P42558 (RAN_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP-binding nuclear protein Ran

Alternative name(s):
GTPase Ran
Ras-like protein TC4
Ras-related nuclear protein

Gene names

Name:

RAN

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle By similarity.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the small GTPase superfamily. Ran family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Nucleus
Ligand	GTP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular protein transport Inferred from electronic annotation. Source: InterPro nucleocytoplasmic transport Inferred from electronic annotation. Source: InterPro small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 216	216	GTP-binding nuclear protein Ran		PRO_0000208701
Regions
	Nucleotide binding	17 – 24	8	GTP By similarity
	Nucleotide binding	65 – 69	5	GTP By similarity
	Nucleotide binding	122 – 125	4	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P42558 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: D5DB00D75C2C0EA4	FASTA	216	24,427
	10 20 30 40 50 60 MAAQGEPQVQ FKLVLVGDGG TGKTTFVKRH LTGEFEKKYV ATLGVEVHPL VFHTNRGPIK 70 80 90 100 110 120 FNVWDTAGQE KFGGLRDGYY IQAQCAIIMF DVTSRVTYKN VPNWHRDLVR VCENIPIVLC 130 140 150 160 170 180 GNKVDIKDRK VKAKSIVFHR KKNLQYYDIS AKSNYNFEKP FLWLARKLIG DPNLEFVAMP 190 200 210 ALAPPEVVMD PALAAQYEQD LQIAQTTALP DEDDDL

References

[1]	"Molecular cloning of a novel ras-like protein from chicken." Trueb J., Trueb B. FEBS Lett. 306:181-184(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X66906 mRNA. Translation: CAA47355.1.
IPI	IPI00582263.
PIR	S24031.
RefSeq	NP_990589.1. NM_205258.2.
UniGene	Gga.4068.
3D structure databases
ProteinModelPortal	P42558.
SMR	P42558. Positions 8-197.
ModBase	Search...
Protein-protein interaction databases
STRING	9031.ENSGALP00000038926.
Proteomic databases
PaxDb	P42558.
PRIDE	P42558.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000004055; ENSGALP00000004046; ENSGALG00000002569.
GeneID	396193.
KEGG	gga:396193.
Organism-specific databases
CTD	5901.
Phylogenomic databases
eggNOG	COG1100.
GeneTree	ENSGT00700000104457.
HOGENOM	HOG000216664.
HOVERGEN	HBG107376.
InParanoid	P42558.
KO	K07936.
OrthoDB	EOG4640CV.
Gene expression databases
ArrayExpress	P42558.
Family and domain databases
InterPro	IPR002041. Ran_GTPase. IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. [Graphical view]
Pfam	PF00071. Ras. 1 hit. [Graphical view]
PRINTS	PR00627. GTPRANTC4.
SMART	SM00176. RAN. 1 hit. [Graphical view]
TIGRFAMs	TIGR00231. small_GTP. 1 hit.
PROSITE	PS51418. RAN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20816245.

Entry information

Entry name

RAN_CHICK

Accession

Primary (citable) accession number: P42558

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	April 3, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program