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Protein

Fe(3+)-pyochelin receptor

Gene

fptA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High-affinity outer membrane receptor required for the transport of Fe3+-pyochelin.

GO - Molecular functioni

  • enterobactin binding Source: CAFA
  • iron ion binding Source: InterPro
  • signaling receptor activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processIon transport, Iron transport, Transport
LigandIron

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-4294-MONOMER

Protein family/group databases

TCDBi1.B.14.1.8 the outer membrane receptor (omr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Fe(3+)-pyochelin receptor
Alternative name(s):
Fe(III)-pyochelin receptor
Gene namesi
Name:fptA
Ordered Locus Names:PA4221
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA4221

Subcellular locationi

GO - Cellular componenti

  • cell outer membrane Source: CAFA
  • integral component of membrane Source: UniProtKB-KW

Keywords - Cellular componenti

Cell outer membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3097981
DrugBankiDB04147 Lauryl Dimethylamine-N-Oxide

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 381 PublicationAdd BLAST38
ChainiPRO_000003475039 – 720Fe(3+)-pyochelin receptorAdd BLAST682

Proteomic databases

PaxDbiP42512
PRIDEiP42512

Interactioni

Protein-protein interaction databases

STRINGi208964.PA4221

Chemistry databases

BindingDBiP42512

Structurei

Secondary structure

1720
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi76 – 78Combined sources3
Beta strandi80 – 87Combined sources8
Helixi88 – 93Combined sources6
Helixi99 – 104Combined sources6
Beta strandi109 – 115Combined sources7
Beta strandi118 – 123Combined sources6
Beta strandi130 – 133Combined sources4
Beta strandi153 – 161Combined sources9
Turni164 – 167Combined sources4
Beta strandi172 – 180Combined sources9
Beta strandi188 – 196Combined sources9
Turni197 – 199Combined sources3
Beta strandi200 – 229Combined sources30
Beta strandi231 – 234Combined sources4
Beta strandi236 – 251Combined sources16
Beta strandi254 – 268Combined sources15
Beta strandi297 – 314Combined sources18
Beta strandi317 – 339Combined sources23
Turni343 – 345Combined sources3
Beta strandi349 – 375Combined sources27
Beta strandi378 – 398Combined sources21
Beta strandi400 – 402Combined sources3
Turni410 – 412Combined sources3
Beta strandi415 – 417Combined sources3
Beta strandi432 – 448Combined sources17
Beta strandi451 – 465Combined sources15
Beta strandi476 – 488Combined sources13
Beta strandi491 – 502Combined sources12
Beta strandi518 – 531Combined sources14
Helixi532 – 534Combined sources3
Beta strandi536 – 553Combined sources18
Beta strandi555 – 557Combined sources3
Beta strandi566 – 586Combined sources21
Beta strandi589 – 604Combined sources16
Beta strandi620 – 630Combined sources11
Helixi633 – 636Combined sources4
Beta strandi638 – 647Combined sources10
Beta strandi650 – 654Combined sources5
Beta strandi657 – 661Combined sources5
Beta strandi664 – 687Combined sources24
Beta strandi694 – 696Combined sources3
Beta strandi704 – 706Combined sources3
Beta strandi711 – 720Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XKWX-ray2.00A56-720[»]
DisProtiDP00176
ProteinModelPortaliP42512
SMRiP42512
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP42512

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi703 – 720TonB C-terminal boxAdd BLAST18

Sequence similaritiesi

Belongs to the TonB-dependent receptor family.Curated

Keywords - Domaini

Signal, TonB box, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG4105CNM Bacteria
COG4773 LUCA
HOGENOMiHOG000217242
InParanoidiP42512
KOiK16088
OMAiTFVGADW
PhylomeDBiP42512

Family and domain databases

Gene3Di2.170.130.10, 1 hit
2.40.170.20, 1 hit
InterProiView protein in InterPro
IPR012910 Plug_dom
IPR037066 Plug_dom_sf
IPR000531 TonB-dep_rcpt_b-brl
IPR036942 TonB_rcpt_b-brl_sf
IPR010917 TonB_rcpt_CS
IPR010105 TonB_sidphr_rcpt
PfamiView protein in Pfam
PF07715 Plug, 1 hit
PF00593 TonB_dep_Rec, 1 hit
TIGRFAMsiTIGR01783 TonB-siderophor, 1 hit
PROSITEiView protein in PROSITE
PS01156 TONB_DEPENDENT_REC_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42512-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTETKVIKG RQGIARNRHT PLCLGLLLAL SPLAAAVADA RKDGETELPD
60 70 80 90 100
MVISGESTSA TQPPGVTTLG KVPLKPRELP QSASVIDHER LEQQNLFSLD
110 120 130 140 150
EAMQQATGVT VQPFQLLTTA YYVRGFKVDS FELDGVPALL GNTASSPQDM
160 170 180 190 200
AIYERVEILR GSNGLLHGTG NPAATVNLVR KRPQREFAAS TTLSAGRWDR
210 220 230 240 250
YRAEVDVGGP LSASGNVRGR AVAAYEDRDY FYDVADQGTR LLYGVTEFDL
260 270 280 290 300
SPDTLLTVGA QYQHIDSITN MAGVPMAKDG SNLGLSRDTY LDVDWDRFKW
310 320 330 340 350
DTYRAFGSLE QQLGGGWKGK VSAEYQEADS RLRYAGSFGA IDPQTGDGGQ
360 370 380 390 400
LMGAAYKFKS IQRSLDANLN GPVRLFGLTH ELLGGVTYAQ GETRQDTARF
410 420 430 440 450
LNLPNTPVNV YRWDPHGVPR PQIGQYTSPG TTTTTQKGLY ALGRIKLAEP
460 470 480 490 500
LTLVVGGRES WWDQDTPATR FKPGRQFTPY GGLIWDFARD WSWYVSYAEV
510 520 530 540 550
YQPQADRQTW NSEPLSPVEG KTYETGIKGE LADGRLNLSL AAFRIDLENN
560 570 580 590 600
PQEDPDHPGP PNNPFYISGG KVRSQGFELE GTGYLTPYWS LSAGYTYTST
610 620 630 640 650
EYLKDSQNDS GTRYSTFTPR HLLRLWSNYD LPWQDRRWSV GGGLQAQSDY
660 670 680 690 700
SVDYRGVSMR QGGYALVNMR LGYKIDEHWT AAVNVNNLFD RTYYQSLSNP
710 720
NWNNRYGEPR SFNVSLRGAF
Length:720
Mass (Da):79,992
Last modified:November 1, 1995 - v1
Checksum:iDA796313116E0CC2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03161 Unassigned DNA Translation: AAC43213.1
AE004091 Genomic DNA Translation: AAG07609.1
PIRiA36942
RefSeqiNP_252911.1, NC_002516.2
WP_003111969.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG07609; AAG07609; PA4221
GeneIDi880419
KEGGipae:PA4221
PATRICifig|208964.12.peg.4422

Entry informationi

Entry nameiFPTA_PSEAE
AccessioniPrimary (citable) accession number: P42512
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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