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Protein

Signal peptidase complex catalytic subunit SEC11A

Gene

Sec11a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum.By similarity

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei56By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Protein family/group databases

MEROPSiS26.009.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase complex catalytic subunit SEC11A (EC:3.4.21.89)
Alternative name(s):
Endopeptidase SP18
Microsomal signal peptidase 18 kDa subunit
Short name:
SPase 18 kDa subunit
SEC11 homolog A
SEC11-like protein 1
SPC18
Gene namesi
Name:Sec11a
Synonyms:Sec11l1, Spc18
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69360. Sec11a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 36Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini37 – 179LumenalSequence analysisAdd BLAST143

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001095461 – 179Signal peptidase complex catalytic subunit SEC11AAdd BLAST179

Proteomic databases

PaxDbiP42667.
PRIDEiP42667.

PTM databases

iPTMnetiP42667.
PhosphoSitePlusiP42667.

Interactioni

Subunit structurei

Component of the microsomal signal peptidase complex which consists of five members: SEC11A, SEC11C, SPCS1, SPCS2 and SPCS3.By similarity

Protein-protein interaction databases

IntActiP42667. 1 interactor.
MINTiMINT-4578243.
STRINGi10116.ENSRNOP00000015218.

Structurei

3D structure databases

ProteinModelPortaliP42667.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3342. Eukaryota.
COG0681. LUCA.
HOGENOMiHOG000111516.
HOVERGENiHBG057279.
InParanoidiP42667.
PhylomeDBiP42667.

Family and domain databases

Gene3Di2.10.109.10. 1 hit.
InterProiIPR019758. Pept_S26A_signal_pept_1_CS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
[Graphical view]
PANTHERiPTHR10806. PTHR10806. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00728. SIGNALPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42667-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSLDFLDDV RRMNKRQLYY QVLNFGMIVS SALMIWKGLM LITGSESPIV
60 70 80 90 100
VVLSGSMEPA FHRGDLLFLT NRVEDPIRVG EIVVFRIEGR EIPIVHRVLK
110 120 130 140 150
IHEKQDGHIK FLTKGDNNAV DDRGLYKQGQ HWLEKKDVVG RARGFVPYIG
160 170
IVTILMNDYP KFSYAVLFLL GLFVLVHRE
Length:179
Mass (Da):20,599
Last modified:November 1, 1995 - v1
Checksum:iDC6C032B0FFB167F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11319 mRNA. Translation: AAA64738.1.
PIRiI57489.
UniGeneiRn.13070.

Genome annotation databases

UCSCiRGD:69360. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11319 mRNA. Translation: AAA64738.1.
PIRiI57489.
UniGeneiRn.13070.

3D structure databases

ProteinModelPortaliP42667.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP42667. 1 interactor.
MINTiMINT-4578243.
STRINGi10116.ENSRNOP00000015218.

Protein family/group databases

MEROPSiS26.009.

PTM databases

iPTMnetiP42667.
PhosphoSitePlusiP42667.

Proteomic databases

PaxDbiP42667.
PRIDEiP42667.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:69360. rat.

Organism-specific databases

RGDi69360. Sec11a.

Phylogenomic databases

eggNOGiKOG3342. Eukaryota.
COG0681. LUCA.
HOGENOMiHOG000111516.
HOVERGENiHBG057279.
InParanoidiP42667.
PhylomeDBiP42667.

Miscellaneous databases

PROiP42667.

Family and domain databases

Gene3Di2.10.109.10. 1 hit.
InterProiIPR019758. Pept_S26A_signal_pept_1_CS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
IPR001733. Peptidase_S26B.
[Graphical view]
PANTHERiPTHR10806. PTHR10806. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00728. SIGNALPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02228. sigpep_I_arch. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC11A_RAT
AccessioniPrimary (citable) accession number: P42667
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.