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P42492 (RIR2_ASFB7) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase small chain

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
Ordered Locus Names:Ba71V-044
ORF Names:F334L
OrganismAfrican swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV) [Reference proteome]
Taxonomic identifier10498 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageAsfarviridaeAsfivirus
Virus hostOrnithodoros (relapsing fever ticks) [TaxID: 6937]
Sus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length334 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 334334Ribonucleoside-diphosphate reductase small chain
PRO_0000190491

Sites

Active site1151 By similarity
Metal binding771Iron 1 By similarity
Metal binding1081Iron 1 By similarity
Metal binding1081Iron 2 By similarity
Metal binding1111Iron 1 By similarity
Metal binding1711Iron 2 By similarity
Metal binding2051Iron 2 By similarity
Metal binding2081Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P42492 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 950195E2F0D719CF

FASTA33439,806
        10         20         30         40         50         60 
MLIFISNMEE LLIENSQRFT IFPIQHPECW NWYKKLESLT WTAQEVDMCK DIDDWEAMPK 

        70         80         90        100        110        120 
PQREFYKQIL AFFVVADEIV IENLLTNFMR EIKVKEVLYF YTMQAAQECV HSEAYSIQVK 

       130        140        150        160        170        180 
TLIPDEKEQQ RIFSGIEKHP IIKKMAQWVR QWMDPDRNTL GERLVGFAAV EGILFQNHFV 

       190        200        210        220        230        240 
AIQFLKEQNI MPGLVSYNEF ISRDEGVHCS FACFLISNYV YNIPEEKIIH KILKEAVELV 

       250        260        270        280        290        300 
DEFINYAFDK ARGRVPGFSK EMLFQYIRYF TDNLCFMMQC KSIYKVGNPF PQMTKFFLNE 

       310        320        330 
VEKTNFFELR PTQYQNCVKD DAFAFKLFLN DDDF 

« Hide

References

[1]"Analysis of the complete nucleotide sequence of African swine fever virus."
Yanez R.J., Rodriguez J.M., Nogal M.L., Yuste L., Enriquez C., Rodriguez J.F., Vinuela E.
Virology 208:249-278(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U18466 Genomic DNA. Translation: AAA65274.1.
RefSeqNP_042738.1. NC_001659.1.

3D structure databases

ProteinModelPortalP42492.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1488809.

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_ASFB7
AccessionPrimary (citable) accession number: P42492
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways