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Protein

Fe(3+)-pyochelin receptor

Gene

fptA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity outer membrane receptor required for the transport of Fe3+-pyochelin.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Protein family/group databases

TCDBi1.B.14.1.8. the outer membrane receptor (omr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Fe(3+)-pyochelin receptor
Alternative name(s):
Fe(III)-pyochelin receptor
Gene namesi
Name:fptA
Ordered Locus Names:PA4221
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA4221.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3097981.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 38381 PublicationAdd
BLAST
Chaini39 – 720682Fe(3+)-pyochelin receptorPRO_0000034750Add
BLAST

Proteomic databases

PaxDbiP42512.
PRIDEiP42512.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA4221.

Chemistry

BindingDBiP42512.

Structurei

Secondary structure

1
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi76 – 783Combined sources
Beta strandi80 – 878Combined sources
Helixi88 – 936Combined sources
Helixi99 – 1046Combined sources
Beta strandi109 – 1157Combined sources
Beta strandi118 – 1236Combined sources
Beta strandi130 – 1334Combined sources
Beta strandi153 – 1619Combined sources
Turni164 – 1674Combined sources
Beta strandi172 – 1809Combined sources
Beta strandi188 – 1969Combined sources
Turni197 – 1993Combined sources
Beta strandi200 – 22930Combined sources
Beta strandi231 – 2344Combined sources
Beta strandi236 – 25116Combined sources
Beta strandi254 – 26815Combined sources
Beta strandi297 – 31418Combined sources
Beta strandi317 – 33923Combined sources
Turni343 – 3453Combined sources
Beta strandi349 – 37527Combined sources
Beta strandi378 – 39821Combined sources
Beta strandi400 – 4023Combined sources
Turni410 – 4123Combined sources
Beta strandi415 – 4173Combined sources
Beta strandi432 – 44817Combined sources
Beta strandi451 – 46515Combined sources
Beta strandi476 – 48813Combined sources
Beta strandi491 – 50212Combined sources
Beta strandi518 – 53114Combined sources
Helixi532 – 5343Combined sources
Beta strandi536 – 55318Combined sources
Beta strandi555 – 5573Combined sources
Beta strandi566 – 58621Combined sources
Beta strandi589 – 60416Combined sources
Beta strandi620 – 63011Combined sources
Helixi633 – 6364Combined sources
Beta strandi638 – 64710Combined sources
Beta strandi650 – 6545Combined sources
Beta strandi657 – 6615Combined sources
Beta strandi664 – 68724Combined sources
Beta strandi694 – 6963Combined sources
Beta strandi704 – 7063Combined sources
Beta strandi711 – 72010Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XKWX-ray2.00A56-720[»]
DisProtiDP00176.
ProteinModelPortaliP42512.
SMRiP42512. Positions 56-720.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42512.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi703 – 72018TonB C-terminal boxAdd
BLAST

Sequence similaritiesi

Belongs to the TonB-dependent receptor family.Curated

Keywords - Domaini

Signal, TonB box, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4105CNM. Bacteria.
COG4773. LUCA.
HOGENOMiHOG000217242.
InParanoidiP42512.
KOiK16088.
OMAiPQDMAVY.
OrthoDBiEOG6CP3R9.
PhylomeDBiP42512.

