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Protein

Fe(3+)-pyochelin receptor

Gene

fptA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity outer membrane receptor required for the transport of Fe3+-pyochelin.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Protein family/group databases

TCDBi1.B.14.1.8. the outer membrane receptor (omr) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Fe(3+)-pyochelin receptor
Alternative name(s):
Fe(III)-pyochelin receptor
Gene namesi
Name:fptA
Ordered Locus Names:PA4221
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA4221.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3097981.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 381 PublicationAdd BLAST38
ChainiPRO_000003475039 – 720Fe(3+)-pyochelin receptorAdd BLAST682

Proteomic databases

PaxDbiP42512.
PRIDEiP42512.

Interactioni

Protein-protein interaction databases

STRINGi208964.PA4221.

Chemistry databases

BindingDBiP42512.

Structurei

Secondary structure

1720
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi76 – 78Combined sources3
Beta strandi80 – 87Combined sources8
Helixi88 – 93Combined sources6
Helixi99 – 104Combined sources6
Beta strandi109 – 115Combined sources7
Beta strandi118 – 123Combined sources6
Beta strandi130 – 133Combined sources4
Beta strandi153 – 161Combined sources9
Turni164 – 167Combined sources4
Beta strandi172 – 180Combined sources9
Beta strandi188 – 196Combined sources9
Turni197 – 199Combined sources3
Beta strandi200 – 229Combined sources30
Beta strandi231 – 234Combined sources4
Beta strandi236 – 251Combined sources16
Beta strandi254 – 268Combined sources15
Beta strandi297 – 314Combined sources18
Beta strandi317 – 339Combined sources23
Turni343 – 345Combined sources3
Beta strandi349 – 375Combined sources27
Beta strandi378 – 398Combined sources21
Beta strandi400 – 402Combined sources3
Turni410 – 412Combined sources3
Beta strandi415 – 417Combined sources3
Beta strandi432 – 448Combined sources17
Beta strandi451 – 465Combined sources15
Beta strandi476 – 488Combined sources13
Beta strandi491 – 502Combined sources12
Beta strandi518 – 531Combined sources14
Helixi532 – 534Combined sources3
Beta strandi536 – 553Combined sources18
Beta strandi555 – 557Combined sources3
Beta strandi566 – 586Combined sources21
Beta strandi589 – 604Combined sources16
Beta strandi620 – 630Combined sources11
Helixi633 – 636Combined sources4
Beta strandi638 – 647Combined sources10
Beta strandi650 – 654Combined sources5
Beta strandi657 – 661Combined sources5
Beta strandi664 – 687Combined sources24
Beta strandi694 – 696Combined sources3
Beta strandi704 – 706Combined sources3
Beta strandi711 – 720Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XKWX-ray2.00A56-720[»]
DisProtiDP00176.
ProteinModelPortaliP42512.
SMRiP42512.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42512.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi703 – 720TonB C-terminal boxAdd BLAST18

Sequence similaritiesi

Belongs to the TonB-dependent receptor family.Curated

Keywords - Domaini

Signal, TonB box, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4105CNM. Bacteria.
COG4773. LUCA.
HOGENOMiHOG000217242.
InParanoidiP42512.
KOiK16088.
OMAiPQDMAVY.
PhylomeDBiP42512.

