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Protein

Caspase-2

Gene

CASP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.

Catalytic activityi

Strict requirement for an Asp residue at P1, with 316-asp being essential for proteolytic activity and has a preferred cleavage sequence of Val-Asp-Val-Ala-Asp-|-.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei277By similarity1
Active sitei320By similarity1

GO - Molecular functioni

  • cysteine-type endopeptidase activity Source: UniProtKB
  • cysteine-type endopeptidase activity involved in apoptotic process Source: GO_Central
  • enzyme binding Source: UniProtKB
  • protein domain specific binding Source: BHF-UCL

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: Reactome
  • aging Source: Ensembl
  • apoptotic process Source: UniProtKB
  • apoptotic signaling pathway Source: UniProtKB
  • brain development Source: Ensembl
  • cellular response to mechanical stimulus Source: UniProtKB
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: UniProtKB
  • ectopic germ cell programmed cell death Source: Ensembl
  • execution phase of apoptosis Source: UniProtKB
  • extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  • intrinsic apoptotic signaling pathway in response to DNA damage Source: UniProtKB
  • luteolysis Source: Ensembl
  • neural retina development Source: Ensembl
  • positive regulation of apoptotic process Source: UniProtKB
  • positive regulation of apoptotic signaling pathway Source: Ensembl
  • positive regulation of neuron apoptotic process Source: Ensembl
  • protein processing Source: BHF-UCL
  • regulation of apoptotic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BioCyciZFISH:HS02869-MONOMER.
BRENDAi3.4.22.55. 2681.
ReactomeiR-HSA-168638. NOD1/2 Signaling Pathway.
R-HSA-205025. NADE modulates death signalling.
R-HSA-6803207. TP53 Regulates Transcription of Caspase Activators and Caspases.
SIGNORiP42575.

Protein family/group databases

MEROPSiC14.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase-2 (EC:3.4.22.55)
Short name:
CASP-2
Alternative name(s):
Neural precursor cell expressed developmentally down-regulated protein 2
Short name:
NEDD-2
Protease ICH-1
Cleaved into the following 3 chains:
Gene namesi
Name:CASP2
Synonyms:ICH1, NEDD2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:1503. CASP2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • cytosol Source: Reactome
  • membrane Source: Ensembl
  • mitochondrion Source: Ensembl
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi320C → S: Loss of function. 1
Mutagenesisi369A → T: Loss of function. 1

Organism-specific databases

DisGeNETi835.
OpenTargetsiENSG00000106144.
PharmGKBiPA26086.

Chemistry databases

ChEMBLiCHEMBL4884.
GuidetoPHARMACOLOGYi1618.

Polymorphism and mutation databases

BioMutaiCASP2.
DMDMi83300977.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
PropeptideiPRO_00000045412 – 169Add BLAST168
ChainiPRO_0000004542170 – 325Caspase-2 subunit p18Add BLAST156
PropeptideiPRO_0000004543326 – 3338
ChainiPRO_0000004544334 – 452Caspase-2 subunit p13Add BLAST119
ChainiPRO_0000004545348 – 452Caspase-2 subunit p12Add BLAST105

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei157PhosphoserineCombined sources1
Modified residuei340PhosphoserineCombined sources1

Post-translational modificationi

The mature protease can process its own propeptide, but not that of other caspases.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Zymogen

Proteomic databases

EPDiP42575.
MaxQBiP42575.
PaxDbiP42575.
PeptideAtlasiP42575.
PRIDEiP42575.

PTM databases

iPTMnetiP42575.
PhosphoSitePlusiP42575.

Miscellaneous databases

PMAP-CutDBP42575.

Expressioni

Tissue specificityi

Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.

Gene expression databases

BgeeiENSG00000106144.
CleanExiHS_CASP2.
ExpressionAtlasiP42575. baseline and differential.
GenevisibleiP42575. HS.

Organism-specific databases

HPAiCAB012175.
HPA050678.

Interactioni

Subunit structurei

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a p18 subunit and a p12 subunit. Interacts with LRDD. Interacts with NOL3 (via CARD domain); inhibits CASP2 activity in a phosphorylation-dependent manner.By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-520342,EBI-520342
CASP2P42575-12EBI-520342,EBI-520357
CRADDP7856016EBI-520342,EBI-520375
PRKDCP785274EBI-520342,EBI-352053

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • protein domain specific binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi107285. 32 interactors.
IntActiP42575. 10 interactors.
MINTiMINT-150255.
STRINGi9606.ENSP00000312664.

