Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P42671

- CAPSH_ADEG1

UniProt

P42671 - CAPSH_ADEG1

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Hexon protein

Gene
N/A
Organism
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps))
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Major capsid protein that self-associates to form 240 hexon trimers, each in the shape of a hexagon, building most of the pseudo T=25 capsid. Assembled into trimeric units with the help of the chaperone shutoff protein. Transported by pre-protein VI to the nucleus where it associates with other structural proteins to form an empty capsid. Might be involved, through its interaction with host dyneins, in the intracellular microtubule-dependent transport of incoming viral capsid to the nucleus (By similarity).By similarity

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. microtubule-dependent intracellular transport of viral material towards nucleus Source: UniProtKB-KW
  2. viral entry into host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cytoplasmic inwards viral transport, Host-virus interaction, Microtubular inwards viral transport, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Hexon protein
Short name:
CP-H
Alternative name(s):
Protein II
OrganismiFowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps))
Taxonomic identifieri10553 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageAdenoviridaeAviadenovirusFowl aviadenovirus A
Virus hostiGalliformes [TaxID: 8976]
ProteomesiUP000001594: Genome

Subcellular locationi

Virion By similarity. Host nucleus By similarity
Note: Forms the capsid icosahedric shell. Present in 720 copies per virion, assembled in 240 trimers (By similarity).By similarity

GO - Cellular componenti

  1. host cell nucleus Source: UniProtKB-KW
  2. intracellular Source: GOC
  3. T=25 icosahedral viral capsid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Host nucleus, T=25 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 942942Hexon proteinPRO_0000221826Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei931 – 9311Phosphotyrosine; by hostBy similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Inductioni

Expressed in the late phase of the viral replicative cycle.

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Homotrimer (By similarity). Interacts with the capsid vertex protein; this interaction binds the peripentonal hexons to the neighboring penton base. Interacts with the hexon-linking protein; this interaction tethers the hexons surrounding the penton to those situated in the central plate of the facet. Interacts with the hexon-interlacing protein; this interaction lashes the hexons together. Interacts with host dyneins DYNC1LI1 and DYNC1I2; this interaction might be involved in intracellular microtubule-dependent transport of incoming viral capsid. Interacts with the shutoff protein; this interaction allows folding and formation of hexons trimers. Interacts with pre-protein VI; this interaction probably allows nuclear import of hexon trimers and possibly pre-capsid assembly (By similarity).By similarity

Structurei

Secondary structure

1
942
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi13 – 175
Beta strandi20 – 234
Turni26 – 283
Helixi31 – 399
Turni40 – 423
Beta strandi47 – 504
Beta strandi59 – 624
Beta strandi69 – 735
Beta strandi82 – 898
Beta strandi106 – 1083
Beta strandi121 – 1233
Beta strandi153 – 1564
Beta strandi188 – 1925
Beta strandi201 – 2033
Beta strandi205 – 2073
Beta strandi209 – 2135
Beta strandi217 – 2193
Beta strandi235 – 2395
Beta strandi252 – 2576
Beta strandi277 – 2793
Helixi295 – 2973
Beta strandi299 – 3013
Helixi306 – 3083
Helixi331 – 34111
Turni349 – 3524
Helixi360 – 3634
Turni383 – 3853
Beta strandi396 – 3983
Beta strandi404 – 4063
Helixi431 – 44313
Helixi445 – 4473
Helixi450 – 4523
Beta strandi453 – 4553
Turni462 – 4643
Helixi471 – 4744
Helixi481 – 4833
Beta strandi486 – 4894
Helixi497 – 4993
Helixi511 – 5166
Beta strandi522 – 5243
Beta strandi530 – 5323
Turni537 – 5415
Beta strandi551 – 5566
Turni559 – 5613
Beta strandi564 – 5674
Turni572 – 5754
Beta strandi584 – 5885
Helixi594 – 60411
Beta strandi619 – 6224
Beta strandi632 – 6409
Beta strandi647 – 6504
Helixi676 – 6783
Beta strandi690 – 6956
Turni696 – 6983
Beta strandi699 – 7024
Beta strandi707 – 7093
Beta strandi711 – 7144
Beta strandi719 – 7224
Turni735 – 74612
Helixi758 – 7603
Beta strandi762 – 7643
Beta strandi766 – 7727
Beta strandi780 – 7867
Beta strandi797 – 8015
Turni806 – 8083
Beta strandi813 – 8153
Beta strandi817 – 8204
Beta strandi838 – 8425
Beta strandi855 – 8573
Beta strandi863 – 8719
Turni878 – 8803
Turni883 – 8864
Beta strandi890 – 8978
Beta strandi909 – 9124
Beta strandi923 – 9253
Beta strandi934 – 9363

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2INYX-ray3.90A1-942[»]
ProteinModelPortaliP42671.
SMRiP42671. Positions 2-942.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42671.