Family and domain databases

Gene3Di2.170.130.10. 1 hit.
2.40.170.20. 1 hit.
InterProiIPR012910. Plug_dom.
IPR000531. TonB-dep_rcpt_b-brl.
IPR010917. TonB_rcpt_CS.
IPR010105. TonB_sidphr_rcpt.
[Graphical view]
PfamiPF07715. Plug. 1 hit.
PF00593. TonB_dep_Rec. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01783. TonB-siderophor. 1 hit.
PROSITEiPS01156. TONB_DEPENDENT_REC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42512-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTETKVIKG RQGIARNRHT PLCLGLLLAL SPLAAAVADA RKDGETELPD
60 70 80 90 100
MVISGESTSA TQPPGVTTLG KVPLKPRELP QSASVIDHER LEQQNLFSLD
110 120 130 140 150
EAMQQATGVT VQPFQLLTTA YYVRGFKVDS FELDGVPALL GNTASSPQDM
160 170 180 190 200
AIYERVEILR GSNGLLHGTG NPAATVNLVR KRPQREFAAS TTLSAGRWDR
210 220 230 240 250
YRAEVDVGGP LSASGNVRGR AVAAYEDRDY FYDVADQGTR LLYGVTEFDL
260 270 280 290 300
SPDTLLTVGA QYQHIDSITN MAGVPMAKDG SNLGLSRDTY LDVDWDRFKW
310 320 330 340 350
DTYRAFGSLE QQLGGGWKGK VSAEYQEADS RLRYAGSFGA IDPQTGDGGQ
360 370 380 390 400
LMGAAYKFKS IQRSLDANLN GPVRLFGLTH ELLGGVTYAQ GETRQDTARF
410 420 430 440 450
LNLPNTPVNV YRWDPHGVPR PQIGQYTSPG TTTTTQKGLY ALGRIKLAEP
460 470 480 490 500
LTLVVGGRES WWDQDTPATR FKPGRQFTPY GGLIWDFARD WSWYVSYAEV
510 520 530 540 550
YQPQADRQTW NSEPLSPVEG KTYETGIKGE LADGRLNLSL AAFRIDLENN
560 570 580 590 600
PQEDPDHPGP PNNPFYISGG KVRSQGFELE GTGYLTPYWS LSAGYTYTST
610 620 630 640 650
EYLKDSQNDS GTRYSTFTPR HLLRLWSNYD LPWQDRRWSV GGGLQAQSDY
660 670 680 690 700
SVDYRGVSMR QGGYALVNMR LGYKIDEHWT AAVNVNNLFD RTYYQSLSNP
710 720
NWNNRYGEPR SFNVSLRGAF
Length:720
Mass (Da):79,992
Last modified:November 1, 1995 - v1
Checksum:iDA796313116E0CC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03161 Unassigned DNA. Translation: AAC43213.1.
AE004091 Genomic DNA. Translation: AAG07609.1.
PIRiA36942.
RefSeqiNP_252911.1. NC_002516.2.
WP_003111969.1. NZ_ASJY01000690.1.

Genome annotation databases

EnsemblBacteriaiAAG07609; AAG07609; PA4221.
GeneIDi880419.
KEGGipae:PA4221.
PATRICi19843132. VBIPseAer58763_4422.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03161 Unassigned DNA. Translation: AAC43213.1.
AE004091 Genomic DNA. Translation: AAG07609.1.
PIRiA36942.
RefSeqiNP_252911.1. NC_002516.2.
WP_003111969.1. NZ_ASJY01000690.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1XKWX-ray2.00A56-720[»]
DisProtiDP00176.
ProteinModelPortaliP42512.
SMRiP42512. Positions 56-720.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA4221.

Chemistry

BindingDBiP42512.
ChEMBLiCHEMBL3097981.

Protein family/group databases

TCDBi1.B.14.1.8. the outer membrane receptor (omr) family.

Proteomic databases

PaxDbiP42512.
PRIDEiP42512.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG07609; AAG07609; PA4221.
GeneIDi880419.
KEGGipae:PA4221.
PATRICi19843132. VBIPseAer58763_4422.

Organism-specific databases

PseudoCAPiPA4221.

Phylogenomic databases

eggNOGiENOG4105CNM. Bacteria.
COG4773. LUCA.
HOGENOMiHOG000217242.
InParanoidiP42512.
KOiK16088.
OMAiPQDMAVY.
OrthoDBiEOG6CP3R9.
PhylomeDBiP42512.

Miscellaneous databases

EvolutionaryTraceiP42512.

Family and domain databases

Gene3Di2.170.130.10. 1 hit.
2.40.170.20. 1 hit.
InterProiIPR012910. Plug_dom.
IPR000531. TonB-dep_rcpt_b-brl.
IPR010917. TonB_rcpt_CS.
IPR010105. TonB_sidphr_rcpt.
[Graphical view]
PfamiPF07715. Plug. 1 hit.
PF00593. TonB_dep_Rec. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01783. TonB-siderophor. 1 hit.
PROSITEiPS01156. TONB_DEPENDENT_REC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "FptA, the Fe(III)-pyochelin receptor of Pseudomonas aeruginosa: a phenolate siderophore receptor homologous to hydroxamate siderophore receptors."
    Ankenbauer R.G., Quan H.N.
    J. Bacteriol. 176:307-319(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 39-51.
    Strain: PAO / IA602.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228.

Entry informationi

Entry nameiFPTA_PSEAE
AccessioniPrimary (citable) accession number: P42512
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 17, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.