunit Potential. |
| Tissue specificity | Expressed in a wide variety of actively proliferating cells and tumor tissues. |
| Sequence similarities | Belongs to the ribosomal protein S27e family. |
| Caution | Was originally (Ref.1) thought to be a protein that could have played a role as a potentially important mediator of cellular proliferative responses to various growth factors and other environmental signals. Capable of specific binding to a cAMP response element in DNA. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| MDM2 | Q00987 | 5 | EBI-356336,EBI-389668 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed Ref.8 | ||||||
| Chain | 2 – 84 | 83 | 40S ribosomal protein S27 HAMAP-Rule MF_00371 | PRO_0000149051 | |||||
Regions | |||||||||
| Zinc finger | 37 – 59 | 23 | C4-type Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 11 | 1 | Phosphoserine Ref.10 Ref.12 | ||||||
| Modified residue | 31 | 1 | Phosphotyrosine By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 5 | 1 | K → R AA sequence Ref.8 | ||||||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "A growth factor-inducible gene encodes a novel nuclear protein with zinc finger structure." Fernandez-Pol J.A., Klos D.J., Hamilton P.D. J. Biol. Chem. 268:21198-21204(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Mammary carcinoma. |
| [2] | "Primary structures and sequence analysis of human ribosomal proteins L39 and S27." Tsui S.K.W., Lee S.M.Y., Fung K.P., Waye M.M.Y., Lee C.Y. Biochem. Mol. Biol. Int. 40:611-616(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart. |
| [3] | "The human ribosomal protein genes: sequencing and comparative analysis of 73 genes." Yoshihama M., Uechi T., Asakawa S., Kawasaki K., Kato S., Higa S., Maeda N., Minoshima S., Tanaka T., Shimizu N., Kenmochi N. Genome Res. 12:379-390(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [4] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Tongue. |
| [5] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [7] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus. |
| [8] | "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry." Vladimirov S.N., Ivanov A.V., Karpova G.G., Musolyamov A.K., Egorov T.A., Thiede B., Wittmann-Liebold B., Otto A. Eur. J. Biochem. 239:144-149(1996) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-11. |
| [9] | "A map of 75 human ribosomal protein genes." Kenmochi N., Kawaguchi T., Rozen S., Davis E., Goodman N., Hudson T.J., Tanaka T., Page D.C. Genome Res. 8:509-523(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 6-74. |
| [10] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [11] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma. |
| [12] | "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [13] | "Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | L19739 mRNA. Translation: AAA59867.1. U57847 mRNA. Translation: AAB02266.1. AB061845 Genomic DNA. Translation: BAB79483.1. AK312070 mRNA. Translation: BAG35006.1. AL358472 Genomic DNA. Translation: CAI14033.1. CH471121 Genomic DNA. Translation: EAW53239.1. CH471055 Genomic DNA. Translation: EAW64624.1. CH471116 Genomic DNA. Translation: EAW88871.1. BC002658 mRNA. Translation: AAH02658.1. BC070219 mRNA. Translation: AAH70219.1. AB007162 Genomic DNA. Translation: BAA25825.1. |
| IPI | IPI00397358. |
| PIR | A48045. |
| RefSeq | NP_001021.1. NM_001030.4. |
| UniGene | Hs.546291. Hs.654475. |
3D structure databases | |
| ProteinModelPortal | P42677. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P42677. 16 interactions. |
| MINT | MINT-5004996. |
| STRING | 9606.ENSP00000357555. |
PTM databases | |
| PhosphoSite | P42677. |
Polymorphism databases | |
| DMDM | 1171014. |
Proteomic databases | |
| PaxDb | P42677. |
| PRIDE | P42677. |
Protocols and materials databases | |
| DNASU | 6232. |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000368567; ENSP00000357555; ENSG00000177954. |
| GeneID | 6232. |
| KEGG | hsa:6232. |
| UCSC | uc001fdv.3. human. |
Organism-specific databases | |
| CTD | 6232. |
| GeneCards | GC01P153963. |
| H-InvDB | HIX0033569. HIX0164279. |
| HGNC | HGNC:10416. RPS27. |
| MIM | 603702. gene. |
| neXtProt | NX_P42677. |
| PharmGKB | PA34820. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | COG2051. |
| HOVERGEN | HBG000252. |
| InParanoid | P42677. |
| KO | K02978. |
| OMA | QEGCSFR. |
| OrthoDB | EOG4H19XB. |
| PhylomeDB | P42677. |
Enzyme and pathway databases | |
| Reactome | REACT_115566. Cell Cycle. REACT_116125. Disease. REACT_17015. Metabolism of proteins. REACT_1762. 3' -UTR-mediated translational regulation. REACT_21257. Metabolism of RNA. REACT_21300. Mitotic M-M/G1 phases. REACT_71. Gene Expression. |
Gene expression databases | |
| ArrayExpress | P42677. |
| Bgee | P42677. |
| CleanEx | HS_RPS27. |
| Genevestigator | P42677. |
| GermOnline | ENSG00000130041. Homo sapiens. ENSG00000177954. Homo sapiens. |
Family and domain databases | |
| Gene3D | 2.20.25.100. 1 hit. |
| HAMAP | MF_00371. Ribosomal_S27e. |
| InterPro | IPR000592. Ribosomal_S27e. IPR023407. Ribosomal_S27e_Zn-bd_dom. IPR011332. Ribosomal_zn-bd_dom. [Graphical view] |
| PANTHER | PTHR11594. PTHR11594. 1 hit. |
| Pfam | PF01667. Ribosomal_S27e. 1 hit. [Graphical view] |
| ProDom | PD004466. Ribosomal_S27e. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SUPFAM | SSF57829. Ribosomal_zn-bd. 1 hit. |
| PROSITE | PS01168. RIBOSOMAL_S27E. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| BindingDB | P42677. |
| ChEMBL | CHEMBL1932893. |
| ChiTaRS | RpS27. human. |
| GenomeRNAi | 6232. |
| NextBio | 24193. |
| SOURCE | Search... |
Entry information
| Entry name | RS27_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P42677 Secondary accession number(s): Q5T4L6 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Ribosomal proteins Ribosomal proteins families and list of entries |
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with
