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Protein

14-3-3-like protein GF14 upsilon

Gene

GRF5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Is associated with a DNA binding complex that binds to the G box, a well-characterized cis-acting DNA regulatory element found in plant genes. May be involved in cell cycle regulation by binding to soluble EDE1 and sequestering it in an inactive form during the early stages of mitosis.1 Publication

GO - Molecular functioni

  • ATP binding Source: TAIR

GO - Biological processi

  • response to cadmium ion Source: TAIR
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-ATH-3371453. Regulation of HSF1-mediated heat shock response.
R-ATH-3371511. HSF1 activation.

Names & Taxonomyi

Protein namesi
Recommended name:
14-3-3-like protein GF14 upsilon
Alternative name(s):
General regulatory factor 5
Gene namesi
Name:GRF5
Ordered Locus Names:At5g16050
ORF Names:F1N13_190
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G16050.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

  • Note: Not associated with microtubules.

GO - Cellular componenti

  • cell wall Source: TAIR
  • cytosol Source: TAIR
  • Golgi apparatus Source: TAIR
  • mitochondrion Source: TAIR
  • nucleus Source: UniProtKB-SubCell
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 26826814-3-3-like protein GF14 upsilonPRO_0000058667Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei267 – 2671PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP42645.
PRIDEiP42645.

PTM databases

iPTMnetiP42645.

Expressioni

Gene expression databases

GenevisibleiP42645. AT.

Interactioni

Subunit structurei

Interacts with EDE1.1 Publication

Protein-protein interaction databases

BioGridi16738. 12 interactions.
IntActiP42645. 6 interactions.
MINTiMINT-7147385.
STRINGi3702.AT5G16050.1.

Structurei

3D structure databases

ProteinModelPortaliP42645.
SMRiP42645. Positions 5-239.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

eggNOGiKOG0841. Eukaryota.
COG5040. LUCA.
HOGENOMiHOG000240379.
KOiK06630.
OMAiNSDHVSI.
OrthoDBiEOG09360IZO.
PhylomeDBiP42645.

Family and domain databases

InterProiIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERiPTHR18860. PTHR18860. 1 hit.
PfamiPF00244. 14-3-3. 1 hit.
[Graphical view]
PIRSFiPIRSF000868. 14-3-3. 1 hit.
PRINTSiPR00305. 1433ZETA.
SMARTiSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMiSSF48445. SSF48445. 1 hit.
PROSITEiPS00796. 1433_1. 1 hit.
PS00797. 1433_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42645-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDSSREEN VYLAKLAEQA ERYEEMVEFM EKVAKTVETE ELTVEERNLL
60 70 80 90 100
SVAYKNVIGA RRASWRIISS IEQKEDSRGN SDHVSIIKDY RGKIETELSK
110 120 130 140 150
ICDGILNLLE AHLIPAASLA ESKVFYLKMK GDYHRYLAEF KTGAERKEAA
160 170 180 190 200
ESTLVAYKSA QDIALADLAP THPIRLGLAL NFSVFYYEIL NSSDRACSLA
210 220 230 240 250
KQAFDEAISE LDTLGEESYK DSTLIMQLLR DNLTLWTSDL NDEAGDDIKE
260
APKEVQKVDE QAQPPPSQ
Length:268
Mass (Da):30,182
Last modified:October 1, 1996 - v2
Checksum:iECB35B7E53F688FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09109 mRNA. Translation: AAB06585.1.
AF001415 Genomic DNA. Translation: AAB62225.1.
AL391145 Genomic DNA. Translation: CAC01804.1.
CP002688 Genomic DNA. Translation: AED92241.1.
AY035170 mRNA. Translation: AAK59674.1.
AY059115 mRNA. Translation: AAL15221.1.
PIRiS71173.
T51388.
RefSeqiNP_568325.1. NM_121610.3.
UniGeneiAt.25563.
At.64750.

Genome annotation databases

EnsemblPlantsiAT5G16050.1; AT5G16050.1; AT5G16050.
GeneIDi831462.
GrameneiAT5G16050.1; AT5G16050.1; AT5G16050.
KEGGiath:AT5G16050.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09109 mRNA. Translation: AAB06585.1.
AF001415 Genomic DNA. Translation: AAB62225.1.
AL391145 Genomic DNA. Translation: CAC01804.1.
CP002688 Genomic DNA. Translation: AED92241.1.
AY035170 mRNA. Translation: AAK59674.1.
AY059115 mRNA. Translation: AAL15221.1.
PIRiS71173.
T51388.
RefSeqiNP_568325.1. NM_121610.3.
UniGeneiAt.25563.
At.64750.

3D structure databases

ProteinModelPortaliP42645.
SMRiP42645. Positions 5-239.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi16738. 12 interactions.
IntActiP42645. 6 interactions.
MINTiMINT-7147385.
STRINGi3702.AT5G16050.1.

PTM databases

iPTMnetiP42645.

Proteomic databases

PaxDbiP42645.
PRIDEiP42645.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G16050.1; AT5G16050.1; AT5G16050.
GeneIDi831462.
GrameneiAT5G16050.1; AT5G16050.1; AT5G16050.
KEGGiath:AT5G16050.

Organism-specific databases

TAIRiAT5G16050.

Phylogenomic databases

eggNOGiKOG0841. Eukaryota.
COG5040. LUCA.
HOGENOMiHOG000240379.
KOiK06630.
OMAiNSDHVSI.
OrthoDBiEOG09360IZO.
PhylomeDBiP42645.

Enzyme and pathway databases

ReactomeiR-ATH-3371453. Regulation of HSF1-mediated heat shock response.
R-ATH-3371511. HSF1 activation.

Miscellaneous databases

PROiP42645.

Gene expression databases

GenevisibleiP42645. AT.

Family and domain databases

InterProiIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERiPTHR18860. PTHR18860. 1 hit.
PfamiPF00244. 14-3-3. 1 hit.
[Graphical view]
PIRSFiPIRSF000868. 14-3-3. 1 hit.
PRINTSiPR00305. 1433ZETA.
SMARTiSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMiSSF48445. SSF48445. 1 hit.
PROSITEiPS00796. 1433_1. 1 hit.
PS00797. 1433_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei14335_ARATH
AccessioniPrimary (citable) accession number: P42645
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.