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Protein

L-serine dehydratase TdcG

Gene

tdcG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-serine = pyruvate + NH3.

Cofactori

[4Fe-4S] clusterCuratedNote: Binds 1 [4Fe-4S] cluster.Curated

Pathwayi: L-threonine degradation via propanoate pathway

This protein is involved in the pathway L-threonine degradation via propanoate pathway, which is part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the pathway L-threonine degradation via propanoate pathway and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGluconeogenesis
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:LSERINEDEAM3-MONOMER.
MetaCyc:LSERINEDEAM3-MONOMER.
BRENDAi4.3.1.17. 2026.
UniPathwayiUPA00052.

Names & Taxonomyi

Protein namesi
Recommended name:
L-serine dehydratase TdcG (EC:4.3.1.17)
Short name:
SDH
Alternative name(s):
L-serine deaminase
Gene namesi
Name:tdcG
Synonyms:yhaP, yhaQ
Ordered Locus Names:b4471, JW5520
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12756. tdcG.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001719051 – 454L-serine dehydratase TdcGAdd BLAST454

Proteomic databases

PaxDbiP42630.
PRIDEiP42630.

Interactioni

Protein-protein interaction databases

BioGridi4259263. 9 interactors.
DIPiDIP-10974N.
IntActiP42630. 3 interactors.
STRINGi316385.ECDH10B_3286.

Structurei

3D structure databases

ProteinModelPortaliP42630.
SMRiP42630.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105EJQ. Bacteria.
COG1760. LUCA.
HOGENOMiHOG000036732.
InParanoidiP42630.
KOiK01752.
PhylomeDBiP42630.

Family and domain databases

Gene3Di3.30.1330.90. 1 hit.
InterProiView protein in InterPro
IPR029009. ASB_dom.
IPR004644. Fe-S_L-Ser_mono.
IPR005130. Ser_deHydtase-like_asu.
IPR005131. Ser_deHydtase_bsu.
PfamiView protein in Pfam
PF03313. SDH_alpha. 1 hit.
PF03315. SDH_beta. 1 hit.
SUPFAMiSSF143548. SSF143548. 1 hit.
TIGRFAMsiTIGR00720. sda_mono. 1 hit.

Sequencei

Sequence statusi: Complete.

P42630-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISAFDIFKI GIGPSSSHTV GPMNAGKSFI DRLESSGLLT ATSHIVVDLY
60 70 80 90 100
GSLSLTGKGH ATDVAIIMGL AGNSPQDVVI DEIPAFIELV TRSGRLPVAS
110 120 130 140 150
GAHIVDFPVA KNIIFHPEML PRHENGMRIT AWKGQEELLS KTYYSVGGGF
160 170 180 190 200
IVEEEHFGLS HDVETSVPYD FHSAGELLKM CDYNGLSISG LMMHNELALR
210 220 230 240 250
SKAEIDAGFA RIWQVMHDGI ERGMNTEGVL PGPLNVPRRA VALRRQLVSS
260 270 280 290 300
DNISNDPMNV IDWINMYALA VSEENAAGGR VVTAPTNGAC GIIPAVLAYY
310 320 330 340 350
DKFRRPVNER SIARYFLAAG AIGALYKMNA SISGAEVGCQ GEIGVACSMA
360 370 380 390 400
AAGLTELLGG SPAQVCNAAE IAMEHNLGLT CDPVAGQVQI PCIERNAINA
410 420 430 440 450
VKAVNAARMA MRRTSAPRVS LDKVIETMYE TGKDMNDKYR ETSRGGLAIK

VVCG
Length:454
Mass (Da):48,522
Last modified:December 7, 2004 - v4
Checksum:iAB44206A490456F4
GO

Sequence cautioni

The sequence AAA57915 differs from that shown. Reason: Frameshift at position 133.Curated
The sequence AAA57916 differs from that shown. Reason: Frameshift at position 133.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57916.1. Frameshift.
U18997 Genomic DNA. Translation: AAA57915.1. Frameshift.
U00096 Genomic DNA. Translation: AAT48169.1.
AP009048 Genomic DNA. Translation: BAE77160.1.
RefSeqiWP_000622126.1. NZ_LN832404.1.
YP_026204.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48169; AAT48169; b4471.
BAE77160; BAE77160; BAE77160.
GeneIDi2847724.
KEGGiecj:JW5520.
eco:b4471.
PATRICifig|511145.12.peg.3206.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTDCG_ECOLI
AccessioniPrimary (citable) accession number: P42630
Secondary accession number(s): P42629, Q2M996, Q6BF45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 7, 2004
Last modified: July 5, 2017
This is version 129 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families