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Protein

Elongation factor Tu

Gene

tuf1

more
Organism
Fibrobacter succinogenes (strain ATCC 19169 / S85)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTPUniRule annotation
Nucleotide bindingi81 – 855GTPUniRule annotation
Nucleotide bindingi136 – 1394GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-HAMAP
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor TuUniRule annotation
Short name:
EF-TuUniRule annotation
Gene namesi
Name:tuf1UniRule annotation
Ordered Locus Names:Fisuc_1279, FSU_1743
AND
Name:tuf2UniRule annotation
Ordered Locus Names:Fisuc_1424, FSU_1892
OrganismiFibrobacter succinogenes (strain ATCC 19169 / S85)
Taxonomic identifieri59374 [NCBI]
Taxonomic lineageiBacteriaFibrobacteresFibrobacteralesFibrobacteraceaeFibrobacter
ProteomesiUP000000517: Chromosome, UP000001497: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 394394Elongation factor TuPRO_0000091325Add
BLAST

Proteomic databases

PRIDEiP42475.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi59374.Fisuc_1424.

Structurei

3D structure databases

ProteinModelPortaliP42475.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 204195tr-type GAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 268G1By similarity
Regioni60 – 645G2By similarity
Regioni81 – 844G3By similarity
Regioni136 – 1394G4By similarity
Regioni174 – 1763G5By similarity

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0050.
HOGENOMiHOG000229290.
KOiK02358.
OMAiDEGGRHN.
OrthoDBiEOG6R5C6X.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42475-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKEHFDRSK PHCNIGTIGH VDHGKTTLTA AICTTLAAKG LAAAKRFDEI
60 70 80 90 100
DNAPEEKARG ITINTSHVEY TTANRHYAHV DCPGHADYVK NMVTGAAQMD
110 120 130 140 150
GAILVVAATD GPMPQTREHI LLAHQVGVPK IVVFMNKCDM VDDAEILDLV
160 170 180 190 200
EMEVRELLSK YDFDGDNTPI IRGSALKALE GDPEYQDKVM ELMNACDEYI
210 220 230 240 250
PLPQRDTDKP FLMPIEDVFT ITGRGTVATG RIERGVVRLN DKVERIGLGE
260 270 280 290 300
TTEYVITGVE MFRKLLDDAQ AGDNVGLLLR GAEKKDIVRG MVLAAPKSVT
310 320 330 340 350
PHTEFKAEIY VLTKDEGGRH TPFMNGYRPQ FYFRTTDVTG TIQLPEGVEM
360 370 380 390
VTPGDTVTIH VNLIAPIAME KQLRFAIREG GRTVGAGSVT EIIK
Length:394
Mass (Da):43,287
Last modified:January 19, 2010 - v2
Checksum:i815F58A7528405D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001792 Genomic DNA. Translation: ACX74879.1.
CP001792 Genomic DNA. Translation: ACX75022.1.
CP002158 Genomic DNA. Translation: ADL26669.1.
CP002158 Genomic DNA. Translation: ADL27312.1.
X76866 Genomic DNA. Translation: CAA54194.1.
RefSeqiWP_014545994.1. NC_017448.1.
YP_003249361.1. NC_013410.1.
YP_003249504.1. NC_013410.1.
YP_005821708.1. NC_017448.1.
YP_005821832.1. NC_017448.1.

Genome annotation databases

EnsemblBacteriaiACX74879; ACX74879; Fisuc_1279.
ACX75022; ACX75022; Fisuc_1424.
ADL26669; ADL26669; FSU_1892.
ADL27312; ADL27312; FSU_1743.
GeneIDi12433311.
12433452.
8521880.
8522029.
KEGGifsc:FSU_1743.
fsc:FSU_1892.
fsu:Fisuc_1279.
fsu:Fisuc_1424.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001792 Genomic DNA. Translation: ACX74879.1.
CP001792 Genomic DNA. Translation: ACX75022.1.
CP002158 Genomic DNA. Translation: ADL26669.1.
CP002158 Genomic DNA. Translation: ADL27312.1.
X76866 Genomic DNA. Translation: CAA54194.1.
RefSeqiWP_014545994.1. NC_017448.1.
YP_003249361.1. NC_013410.1.
YP_003249504.1. NC_013410.1.
YP_005821708.1. NC_017448.1.
YP_005821832.1. NC_017448.1.

3D structure databases

ProteinModelPortaliP42475.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi59374.Fisuc_1424.

Proteomic databases

PRIDEiP42475.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACX74879; ACX74879; Fisuc_1279.
ACX75022; ACX75022; Fisuc_1424.
ADL26669; ADL26669; FSU_1892.
ADL27312; ADL27312; FSU_1743.
GeneIDi12433311.
12433452.
8521880.
8522029.
KEGGifsc:FSU_1743.
fsc:FSU_1892.
fsu:Fisuc_1279.
fsu:Fisuc_1424.

Phylogenomic databases

eggNOGiCOG0050.
HOGENOMiHOG000229290.
KOiK02358.
OMAiDEGGRHN.
OrthoDBiEOG6R5C6X.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of Fibrobacter succinogenes subsp. succinogenes S85."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Weimer P.J.
    , Stevenson D.M., Boyum J., Brumm P.I., Mead D.
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19169 / S85.
  2. "Complete sequence of Fibrobacter succinogenes subsp. succinogenes S85."
    Durkin A.S., Nelson K.E., Morrison M., Forsberg C.W., Wilson D.B., Russell J.B., Cann I.K.O., Mackie R.I., White B.A.
    Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19169 / S85.
  3. "Phylogenetic relationships of Bacteria based on comparative sequence analysis of elongation factor Tu and ATP-synthase beta-subunit genes."
    Ludwig W., Neumaier J., Klugbauer N., Brockmann E., Roller C., Klugbauer S., Reetz K., Schachtner I., Ludvigsen A., Bachleitner M., Fischer U., Schleifer K.H.
    Antonie Van Leeuwenhoek 64:285-305(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 20-394.

Entry informationi

Entry nameiEFTU_FIBSS
AccessioniPrimary (citable) accession number: P42475
Secondary accession number(s): C9RQP3, D9SB12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 19, 2010
Last modified: January 7, 2015
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.