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Protein

L-serine dehydratase TdcG

Gene

tdcG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-serine = pyruvate + NH3.

Cofactori

[4Fe-4S] clusterCuratedNote: Binds 1 [4Fe-4S] cluster.Curated

Pathwayi: L-threonine degradation via propanoate pathway

This protein is involved in the pathway L-threonine degradation via propanoate pathway, which is part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the pathway L-threonine degradation via propanoate pathway and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGluconeogenesis
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:LSERINEDEAM3-MONOMER
MetaCyc:LSERINEDEAM3-MONOMER
BRENDAi4.3.1.17 2026
UniPathwayiUPA00052

Names & Taxonomyi

Protein namesi
Recommended name:
L-serine dehydratase TdcG (EC:4.3.1.17)
Short name:
SDH
Alternative name(s):
L-serine deaminase
Gene namesi
Name:tdcG
Synonyms:yhaP, yhaQ
Ordered Locus Names:b4471, JW5520
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12756 tdcG

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001719051 – 454L-serine dehydratase TdcGAdd BLAST454

Proteomic databases

PaxDbiP42630
PRIDEiP42630

Interactioni

Protein-protein interaction databases

BioGridi4259263, 9 interactors
DIPiDIP-10974N
IntActiP42630, 3 interactors
STRINGi316385.ECDH10B_3286

Structurei

3D structure databases

ProteinModelPortaliP42630
SMRiP42630
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105EJQ Bacteria
COG1760 LUCA
HOGENOMiHOG000036732
InParanoidiP42630
KOiK01752
OMAiMKNEIAM
PhylomeDBiP42630

Family and domain databases

Gene3Di3.30.1330.90, 1 hit
InterProiView protein in InterPro
IPR029009 ASB_dom_sf
IPR004644 Fe-S_L-Ser_mono
IPR005130 Ser_deHydtase-like_asu
IPR005131 Ser_deHydtase_bsu
PfamiView protein in Pfam
PF03313 SDH_alpha, 1 hit
PF03315 SDH_beta, 1 hit
SUPFAMiSSF143548 SSF143548, 1 hit
TIGRFAMsiTIGR00720 sda_mono, 1 hit

Sequencei

Sequence statusi: Complete.

P42630-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISAFDIFKI GIGPSSSHTV GPMNAGKSFI DRLESSGLLT ATSHIVVDLY
60 70 80 90 100
GSLSLTGKGH ATDVAIIMGL AGNSPQDVVI DEIPAFIELV TRSGRLPVAS
110 120 130 140 150
GAHIVDFPVA KNIIFHPEML PRHENGMRIT AWKGQEELLS KTYYSVGGGF
160 170 180 190 200
IVEEEHFGLS HDVETSVPYD FHSAGELLKM CDYNGLSISG LMMHNELALR
210 220 230 240 250
SKAEIDAGFA RIWQVMHDGI ERGMNTEGVL PGPLNVPRRA VALRRQLVSS
260 270 280 290 300
DNISNDPMNV IDWINMYALA VSEENAAGGR VVTAPTNGAC GIIPAVLAYY
310 320 330 340 350
DKFRRPVNER SIARYFLAAG AIGALYKMNA SISGAEVGCQ GEIGVACSMA
360 370 380 390 400
AAGLTELLGG SPAQVCNAAE IAMEHNLGLT CDPVAGQVQI PCIERNAINA
410 420 430 440 450
VKAVNAARMA MRRTSAPRVS LDKVIETMYE TGKDMNDKYR ETSRGGLAIK

VVCG
Length:454
Mass (Da):48,522
Last modified:December 7, 2004 - v4
Checksum:iAB44206A490456F4
GO

Sequence cautioni

The sequence AAA57915 differs from that shown. Reason: Frameshift at position 133.Curated
The sequence AAA57916 differs from that shown. Reason: Frameshift at position 133.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA57916.1 Frameshift.
U18997 Genomic DNA Translation: AAA57915.1 Frameshift.
U00096 Genomic DNA Translation: AAT48169.1
AP009048 Genomic DNA Translation: BAE77160.1
RefSeqiWP_000622126.1, NZ_LN832404.1
YP_026204.1, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAT48169; AAT48169; b4471
BAE77160; BAE77160; BAE77160
GeneIDi2847724
KEGGiecj:JW5520
eco:b4471
PATRICifig|511145.12.peg.3206

Similar proteinsi

Entry informationi

Entry nameiTDCG_ECOLI
AccessioniPrimary (citable) accession number: P42630
Secondary accession number(s): P42629, Q2M996, Q6BF45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 7, 2004
Last modified: March 28, 2018
This is version 131 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health