Chemistry databases

BindingDBiP42575.

Structurei

Secondary structure

1452
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi181 – 187Combined sources7
Helixi188 – 190Combined sources3
Beta strandi197 – 206Combined sources10
Beta strandi212 – 214Combined sources3
Helixi222 – 235Combined sources14
Beta strandi238 – 245Combined sources8
Helixi248 – 259Combined sources12
Helixi262 – 265Combined sources4
Beta strandi267 – 276Combined sources10
Beta strandi282 – 284Combined sources3
Beta strandi290 – 292Combined sources3
Helixi293 – 299Combined sources7
Turni302 – 304Combined sources3
Helixi306 – 308Combined sources3
Beta strandi313 – 319Combined sources7
Beta strandi321 – 324Combined sources4
Beta strandi363 – 370Combined sources8
Beta strandi377 – 379Combined sources3
Turni380 – 382Combined sources3
Helixi385 – 397Combined sources13
Turni398 – 400Combined sources3
Helixi403 – 415Combined sources13
Turni425 – 428Combined sources4
Beta strandi434 – 437Combined sources4
Beta strandi440 – 442Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PYOX-ray1.65A/C167-333[»]
B/D348-452[»]
2P2CX-ray3.24A/C/E/G/I/K167-333[»]
B/D/F/H/J/L348-452[»]
3R5JX-ray1.77A/C175-333[»]
B/D349-452[»]
3R6GX-ray2.07A/C175-333[»]
B/D349-452[»]
3R6LX-ray1.90A/C175-333[»]
B/D349-452[»]
3R7BX-ray1.80A/C175-333[»]
B/D349-452[»]
3R7NX-ray2.33A/C175-333[»]
B/D349-452[»]
3R7SX-ray2.25A/C175-333[»]
B/D349-452[»]
3RJMX-ray2.55A/C167-333[»]
B/D348-452[»]
ProteinModelPortaliP42575.
SMRiP42575.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42575.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 121CARDPROSITE-ProRule annotationAdd BLAST90

Sequence similaritiesi

Belongs to the peptidase C14A family.Curated
Contains 1 CARD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
GeneTreeiENSGT00760000118912.
HOVERGENiHBG103962.
InParanoidiP42575.
KOiK02186.
OMAiPNLQNKP.
OrthoDBiEOG091G05YD.
PhylomeDBiP42575.
TreeFamiTF102023.

Family and domain databases

CDDicd00032. CASc. 1 hit.
Gene3Di1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProiIPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR011029. DEATH-like_dom.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A.
IPR017350. Pept_C14A_CASP1-typ.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52129. SSF52129. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Isoforms differ in the N- and C-termini.
Isoform 1 (identifier: P42575-1) [UniParc]FASTAAdd to basket
Also known as: ICH-1L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPSAGSWS TFQHKELMAA DRGRRILGVC GMHPHHQETL KKNRVVLAKQ
60 70 80 90 100
LLLSELLEHL LEKDIITLEM RELIQAKVGS FSQNVELLNL LPKRGPQAFD
110 120 130 140 150
AFCEALRETK QGHLEDMLLT TLSGLQHVLP PLSCDYDLSL PFPVCESCPL
160 170 180 190 200
YKKLRLSTDT VEHSLDNKDG PVCLQVKPCT PEFYQTHFQL AYRLQSRPRG
210 220 230 240 250
LALVLSNVHF TGEKELEFRS GGDVDHSTLV TLFKLLGYDV HVLCDQTAQE
260 270 280 290 300
MQEKLQNFAQ LPAHRVTDSC IVALLSHGVE GAIYGVDGKL LQLQEVFQLF
310 320 330 340 350
DNANCPSLQN KPKMFFIQAC RGDETDRGVD QQDGKNHAGS PGCEESDAGK
360 370 380 390 400
EKLPKMRLPT RSDMICGYAC LKGTAAMRNT KRGSWYIEAL AQVFSERACD
410 420 430 440 450
MHVADMLVKV NALIKDREGY APGTEFHRCK EMSEYCSTLC RHLYLFPGHP

PT
Note: Acts as a positive regulator of apoptosis.
Length:452
Mass (Da):50,685
Last modified:December 6, 2005 - v2
Checksum:i6EF0ED05EF808385
GO
Isoform 2 (identifier: P42575-2) [UniParc]FASTAAdd to basket
Also known as: ICH-1S

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.
     323-452: DETDRGVDQQ...LYLFPGHPPT → GGAIGSLGHLLLFTAATASLAL

Note: Acts as a negative regulator of apoptosis.
Show »
Length:313
Mass (Da):34,923
Checksum:iFA1E307A41B8299E
GO
Isoform 3 (identifier: P42575-3) [UniParc]FASTAAdd to basket
Also known as: Casp-2L-Pro

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: Missing.
     107-108: RE → HS
     109-452: Missing.

