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Protein

Probable serine transporter

Gene

dlsT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Transports both D- and L-serine (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:YHAO-MONOMER.
ECOL316407:JW5519-MONOMER.

Protein family/group databases

TCDBi2.A.42.2.4. the hydroxy/aromatic amino acid permease (haaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine transporter
Gene namesi
Name:dlsT
Synonyms:yhaO
Ordered Locus Names:b3110, JW5519
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12754. yhaO.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 48CytoplasmicSequence analysisAdd BLAST48
Transmembranei49 – 69HelicalSequence analysisAdd BLAST21
Topological domaini70 – 110PeriplasmicSequence analysisAdd BLAST41
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 149CytoplasmicSequence analysisAdd BLAST18
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Topological domaini171 – 182PeriplasmicSequence analysisAdd BLAST12
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 214CytoplasmicSequence analysisAdd BLAST11
Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
Topological domaini236 – 264PeriplasmicSequence analysisAdd BLAST29
Transmembranei265 – 285HelicalSequence analysisAdd BLAST21
Topological domaini286 – 297CytoplasmicSequence analysisAdd BLAST12
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
Topological domaini340 – 367CytoplasmicSequence analysisAdd BLAST28
Transmembranei368 – 388HelicalSequence analysisAdd BLAST21
Topological domaini389PeriplasmicSequence analysis1
Transmembranei390 – 410HelicalSequence analysisAdd BLAST21
Topological domaini411 – 421CytoplasmicSequence analysisAdd BLAST11
Transmembranei422 – 442HelicalSequence analysisAdd BLAST21
Topological domaini443PeriplasmicSequence analysis1

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000938171 – 443Probable serine transporterAdd BLAST443

Proteomic databases

PaxDbiP42628.
PRIDEiP42628.

Interactioni

Protein-protein interaction databases

BioGridi4259267. 126 interactors.
STRINGi511145.b3110.

Structurei

3D structure databases

ProteinModelPortaliP42628.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C44. Bacteria.
COG0814. LUCA.
HOGENOMiHOG000275613.
OMAiHKYKGVS.
PhylomeDBiP42628.

Sequencei

Sequence statusi: Complete.

P42628-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIASNKGVI ADASTPAGRA GMSESEWREA IKFDSTDTGW VIMSIGMAIG
60 70 80 90 100
AGIVFLPVQV GLMGLWVFLL SSVIGYPAMY LFQRLFINTL AESPECKDYP
110 120 130 140 150
SVISGYLGKN WGILLGALYF VMLVIWMFVY STAITNDSAS YLHTFGVTEG
160 170 180 190 200
LLSDSPFYGL VLICILVAIS SRGEKLLFKI STGMVLTKLL VVAALGVSMV
210 220 230 240 250
GMWHLYNVGS LPPLGLLVKN AIITLPFTLT SILFIQTLSP MVISYRSREK
260 270 280 290 300
SIEVARHKAL RAMNIAFGIL FVTVFFYAVS FTLAMGHDEA VKAYEQNISA
310 320 330 340 350
LAIAAQFISG DGAAWVKVVS VILNIFAVMT AFFGVYLGFR EATQGIVMNI
360 370 380 390 400
LRRKMPAEKI NENLVQRGIM IFAILLAWSA IVLNAPVLSF TSICSPIFGM
410 420 430 440
VGCLIPAWLV YKVPALHKYK GMSLYLIIVT GLLLCVSPFL AFS
Length:443
Mass (Da):48,315
Last modified:October 11, 2004 - v3
Checksum:iB24A2D8E1A61E631
GO

Sequence cautioni

The sequence AAA57914 differs from that shown. Reason: Frameshift at positions 14 and 21.Curated
The sequence BAE77159 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57914.1. Frameshift.
U00096 Genomic DNA. Translation: AAT48168.3.
AP009048 Genomic DNA. Translation: BAE77159.1. Different initiation.
RefSeqiWP_000401598.1. NZ_LN832404.1.
YP_026203.3. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48168; AAT48168; b3110.
BAE77159; BAE77159; BAE77159.
GeneIDi947628.
KEGGiecj:JW5519.
eco:b3110.
PATRICi32121638. VBIEscCol129921_3205.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57914.1. Frameshift.
U00096 Genomic DNA. Translation: AAT48168.3.
AP009048 Genomic DNA. Translation: BAE77159.1. Different initiation.
RefSeqiWP_000401598.1. NZ_LN832404.1.
YP_026203.3. NC_000913.3.

3D structure databases

ProteinModelPortaliP42628.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259267. 126 interactors.
STRINGi511145.b3110.

Protein family/group databases

TCDBi2.A.42.2.4. the hydroxy/aromatic amino acid permease (haaap) family.

Proteomic databases

PaxDbiP42628.
PRIDEiP42628.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48168; AAT48168; b3110.
BAE77159; BAE77159; BAE77159.
GeneIDi947628.
KEGGiecj:JW5519.
eco:b3110.
PATRICi32121638. VBIEscCol129921_3205.

Organism-specific databases

EchoBASEiEB2609.
EcoGeneiEG12754. yhaO.

Phylogenomic databases

eggNOGiENOG4105C44. Bacteria.
COG0814. LUCA.
HOGENOMiHOG000275613.
OMAiHKYKGVS.
PhylomeDBiP42628.

Enzyme and pathway databases

BioCyciEcoCyc:YHAO-MONOMER.
ECOL316407:JW5519-MONOMER.

Miscellaneous databases

PROiP42628.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiDLST_ECOLI
AccessioniPrimary (citable) accession number: P42628
Secondary accession number(s): Q2M997, Q6BF46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.