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P42525 (ERK1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Extracellular signal-regulated kinase 1

Short name=ERK1
EC=2.7.11.24
Alternative name(s):
MAP kinase 1
Gene names
Name:erkA
Synonyms:erk1
ORF Names:DDB_G0286353
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length529 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Kinase involved in a signal transduction pathway. Ref.2

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Enzyme regulation

Activated by tyrosine and threonine phosphorylation By similarity.

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases By similarity.

Post-translational modification

Dually phosphorylated on Thr-309 and Tyr-311, which activates the enzyme By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence AAA59387.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 529529Extracellular signal-regulated kinase 1
PRO_0000186308

Regions

Domain149 – 439291Protein kinase
Nucleotide binding155 – 1639ATP By similarity
Motif309 – 3113TXY

Sites

Active site2751Proton acceptor By similarity
Binding site1781ATP By similarity

Amino acid modifications

Modified residue3091Phosphothreonine By similarity
Modified residue3111Phosphotyrosine By similarity

Experimental info

Sequence conflict3891R → RSL in AAA59387. Ref.1
Sequence conflict5171Q → P in AAA59387. Ref.1
Sequence conflict5291N → INN in AAA59387. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P42525 [UniParc].

Last modified December 4, 2007. Version 2.
Checksum: 495C8ACD0215A3A7

FASTA52961,303
        10         20         30         40         50         60 
MEPEFDHFQS QMDSDNTHQS TMFNVQDNNA ILMSGMENVL QSPRQLQAAA QAQQQAAAQA 

        70         80         90        100        110        120 
QQQQVQAQQV QAQQAQQQQQ QQQNQQQQQQ QQNQQNQQQQ QNQQQQSQQM TQQQLQQLMP 

       130        140        150        160        170        180 
PPPTSDTSNF NDNISYFVYG SQFTVPRRYS IVKCIGHGAY GVVCSAKDNL TGEKVAIKKI 

       190        200        210        220        230        240 
SKAFDNLKDT KRTLREIHLL RHFKHENLIS IKDILKPNSK EQFEDVYIVS ELMDTDLHQI 

       250        260        270        280        290        300 
ITSPQPLSDD HCQYFVYQML RGLKHIHSAN VLHRDLKPSN LLINEDCLLK ICDLGLARVE 

       310        320        330        340        350        360 
DATHQGFMTE YVATRWYRAP EVILSWNKYT KAIDIWSVGC IFAELLGRKP LFQGKDYIHQ 

       370        380        390        400        410        420 
ITLIIETIGS PSEEDICNIA NEQARQFIRN MGNQPKVNFA NMFPKANPDA IDLLERMLYF 

       430        440        450        460        470        480 
DPSKRLTVEE ALAHPYFQSL HDPSDEPICL HKFSLNFEAW DLNRDLLKEL IYNEMLAYHP 

       490        500        510        520 
EDPQAPYYTD LNNPNFNLSR IQSSSELFNL LQQQKQQIHQ QVNQQSIKN 

« Hide

References

« Hide 'large scale' references
[1]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[2]"Identification and functional analysis of a developmentally regulated extracellular signal-regulated kinase gene in Dictyostelium discoideum."
Gaskins C.J., Maeda M., Firtel R.A.
Mol. Cell. Biol. 14:6996-7012(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 96-529, FUNCTION.
Strain: AX3.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000085 Genomic DNA. Translation: EAL64201.1.
U11077 mRNA. Translation: AAA59387.1. Different initiation.
PIRA56042.
RefSeqXP_637704.1. XM_632612.1.

3D structure databases

ProteinModelPortalP42525.
SMRP42525. Positions 132-481.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0201635.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0201635; DDB0201635; DDB_G0286353.
GeneID8625569.
KEGGddi:DDB_G0286353.

Organism-specific databases

dictyBaseDDB_G0286353. erkA.

Phylogenomic databases

eggNOGCOG0515.
OMATIDEFHA.
PhylomeDBP42525.

Enzyme and pathway databases

BRENDA2.7.11.24. 1939.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSPR01773. P38MAPKINASE.
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROP42525.

Entry information

Entry nameERK1_DICDI
AccessionPrimary (citable) accession number: P42525
Secondary accession number(s): Q54LX6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 4, 2007
Last modified: July 9, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase