Reviewed, UniProtKB/Swiss-Prot P42492 (RIR2_ASFB7)

Names and origin

Protein names

Recommended name:
    Ribonucleoside-diphosphate reductase small chain
    EC=1.17.4.1
Alternative name(s):
    Ribonucleotide reductase small subunit

Gene names

Ordered Locus Names:	Ba71V-044
ORF Names:	F334L

Organism

African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV)

Taxonomic identifier

10498 [NCBI]

Taxonomic lineage

Viruses › dsDNA viruses, no RNA stage › Asfarviridae › Asfivirus

Virus host

Ornithodoros (relapsing fever ticks) [TaxID: 6937]
Sus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.
Catalytic activity	2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.
Cofactor	Binds 2 iron ions per subunit By similarity.
Pathway	Genetic information processing; DNA replication.
Subunit structure	Heterodimer of a large and a small chain By similarity.
Sequence similarities	Belongs to the ribonucleoside diphosphate reductase small chain family.

Ontologies

Keywords
Biological process	DNA replication
Ligand	Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome Virus reference strain
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW deoxyribonucleoside diphosphate metabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW ribonucleoside-diphosphate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 334	334	Ribonucleoside-diphosphate reductase small chain		PRO_0000190491
Sites
	Active site	115	1	By similarity
	Metal binding	77	1	Iron 1 By similarity
	Metal binding	108	1	Iron 1 By similarity
	Metal binding	108	1	Iron 2 By similarity
	Metal binding	111	1	Iron 1 By similarity
	Metal binding	171	1	Iron 2 By similarity
	Metal binding	205	1	Iron 2 By similarity
	Metal binding	208	1	Iron 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	P42492-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 950195E2F0D719CF	FASTA	334	39,806
	10 20 30 40 50 60 MLIFISNMEE LLIENSQRFT IFPIQHPECW NWYKKLESLT WTAQEVDMCK DIDDWEAMPK 70 80 90 100 110 120 PQREFYKQIL AFFVVADEIV IENLLTNFMR EIKVKEVLYF YTMQAAQECV HSEAYSIQVK 130 140 150 160 170 180 TLIPDEKEQQ RIFSGIEKHP IIKKMAQWVR QWMDPDRNTL GERLVGFAAV EGILFQNHFV 190 200 210 220 230 240 AIQFLKEQNI MPGLVSYNEF ISRDEGVHCS FACFLISNYV YNIPEEKIIH KILKEAVELV 250 260 270 280 290 300 DEFINYAFDK ARGRVPGFSK EMLFQYIRYF TDNLCFMMQC KSIYKVGNPF PQMTKFFLNE 310 320 330 VEKTNFFELR PTQYQNCVKD DAFAFKLFLN DDDF

References

[1]	"Analysis of the complete nucleotide sequence of African swine fever virus." Yanez R.J., Rodriguez J.M., Nogal M.L., Yuste L., Enriquez C., Rodriguez J.F., Vinuela E. Virology 208:249-278(1995) [PubMed: 11831707] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U18466 Genomic DNA. Translation: AAA65274.1.
RefSeq	NP_042738.1.
3D structure databases
SMR	P42492. Positions 7-293.
ModBase	Search...
Genome annotation databases
GeneID	1488809.
Family and domain databases
InterPro	IPR009078. Ferritin/RR-like. IPR012348. Ribncl_red_rel. IPR000358. Ribonucl_redctse. [Graphical view]
Gene3D	G3DSA:1.10.620.20. Ribncl_red_rel. 1 hit.
PANTHER	PTHR23409. Ribonucl_redctse. 1 hit.
Pfam	PF00268. Ribonuc_red_sm. 1 hit. [Graphical view]
PROSITE	PS00368. RIBORED_SMALL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RIR2_ASFB7

Accession

Primary (citable) accession number: P42492

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 19, 2010
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Virus (Virus annotation project)