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P42642 (NOV_COTJA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein NOV
Alternative name(s):
CCN family member 3
Nephroblastoma-overexpressed gene protein
Gene names
Name:NOV
Synonyms:CCN3
OrganismCoturnix coturnix japonica (Japanese quail) (Coturnix japonica)
Taxonomic identifier93934 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePerdicinaeCoturnix

Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Immediate-early protein likely to play a role in cell growth regulation By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the CCN family.

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Contains 1 IGFBP N-terminal domain.

Contains 1 TSP type-1 domain.

Contains 1 VWFC domain.

Ontologies

Keywords
   Cellular componentSecreted
   DiseaseProto-oncogene
   DomainSignal
   Molecular functionGrowth factor
   PTMDisulfide bond
Glycoprotein
Gene Ontology (GO)
   Biological_processregulation of cell growth

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 353327Protein NOV
PRO_0000014414

Regions

Domain29 – 10375IGFBP N-terminal
Domain106 – 17267VWFC
Domain203 – 24846TSP type-1
Domain260 – 33475CTCK

Amino acid modifications

Glycosylation2761N-linked (GlcNAc...) Potential
Disulfide bond260 ↔ 297 By similarity
Disulfide bond277 ↔ 311 By similarity
Disulfide bond288 ↔ 327 By similarity
Disulfide bond291 ↔ 329 By similarity
Disulfide bond296 ↔ 333 By similarity

Sequences

Sequence LengthMass (Da)Tools
P42642 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 717D9F8533882E89

FASTA35338,667
        10         20         30         40         50         60 
MEPGGGHSLP VLLLLLLLLL LRPSEVNGRE APCPRPCGGR CPAEPPRCAP GVPAVLDGCG 

        70         80         90        100        110        120 
CCLVCARQRG ESCSPLLPCD ESGGLYCDRG PEDGGGTGIC MVLEGDNCVF DGMIYRNGET 

       130        140        150        160        170        180 
FQPSCKYQCT CRDGQIGCLP RCNLGLLLPG PDCPFPRKIE VPGECCEKWV CEPRDEVLLG 

       190        200        210        220        230        240 
GFAMAAYRQE ATLGIDVSDS SANCIEQTTE WSACSRSCGM GFSTRVTNRN QQCEMVKQTR 

       250        260        270        280        290        300 
LCMMRPCENE EPSDKKGKKC IRTKKSMKAV RFEYKNCTSV QTYKPRYCGL CNDGRCCTPH 

       310        320        330        340        350 
NTKTIQVEFR CPQGKFLKKP MMLINTCVCH GNCPQSNNAF FQPLDPMSSE AKI 

« Hide

References

[1]Weiskirchen R., Bister K.
Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U13063 mRNA. Translation: AAA21128.1.

3D structure databases

ProteinModelPortalP42642.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG000635.

Family and domain databases

InterProIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNOV_COTJA
AccessionPrimary (citable) accession number: P42642
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families