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Protein

Inner membrane protein alx

Gene

alx

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciEcoCyc:G7607-MONOMER.
ECOL316407:JW5515-MONOMER.

Protein family/group databases

TCDBi2.A.109.1.7. the tellurium ion resistance (terc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Inner membrane protein alx
Gene namesi
Name:alx
Synonyms:ygjT
Ordered Locus Names:b3088, JW5515
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12731. alx.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6PeriplasmicSequence analysis6
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Topological domaini28 – 43CytoplasmicSequence analysisAdd BLAST16
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Topological domaini65 – 89PeriplasmicSequence analysisAdd BLAST25
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Topological domaini111 – 113CytoplasmicSequence analysis3
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135PeriplasmicSequence analysis1
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 198CytoplasmicSequence analysisAdd BLAST42
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 225PeriplasmicSequence analysis6
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Topological domaini247 – 261CytoplasmicSequence analysisAdd BLAST15
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Topological domaini283 – 286PeriplasmicSequence analysis4
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21
Topological domaini308 – 321CytoplasmicSequence analysisAdd BLAST14

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001034101 – 321Inner membrane protein alxAdd BLAST321

Proteomic databases

PaxDbiP42601.
PRIDEiP42601.

Expressioni

Inductioni

By extreme alkaline conditions.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi4262405. 14 interactors.
STRINGi511145.b3088.

Structurei

3D structure databases

ProteinModelPortaliP42601.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TerC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DU1. Bacteria.
COG0861. LUCA.
HOGENOMiHOG000230189.
InParanoidiP42601.
OMAiHLRMTDS.
PhylomeDBiP42601.

Family and domain databases

InterProiIPR005496. Integral_membrane_TerC.
IPR022369. Integral_membrane_TerC_rswitch.
[Graphical view]
PANTHERiPTHR30238:SF0. PTHR30238:SF0. 1 hit.
PfamiPF03741. TerC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03718. R_switched_Alx. 1 hit.

Sequencei

Sequence statusi: Complete.

P42601-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTVGTPLLW GGFAVVVAIM LAIDLLLQGR RGAHAMTMKQ AAAWSLVWVT
60 70 80 90 100
LSLLFNAAFW WYLVQTEGRA VADPQALAFL TGYLIEKSLA VDNVFVWLML
110 120 130 140 150
FSYFSVPAAL QRRVLVYGVL GAIVLRTIMI FTGSWLISQF DWILYIFGAF
160 170 180 190 200
LLFTGVKMAL AHEDESGIGD KPLVRWLRGH LRMTDTIDNE HFFVRKNGLL
210 220 230 240 250
YATPLMLVLI LVELSDVIFA VDSIPAIFAV TTDPFIVLTS NLFAILGLRA
260 270 280 290 300
MYFLLAGVAE RFSMLKYGLA VILVFIGIKM LIVDFYHIPI AVSLGVVFGI
310 320
LVMTFIINAW VNYRHDKQRG G
Length:321
Mass (Da):35,909
Last modified:October 11, 2004 - v2
Checksum:iB6E1C173442799C3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti172 – 179PLVRWLRG → RWCAGYAV in AAA57890 (PubMed:9278503).Curated8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57890.1.
U00096 Genomic DNA. Translation: AAT48166.1.
AP009048 Genomic DNA. Translation: BAE77138.1.
PIRiE65097.
RefSeqiWP_001098806.1. NZ_LN832404.1.
YP_026201.1. NC_000913.3.

Genome annotation databases

EnsemblBacteriaiAAT48166; AAT48166; b3088.
BAE77138; BAE77138; BAE77138.
GeneIDi947607.
KEGGiecj:JW5515.
eco:b3088.
PATRICi32121594. VBIEscCol129921_3183.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA. Translation: AAA57890.1.
U00096 Genomic DNA. Translation: AAT48166.1.
AP009048 Genomic DNA. Translation: BAE77138.1.
PIRiE65097.
RefSeqiWP_001098806.1. NZ_LN832404.1.
YP_026201.1. NC_000913.3.

3D structure databases

ProteinModelPortaliP42601.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262405. 14 interactors.
STRINGi511145.b3088.

Protein family/group databases

TCDBi2.A.109.1.7. the tellurium ion resistance (terc) family.

Proteomic databases

PaxDbiP42601.
PRIDEiP42601.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAT48166; AAT48166; b3088.
BAE77138; BAE77138; BAE77138.
GeneIDi947607.
KEGGiecj:JW5515.
eco:b3088.
PATRICi32121594. VBIEscCol129921_3183.

Organism-specific databases

EchoBASEiEB2589.
EcoGeneiEG12731. alx.

Phylogenomic databases

eggNOGiENOG4105DU1. Bacteria.
COG0861. LUCA.
HOGENOMiHOG000230189.
InParanoidiP42601.
OMAiHLRMTDS.
PhylomeDBiP42601.

Enzyme and pathway databases

BioCyciEcoCyc:G7607-MONOMER.
ECOL316407:JW5515-MONOMER.

Miscellaneous databases

PROiP42601.

Family and domain databases

InterProiIPR005496. Integral_membrane_TerC.
IPR022369. Integral_membrane_TerC_rswitch.
[Graphical view]
PANTHERiPTHR30238:SF0. PTHR30238:SF0. 1 hit.
PfamiPF03741. TerC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03718. R_switched_Alx. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiALX_ECOLI
AccessioniPrimary (citable) accession number: P42601
Secondary accession number(s): Q2M9B8, Q6BF48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 11, 2004
Last modified: November 2, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.