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Protein

Vitellogenic carboxypeptidase

Gene

VCP

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in activating hydrolytic enzymes that are involved in the degradation of yolk proteins in developing embryos or may function as an exopeptidase in the degradation of vitellogenin.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei207 – 2071By similarity
Active sitei391 – 3911By similarity
Active sitei448 – 4481By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Protein family/group databases

ESTHERiaedae-vcp. Carboxypeptidase_S10.
MEROPSiS10.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Vitellogenic carboxypeptidase (EC:3.4.16.-)
Gene namesi
Name:VCP
ORF Names:AAEL006563
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
Proteomesi
  • UP000008820 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 19191 PublicationAdd
BLAST
Chaini20 – 471452Vitellogenic carboxypeptidasePRO_0000004336Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi135 – 1351N-linked (GlcNAc...)Curated

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Synthesized in the fat body of vitellogenic females, secreted into the hemolymph and accumulates in yolk bodies of developing oocytes.1 Publication

Developmental stagei

Maximally present at the middle of embryonic development and disappears by the end.1 Publication

Inductioni

By 20-hydroxyecdysone.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi7159.AAEL006563-PA.

Structurei

3D structure databases

ProteinModelPortaliP42660.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
HOGENOMiHOG000252949.
InParanoidiP42660.
OMAiFNSSECA.
OrthoDBiEOG091G06AA.
PhylomeDBiP42660.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR033124. Ser_caboxypep_his_AS.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42660-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKFHLLVLI AFTCYTCSDA TLWNPYKKLM RGSASPRRPG ESGEPLFLTP
60 70 80 90 100
LLQDGKIEEA RNKARVNHPM LSSVESYSGF MTVDAKHNSN LFFWYVPAKN
110 120 130 140 150
NREQAPILVW LQGGPGASSL FGMFEENGPF HIHRNKSVKQ REYSWHQNHH
160 170 180 190 200
MIYIDNPVGT GFSFTDSDEG YSTNEEHVGE NLMKFIQQFF VLFPNLLKHP
210 220 230 240 250
FYISGESYGG KFVPAFGYAI HNSQSQPKIN LQGLAIGDGY TDPLNQLNYG
260 270 280 290 300
EYLYELGLID LNGRKKFDED TAAAIACAER KDMKCANRLI QGLFDGLDGQ
310 320 330 340 350
ESYFKKVTGF SSYYNFIKGD EESKQDSVLM EFLSNPEVRK GIHVGELPFH
360 370 380 390 400
DSDGHNKVAE MLSEDTLDTV APWVSKLLSH YRVLFYNGQL DIICAYPMTV
410 420 430 440 450
DFLMKMPFDG DSEYKRANRE IYRVDGEIAG YKKRAGRLQE VLIRNAGHMV
460 470
PRDQPKWAFD MITSFTHKNY L
Length:471
Mass (Da):53,766
Last modified:July 22, 2008 - v3
Checksum:i91FD6331DD156472
GO

Sequence cautioni

The sequence AAA17682 differs from that shown. Reason: Frameshift at position 426. Lacks the last active site residue.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371R → P in AAC41580 (PubMed:9087558).Curated
Sequence conflicti136 – 1361K → N in AAA17682 (PubMed:1961751).Curated
Sequence conflicti284 – 2852KC → NS in AAC41580 (PubMed:9087558).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M79452 mRNA. Translation: AAA17682.1. Frameshift.
L46594 Genomic DNA. Translation: AAC41580.1.
CH477395 Genomic DNA. Translation: EAT41863.1.
PIRiA41612.
RefSeqiXP_001652056.1. XM_001652006.1.
UniGeneiAae.5325.

Genome annotation databases

EnsemblMetazoaiAAEL006563-RA; AAEL006563-PA; AAEL006563.
GeneIDi5568117.
KEGGiaag:AaeL_AAEL006563.
VectorBaseiAAEL006563-RA; AAEL006563-PA; AAEL006563.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M79452 mRNA. Translation: AAA17682.1. Frameshift.
L46594 Genomic DNA. Translation: AAC41580.1.
CH477395 Genomic DNA. Translation: EAT41863.1.
PIRiA41612.
RefSeqiXP_001652056.1. XM_001652006.1.
UniGeneiAae.5325.

3D structure databases

ProteinModelPortaliP42660.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7159.AAEL006563-PA.

Protein family/group databases

ESTHERiaedae-vcp. Carboxypeptidase_S10.
MEROPSiS10.003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAAEL006563-RA; AAEL006563-PA; AAEL006563.
GeneIDi5568117.
KEGGiaag:AaeL_AAEL006563.
VectorBaseiAAEL006563-RA; AAEL006563-PA; AAEL006563.

Organism-specific databases

CTDi5568117.

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
HOGENOMiHOG000252949.
InParanoidiP42660.
OMAiFNSSECA.
OrthoDBiEOG091G06AA.
PhylomeDBiP42660.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR033124. Ser_caboxypep_his_AS.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00560. CARBOXYPEPT_SER_HIS. 1 hit.
PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVCP_AEDAE
AccessioniPrimary (citable) accession number: P42660
Secondary accession number(s): Q175U2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 22, 2008
Last modified: September 7, 2016
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.