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P42525

- ERK1_DICDI

UniProt

P42525 - ERK1_DICDI

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Protein
Extracellular signal-regulated kinase 1
Gene
erkA, erk1, DDB_G0286353
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Kinase involved in a signal transduction pathway.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Magnesium By similarity.

Enzyme regulationi

Activated by tyrosine and threonine phosphorylation By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei178 – 1781ATP By similarity
Active sitei275 – 2751Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi155 – 1639ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC
  3. protein kinase activity Source: dictyBase

GO - Biological processi

  1. MAPK cascade Source: dictyBase
  2. aggregation involved in sorocarp development Source: dictyBase
  3. chemotaxis to cAMP Source: dictyBase
  4. mitotic nuclear division Source: UniProtKB-KW
  5. protein phosphorylation Source: dictyBase
  6. sorocarp development Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.24. 1939.
ReactomeiREACT_204254. NOD1/2 Signaling Pathway.
REACT_206814. Signaling by FGFR.
REACT_208820. activated TAK1 mediates p38 MAPK activation.
REACT_209442. ERK1 activation.
REACT_209920. CDO in myogenesis.
REACT_210783. p38MAPK events.
REACT_214343. Oxidative Stress Induced Senescence.
REACT_220482. ADP signalling through P2Y purinoceptor 1.
REACT_220796. Signal transduction by L1.
REACT_221153. ERK2 activation.
REACT_221807. ERK/MAPK targets.
REACT_226365. Signalling to ERK5.
REACT_227492. Regulation of HSF1-mediated heat shock response.

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular signal-regulated kinase 1 (EC:2.7.11.24)
Short name:
ERK1
Alternative name(s):
MAP kinase 1
Gene namesi
Name:erkA
Synonyms:erk1
ORF Names:DDB_G0286353
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 4, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0286353. erkA.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: dictyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 529529Extracellular signal-regulated kinase 1
PRO_0000186308Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei309 – 3091Phosphothreonine By similarity
Modified residuei311 – 3111Phosphotyrosine By similarity

Post-translational modificationi

Dually phosphorylated on Thr-309 and Tyr-311, which activates the enzyme By similarity.

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0201635.

Structurei

3D structure databases

ProteinModelPortaliP42525.
SMRiP42525. Positions 132-481.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini149 – 439291Protein kinase
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi309 – 3113TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases By similarity.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
KOiK04371.
OMAiTIDEFHA.
PhylomeDBiP42525.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR01773. P38MAPKINASE.
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42525-1 [UniParc]FASTAAdd to Basket

« Hide

MEPEFDHFQS QMDSDNTHQS TMFNVQDNNA ILMSGMENVL QSPRQLQAAA    50
QAQQQAAAQA QQQQVQAQQV QAQQAQQQQQ QQQNQQQQQQ QQNQQNQQQQ 100
QNQQQQSQQM TQQQLQQLMP PPPTSDTSNF NDNISYFVYG SQFTVPRRYS 150
IVKCIGHGAY GVVCSAKDNL TGEKVAIKKI SKAFDNLKDT KRTLREIHLL 200
RHFKHENLIS IKDILKPNSK EQFEDVYIVS ELMDTDLHQI ITSPQPLSDD 250
HCQYFVYQML RGLKHIHSAN VLHRDLKPSN LLINEDCLLK ICDLGLARVE 300
DATHQGFMTE YVATRWYRAP EVILSWNKYT KAIDIWSVGC IFAELLGRKP 350
LFQGKDYIHQ ITLIIETIGS PSEEDICNIA NEQARQFIRN MGNQPKVNFA 400
NMFPKANPDA IDLLERMLYF DPSKRLTVEE ALAHPYFQSL HDPSDEPICL 450
HKFSLNFEAW DLNRDLLKEL IYNEMLAYHP EDPQAPYYTD LNNPNFNLSR 500
IQSSSELFNL LQQQKQQIHQ QVNQQSIKN 529
Length:529
Mass (Da):61,303
Last modified:December 4, 2007 - v2
Checksum:i495C8ACD0215A3A7
GO

Sequence cautioni

The sequence AAA59387.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti389 – 3891R → RSL in AAA59387. 1 Publication
Sequence conflicti517 – 5171Q → P in AAA59387. 1 Publication
Sequence conflicti529 – 5291N → INN in AAA59387. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000085 Genomic DNA. Translation: EAL64201.1.
U11077 mRNA. Translation: AAA59387.1. Different initiation.
PIRiA56042.
RefSeqiXP_637704.1. XM_632612.1.

Genome annotation databases

EnsemblProtistsiDDB0201635; DDB0201635; DDB_G0286353.
GeneIDi8625569.
KEGGiddi:DDB_G0286353.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000085 Genomic DNA. Translation: EAL64201.1 .
U11077 mRNA. Translation: AAA59387.1 . Different initiation.
PIRi A56042.
RefSeqi XP_637704.1. XM_632612.1.

3D structure databases

ProteinModelPortali P42525.
SMRi P42525. Positions 132-481.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0201635.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0201635 ; DDB0201635 ; DDB_G0286353 .
GeneIDi 8625569.
KEGGi ddi:DDB_G0286353.

Organism-specific databases

dictyBasei DDB_G0286353. erkA.

Phylogenomic databases

eggNOGi COG0515.
KOi K04371.
OMAi TIDEFHA.
PhylomeDBi P42525.

Enzyme and pathway databases

BRENDAi 2.7.11.24. 1939.
Reactomei REACT_204254. NOD1/2 Signaling Pathway.
REACT_206814. Signaling by FGFR.
REACT_208820. activated TAK1 mediates p38 MAPK activation.
REACT_209442. ERK1 activation.
REACT_209920. CDO in myogenesis.
REACT_210783. p38MAPK events.
REACT_214343. Oxidative Stress Induced Senescence.
REACT_220482. ADP signalling through P2Y purinoceptor 1.
REACT_220796. Signal transduction by L1.
REACT_221153. ERK2 activation.
REACT_221807. ERK/MAPK targets.
REACT_226365. Signalling to ERK5.
REACT_227492. Regulation of HSF1-mediated heat shock response.

Miscellaneous databases

PROi P42525.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
PRINTSi PR01773. P38MAPKINASE.
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "Identification and functional analysis of a developmentally regulated extracellular signal-regulated kinase gene in Dictyostelium discoideum."
    Gaskins C.J., Maeda M., Firtel R.A.
    Mol. Cell. Biol. 14:6996-7012(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 96-529, FUNCTION.
    Strain: AX3.

Entry informationi

Entry nameiERK1_DICDI
AccessioniPrimary (citable) accession number: P42525
Secondary accession number(s): Q54LX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 4, 2007
Last modified: September 3, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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