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Protein

Prosialokinin

Gene

AAEL000229

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Vasodilatory peptide. May activate macrophages at the site of feeding.2 Publications

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Names & Taxonomyi

Protein namesi
Recommended name:
Prosialokinin
Cleaved into the following chain:
Alternative name(s):
Sialokinin I
Short name:
Sia I
Sialokinin II
Short name:
Sia II
Sialokinin-1
Sialokinin-2
Gene namesi
ORF Names:AAEL000229
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
Proteomesi
  • UP000008820 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
PropeptideiPRO_000034449524 – 74Sequence analysisAdd BLAST51
PeptideiPRO_000004443075 – 84Sialokinin10

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei84Methionine amide1 Publication1

Keywords - PTMi

Amidation

Expressioni

Tissue specificityi

Expressed exclusively in the medial lobe of female salivary glands.1 Publication

Family & Domainsi

Sequence similaritiesi

Belongs to the tachykinin family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR013055. Tachy_Neuro_lke_CS.
PROSITEiView protein in PROSITE
PS00267. TACHYKININ. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42634-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMFITVQIV IVLVLAVLSE AASLPTATER KDAMDEGPNQ SDEPEGSVAD
60 70 80
PSTKDDDYSD SLKQDEKYYK VRLLNTGDKF YGLMG
Length:85
Mass (Da):9,377
Last modified:July 22, 2008 - v2
Checksum:i64152347F70A8A81
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2N → K in AAD17916 (PubMed:10620041).Curated1
Sequence conflicti15L → F in AAD17916 (PubMed:10620041).Curated1
Sequence conflicti24L → F in AAD17916 (PubMed:10620041).Curated1
Sequence conflicti30R → T in AAD16886 (PubMed:10620041).Curated1
Sequence conflicti30R → T in AAD16885 (PubMed:10620041).Curated1
Sequence conflicti50 – 51DP → NT in AAD16886 (PubMed:10620041).Curated2
Sequence conflicti50 – 51DP → NT in AAD16885 (PubMed:10620041).Curated2
Sequence conflicti54K → E in AAD16886 (PubMed:10620041).Curated1
Sequence conflicti54K → E in AAD16885 (PubMed:10620041).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti75N → D in allele Red. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF108099 Genomic DNA. Translation: AAD17916.1.
AF108100 mRNA. Translation: AAD16884.1.
AF108101 mRNA. Translation: AAD16885.1.
AF108102 mRNA. Translation: AAD16886.1.
CH477189 Genomic DNA. Translation: EAT48743.1.
PIRiA49581.
B49581.
RefSeqiXP_001660125.1. XM_001660075.1.
UniGeneiAae.23680.

Genome annotation databases

EnsemblMetazoaiAAEL000229-RA; AAEL000229-PA; AAEL000229.
GeneIDi5572020.
KEGGiaag:AaeL_AAEL000229.
VectorBaseiAAEL000229-RA; AAEL000229-PA; AAEL000229.

Keywords - Coding sequence diversityi

Polymorphism

Entry informationi

Entry nameiTKSIA_AEDAE
AccessioniPrimary (citable) accession number: P42634
Secondary accession number(s): P42635
, Q17PU8, Q9TW63, Q9UAR7, Q9UAR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 22, 2008
Last modified: October 25, 2017
This is version 71 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families