Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein NOV

Gene

NOV

Organism
Coturnix japonica (Japanese quail) (Coturnix coturnix japonica)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Immediate-early protein likely to play a role in cell growth regulation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein NOV
Alternative name(s):
CCN family member 3
Nephroblastoma-overexpressed gene protein
Gene namesi
Name:NOV
Synonyms:CCN3
OrganismiCoturnix japonica (Japanese quail) (Coturnix coturnix japonica)
Taxonomic identifieri93934 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePerdicinaeCoturnix

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001441427 – 353Protein NOVAdd BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi260 ↔ 297By similarity
Glycosylationi276N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi277 ↔ 311By similarity
Disulfide bondi288 ↔ 327By similarity
Disulfide bondi291 ↔ 329By similarity
Disulfide bondi296 ↔ 333By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP42642

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliP42642
SMRiP42642
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 103IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST75
Domaini106 – 172VWFCPROSITE-ProRule annotationAdd BLAST67
Domaini203 – 248TSP type-1PROSITE-ProRule annotationAdd BLAST46
Domaini260 – 334CTCKPROSITE-ProRule annotationAdd BLAST75

Sequence similaritiesi

Belongs to the CCN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG000635

Family and domain databases

InterProiView protein in InterPro
IPR006207 Cys_knot_C
IPR006208 Glyco_hormone_CN
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
IPR012395 IGFBP_CNN
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR001007 VWF_dom
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
PF00219 IGFBP, 1 hit
PF00093 VWC, 1 hit
PIRSFiPIRSF036495 IGFBP_rP_CNN, 1 hit
SMARTiView protein in SMART
SM00041 CT, 1 hit
SM00121 IB, 1 hit
SM00209 TSP1, 1 hit
SM00214 VWC, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF82895 SSF82895, 1 hit
PROSITEiView protein in PROSITE
PS01185 CTCK_1, 1 hit
PS01225 CTCK_2, 1 hit
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS50092 TSP1, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42642-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGGGHSLP VLLLLLLLLL LRPSEVNGRE APCPRPCGGR CPAEPPRCAP
60 70 80 90 100
GVPAVLDGCG CCLVCARQRG ESCSPLLPCD ESGGLYCDRG PEDGGGTGIC
110 120 130 140 150
MVLEGDNCVF DGMIYRNGET FQPSCKYQCT CRDGQIGCLP RCNLGLLLPG
160 170 180 190 200
PDCPFPRKIE VPGECCEKWV CEPRDEVLLG GFAMAAYRQE ATLGIDVSDS
210 220 230 240 250
SANCIEQTTE WSACSRSCGM GFSTRVTNRN QQCEMVKQTR LCMMRPCENE
260 270 280 290 300
EPSDKKGKKC IRTKKSMKAV RFEYKNCTSV QTYKPRYCGL CNDGRCCTPH
310 320 330 340 350
NTKTIQVEFR CPQGKFLKKP MMLINTCVCH GNCPQSNNAF FQPLDPMSSE

AKI
Length:353
Mass (Da):38,667
Last modified:November 1, 1995 - v1
Checksum:i717D9F8533882E89
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13063 mRNA Translation: AAA21128.1
RefSeqiNP_001310148.1, NM_001323219.1

Genome annotation databases

GeneIDi107310512
KEGGicjo:107310512

Entry informationi

Entry nameiNOV_COTJA
AccessioniPrimary (citable) accession number: P42642
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health