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Protein

Putative membrane-bound redox modulator Alx

Gene

alx

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has been proposed to be a redox modulator.1 Publication

Enzyme and pathway databases

BioCyciEcoCyc:G7607-MONOMER

Protein family/group databases

TCDBi2.A.109.1.7 the tellurium ion resistance (terc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Putative membrane-bound redox modulator Alx
Gene namesi
Name:alx1 Publication
Synonyms:ygjT
Ordered Locus Names:b3088, JW5515
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12731 alx

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6PeriplasmicSequence analysis6
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Topological domaini28 – 43CytoplasmicSequence analysisAdd BLAST16
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Topological domaini65 – 89PeriplasmicSequence analysisAdd BLAST25
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Topological domaini111 – 113CytoplasmicSequence analysis3
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135PeriplasmicSequence analysis1
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 198CytoplasmicSequence analysisAdd BLAST42
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 225PeriplasmicSequence analysis6
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Topological domaini247 – 261CytoplasmicSequence analysisAdd BLAST15
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Topological domaini283 – 286PeriplasmicSequence analysis4
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21
Topological domaini308 – 321CytoplasmicSequence analysis1 PublicationAdd BLAST14

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001034101 – 321Putative membrane-bound redox modulator AlxAdd BLAST321

Proteomic databases

PaxDbiP42601
PRIDEiP42601

Expressioni

Inductioni

By extreme alkaline conditions.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi4262405, 14 interactors
STRINGi316385.ECDH10B_3264

Structurei

3D structure databases

ProteinModelPortaliP42601
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TerC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DU1 Bacteria
COG0861 LUCA
HOGENOMiHOG000230189
InParanoidiP42601
OMAiADHAREY
PhylomeDBiP42601

Family and domain databases

InterProiView protein in InterPro
IPR005496 Integral_membrane_TerC
IPR022369 Integral_membrane_TerC_rswitch
PANTHERiPTHR30238:SF0 PTHR30238:SF0, 1 hit
PfamiView protein in Pfam
PF03741 TerC, 1 hit
TIGRFAMsiTIGR03718 R_switched_Alx, 1 hit

Sequencei

Sequence statusi: Complete.

P42601-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTVGTPLLW GGFAVVVAIM LAIDLLLQGR RGAHAMTMKQ AAAWSLVWVT
60 70 80 90 100
LSLLFNAAFW WYLVQTEGRA VADPQALAFL TGYLIEKSLA VDNVFVWLML
110 120 130 140 150
FSYFSVPAAL QRRVLVYGVL GAIVLRTIMI FTGSWLISQF DWILYIFGAF
160 170 180 190 200
LLFTGVKMAL AHEDESGIGD KPLVRWLRGH LRMTDTIDNE HFFVRKNGLL
210 220 230 240 250
YATPLMLVLI LVELSDVIFA VDSIPAIFAV TTDPFIVLTS NLFAILGLRA
260 270 280 290 300
MYFLLAGVAE RFSMLKYGLA VILVFIGIKM LIVDFYHIPI AVSLGVVFGI
310 320
LVMTFIINAW VNYRHDKQRG G
Length:321
Mass (Da):35,909
Last modified:October 11, 2004 - v2
Checksum:iB6E1C173442799C3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti172 – 179PLVRWLRG → RWCAGYAV in AAA57890 (PubMed:9278503).Curated8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA57890.1
U00096 Genomic DNA Translation: AAT48166.1
AP009048 Genomic DNA Translation: BAE77138.1
PIRiE65097
RefSeqiWP_001098806.1, NZ_LN832404.1
YP_026201.1, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAT48166; AAT48166; b3088
BAE77138; BAE77138; BAE77138
GeneIDi947607
KEGGiecj:JW5515
eco:b3088
PATRICifig|1411691.4.peg.3641

Similar proteinsi

Entry informationi

Entry nameiALX_ECOLI
AccessioniPrimary (citable) accession number: P42601
Secondary accession number(s): Q2M9B8, Q6BF48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 11, 2004
Last modified: March 28, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health