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P42568

- AF9_HUMAN

UniProt

P42568 - AF9_HUMAN

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Protein

Protein AF-9

Gene
MLLT3, AF9, YEATS3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei375 – 3751KMT2A/MLL1 fusion point (in acute myeloid leukemia patient CO)
Sitei481 – 4811KMT2A/MLL1 fusion point (in acute myeloid leukemia patient F1)

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. negative regulation of canonical Wnt signaling pathway Source: MGI
  3. positive regulation of Wnt signaling pathway, planar cell polarity pathway Source: MGI
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. segment specification Source: Ensembl
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein AF-9
Alternative name(s):
ALL1-fused gene from chromosome 9 protein
Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein
YEATS domain-containing protein 3
Gene namesi
Name:MLLT3
Synonyms:AF9, YEATS3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:7136. MLLT3.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: UniProt
  2. nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving MLLT3 is associated with acute leukemias. Translocation t(9;11)(p22;q23) with KMT2A/MLL1. The result is a rogue activator protein.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

PharmGKBiPA30852.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568Protein AF-9PRO_0000215921Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei288 – 2881Phosphoserine1 Publication
Modified residuei294 – 2941Phosphoserine2 Publications
Modified residuei412 – 4121Phosphoserine1 Publication
Modified residuei419 – 4191Phosphoserine1 Publication
Modified residuei429 – 4291Phosphoserine1 Publication
Modified residuei483 – 4831Phosphoserine3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP42568.
PaxDbiP42568.
PRIDEiP42568.

PTM databases

PhosphoSiteiP42568.

Expressioni

Gene expression databases

ArrayExpressiP42568.
BgeeiP42568.
CleanExiHS_MLLT3.
GenevestigatoriP42568.

Organism-specific databases

HPAiHPA001824.

Interactioni

Subunit structurei

Component of the super elongation complex (SEC), at least composed of EAF1, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Interacts with BCOR. Interacts with ALKBH4 and CBX8.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AFF4Q9UHB74EBI-716132,EBI-395282
DOT1LQ8TEK33EBI-716132,EBI-2619253

Protein-protein interaction databases

BioGridi110446. 36 interactions.
DIPiDIP-56409N.
IntActiP42568. 22 interactions.
MINTiMINT-1389464.
STRINGi9606.ENSP00000369695.

Structurei

Secondary structure

1
568
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi504 – 51512
Helixi523 – 5319
Beta strandi536 – 5383
Beta strandi543 – 5453
Turni547 – 5493
Helixi552 – 56110

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LM0NMR-A490-568[»]
ProteinModelPortaliP42568.
SMRiP42568. Positions 29-136, 460-568.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 112105YEATSAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi295 – 3006Nuclear localization signal Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi149 – 19446Poly-SerAdd
BLAST
Compositional biasi383 – 3919Poly-Ser
Compositional biasi466 – 4694Poly-Pro

Sequence similaritiesi

Contains 1 YEATS domain.

Phylogenomic databases

eggNOGiCOG5033.
HOVERGENiHBG004191.
InParanoidiP42568.
KOiK15187.
OMAiPNRSVHT.
OrthoDBiEOG71G9V5.
PhylomeDBiP42568.
TreeFamiTF314586.

