Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Modulator protein MzrA

Gene

mzrA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR. Links the two-component systems CpxA/CpxR and EnvZ/OmpR.UniRule annotation2 Publications

GO - Biological processi

  • regulation of protein kinase activity Source: EcoCyc
Complete GO annotation...

Enzyme and pathway databases

BioCyciEcoCyc:G7610-MONOMER.
ECOL316407:JW3067-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Modulator protein MzrAUniRule annotation
Gene namesi
Name:mzrAUniRule annotation
Synonyms:ecfM, yqjB
Ordered Locus Names:b3096, JW3067
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12741. mzrA.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicUniRule annotation
Transmembranei11 – 3121HelicalUniRule annotationAdd
BLAST
Topological domaini32 – 12796PeriplasmicUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi51 – 511D → A: Loss of activity. Decreases interaction with EnvZ. 1 Publication
Mutagenesisi67 – 671K → A: No change in activity. 1 Publication
Mutagenesisi74 – 741D → A: No change in activity. 1 Publication
Mutagenesisi78 – 781I → F: Loss of activity. Decreases interaction with EnvZ. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 127127Modulator protein MzrAPRO_0000169427Add
BLAST

Proteomic databases

PaxDbiP42615.

Expressioni

Inductioni

Regulated by the CpxA/CpxR two-component system. Negatively regulated by EnvZ/OmpR.2 Publications

Interactioni

Subunit structurei

Interacts with EnvZ.UniRule annotation2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
envZP0AEJ43EBI-6412632,EBI-1121750

Protein-protein interaction databases

BioGridi4259422. 9 interactions.
IntActiP42615. 1 interaction.
STRINGi511145.b3096.

Structurei

3D structure databases

ProteinModelPortaliP42615.
SMRiP42615. Positions 33-104.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Interacts with EnvZ through its soluble periplasmic region.1 Publication

Sequence similaritiesi

Belongs to the MzrA family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105IYR. Bacteria.
ENOG4112345. LUCA.
HOGENOMiHOG000125148.
OMAiKHETTLE.

Family and domain databases

HAMAPiMF_00904. Modulator_MzrA. 1 hit.
InterProiIPR026574. Modulator_MzrA.
IPR027398. SecD-TM.
[Graphical view]
PfamiPF13721. SecD-TM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQIPRMSLRQ LAWSGAVLLL VGTLLLAWSA VRQQESTLAI RAVHQGTTMP
60 70 80 90 100
DGFSIWHHLD AHGIPFKSIT PKNDTLLITF DSSDQSAAAK AVLDRTLPHG
110 120
YIIAQQDNNS QAMQWLTRLR DNSHRFG
Length:127
Mass (Da):14,172
Last modified:November 1, 1995 - v1
Checksum:i814A6F43756E7E86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57900.1.
U00096 Genomic DNA. Translation: AAC76131.1.
AP009048 Genomic DNA. Translation: BAE77146.1.
PIRiE65098.
RefSeqiNP_417567.1. NC_000913.3.
WP_001166760.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76131; AAC76131; b3096.
BAE77146; BAE77146; BAE77146.
GeneIDi947619.
KEGGiecj:JW3067.
eco:b3096.
PATRICi32121612. VBIEscCol129921_3192.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57900.1.
U00096 Genomic DNA. Translation: AAC76131.1.
AP009048 Genomic DNA. Translation: BAE77146.1.
PIRiE65098.
RefSeqiNP_417567.1. NC_000913.3.
WP_001166760.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP42615.
SMRiP42615. Positions 33-104.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4259422. 9 interactions.
IntActiP42615. 1 interaction.
STRINGi511145.b3096.

Proteomic databases

PaxDbiP42615.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76131; AAC76131; b3096.
BAE77146; BAE77146; BAE77146.
GeneIDi947619.
KEGGiecj:JW3067.
eco:b3096.
PATRICi32121612. VBIEscCol129921_3192.

Organism-specific databases

EchoBASEiEB2597.
EcoGeneiEG12741. mzrA.

Phylogenomic databases

eggNOGiENOG4105IYR. Bacteria.
ENOG4112345. LUCA.
HOGENOMiHOG000125148.
OMAiKHETTLE.

Enzyme and pathway databases

BioCyciEcoCyc:G7610-MONOMER.
ECOL316407:JW3067-MONOMER.

Miscellaneous databases

PROiP42615.

Family and domain databases

HAMAPiMF_00904. Modulator_MzrA. 1 hit.
InterProiIPR026574. Modulator_MzrA.
IPR027398. SecD-TM.
[Graphical view]
PfamiPF13721. SecD-TM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMZRA_ECOLI
AccessioniPrimary (citable) accession number: P42615
Secondary accession number(s): Q2M9B0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.