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P42577 (FRIS_LYMST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Soma ferritin

EC=1.16.3.1
OrganismLymnaea stagnalis (Great pond snail) (Helix stagnalis)
Taxonomic identifier6523 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraPanpulmonataHygrophilaLymnaeoideaLymnaeidaeLymnaea

Protein attributes

Sequence length174 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation By similarity.

Catalytic activity

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Subunit structure

Oligomer of 12 or 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric mineral iron core is deposited By similarity.

Subcellular location

Cytoplasm.

Tissue specificity

Expressed in somatic tissues but not in oocytes.

Sequence similarities

Belongs to the ferritin family.

Contains 1 ferritin-like diiron domain.

Ontologies

Keywords
   Biological processIron storage
   Cellular componentCytoplasm
   LigandIron
Metal-binding
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processcellular iron ion homeostasis

Inferred from electronic annotation. Source: UniProtKB-KW

iron ion transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionferric iron binding

Inferred from electronic annotation. Source: InterPro

ferroxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain2 – 174173Soma ferritin
PRO_0000201070

Regions

Domain8 – 157150Ferritin-like diiron

Sites

Metal binding251Iron 1 By similarity
Metal binding601Iron 1 By similarity
Metal binding601Iron 2 By similarity
Metal binding631Iron 1 By similarity
Metal binding1051Iron 2 By similarity
Metal binding1391Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P42577 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 2787604323BF702E

FASTA17420,140
        10         20         30         40         50         60 
MSVSQARQNY HAESEAGINR QINMELYASY SYQSMAYYFD RDDVALPGFH KFFKHQSEEE 

        70         80         90        100        110        120 
REHAEKLMKY QNKRGGRIVL QDIKKPDRDE WGTGLEAMQV ALQLEKSVNQ SLLDLHKLCT 

       130        140        150        160        170 
SHDDAQMADF LESEFLEEQV KSIKELSDYI TNLKRVGPGL GEYIFDKETL SSSS 

« Hide

References

[1]"cDNA cloning and deduced amino acid sequence of two ferritins: soma ferritin and yolk ferritin, from the snail Lymnaea stagnalis L."
von Darl M., Harrison M., Bottke W.
Eur. J. Biochem. 222:353-366(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Visceral mass.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X56778 mRNA. Translation: CAA40096.1.
PIRS45603.

3D structure databases

ProteinModelPortalP42577.
SMRP42577. Positions 3-170.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.1260.10. 1 hit.
InterProIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERPTHR11431. PTHR11431. 1 hit.
PfamPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00540. FERRITIN_1. 1 hit.
PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFRIS_LYMST
AccessionPrimary (citable) accession number: P42577
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families