Family and domain databases

InterProiIPR005033. YEATS.
[Graphical view]
PANTHERiPTHR23195. PTHR23195. 1 hit.
PfamiPF03366. YEATS. 1 hit.
[Graphical view]
PROSITEiPS51037. YEATS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P42568-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MASSCAVQVK LELGHRAQVR KKPTVEGFTH DWMVFVRGPE HSNIQHFVEK    50
VVFHLHESFP RPKRVCKDPP YKVEESGYAG FILPIEVYFK NKEEPRKVRF 100
DYDLFLHLEG HPPVNHLRCE KLTFNNPTED FRRKLLKAGG DPNRSIHTSS 150
SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS TSFSKPHKLM 200
KEHKEKPSKD SREHKSAFKE PSRDHNKSSK ESSKKPKENK PLKEEKIVPK 250
MAFKEPKPMS KEPKPDSNLL TITSGQDKKA PSKRPPISDS EELSAKKRKK 300
SSSEALFKSF SSAPPLILTC SADKKQIKDK SHVKMGKVKI ESETSEKKKS 350
TLPPFDDIVD PNDSDVEENI SSKSDSEQPS PASSSSSSSS SFTPSQTRQQ 400
GPLRSIMKDL HSDDNEEESD EVEDNDNDSE MERPVNRGGS RSRRVSLSDG 450
SDSESSSASS PLHHEPPPPL LKTNNNQILE VKSPIKQSKS DKQIKNGECD 500
KAYLDELVEL HRRLMTLRER HILQQIVNLI EETGHFHITN TTFDFDLCSL 550
DKTTVRKLQS YLETSGTS 568
Length:568
Mass (Da):63,351
Last modified:November 25, 2008 - v2
Checksum:i0A020B7FB34132F9
GO
Isoform 2 (identifier: P42568-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MASS → M

Note: No experimental confirmation available.

Show »
Length:565
Mass (Da):63,106
Checksum:iE8D74987AC7356CC
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 44MASS → M in isoform 2. VSP_054924

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61A → S in AAA58361. 1 Publication
Sequence conflicti6 – 61A → S in BAG35760. 1 Publication
Sequence conflicti173 – 1731S → G in AAH36089. 1 Publication
Sequence conflicti419 – 4191S → P in BAG35760. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13744 mRNA. Translation: AAA58361.1.
AK301474 mRNA. Translation: BAH13491.1.
AK312914 mRNA. Translation: BAG35760.1.
AL512635, AL354879, AL513498 Genomic DNA. Translation: CAH70705.1.
AL354879, AL512635, AL513498 Genomic DNA. Translation: CAI14771.1.
AL163193 Genomic DNA. No translation available.
AL627410 Genomic DNA. No translation available.
CH471071 Genomic DNA. Translation: EAW58631.1.
CH471071 Genomic DNA. Translation: EAW58632.1.
BC036089 mRNA. Translation: AAH36089.1.
CCDSiCCDS6494.1. [P42568-1]
CCDS69579.1. [P42568-2]
PIRiI39411.
RefSeqiNP_001273620.1. NM_001286691.1. [P42568-2]
NP_004520.2. NM_004529.3. [P42568-1]
UniGeneiHs.317248.
Hs.591085.

Genome annotation databases

EnsembliENST00000380338; ENSP00000369695; ENSG00000171843.
ENST00000429426; ENSP00000410482; ENSG00000171843.
GeneIDi4300.
KEGGihsa:4300.
UCSCiuc003zoe.2. human. [P42568-1]

Polymorphism databases

DMDMi215273971.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L13744 mRNA. Translation: AAA58361.1 .
AK301474 mRNA. Translation: BAH13491.1 .
AK312914 mRNA. Translation: BAG35760.1 .
AL512635 , AL354879 , AL513498 Genomic DNA. Translation: CAH70705.1 .
AL354879 , AL512635 , AL513498 Genomic DNA. Translation: CAI14771.1 .
AL163193 Genomic DNA. No translation available.
AL627410 Genomic DNA. No translation available.
CH471071 Genomic DNA. Translation: EAW58631.1 .
CH471071 Genomic DNA. Translation: EAW58632.1 .
BC036089 mRNA. Translation: AAH36089.1 .
CCDSi CCDS6494.1. [P42568-1 ]
CCDS69579.1. [P42568-2 ]
PIRi I39411.
RefSeqi NP_001273620.1. NM_001286691.1. [P42568-2 ]
NP_004520.2. NM_004529.3. [P42568-1 ]
UniGenei Hs.317248.
Hs.591085.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LM0 NMR - A 490-568 [» ]
ProteinModelPortali P42568.
SMRi P42568. Positions 29-136, 460-568.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110446. 36 interactions.
DIPi DIP-56409N.
IntActi P42568. 22 interactions.
MINTi MINT-1389464.
STRINGi 9606.ENSP00000369695.

