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Reviewed, UniProtKB/Swiss-Prot P42601 (ALX_ECOLI)

Last modified June 16, 2009. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Inner membrane protein alx
Gene names
Name: alx
Synonyms: ygjT
Ordered Locus Names: b3088, JW5515
OrganismEscherichia coli (strain K12) [Complete proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

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Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Subcellular location

Cell inner membrane; Multi-pass membrane protein.

Induction

By extreme alkaline conditions. Ref.4 Ref.5

Sequence similarities

Belongs to the terC family.

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Ontologies

Keywords
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 321321Inner membrane protein alx
PRO_0000103410

Regions

Topological domain1 – 66Periplasmic Potential
Transmembrane7 – 2721 Potential
Topological domain28 – 4316Cytoplasmic Potential
Transmembrane44 – 6421 Potential
Topological domain65 – 8925Periplasmic Potential
Transmembrane90 – 11021 Potential
Topological domain111 – 1133Cytoplasmic Potential
Transmembrane114 – 13421 Potential
Topological domain1351Periplasmic Potential
Transmembrane136 – 15621 Potential
Topological domain157 – 19842Cytoplasmic Potential
Transmembrane199 – 21921 Potential
Topological domain220 – 2256Periplasmic Potential
Transmembrane226 – 24621 Potential
Topological domain247 – 26115Cytoplasmic Potential
Transmembrane262 – 28221 Potential
Topological domain283 – 2864Periplasmic Potential
Transmembrane287 – 30721 Potential
Topological domain308 – 32114Cytoplasmic Potential

Experimental info

Sequence conflict172 – 1798PLVRWLRG → RWCAGYAV in AAA57890. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P42601-1 [UniParc].

Last modified October 11, 2004. Version 2.
Checksum: B6E1C173442799C3

FASTA32135,909
        10         20         30         40         50         60 
MNTVGTPLLW GGFAVVVAIM LAIDLLLQGR RGAHAMTMKQ AAAWSLVWVT LSLLFNAAFW 

        70         80         90        100        110        120 
WYLVQTEGRA VADPQALAFL TGYLIEKSLA VDNVFVWLML FSYFSVPAAL QRRVLVYGVL 

       130        140        150        160        170        180 
GAIVLRTIMI FTGSWLISQF DWILYIFGAF LLFTGVKMAL AHEDESGIGD KPLVRWLRGH 

       190        200        210        220        230        240 
LRMTDTIDNE HFFVRKNGLL YATPLMLVLI LVELSDVIFA VDSIPAIFAV TTDPFIVLTS 

       250        260        270        280        290        300 
NLFAILGLRA MYFLLAGVAE RFSMLKYGLA VILVFIGIKM LIVDFYHIPI AVSLGVVFGI 

       310        320 
LVMTFIINAW VNYRHDKQRG G

« Hide

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References

« Hide 'large scale' references
[1]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[2]"Escherichia coli K-12: a cooperatively developed annotation snapshot -- 2005."
Riley M., Abe T., Arnaud M.B., Berlyn M.K.B., Blattner F.R., Chaudhuri R.R., Glasner J.D., Horiuchi T., Keseler I.M., Kosuge T., Mori H., Perna N.T., Plunkett G. III, Rudd K.E., Serres M.H., Thomas G.H., Thomson N.R., Wishart D., Wanner B.L.
Nucleic Acids Res. 34:1-9(2006) [PubMed: 16397293] [Abstract]
Cited for: SEQUENCE REVISION TO 172-179.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]"Alkaline induction of a novel gene locus, alx, in Escherichia coli."
Bingham R.J., Hall K.S., Slonczewski J.L.
J. Bacteriol. 172:2184-2186(1990) [PubMed: 2108134] [Abstract]
Cited for: GENE NAME, INDUCTION.
Strain: K12.
[5]"pH-dependent expression of periplasmic proteins and amino acid catabolism in Escherichia coli."
Stancik L.M., Stancik D.M., Schmidt B., Barnhart D.M., Yoncheva Y.N., Slonczewski J.L.
J. Bacteriol. 184:4246-4258(2002) [PubMed: 12107143] [Abstract]
Cited for: INDUCTION.
Strain: K12.
[6]"Global topology analysis of the Escherichia coli inner membrane proteome."
Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
Science 308:1321-1323(2005) [PubMed: 15919996] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: K12 / MG1655 / ATCC 47076.

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Cross-references

Sequence databases

U18997 Genomic DNA. Translation: AAA57890.1.
U00096 Genomic DNA. Translation: AAT48166.1.
AP009048 Genomic DNA. Translation: BAE77138.1.
PIRE65097.
RefSeqAP_003637.1.
YP_026201.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID947607.
GenomeReviewsGene locus JW5515 in contig AP009048_GR.
Gene locus b3088 in contig U00096_GR.
KEGGecj:JW5515.
eco:b3088.

Organism-specific databases

EchoBASEEB2589.
EcoGeneEG12731. alx.
CMRSearch...

Phylogenomic databases

HOGENOMP42601.
OMAP42601. WMRSHLR.

Enzyme and pathway databases

BioCycEcoCyc:G7607-MON.

Family and domain databases

InterProIPR005496. TerC.
[Graphical view]
PfamPF03741. TerC. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameALX_ECOLI
AccessionPrimary (citable) accession number: P42601
Secondary accession number(s): Q2M9B8, Q6BF48
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 11, 2004
Last modified: June 16, 2009
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents