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Protein

Neurolysin, mitochondrial

Gene

NLN

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A.By similarity

Catalytic activityi

Preferential cleavage in neurotensin: 10-Pro-|-Tyr-11.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi497Zinc; catalyticPROSITE-ProRule annotation1
Active sitei498PROSITE-ProRule annotation1
Metal bindingi501Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi504Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM03.002

Names & Taxonomyi

Protein namesi
Recommended name:
Neurolysin, mitochondrial (EC:3.4.24.16)
Alternative name(s):
Microsomal endopeptidase
Short name:
MEP
Mitochondrial oligopeptidase M
Neurotensin endopeptidase
Gene namesi
Name:NLN
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 37MitochondrionBy similarityAdd BLAST37
ChainiPRO_000002857738 – 704Neurolysin, mitochondrialAdd BLAST667

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei664N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP42675

Interactioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000008123

Structurei

3D structure databases

ProteinModelPortaliP42675
SMRiP42675
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2089 Eukaryota
COG0339 LUCA
HOGENOMiHOG000245985
HOVERGENiHBG000238
InParanoidiP42675
KOiK01393

Family and domain databases

Gene3Di1.10.1370.10, 2 hits
1.20.1050.40, 1 hit
3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR024079 MetalloPept_cat_dom_sf
IPR024077 Neurolysin/TOP_dom2
IPR024080 Neurolysin/TOP_N
IPR001567 Pept_M3A_M3B
PfamiView protein in Pfam
PF01432 Peptidase_M3, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42675-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIARCFSAVR GLHRVGGSRI LFKMTLGREV MSPLQAVSSY TAAGRNVLRW
60 70 80 90 100
DLSPEQIKTR TEELIAQTKQ VYDSVGMLDI KDVTYENCLQ ALADVEVKYI
110 120 130 140 150
VERTMLDFPQ HVSTDREVRA ASTEADKRLS RFDIEMSMRE DIFQRIVHLQ
160 170 180 190 200
ETCDLEKIKP EARRYLEKSV KMGRRNGLHL PEEVQNEIKS MKKRMSELCI
210 220 230 240 250
DFNKNLNEDD TFLVFSKAEL GALPDDFIDS LEKMDDDKYK ITLKYPHYFP
260 270 280 290 300
VMKKCCIPET RRRMEMAFNT RCKEENTVIL QQLLPLRAQV AKLLGYSTHA
310 320 330 340 350
DFVLEMNTAK STSRVTAFLD DLSQKLKPLG EAEREFILSL KKKECEEKGF
360 370 380 390 400
EYDGKINAWD LHYYMTQTEE LKYSIDQEFI KEYFPIEVVT EGLLNIYQEL
410 420 430 440 450
LGLSFEQVAD AHVWNPSVTL YTVKDKATGE VLGQFYLDLY PREGKYNHAA
460 470 480 490 500
CFGLQPGCLL PDGSRMLSVA ALVVNFSQPV AGRPSLLRHD EVRTYFHEFG
510 520 530 540 550
HVMHQICAQT DFARFSGTNV ETDFVEVPSQ MLENWVWDID SLRRLSKHYK
560 570 580 590 600
DGNPIADDLL EKLVASRLVN TGLLTLRQIV LSKVDQSLHT NSSLDAASEY
610 620 630 640 650
ARYCTDILGV AATPGTNMPA TFGHLAGGYD GQYYGYLWSE VFSMDMFYSC
660 670 680 690 700
FKKEGIMNPE VGMKYRNLIL RPGGSLDGMD MLQNFLQREP NQKAFLMSRG

LQAP
Length:704
Mass (Da):80,689
Last modified:November 1, 1995 - v1
Checksum:iA1B7E4DE38E8088C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13310 mRNA Translation: BAA02570.1
PIRiA45985
RefSeqiXP_008260508.1, XM_008262286.1

Genome annotation databases

GeneIDi100357326
KEGGiocu:100357326

Similar proteinsi

Entry informationi

Entry nameiNEUL_RABIT
AccessioniPrimary (citable) accession number: P42675
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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