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P42475

- EFTU_FIBSS

UniProt

P42475 - EFTU_FIBSS

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Protein
Elongation factor Tu
Gene
tuf1, Fisuc_1279, FSU_1743
tuf2, Fisuc_1424, FSU_1892
Organism
Fibrobacter succinogenes (strain ATCC 19169 / S85)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTP By similarity
Nucleotide bindingi81 – 855GTP By similarity
Nucleotide bindingi136 – 1394GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. GTPase activity Source: InterPro
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor Tu
Short name:
EF-Tu
Gene namesi
Name:tuf1
Ordered Locus Names:Fisuc_1279, FSU_1743
AND
Name:tuf2
Ordered Locus Names:Fisuc_1424, FSU_1892
OrganismiFibrobacter succinogenes (strain ATCC 19169 / S85)
Taxonomic identifieri59374 [NCBI]
Taxonomic lineageiBacteriaFibrobacteresFibrobacteralesFibrobacteraceaeFibrobacter
ProteomesiUP000000517: Chromosome, UP000001497: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Elongation factor TuUniRule annotation
PRO_0000091325Add
BLAST

Proteomic databases

PRIDEiP42475.

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi59374.Fisuc_1424.

Structurei

3D structure databases

ProteinModelPortaliP42475.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 204195tr-type G
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 268G1 By similarity
Regioni60 – 645G2 By similarity
Regioni81 – 844G3 By similarity
Regioni136 – 1394G4 By similarity
Regioni174 – 1763G5 By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0050.
HOGENOMiHOG000229290.
KOiK02358.
OMAiKWVDAIW.
OrthoDBiEOG6R5C6X.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42475-1 [UniParc]FASTAAdd to Basket

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MAKEHFDRSK PHCNIGTIGH VDHGKTTLTA AICTTLAAKG LAAAKRFDEI    50
DNAPEEKARG ITINTSHVEY TTANRHYAHV DCPGHADYVK NMVTGAAQMD 100
GAILVVAATD GPMPQTREHI LLAHQVGVPK IVVFMNKCDM VDDAEILDLV 150
EMEVRELLSK YDFDGDNTPI IRGSALKALE GDPEYQDKVM ELMNACDEYI 200
PLPQRDTDKP FLMPIEDVFT ITGRGTVATG RIERGVVRLN DKVERIGLGE 250
TTEYVITGVE MFRKLLDDAQ AGDNVGLLLR GAEKKDIVRG MVLAAPKSVT 300
PHTEFKAEIY VLTKDEGGRH TPFMNGYRPQ FYFRTTDVTG TIQLPEGVEM 350
VTPGDTVTIH VNLIAPIAME KQLRFAIREG GRTVGAGSVT EIIK 394
Length:394
Mass (Da):43,287
Last modified:January 19, 2010 - v2
Checksum:i815F58A7528405D9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001792 Genomic DNA. Translation: ACX74879.1.
CP001792 Genomic DNA. Translation: ACX75022.1.
CP002158 Genomic DNA. Translation: ADL26669.1.
CP002158 Genomic DNA. Translation: ADL27312.1.
X76866 Genomic DNA. Translation: CAA54194.1.
RefSeqiWP_014545994.1. NC_017448.1.
YP_003249361.1. NC_013410.1.
YP_003249504.1. NC_013410.1.
YP_005821708.1. NC_017448.1.
YP_005821832.1. NC_017448.1.

Genome annotation databases

EnsemblBacteriaiACX74879; ACX74879; Fisuc_1279.
ACX75022; ACX75022; Fisuc_1424.
ADL26669; ADL26669; FSU_1892.
ADL27312; ADL27312; FSU_1743.
GeneIDi12433311.
12433452.
8521880.
8522029.
KEGGifsc:FSU_1743.
fsc:FSU_1892.
fsu:Fisuc_1279.
fsu:Fisuc_1424.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001792 Genomic DNA. Translation: ACX74879.1 .
CP001792 Genomic DNA. Translation: ACX75022.1 .
CP002158 Genomic DNA. Translation: ADL26669.1 .
CP002158 Genomic DNA. Translation: ADL27312.1 .
X76866 Genomic DNA. Translation: CAA54194.1 .
RefSeqi WP_014545994.1. NC_017448.1.
YP_003249361.1. NC_013410.1.
YP_003249504.1. NC_013410.1.
YP_005821708.1. NC_017448.1.
YP_005821832.1. NC_017448.1.

3D structure databases

ProteinModelPortali P42475.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 59374.Fisuc_1424.

Proteomic databases

PRIDEi P42475.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACX74879 ; ACX74879 ; Fisuc_1279 .
ACX75022 ; ACX75022 ; Fisuc_1424 .
ADL26669 ; ADL26669 ; FSU_1892 .
ADL27312 ; ADL27312 ; FSU_1743 .
GeneIDi 12433311.
12433452.
8521880.
8522029.
KEGGi fsc:FSU_1743.
fsc:FSU_1892.
fsu:Fisuc_1279.
fsu:Fisuc_1424.

Phylogenomic databases

eggNOGi COG0050.
HOGENOMi HOG000229290.
KOi K02358.
OMAi KWVDAIW.
OrthoDBi EOG6R5C6X.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00118_B. EF_Tu_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view ]
Pfami PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SUPFAMi SSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Fibrobacter succinogenes subsp. succinogenes S85."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Weimer P.J.
    , Stevenson D.M., Boyum J., Brumm P.I., Mead D.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19169 / S85.
  2. "Complete sequence of Fibrobacter succinogenes subsp. succinogenes S85."
    Durkin A.S., Nelson K.E., Morrison M., Forsberg C.W., Wilson D.B., Russell J.B., Cann I.K.O., Mackie R.I., White B.A.
    Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19169 / S85.
  3. "Phylogenetic relationships of Bacteria based on comparative sequence analysis of elongation factor Tu and ATP-synthase beta-subunit genes."
    Ludwig W., Neumaier J., Klugbauer N., Brockmann E., Roller C., Klugbauer S., Reetz K., Schachtner I., Ludvigsen A., Bachleitner M., Fischer U., Schleifer K.H.
    Antonie Van Leeuwenhoek 64:285-305(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-394.

Entry informationi

Entry nameiEFTU_FIBSS
AccessioniPrimary (citable) accession number: P42475
Secondary accession number(s): C9RQP3, D9SB12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 19, 2010
Last modified: September 3, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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