Note: May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death.
Show »
Length:91
Mass (Da):10,309
Checksum:iE80E3D9233686A98
GO

Sequence cautioni

The sequence AAA58959 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAO25653 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAP22346 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAP22349 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD92877 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti309 – 322QNKPK…QACRG → EEVTSLSILSAFVT in BAD92877 (Ref. 10) CuratedAdd BLAST14

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055621105A → G.Corresponds to variant rs4647298dbSNPEnsembl.1
Natural variantiVAR_016334172V → L.3 PublicationsCorresponds to variant rs4647297dbSNPEnsembl.1
Natural variantiVAR_016335178P → A.1 PublicationCorresponds to variant rs4647298dbSNPEnsembl.1
Natural variantiVAR_016336441R → G.1 PublicationCorresponds to variant rs4647338dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0008011 – 31Missing in isoform 2. 2 PublicationsAdd BLAST31
Alternative sequenceiVSP_0462801 – 17Missing in isoform 3. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_046281107 – 108RE → HS in isoform 3. 1 Publication2
Alternative sequenceiVSP_046282109 – 452Missing in isoform 3. 1 PublicationAdd BLAST344
Alternative sequenceiVSP_000802323 – 452DETDR…GHPPT → GGAIGSLGHLLLFTAATASL AL in isoform 2. 2 PublicationsAdd BLAST130

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13021 mRNA. Translation: AAA58959.1. Different initiation.
U13022 mRNA. Translation: AAA58960.1.
AF314174 mRNA. Translation: AAK00299.1.
AF314175 mRNA. Translation: AAK00300.1.
CR541748 mRNA. Translation: CAG46548.1.
AK291274 mRNA. Translation: BAF83963.1.
AY219042 Genomic DNA. Translation: AAO25653.1. Different initiation.
AC073342 Genomic DNA. Translation: AAP22346.1. Different initiation.
AC073342 Genomic DNA. Translation: AAP22347.1.
AC073342 Genomic DNA. Translation: AAP22348.1.
AC073342 Genomic DNA. Translation: AAP22349.1. Different initiation.
CH471198 Genomic DNA. Translation: EAW51863.1.
CH471198 Genomic DNA. Translation: EAW51867.1.
CH471198 Genomic DNA. Translation: EAW51870.1.
BC002427 mRNA. Translation: AAH02427.2.
BT007240 mRNA. Translation: AAP35904.1.
AB209640 mRNA. Translation: BAD92877.1. Different initiation.
CCDSiCCDS5879.1. [P42575-1]
PIRiA54821.
RefSeqiNP_001215.1. NM_001224.4.
NP_116764.2. NM_032982.3. [P42575-1]
NP_116765.2. NM_032983.3.
UniGeneiHs.368982.

