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P42475 (EFTU_FIBSS) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Elongation factor Tu

Short name=EF-Tu
Gene names
Name:tuf1
Ordered Locus Names:Fisuc_1279, FSU_1743
AND
Name:tuf2
Ordered Locus Names:Fisuc_1424, FSU_1892
OrganismFibrobacter succinogenes (strain ATCC 19169 / S85) [Complete proteome] [HAMAP]
Taxonomic identifier59374 [NCBI]
Taxonomic lineageBacteriaFibrobacteresFibrobacteralesFibrobacteraceaeFibrobacter

Protein attributes

Sequence length394 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis By similarity. HAMAP-Rule MF_00118

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00118

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00118.

Sequence similarities

Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionElongation factor
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

GTPase activity

Inferred from electronic annotation. Source: InterPro

translation elongation factor activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 394394Elongation factor Tu HAMAP-Rule MF_00118
PRO_0000091325

Regions

Nucleotide binding19 – 268GTP By similarity
Nucleotide binding81 – 855GTP By similarity
Nucleotide binding136 – 1394GTP By similarity

Sequences

Sequence LengthMass (Da)Tools
P42475 [UniParc].

Last modified January 19, 2010. Version 2.
Checksum: 815F58A7528405D9

FASTA39443,287
        10         20         30         40         50         60 
MAKEHFDRSK PHCNIGTIGH VDHGKTTLTA AICTTLAAKG LAAAKRFDEI DNAPEEKARG 

        70         80         90        100        110        120 
ITINTSHVEY TTANRHYAHV DCPGHADYVK NMVTGAAQMD GAILVVAATD GPMPQTREHI 

       130        140        150        160        170        180 
LLAHQVGVPK IVVFMNKCDM VDDAEILDLV EMEVRELLSK YDFDGDNTPI IRGSALKALE 

       190        200        210        220        230        240 
GDPEYQDKVM ELMNACDEYI PLPQRDTDKP FLMPIEDVFT ITGRGTVATG RIERGVVRLN 

       250        260        270        280        290        300 
DKVERIGLGE TTEYVITGVE MFRKLLDDAQ AGDNVGLLLR GAEKKDIVRG MVLAAPKSVT 

       310        320        330        340        350        360 
PHTEFKAEIY VLTKDEGGRH TPFMNGYRPQ FYFRTTDVTG TIQLPEGVEM VTPGDTVTIH 

       370        380        390 
VNLIAPIAME KQLRFAIREG GRTVGAGSVT EIIK 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequence of Fibrobacter succinogenes subsp. succinogenes S85."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Weimer P.J. expand/collapse author list , Stevenson D.M., Boyum J., Brumm P.I., Mead D.
Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 19169 / S85.
[2]"Complete sequence of Fibrobacter succinogenes subsp. succinogenes S85."
Durkin A.S., Nelson K.E., Morrison M., Forsberg C.W., Wilson D.B., Russell J.B., Cann I.K.O., Mackie R.I., White B.A.
Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 19169 / S85.
[3]"Phylogenetic relationships of Bacteria based on comparative sequence analysis of elongation factor Tu and ATP-synthase beta-subunit genes."
Ludwig W., Neumaier J., Klugbauer N., Brockmann E., Roller C., Klugbauer S., Reetz K., Schachtner I., Ludvigsen A., Bachleitner M., Fischer U., Schleifer K.H.
Antonie Van Leeuwenhoek 64:285-305(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-394.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001792 Genomic DNA. Translation: ACX74879.1.
CP001792 Genomic DNA. Translation: ACX75022.1.
CP002158 Genomic DNA. Translation: ADL26669.1.
CP002158 Genomic DNA. Translation: ADL27312.1.
X76866 Genomic DNA. Translation: CAA54194.1.
RefSeqYP_003249361.1. NC_013410.1.
YP_003249504.1. NC_013410.1.
YP_005821708.1. NC_017448.1.
YP_005821832.1. NC_017448.1.

3D structure databases

ProteinModelPortalP42475.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING59374.Fisuc_1424.

Proteomic databases

PRIDEP42475.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACX74879; ACX74879; Fisuc_1279.
ACX75022; ACX75022; Fisuc_1424.
ADL26669; ADL26669; FSU_1892.
ADL27312; ADL27312; FSU_1743.
GeneID12433311.
12433452.
8521880.
8522029.
KEGGfsc:FSU_1743.
fsc:FSU_1892.
fsu:Fisuc_1279.
fsu:Fisuc_1424.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0050.
HOGENOMHOG000229290.
KOK02358.
OMAVTPHTEF.
OrthoDBEOG6R5C6X.
ProtClustDBCLSK2558239.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00118_B. EF_Tu_B.
InterProIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSPR00315. ELONGATNFCT.
SUPFAMSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEFTU_FIBSS
AccessionPrimary (citable) accession number: P42475
Secondary accession number(s): C9RQP3, D9SB12
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 19, 2010
Last modified: April 16, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families