Family & Domainsi

Sequence similaritiesi

Belongs to the adenoviridae hexon protein family.Curated

Family and domain databases

Gene3Di2.70.9.10. 2 hits.
3.90.249.10. 3 hits.
InterProiIPR016108. Adenovirus_Pll_hexon_C.
IPR016107. Adenovirus_Pll_hexon_N.
IPR016110. Adenovirus_Pll_hexon_sub3.
IPR016111. Hexon_subdom4.
IPR016112. VP_dsDNA_II.
[Graphical view]
PfamiPF01065. Adeno_hexon. 1 hit.
PF03678. Adeno_hexon_C. 1 hit.
[Graphical view]
SUPFAMiSSF49749. SSF49749. 2 hits.

Sequencei

Sequence statusi: Complete.

P42671-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTALTPDLTT ATPRLQYFHI AGPGTREYLS EDLQQFISAT GSYFDLKNKF
60 70 80 90 100
RQTVVAPTRN VTTEKAQRLQ IRFYPIQTDD TPNSYRVRYS VNVGDSWVLD
110 120 130 140 150
MGATYFDIKG VLDRGPSFKP YGGTAYNPLA PREAIFNTWV ESTGPQTNVV
160 170 180 190 200
GQMTNVYTNQ TRNDKTATLQ QVNSISGVVP NVNLGPGLSQ LASRADVDNI
210 220 230 240 250
GVVGRFAKVD SAGVKQAYGA YVKPVKDDGS QSLNQTAYWL MDNGGTNYLG
260 270 280 290 300
ALAVEDYTQT LSYPDTVLVT PPTAYQQVNS GTMRACRPNY IGFRDNFINL
310 320 330 340 350
LYHDSGVCSG TLNSERSGMN VVVELQDRNT ELSYQYMLAD MMSRHHYFAL
360 370 380 390 400
WNQAVDQYDH DVRVFNNDGY EEGVPTYAFL PDGHGAGEDN GPDLSNVKIY
410 420 430 440 450
TNGQQDKGNV VAGTVSTQLN FGTIPSYEID IAAATRRNFI MSNIADYLPD
460 470 480 490 500
KYKFSIRGFD PVTDNIDPTT YFYMNRRVPL TNVVDLFTNI GARWSVDQMD
510 520 530 540 550
NVNPFNHHRN WGLKYRSQLL GNSRYCRFHI QVPQKYFAIK NLLLLPGTYT
560 570 580 590 600
YEWVLRKDPN MILQSSLGND LRADGAQIVY TEVNLMANFM PMDHNTSNQL
610 620 630 640 650
ELMLRNATND QTFADYLGAK NALYNVPAGS TLLTINIPAR TWEGMRGWSF
660 670 680 690 700
TRLKASETPQ LGAQYDVGFK YSGSIPYSDG TFYLSHTFRS MSVLFDTSIN
710 720 730 740 750
WPGNDRLLTP NLFEIKRPVA TDSEGFTMSQ CDMTKDWFLV QMATNYNYVY
760 770 780 790 800
NGYRFWPDRH YFHYDFLRNF DPMSRQGPNF LDTTLYDLVS STPVVNDTGS
810 820 830 840 850
QPSQDNVRNN SGFIAPRSWP VWTAQQGEAW PANWPYPLIG NDAISSNQTV
860 870 880 890 900
NYKKFLCDNY LWTVPFSSDF MYMGELTDLG QNPMYTNNSH SMVINFELDP
910 920 930 940
MDENTYVYML YGVFDTVRVN QPERNVLAMA YFRTPFATGN AV
Length:942
Mass (Da):106,709
Last modified:November 1, 1997 - v2
Checksum:i7F4CE8D3F17D051B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U46933 Genomic DNA. Translation: AAC54912.1.
L13161 Genomic DNA. Translation: AAA51401.1.
RefSeqiNP_043886.1. NC_001720.1.

Genome annotation databases

GeneIDi1476562.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U46933 Genomic DNA. Translation: AAC54912.1 .
L13161 Genomic DNA. Translation: AAA51401.1 .
RefSeqi NP_043886.1. NC_001720.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2INY X-ray 3.90 A 1-942 [» ]
ProteinModelPortali P42671.
SMRi P42671. Positions 2-942.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 1476562.

Miscellaneous databases

EvolutionaryTracei P42671.

Family and domain databases

Gene3Di 2.70.9.10. 2 hits.
3.90.249.10. 3 hits.
InterProi IPR016108. Adenovirus_Pll_hexon_C.
IPR016107. Adenovirus_Pll_hexon_N.
IPR016110. Adenovirus_Pll_hexon_sub3.
IPR016111. Hexon_subdom4.
IPR016112. VP_dsDNA_II.
[Graphical view ]
Pfami PF01065. Adeno_hexon. 1 hit.
PF03678. Adeno_hexon_C. 1 hit.
[Graphical view ]
SUPFAMi SSF49749. SSF49749. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence and genomic organization of the avian adenovirus CELO."
    Chiocca S., Kurzbauer R., Schaffner G., Baker A., Mautner V., Cotten M.
    J. Virol. 70:2939-2949(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Organization of the avian adenovirus genome and the structure of its endopeptidase."
    Cai F., Weber J.M.
    Virology 196:358-362(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 913-942.

Entry informationi

Entry nameiCAPSH_ADEG1
AccessioniPrimary (citable) accession number: P42671
Secondary accession number(s): Q64758
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell (By similarity).By similarity

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3