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Protein

GTP-binding nuclear protein Ran

Gene

RAN

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensure the directionality of the transport.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 24GTPBy similarity8
Nucleotide bindingi65 – 69GTPBy similarity5
Nucleotide bindingi122 – 125GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-1655829. Regulation of cholesterol biosynthesis by SREBP (SREBF).
R-GGA-203927. MicroRNA (miRNA) biogenesis.
R-GGA-5578749. Transcriptional regulation by small RNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding nuclear protein Ran
Alternative name(s):
GTPase Ran
Ras-like protein TC4
Ras-related nuclear protein
Gene namesi
Name:RAN
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 15

Subcellular locationi

  • Nucleus By similarity
  • Nucleus envelope By similarity
  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002087011 – 216GTP-binding nuclear protein RanAdd BLAST216

Proteomic databases

PaxDbiP42558.
PRIDEiP42558.

Expressioni

Gene expression databases

BgeeiENSGALG00000002569.

Interactioni

Subunit structurei

Monomer (By similarity). Interacts (GDP-bound form) with NUTF2; regulates RAN nuclear import (By similarity).By similarity

Protein-protein interaction databases

BioGridi676453. 1 interactor.
STRINGi9031.ENSGALP00000038926.

Structurei

3D structure databases

ProteinModelPortaliP42558.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ran family.Curated

Phylogenomic databases

eggNOGiKOG0096. Eukaryota.
ENOG410XNRS. LUCA.
GeneTreeiENSGT00840000129836.
HOGENOMiHOG000216664.
HOVERGENiHBG107376.
InParanoidiP42558.
KOiK07936.
OMAiVEMPALK.
OrthoDBiEOG091G0L3X.
PhylomeDBiP42558.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR002041. Ran_GTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00627. GTPRANTC4.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51418. RAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42558-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAQGEPQVQ FKLVLVGDGG TGKTTFVKRH LTGEFEKKYV ATLGVEVHPL
60 70 80 90 100
VFHTNRGPIK FNVWDTAGQE KFGGLRDGYY IQAQCAIIMF DVTSRVTYKN
110 120 130 140 150
VPNWHRDLVR VCENIPIVLC GNKVDIKDRK VKAKSIVFHR KKNLQYYDIS
160 170 180 190 200
AKSNYNFEKP FLWLARKLIG DPNLEFVAMP ALAPPEVVMD PALAAQYEQD
210
LQIAQTTALP DEDDDL
Length:216
Mass (Da):24,427
Last modified:November 1, 1995 - v1
Checksum:iD5DB00D75C2C0EA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66906 mRNA. Translation: CAA47355.1.
PIRiS24031.
RefSeqiNP_990589.1. NM_205258.2.
UniGeneiGga.4068.

Genome annotation databases

EnsembliENSGALT00000055724; ENSGALP00000054241; ENSGALG00000002569.
ENSGALT00000063787; ENSGALP00000047624; ENSGALG00000002569.
GeneIDi396193.
KEGGigga:396193.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66906 mRNA. Translation: CAA47355.1.
PIRiS24031.
RefSeqiNP_990589.1. NM_205258.2.
UniGeneiGga.4068.

3D structure databases

ProteinModelPortaliP42558.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi676453. 1 interactor.
STRINGi9031.ENSGALP00000038926.

Proteomic databases

PaxDbiP42558.
PRIDEiP42558.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000055724; ENSGALP00000054241; ENSGALG00000002569.
ENSGALT00000063787; ENSGALP00000047624; ENSGALG00000002569.
GeneIDi396193.
KEGGigga:396193.

Organism-specific databases

CTDi5901.

Phylogenomic databases

eggNOGiKOG0096. Eukaryota.
ENOG410XNRS. LUCA.
GeneTreeiENSGT00840000129836.
HOGENOMiHOG000216664.
HOVERGENiHBG107376.
InParanoidiP42558.
KOiK07936.
OMAiVEMPALK.
OrthoDBiEOG091G0L3X.
PhylomeDBiP42558.

Enzyme and pathway databases

ReactomeiR-GGA-1655829. Regulation of cholesterol biosynthesis by SREBP (SREBF).
R-GGA-203927. MicroRNA (miRNA) biogenesis.
R-GGA-5578749. Transcriptional regulation by small RNAs.

Miscellaneous databases

PROiP42558.

Gene expression databases

BgeeiENSGALG00000002569.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR002041. Ran_GTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00627. GTPRANTC4.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51418. RAN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAN_CHICK
AccessioniPrimary (citable) accession number: P42558
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.