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Protein

UTP pyrophosphatase

Gene

ygjP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Specifically catalyzes the hydrolysis of UTP to UMP and diphosphate in vitro, albeit at apparently slow rate. Shows no activity towards ATP, GTP, CTP, dTTP and ITP as substrates.1 Publication

Catalytic activityi

UTP + H2O = UMP + diphosphate.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandNucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:G7604-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
UTP pyrophosphatase1 Publication (EC:3.6.1.-1 Publication)
Gene namesi
Name:ygjPImported
Synonyms:upp1 Publication
Ordered Locus Names:b3085, JW5514
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12727 ygjP

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001694241 – 167UTP pyrophosphataseAdd BLAST167

Proteomic databases

PaxDbiP42597
PRIDEiP42597

Interactioni

Protein-protein interaction databases

BioGridi4260874, 23 interactors
STRINGi316385.ECDH10B_3260

Structurei

3D structure databases

ProteinModelPortaliP42597
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG4108VKG Bacteria
COG1451 LUCA
HOGENOMiHOG000276637
InParanoidiP42597
KOiK07043
OMAiLCCYMEP
PhylomeDBiP42597

Family and domain databases

InterProiView protein in InterPro
IPR002725 DUF45
PfamiView protein in Pfam
PF01863 DUF45, 1 hit

Sequencei

Sequence statusi: Complete.

P42597-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNLTYLQGY PEQLLSQVRT LINEQRLGDV LAKRYPGTHD YATDKALWQY
60 70 80 90 100
TQDLKNQFLR NAPPINKVMY DNKIHVLKNA LGLHTAVSRV QGGKLKAKVE
110 120 130 140 150
IRVATVFRNA PEPFLRMIVV HELAHLKEKE HNKAFYQLCC HMEPQYHQLE
160
FDTRLWLTQL SLGQNKI
Length:167
Mass (Da):19,483
Last modified:December 4, 2007 - v2
Checksum:i4E9BB4FE99F385EB
GO

Sequence cautioni

The sequence AAA57886 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18997 Genomic DNA Translation: AAA57886.1 Different initiation.
U00096 Genomic DNA Translation: AAC76120.2
AP009048 Genomic DNA Translation: BAE77135.1
PIRiB65097
RefSeqiNP_417556.2, NC_000913.3
WP_001333820.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76120; AAC76120; b3085
BAE77135; BAE77135; BAE77135
GeneIDi947650
KEGGiecj:JW5514
eco:b3085
PATRICifig|511145.12.peg.3180

Similar proteinsi

Entry informationi

Entry nameiUTPP_ECOLI
AccessioniPrimary (citable) accession number: P42597
Secondary accession number(s): Q2M9C1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 4, 2007
Last modified: March 28, 2018
This is version 109 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health