Family and domain databases

Gene3Di2.170.130.10. 1 hit.
2.40.170.20. 1 hit.
InterProiIPR012910. Plug_dom.
IPR000531. TonB-dep_rcpt_b-brl.
IPR010917. TonB_rcpt_CS.
IPR010105. TonB_sidphr_rcpt.
[Graphical view]
PfamiPF07715. Plug. 1 hit.
PF00593. TonB_dep_Rec. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01783. TonB-siderophor. 1 hit.
PROSITEiPS01156. TONB_DEPENDENT_REC_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42512-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTETKVIKG RQGIARNRHT PLCLGLLLAL SPLAAAVADA RKDGETELPD
60 70 80 90 100
MVISGESTSA TQPPGVTTLG KVPLKPRELP QSASVIDHER LEQQNLFSLD
110 120 130 140 150
EAMQQATGVT VQPFQLLTTA YYVRGFKVDS FELDGVPALL GNTASSPQDM
160 170 180 190 200
AIYERVEILR GSNGLLHGTG NPAATVNLVR KRPQREFAAS TTLSAGRWDR
210 220 230 240 250
YRAEVDVGGP LSASGNVRGR AVAAYEDRDY FYDVADQGTR LLYGVTEFDL
260 270 280 290 300
SPDTLLTVGA QYQHIDSITN MAGVPMAKDG SNLGLSRDTY LDVDWDRFKW
310 320 330 340 350
DTYRAFGSLE QQLGGGWKGK VSAEYQEADS RLRYAGSFGA IDPQTGDGGQ
360 370 380 390 400
LMGAAYKFKS IQRSLDANLN GPVRLFGLTH ELLGGVTYAQ GETRQDTARF
410 420 430 440 450
LNLPNTPVNV YRWDPHGVPR PQIGQYTSPG TTTTTQKGLY ALGRIKLAEP
460 470 480 490 500
LTLVVGGRES WWDQDTPATR FKPGRQFTPY GGLIWDFARD WSWYVSYAEV
510 520 530 540 550
YQPQADRQTW NSEPLSPVEG KTYETGIKGE LADGRLNLSL AAFRIDLENN
560 570 580 590 600
PQEDPDHPGP PNNPFYISGG KVRSQGFELE GTGYLTPYWS LSAGYTYTST
610 620 630 640 650
EYLKDSQNDS GTRYSTFTPR HLLRLWSNYD LPWQDRRWSV GGGLQAQSDY
660 670 680 690 700
SVDYRGVSMR QGGYALVNMR LGYKIDEHWT AAVNVNNLFD RTYYQSLSNP
710 720
NWNNRYGEPR SFNVSLRGAF
Length:720
Mass (Da):79,992
Last modified:November 1, 1995 - v1
Checksum:iDA796313116E0CC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03161 Unassigned DNA. Translation: AAC43213.1.
AE004091 Genomic DNA. Translation: AAG07609.1.
PIRiA36942.
RefSeqiNP_252911.1. NC_002516.2.
WP_003111969.1. NZ_ASJY01000690.1.

Genome annotation databases

EnsemblBacteriaiAAG07609; AAG07609; PA4221.
GeneIDi880419.
KEGGipae:PA4221.
PATRICi19843132. VBIPseAer58763_4422.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03161 Unassigned DNA. Translation: AAC43213.1.
AE004091 Genomic DNA. Translation: AAG07609.1.
PIRiA36942.
RefSeqiNP_252911.1. NC_002516.2.
WP_003111969.1. NZ_ASJY01000690.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XKWX-ray2.00A56-720[»]
DisProtiDP00176.
ProteinModelPortaliP42512.
SMRiP42512.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA4221.

Chemistry databases

BindingDBiP42512.
ChEMBLiCHEMBL3097981.

Protein family/group databases

TCDBi1.B.14.1.8. the outer membrane receptor (omr) family.

Proteomic databases

PaxDbiP42512.
PRIDEiP42512.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG07609; AAG07609; PA4221.
GeneIDi880419.
KEGGipae:PA4221.
PATRICi19843132. VBIPseAer58763_4422.

Organism-specific databases

PseudoCAPiPA4221.

Phylogenomic databases

eggNOGiENOG4105CNM. Bacteria.
COG4773. LUCA.
HOGENOMiHOG000217242.
InParanoidiP42512.
KOiK16088.
OMAiPQDMAVY.
PhylomeDBiP42512.

Miscellaneous databases

EvolutionaryTraceiP42512.

Family and domain databases

Gene3Di2.170.130.10. 1 hit.
2.40.170.20. 1 hit.
InterProiIPR012910. Plug_dom.
IPR000531. TonB-dep_rcpt_b-brl.
IPR010917. TonB_rcpt_CS.
IPR010105. TonB_sidphr_rcpt.
[Graphical view]
PfamiPF07715. Plug. 1 hit.
PF00593. TonB_dep_Rec. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01783. TonB-siderophor. 1 hit.
PROSITEiPS01156. TONB_DEPENDENT_REC_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFPTA_PSEAE
AccessioniPrimary (citable) accession number: P42512
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.