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P42475

- EFTU_FIBSS

UniProt

P42475 - EFTU_FIBSS

Protein

Elongation factor Tu

Gene

tuf1

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Organism
Fibrobacter succinogenes (strain ATCC 19169 / S85)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (19 Jan 2010)
      Previous versions | rss
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    • Comment

    Functioni

    This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi19 – 268GTPUniRule annotation
    Nucleotide bindingi81 – 855GTPUniRule annotation
    Nucleotide bindingi136 – 1394GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: UniProtKB-HAMAP
    3. translation elongation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Elongation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongation factor TuUniRule annotation
    Short name:
    EF-TuUniRule annotation
    Gene namesi
    Name:tuf1UniRule annotation
    Ordered Locus Names:Fisuc_1279, FSU_1743
    AND
    Name:tuf2UniRule annotation
    Ordered Locus Names:Fisuc_1424, FSU_1892
    OrganismiFibrobacter succinogenes (strain ATCC 19169 / S85)
    Taxonomic identifieri59374 [NCBI]
    Taxonomic lineageiBacteriaFibrobacteresFibrobacteralesFibrobacteraceaeFibrobacter
    ProteomesiUP000000517: Chromosome, UP000001497: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 394394Elongation factor TuPRO_0000091325Add
    BLAST

    Proteomic databases

    PRIDEiP42475.

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi59374.Fisuc_1424.

    Structurei

    3D structure databases

    ProteinModelPortaliP42475.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 204195tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni19 – 268G1By similarity
    Regioni60 – 645G2By similarity
    Regioni81 – 844G3By similarity
    Regioni136 – 1394G4By similarity
    Regioni174 – 1763G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0050.
    HOGENOMiHOG000229290.
    KOiK02358.
    OMAiKWVDAIW.
    OrthoDBiEOG6R5C6X.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00118_B. EF_Tu_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004541. Transl_elong_EFTu/EF1A_bac/org.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view]
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SUPFAMiSSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS00301. G_TR_1. 1 hit.
    PS51722. G_TR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P42475-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKEHFDRSK PHCNIGTIGH VDHGKTTLTA AICTTLAAKG LAAAKRFDEI    50
    DNAPEEKARG ITINTSHVEY TTANRHYAHV DCPGHADYVK NMVTGAAQMD 100
    GAILVVAATD GPMPQTREHI LLAHQVGVPK IVVFMNKCDM VDDAEILDLV 150
    EMEVRELLSK YDFDGDNTPI IRGSALKALE GDPEYQDKVM ELMNACDEYI 200
    PLPQRDTDKP FLMPIEDVFT ITGRGTVATG RIERGVVRLN DKVERIGLGE 250
    TTEYVITGVE MFRKLLDDAQ AGDNVGLLLR GAEKKDIVRG MVLAAPKSVT 300
    PHTEFKAEIY VLTKDEGGRH TPFMNGYRPQ FYFRTTDVTG TIQLPEGVEM 350
    VTPGDTVTIH VNLIAPIAME KQLRFAIREG GRTVGAGSVT EIIK 394
    Length:394
    Mass (Da):43,287
    Last modified:January 19, 2010 - v2
    Checksum:i815F58A7528405D9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001792 Genomic DNA. Translation: ACX74879.1.
    CP001792 Genomic DNA. Translation: ACX75022.1.
    CP002158 Genomic DNA. Translation: ADL26669.1.
    CP002158 Genomic DNA. Translation: ADL27312.1.
    X76866 Genomic DNA. Translation: CAA54194.1.
    RefSeqiWP_014545994.1. NC_017448.1.
    YP_003249361.1. NC_013410.1.
    YP_003249504.1. NC_013410.1.
    YP_005821708.1. NC_017448.1.
    YP_005821832.1. NC_017448.1.

    Genome annotation databases

    EnsemblBacteriaiACX74879; ACX74879; Fisuc_1279.
    ACX75022; ACX75022; Fisuc_1424.
    ADL26669; ADL26669; FSU_1892.
    ADL27312; ADL27312; FSU_1743.
    GeneIDi12433311.
    12433452.
    8521880.
    8522029.
    KEGGifsc:FSU_1743.
    fsc:FSU_1892.
    fsu:Fisuc_1279.
    fsu:Fisuc_1424.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001792 Genomic DNA. Translation: ACX74879.1 .
    CP001792 Genomic DNA. Translation: ACX75022.1 .
    CP002158 Genomic DNA. Translation: ADL26669.1 .
    CP002158 Genomic DNA. Translation: ADL27312.1 .
    X76866 Genomic DNA. Translation: CAA54194.1 .
    RefSeqi WP_014545994.1. NC_017448.1.
    YP_003249361.1. NC_013410.1.
    YP_003249504.1. NC_013410.1.
    YP_005821708.1. NC_017448.1.
    YP_005821832.1. NC_017448.1.

    3D structure databases

    ProteinModelPortali P42475.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 59374.Fisuc_1424.

    Proteomic databases

    PRIDEi P42475.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACX74879 ; ACX74879 ; Fisuc_1279 .
    ACX75022 ; ACX75022 ; Fisuc_1424 .
    ADL26669 ; ADL26669 ; FSU_1892 .
    ADL27312 ; ADL27312 ; FSU_1743 .
    GeneIDi 12433311.
    12433452.
    8521880.
    8522029.
    KEGGi fsc:FSU_1743.
    fsc:FSU_1892.
    fsu:Fisuc_1279.
    fsu:Fisuc_1424.

    Phylogenomic databases

    eggNOGi COG0050.
    HOGENOMi HOG000229290.
    KOi K02358.
    OMAi KWVDAIW.
    OrthoDBi EOG6R5C6X.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00118_B. EF_Tu_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004541. Transl_elong_EFTu/EF1A_bac/org.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view ]
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SUPFAMi SSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00485. EF-Tu. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS00301. G_TR_1. 1 hit.
    PS51722. G_TR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Fibrobacter succinogenes subsp. succinogenes S85."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Weimer P.J.
      , Stevenson D.M., Boyum J., Brumm P.I., Mead D.
      Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 19169 / S85.
    2. "Complete sequence of Fibrobacter succinogenes subsp. succinogenes S85."
      Durkin A.S., Nelson K.E., Morrison M., Forsberg C.W., Wilson D.B., Russell J.B., Cann I.K.O., Mackie R.I., White B.A.
      Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 19169 / S85.
    3. "Phylogenetic relationships of Bacteria based on comparative sequence analysis of elongation factor Tu and ATP-synthase beta-subunit genes."
      Ludwig W., Neumaier J., Klugbauer N., Brockmann E., Roller C., Klugbauer S., Reetz K., Schachtner I., Ludvigsen A., Bachleitner M., Fischer U., Schleifer K.H.
      Antonie Van Leeuwenhoek 64:285-305(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-394.

    Entry informationi

    Entry nameiEFTU_FIBSS
    AccessioniPrimary (citable) accession number: P42475
    Secondary accession number(s): C9RQP3, D9SB12
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: January 19, 2010
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3