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P42568

- AF9_HUMAN

UniProt

P42568 - AF9_HUMAN

Protein

Protein AF-9

Gene

MLLT3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.2 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei375 – 3751KMT2A/MLL1 fusion point (in acute myeloid leukemia patient CO)
    Sitei481 – 4811KMT2A/MLL1 fusion point (in acute myeloid leukemia patient F1)

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. anterior/posterior pattern specification Source: Ensembl
    2. negative regulation of canonical Wnt signaling pathway Source: MGI
    3. positive regulation of Wnt signaling pathway, planar cell polarity pathway Source: MGI
    4. regulation of transcription, DNA-templated Source: UniProtKB-KW
    5. segment specification Source: Ensembl
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein AF-9
    Alternative name(s):
    ALL1-fused gene from chromosome 9 protein
    Myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein
    YEATS domain-containing protein 3
    Gene namesi
    Name:MLLT3
    Synonyms:AF9, YEATS3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:7136. MLLT3.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: UniProt
    2. nucleus Source: ProtInc

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving MLLT3 is associated with acute leukemias. Translocation t(9;11)(p22;q23) with KMT2A/MLL1. The result is a rogue activator protein.

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    PharmGKBiPA30852.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 568568Protein AF-9PRO_0000215921Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei288 – 2881Phosphoserine1 Publication
    Modified residuei294 – 2941Phosphoserine2 Publications
    Modified residuei412 – 4121Phosphoserine1 Publication
    Modified residuei419 – 4191Phosphoserine1 Publication
    Modified residuei429 – 4291Phosphoserine1 Publication
    Modified residuei483 – 4831Phosphoserine3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP42568.
    PaxDbiP42568.
    PRIDEiP42568.

    PTM databases

    PhosphoSiteiP42568.

    Expressioni

    Gene expression databases

    ArrayExpressiP42568.
    BgeeiP42568.
    CleanExiHS_MLLT3.
    GenevestigatoriP42568.

    Organism-specific databases

    HPAiHPA001824.

    Interactioni

    Subunit structurei

    Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Interacts with BCOR. Interacts with ALKBH4 and CBX8.7 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AFF4Q9UHB74EBI-716132,EBI-395282
    DOT1LQ8TEK33EBI-716132,EBI-2619253

    Protein-protein interaction databases

    BioGridi110446. 36 interactions.
    DIPiDIP-56409N.
    IntActiP42568. 25 interactions.
    MINTiMINT-1389464.
    STRINGi9606.ENSP00000369695.

    Structurei

    Secondary structure

    1
    568
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi504 – 51512
    Helixi523 – 5319
    Beta strandi536 – 5383
    Beta strandi543 – 5453
    Turni547 – 5493
    Helixi552 – 56110

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2LM0NMR-A490-568[»]
    ProteinModelPortaliP42568.
    SMRiP42568. Positions 29-136, 460-568.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 112105YEATSPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi295 – 3006Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi149 – 19446Poly-SerAdd
    BLAST
    Compositional biasi383 – 3919Poly-Ser
    Compositional biasi466 – 4694Poly-Pro

    Sequence similaritiesi

    Contains 1 YEATS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5033.
    HOVERGENiHBG004191.
    InParanoidiP42568.
    KOiK15187.
    OMAiPNRSVHT.
    OrthoDBiEOG71G9V5.
    PhylomeDBiP42568.
    TreeFamiTF314586.

    Family and domain databases

    InterProiIPR005033. YEATS.
    [Graphical view]
    PANTHERiPTHR23195. PTHR23195. 1 hit.
    PfamiPF03366. YEATS. 1 hit.
    [Graphical view]
    PROSITEiPS51037. YEATS. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P42568-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASSCAVQVK LELGHRAQVR KKPTVEGFTH DWMVFVRGPE HSNIQHFVEK    50
    VVFHLHESFP RPKRVCKDPP YKVEESGYAG FILPIEVYFK NKEEPRKVRF 100
    DYDLFLHLEG HPPVNHLRCE KLTFNNPTED FRRKLLKAGG DPNRSIHTSS 150
    SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS SSSSSSSSSS TSFSKPHKLM 200
    KEHKEKPSKD SREHKSAFKE PSRDHNKSSK ESSKKPKENK PLKEEKIVPK 250
    MAFKEPKPMS KEPKPDSNLL TITSGQDKKA PSKRPPISDS EELSAKKRKK 300
    SSSEALFKSF SSAPPLILTC SADKKQIKDK SHVKMGKVKI ESETSEKKKS 350
    TLPPFDDIVD PNDSDVEENI SSKSDSEQPS PASSSSSSSS SFTPSQTRQQ 400
    GPLRSIMKDL HSDDNEEESD EVEDNDNDSE MERPVNRGGS RSRRVSLSDG 450
    SDSESSSASS PLHHEPPPPL LKTNNNQILE VKSPIKQSKS DKQIKNGECD 500
    KAYLDELVEL HRRLMTLRER HILQQIVNLI EETGHFHITN TTFDFDLCSL 550
    DKTTVRKLQS YLETSGTS 568
    Length:568
    Mass (Da):63,351
    Last modified:November 25, 2008 - v2
    Checksum:i0A020B7FB34132F9
    GO
    Isoform 2 (identifier: P42568-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-4: MASS → M

    Note: No experimental confirmation available.

    Show »
    Length:565
    Mass (Da):63,106
    Checksum:iE8D74987AC7356CC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61A → S in AAA58361. (PubMed:8506309)Curated
    Sequence conflicti6 – 61A → S in BAG35760. (PubMed:14702039)Curated
    Sequence conflicti173 – 1731S → G in AAH36089. (PubMed:15489334)Curated
    Sequence conflicti419 – 4191S → P in BAG35760. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 44MASS → M in isoform 2. 1 PublicationVSP_054924

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13744 mRNA. Translation: AAA58361.1.
    AK301474 mRNA. Translation: BAH13491.1.
    AK312914 mRNA. Translation: BAG35760.1.
    AL512635, AL354879, AL513498 Genomic DNA. Translation: CAH70705.1.
    AL354879, AL512635, AL513498 Genomic DNA. Translation: CAI14771.1.
    AL163193 Genomic DNA. No translation available.
    AL627410 Genomic DNA. No translation available.
    CH471071 Genomic DNA. Translation: EAW58631.1.
    CH471071 Genomic DNA. Translation: EAW58632.1.
    BC036089 mRNA. Translation: AAH36089.1.
    CCDSiCCDS6494.1. [P42568-1]
    CCDS69579.1. [P42568-2]
    PIRiI39411.
    RefSeqiNP_001273620.1. NM_001286691.1. [P42568-2]
    NP_004520.2. NM_004529.3. [P42568-1]
    UniGeneiHs.317248.
    Hs.591085.

    Genome annotation databases

    EnsembliENST00000380338; ENSP00000369695; ENSG00000171843. [P42568-1]
    GeneIDi4300.
    KEGGihsa:4300.
    UCSCiuc003zoe.2. human. [P42568-1]

    Polymorphism databases

    DMDMi215273971.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L13744 mRNA. Translation: AAA58361.1 .
    AK301474 mRNA. Translation: BAH13491.1 .
    AK312914 mRNA. Translation: BAG35760.1 .
    AL512635 , AL354879 , AL513498 Genomic DNA. Translation: CAH70705.1 .
    AL354879 , AL512635 , AL513498 Genomic DNA. Translation: CAI14771.1 .
    AL163193 Genomic DNA. No translation available.
    AL627410 Genomic DNA. No translation available.
    CH471071 Genomic DNA. Translation: EAW58631.1 .
    CH471071 Genomic DNA. Translation: EAW58632.1 .
    BC036089 mRNA. Translation: AAH36089.1 .
    CCDSi CCDS6494.1. [P42568-1 ]
    CCDS69579.1. [P42568-2 ]
    PIRi I39411.
    RefSeqi NP_001273620.1. NM_001286691.1. [P42568-2 ]
    NP_004520.2. NM_004529.3. [P42568-1 ]
    UniGenei Hs.317248.
    Hs.591085.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2LM0 NMR - A 490-568 [» ]
    ProteinModelPortali P42568.
    SMRi P42568. Positions 29-136, 460-568.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110446. 36 interactions.
    DIPi DIP-56409N.
    IntActi P42568. 25 interactions.
    MINTi MINT-1389464.
    STRINGi 9606.ENSP00000369695.

    PTM databases

    PhosphoSitei P42568.

    Polymorphism databases

    DMDMi 215273971.

    Proteomic databases

    MaxQBi P42568.
    PaxDbi P42568.
    PRIDEi P42568.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000380338 ; ENSP00000369695 ; ENSG00000171843 . [P42568-1 ]
    GeneIDi 4300.
    KEGGi hsa:4300.
    UCSCi uc003zoe.2. human. [P42568-1 ]

    Organism-specific databases

    CTDi 4300.
    GeneCardsi GC09M020334.
    HGNCi HGNC:7136. MLLT3.
    HPAi HPA001824.
    MIMi 159558. gene.
    neXtProti NX_P42568.
    PharmGKBi PA30852.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5033.
    HOVERGENi HBG004191.
    InParanoidi P42568.
    KOi K15187.
    OMAi PNRSVHT.
    OrthoDBi EOG71G9V5.
    PhylomeDBi P42568.
    TreeFami TF314586.

    Miscellaneous databases

    GeneWikii MLLT3.
    GenomeRNAii 4300.
    NextBioi 16927.
    PROi P42568.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P42568.
    Bgeei P42568.
    CleanExi HS_MLLT3.
    Genevestigatori P42568.

    Family and domain databases

    InterProi IPR005033. YEATS.
    [Graphical view ]
    PANTHERi PTHR23195. PTHR23195. 1 hit.
    Pfami PF03366. YEATS. 1 hit.
    [Graphical view ]
    PROSITEi PS51037. YEATS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs."
      Nakamura T., Alder H., Gu Y., Prasad R., Canaani O., Kamada N., Gale R.P., Lange B., Crist W.M., Nowell P.C., Croce C.M., Canaani E.
      Proc. Natl. Acad. Sci. U.S.A. 90:4631-4635(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Synovium.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    6. "BCoR, a novel corepressor involved in BCL-6 repression."
      Huynh K.D., Fischle W., Verdin E., Bardwell V.J.
      Genes Dev. 14:1810-1823(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BCOR.
    7. "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3."
      Garcia-Cuellar M.P., Zilles O., Schreiner S.A., Birke M., Winkler T.H., Slany R.K.
      Oncogene 20:411-419(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CBX8.
    8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-294 AND SER-483, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-288; SER-294 AND SER-483, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-412; SER-419 AND SER-429, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. "HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription."
      He N., Liu M., Hsu J., Xue Y., Chou S., Burlingame A., Krogan N.J., Alber T., Zhou Q.
      Mol. Cell 38:428-438(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN THE SEC COMPLEX.
    13. "AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia."
      Lin C., Smith E.R., Takahashi H., Lai K.C., Martin-Brown S., Florens L., Washburn M.P., Conaway J.W., Conaway R.C., Shilatifard A.
      Mol. Cell 37:429-437(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN THE SEC COMPLEX.
    14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-483, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. Cited for: IDENTIFICATION IN THE SEC COMPLEX.
    16. "The super elongation complex (SEC) family in transcriptional control."
      Luo Z., Lin C., Shilatifard A.
      Nat. Rev. Mol. Cell Biol. 13:543-547(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON THE SUPER ELONGATION COMPLEX.
    17. "Human ALKBH4 interacts with proteins associated with transcription."
      Bjornstad L.G., Meza T.J., Otterlei M., Olafsrud S.M., Meza-Zepeda L.A., Falnes P.O.
      PLoS ONE 7:E49045-E49045(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ALKBH4.
    18. "Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding."
      Leach B.I., Kuntimaddi A., Schmidt C.R., Cierpicki T., Johnson S.A., Bushweller J.H.
      Structure 21:176-183(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 490-568 IN COMPLEX WITH AFF1.

    Entry informationi

    Entry nameiAF9_HUMAN
    AccessioniPrimary (citable) accession number: P42568
    Secondary accession number(s): B1AMQ2
    , B2R7B3, B7Z755, D3DRJ8, Q8IVB0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3