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P42578 (FRIY_LYMST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Yolk ferritin

EC=1.16.3.1
OrganismLymnaea stagnalis (Great pond snail) (Helix stagnalis)
Taxonomic identifier6523 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraPanpulmonataHygrophilaLymnaeoideaLymnaeidaeLymnaea

Protein attributes

Sequence length239 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation By similarity.

Catalytic activity

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Subunit structure

Oligomer of 12 or 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric ferric iron core is deposited By similarity.

Subcellular location

Secreted.

Tissue specificity

Midgut gland and bloodstream.

Developmental stage

First detected during pregastrulation stage, levels increase up to the hatching stage, and is still present at the late veliger stage.

Domain

Contains an 'insertion' sequence of 42 residues which is not present in other ferritins.

Sequence similarities

Belongs to the ferritin family.

Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
   Biological processIron storage
   Cellular componentSecreted
   DomainSignal
   LigandIron
Metal-binding
   Molecular functionOxidoreductase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processcellular iron ion homeostasis

Inferred from electronic annotation. Source: UniProtKB-KW

iron ion transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionferric iron binding

Inferred from electronic annotation. Source: InterPro

ferroxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Ref.1
Chain19 – 239221Yolk ferritin
PRO_0000008852

Regions

Domain27 – 217191Ferritin-like diiron
Region105 – 14642Insertion; not present in other ferritins

Sites

Metal binding441Iron 1 By similarity
Metal binding791Iron 1 By similarity
Metal binding791Iron 2 By similarity
Metal binding1651Iron 2 By similarity
Metal binding1991Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P42578 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: E1C5873012DEEFFC

FASTA23927,338
        10         20         30         40         50         60 
MNSVLFLTLA VCSSLAYGKE FVATVRQNYK ENINQLLEQQ IQKELAASYI YQAYASYFQR 

        70         80         90        100        110        120 
ADVSLPGIKK FFSDASSEER DDAQSLIDYI NQRGGHVQYD KIDLKDACET VMKFVTSDTS 

       130        140        150        160        170        180 
GLEEFRDRRM CICGFVATKT INDNCGERSD WKEGLIAFED TLAIERYVNA QLLDIHKKAD 

       190        200        210        220        230 
DEKDAHLTHI LEHEFLEEQV SSINKIAHAI TRLRSFEQGS GNNYKLGRVY LRPTPQISH 

« Hide

References

[1]"cDNA cloning and deduced amino acid sequence of two ferritins: soma ferritin and yolk ferritin, from the snail Lymnaea stagnalis L."
von Darl M., Harrison M., Bottke W.
Eur. J. Biochem. 222:353-366(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 19-38.
Tissue: Midgut.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X56779 mRNA. Translation: CAA40097.1.
PIRS45604.

3D structure databases

ProteinModelPortalP42578.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.1260.10. 2 hits.
InterProIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERPTHR11431. PTHR11431. 1 hit.
PfamPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 2 hits.
PROSITEPS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFRIY_LYMST
AccessionPrimary (citable) accession number: P42578
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families