Genome annotation databases

EnsembliENST00000310447; ENSP00000312664; ENSG00000106144. [P42575-1]
GeneIDi835.
KEGGihsa:835.
UCSCiuc003wco.3. human. [P42575-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13021 mRNA. Translation: AAA58959.1. Different initiation.
U13022 mRNA. Translation: AAA58960.1.
AF314174 mRNA. Translation: AAK00299.1.
AF314175 mRNA. Translation: AAK00300.1.
CR541748 mRNA. Translation: CAG46548.1.
AK291274 mRNA. Translation: BAF83963.1.
AY219042 Genomic DNA. Translation: AAO25653.1. Different initiation.
AC073342 Genomic DNA. Translation: AAP22346.1. Different initiation.
AC073342 Genomic DNA. Translation: AAP22347.1.
AC073342 Genomic DNA. Translation: AAP22348.1.
AC073342 Genomic DNA. Translation: AAP22349.1. Different initiation.
CH471198 Genomic DNA. Translation: EAW51863.1.
CH471198 Genomic DNA. Translation: EAW51867.1.
CH471198 Genomic DNA. Translation: EAW51870.1.
BC002427 mRNA. Translation: AAH02427.2.
BT007240 mRNA. Translation: AAP35904.1.
AB209640 mRNA. Translation: BAD92877.1. Different initiation.
CCDSiCCDS5879.1. [P42575-1]
PIRiA54821.
RefSeqiNP_001215.1. NM_001224.4.
NP_116764.2. NM_032982.3. [P42575-1]
NP_116765.2. NM_032983.3.
UniGeneiHs.368982.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PYOX-ray1.65A/C167-333[»]
B/D348-452[»]
2P2CX-ray3.24A/C/E/G/I/K167-333[»]
B/D/F/H/J/L348-452[»]
3R5JX-ray1.77A/C175-333[»]
B/D349-452[»]
3R6GX-ray2.07A/C175-333[»]
B/D349-452[»]
3R6LX-ray1.90A/C175-333[»]
B/D349-452[»]
3R7BX-ray1.80A/C175-333[»]
B/D349-452[»]
3R7NX-ray2.33A/C175-333[»]
B/D349-452[»]
3R7SX-ray2.25A/C175-333[»]
B/D349-452[»]
3RJMX-ray2.55A/C167-333[»]
B/D348-452[»]
ProteinModelPortaliP42575.
SMRiP42575.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107285. 32 interactors.
IntActiP42575. 10 interactors.
MINTiMINT-150255.
STRINGi9606.ENSP00000312664.

Chemistry databases

BindingDBiP42575.
ChEMBLiCHEMBL4884.
GuidetoPHARMACOLOGYi1618.

Protein family/group databases

MEROPSiC14.006.

PTM databases

iPTMnetiP42575.
PhosphoSitePlusiP42575.

Polymorphism and mutation databases

BioMutaiCASP2.
DMDMi83300977.

Proteomic databases

EPDiP42575.
MaxQBiP42575.
PaxDbiP42575.
PeptideAtlasiP42575.
PRIDEiP42575.

Protocols and materials databases

DNASUi835.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310447; ENSP00000312664; ENSG00000106144. [P42575-1]
GeneIDi835.
KEGGihsa:835.
UCSCiuc003wco.3. human. [P42575-1]

Organism-specific databases

CTDi835.
DisGeNETi835.
GeneCardsiCASP2.
HGNCiHGNC:1503. CASP2.
HPAiCAB012175.
HPA050678.
MIMi600639. gene.
neXtProtiNX_P42575.
OpenTargetsiENSG00000106144.
PharmGKBiPA26086.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3573. Eukaryota.
ENOG410ZQIE. LUCA.
GeneTreeiENSGT00760000118912.
HOVERGENiHBG103962.
InParanoidiP42575.
KOiK02186.
OMAiPNLQNKP.
OrthoDBiEOG091G05YD.
PhylomeDBiP42575.
TreeFamiTF102023.

Enzyme and pathway databases

BioCyciZFISH:HS02869-MONOMER.
BRENDAi3.4.22.55. 2681.
ReactomeiR-HSA-168638. NOD1/2 Signaling Pathway.
R-HSA-205025. NADE modulates death signalling.
R-HSA-6803207. TP53 Regulates Transcription of Caspase Activators and Caspases.
SIGNORiP42575.

Miscellaneous databases

ChiTaRSiCASP2. human.
EvolutionaryTraceiP42575.
GeneWikiiCaspase_2.
GenomeRNAii835.
PMAP-CutDBP42575.
PROiP42575.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106144.
CleanExiHS_CASP2.
ExpressionAtlasiP42575. baseline and differential.
GenevisibleiP42575. HS.

Family and domain databases

CDDicd00032. CASc. 1 hit.
Gene3Di1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProiIPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR033139. Caspase_cys_AS.
IPR016129. Caspase_his_AS.
IPR011029. DEATH-like_dom.
IPR002138. Pept_C14_p10.
IPR001309. Pept_C14_p20.
IPR015917. Pept_C14A.
IPR017350. Pept_C14A_CASP1-typ.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
SSF52129. SSF52129. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCASP2_HUMAN
AccessioniPrimary (citable) accession number: P42575
Secondary accession number(s): A8K5F9
, D3DXD6, E9PDN0, P42576, Q59F21, Q7KZL6, Q86UJ3, Q9BUP7, Q9BZK9, Q9BZL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 6, 2005
Last modified: November 30, 2016
This is version 176 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.