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Protein

Pirin-like protein YhaK

Gene

yhaK

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Does not have quercetin 2,3-dioxygenase activity.1 Publication

Enzyme and pathway databases

BioCyciEcoCyc:G7620-MONOMER.
ECOL316407:JW3077-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pirin-like protein YhaK
Gene namesi
Name:yhaK
Ordered Locus Names:b3106, JW3077
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12750. yhaK.

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233Pirin-like protein YhaKPRO_0000214061Add
BLAST

Proteomic databases

PaxDbiP42624.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi4259260. 11 interactions.
IntActiP42624. 12 interactions.
STRINGi511145.b3106.

Structurei

Secondary structure

1
233
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi11 – 133Combined sources
Helixi17 – 193Combined sources
Beta strandi22 – 254Combined sources
Beta strandi40 – 489Combined sources
Beta strandi53 – 575Combined sources
Beta strandi60 – 7718Combined sources
Beta strandi82 – 865Combined sources
Beta strandi89 – 935Combined sources
Beta strandi101 – 1055Combined sources
Beta strandi108 – 1103Combined sources
Beta strandi112 – 1209Combined sources
Beta strandi129 – 1346Combined sources
Beta strandi138 – 14710Combined sources
Helixi149 – 1513Combined sources
Beta strandi156 – 1583Combined sources
Beta strandi160 – 1667Combined sources
Beta strandi171 – 1755Combined sources
Beta strandi177 – 18812Combined sources
Beta strandi190 – 1945Combined sources
Beta strandi197 – 2026Combined sources
Beta strandi207 – 2126Combined sources
Beta strandi214 – 23118Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VECX-ray1.85A2-233[»]
ProteinModelPortaliP42624.
SMRiP42624. Positions 7-233.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42624.

Family & Domainsi

Sequence similaritiesi

Belongs to the pirin family.Curated

Phylogenomic databases

eggNOGiENOG4108CNN. Bacteria.
COG1741. LUCA.
HOGENOMiHOG000114206.
InParanoidiP42624.
KOiK06911.
OMAiTQPGISY.
OrthoDBiEOG6FBWWJ.
PhylomeDBiP42624.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR012093. Pirin.
IPR003829. Pirin_N_dom.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR13903. PTHR13903. 1 hit.
PfamiPF02678. Pirin. 1 hit.
[Graphical view]
PIRSFiPIRSF006232. Pirin. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

P42624-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MITTRTARQC GQADYGWLQA RYTFSFGHYF DPKLLGYASL RVLNQEVLAP
60 70 80 90 100
GAAFQPRTYP KVDILNVILD GEAEYRDSEG NHVQASAGEA LLLSTQPGVS
110 120 130 140 150
YSEHNLSKDK PLTRMQLWLD ACPQRENPLI QKLALNMGKQ QLIASPEGAM
160 170 180 190 200
GSLQLRQQVW LHHIVLDKGE SANFQLHGPR AYLQSIHGKF HALTHHEEKA
210 220 230
ALTCGDGAFI RDEANITLVA DSPLRALLID LPV
Length:233
Mass (Da):25,895
Last modified:November 1, 1995 - v1
Checksum:i7C09B140A74E6B24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57910.1.
U00096 Genomic DNA. Translation: AAC76141.1.
AP009048 Genomic DNA. Translation: BAE77156.1.
PIRiG65099.
RefSeqiNP_417577.1. NC_000913.3.
WP_000633576.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76141; AAC76141; b3106.
BAE77156; BAE77156; BAE77156.
GeneIDi947620.
KEGGiecj:JW3077.
eco:b3106.
PATRICi32121632. VBIEscCol129921_3202.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57910.1.
U00096 Genomic DNA. Translation: AAC76141.1.
AP009048 Genomic DNA. Translation: BAE77156.1.
PIRiG65099.
RefSeqiNP_417577.1. NC_000913.3.
WP_000633576.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VECX-ray1.85A2-233[»]
ProteinModelPortaliP42624.
SMRiP42624. Positions 7-233.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259260. 11 interactions.
IntActiP42624. 12 interactions.
STRINGi511145.b3106.

Proteomic databases

PaxDbiP42624.

Protocols and materials databases

DNASUi947620.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76141; AAC76141; b3106.
BAE77156; BAE77156; BAE77156.
GeneIDi947620.
KEGGiecj:JW3077.
eco:b3106.
PATRICi32121632. VBIEscCol129921_3202.

Organism-specific databases

EchoBASEiEB2606.
EcoGeneiEG12750. yhaK.

Phylogenomic databases

eggNOGiENOG4108CNN. Bacteria.
COG1741. LUCA.
HOGENOMiHOG000114206.
InParanoidiP42624.
KOiK06911.
OMAiTQPGISY.
OrthoDBiEOG6FBWWJ.
PhylomeDBiP42624.

Enzyme and pathway databases

BioCyciEcoCyc:G7620-MONOMER.
ECOL316407:JW3077-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP42624.
PROiP42624.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR012093. Pirin.
IPR003829. Pirin_N_dom.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR13903. PTHR13903. 1 hit.
PfamiPF02678. Pirin. 1 hit.
[Graphical view]
PIRSFiPIRSF006232. Pirin. 1 hit.
SUPFAMiSSF51182. SSF51182. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  3. "The crystal structure of the protein YhaK from Escherichia coli reveals a new subclass of redox sensitive enterobacterial bicupins."
    Gurmu D., Lu J., Johnson K.A., Nordlund P., Holmgren A., Erlandsen H.
    Proteins 74:18-31(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS), FUNCTION, SUBUNIT, SUBCELLULAR LOCATION, LACK OF QUERCETINASE ACTIVITY.

Entry informationi

Entry nameiYHAK_ECOLI
AccessioniPrimary (citable) accession number: P42624
Secondary accession number(s): Q2M9A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 20, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Contains Cys residues that are easily oxidized.

Caution

Lacks the conserved His residues required for metal binding. Its function must therefore be different from the metal-dependent roles proposed for other family members.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.