PTM databases

PhosphoSitei P42568.

Polymorphism databases

DMDMi 215273971.

Proteomic databases

MaxQBi P42568.
PaxDbi P42568.
PRIDEi P42568.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000380338 ; ENSP00000369695 ; ENSG00000171843 .
ENST00000429426 ; ENSP00000410482 ; ENSG00000171843 .
GeneIDi 4300.
KEGGi hsa:4300.
UCSCi uc003zoe.2. human. [P42568-1 ]

Organism-specific databases

CTDi 4300.
GeneCardsi GC09M020334.
HGNCi HGNC:7136. MLLT3.
HPAi HPA001824.
MIMi 159558. gene.
neXtProti NX_P42568.
PharmGKBi PA30852.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5033.
HOVERGENi HBG004191.
InParanoidi P42568.
KOi K15187.
OMAi PNRSVHT.
OrthoDBi EOG71G9V5.
PhylomeDBi P42568.
TreeFami TF314586.

Miscellaneous databases

GeneWikii MLLT3.
GenomeRNAii 4300.
NextBioi 16927.
PROi P42568.
SOURCEi Search...

Gene expression databases

ArrayExpressi P42568.
Bgeei P42568.
CleanExi HS_MLLT3.
Genevestigatori P42568.

Family and domain databases

InterProi IPR005033. YEATS.
[Graphical view ]
PANTHERi PTHR23195. PTHR23195. 1 hit.
Pfami PF03366. YEATS. 1 hit.
[Graphical view ]
PROSITEi PS51037. YEATS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs."
    Nakamura T., Alder H., Gu Y., Prasad R., Canaani O., Kamada N., Gale R.P., Lange B., Crist W.M., Nowell P.C., Croce C.M., Canaani E.
    Proc. Natl. Acad. Sci. U.S.A. 90:4631-4635(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Synovium.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  6. "BCoR, a novel corepressor involved in BCL-6 repression."
    Huynh K.D., Fischle W., Verdin E., Bardwell V.J.
    Genes Dev. 14:1810-1823(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BCOR.
  7. "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3."
    Garcia-Cuellar M.P., Zilles O., Schreiner S.A., Birke M., Winkler T.H., Slany R.K.
    Oncogene 20:411-419(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CBX8.
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-294 AND SER-483, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288; SER-294 AND SER-483, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-412; SER-419 AND SER-429, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription."
    He N., Liu M., Hsu J., Xue Y., Chou S., Burlingame A., Krogan N.J., Alber T., Zhou Q.
    Mol. Cell 38:428-438(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE SEC COMPLEX.
  13. "AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia."
    Lin C., Smith E.R., Takahashi H., Lai K.C., Martin-Brown S., Florens L., Washburn M.P., Conaway J.W., Conaway R.C., Shilatifard A.
    Mol. Cell 37:429-437(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE SEC COMPLEX.
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-483, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. "The super elongation complex (SEC) family in transcriptional control."
    Luo Z., Lin C., Shilatifard A.
    Nat. Rev. Mol. Cell Biol. 13:543-547(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON THE SUPER ELONGATION COMPLEX.
  16. "Human ALKBH4 interacts with proteins associated with transcription."
    Bjornstad L.G., Meza T.J., Otterlei M., Olafsrud S.M., Meza-Zepeda L.A., Falnes P.O.
    PLoS ONE 7:E49045-E49045(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ALKBH4.
  17. "Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding."
    Leach B.I., Kuntimaddi A., Schmidt C.R., Cierpicki T., Johnson S.A., Bushweller J.H.
    Structure 21:176-183(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 490-568 IN COMPLEX WITH AFF1.

Entry informationi

Entry nameiAF9_HUMAN
AccessioniPrimary (citable) accession number: P42568
Secondary accession number(s): B1AMQ2
, B2R7B3, B7Z755, D3DRJ8, Q8IVB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 25, 2008
Last modified: September 3, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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