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P42457

- CISY_CORGL

UniProt

P42457 - CISY_CORGL

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Protein
Citrate synthase
Gene
gltA, Cgl0829, cg0949
Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Enzyme regulationi

Weakly inhibited by ATP (apparent Ki = 10 mm).

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei316 – 3161 By similarity
Active sitei372 – 3721 By similarity

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: InterPro

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

BioCyciCGLU196627:GJDM-824-MONOMER.
UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase (EC:2.3.3.16)
Gene namesi
Name:gltA
Ordered Locus Names:Cgl0829, cg0949
OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Taxonomic identifieri196627 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Citrate synthase
PRO_0000169940Add
BLAST

Proteomic databases

PRIDEiP42457.

Interactioni

Subunit structurei

Homohexamer By similarity.

Protein-protein interaction databases

STRINGi196627.cg0949.

Structurei

3D structure databases

ProteinModelPortaliP42457.
SMRiP42457. Positions 13-437.

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.

Phylogenomic databases

eggNOGiCOG0372.
HOGENOMiHOG000021224.
KOiK01647.
OMAiYSGIIFR.
OrthoDBiEOG6P8TP4.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
TIGRFAMsiTIGR01798. cit_synth_I. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42457-1 [UniParc]FASTAAdd to Basket

« Hide

MFERDIVATD NNKAVLHYPG GEFEMDIIEA SEGNNGVVLG KMLSETGLIT    50
FDPGYVSTGS TESKITYIDG DAGILRYRGY DIADLAENAT FNEVSYLLIN 100
GELPTPDELH KFNDEIRHHT LLDEDFKSQF NVFPRDAHPM ATLASSVNIL 150
STYYQDQLNP LDEAQLDKAT VRLMAKVPML AAYAHRARKG APYMYPDNSL 200
NARENFLRMM FGYPTEPYEI DPIMVKALDK LLILHADHEQ NCSTSTVRMI 250
GSAQANMFVS IAGGINALSG PLHGGANQAV LEMLEDIKSN HGGDATEFMN 300
KVKNKEDGVR LMGFGHRVYK NYDPRAAIVK ETAHEILEHL GGDDLLDLAI 350
KLEEIALADD YFISRKLYPN VDFYTGLIYR AMGFPTDFFT VLFAIGRLPG 400
WIAHYREQLG AAGNKINRPR QVYTGNESRK LVPREER 437
Length:437
Mass (Da):48,929
Last modified:November 1, 1995 - v1
Checksum:i921780BF2C59676B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X66112 Genomic DNA. Translation: CAA46902.1.
BA000036 Genomic DNA. Translation: BAB98222.1.
BX927150 Genomic DNA. Translation: CAF19535.1.
PIRiI40717.
RefSeqiNP_600058.1. NC_003450.3.
WP_011013914.1. NC_006958.1.
YP_225121.1. NC_006958.1.

Genome annotation databases

EnsemblBacteriaiBAB98222; BAB98222; BAB98222.
CAF19535; CAF19535; cg0949.
GeneIDi1018824.
KEGGicgb:cg0949.
cgl:NCgl0795.
PATRICi21493706. VBICorGlu203724_0813.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X66112 Genomic DNA. Translation: CAA46902.1 .
BA000036 Genomic DNA. Translation: BAB98222.1 .
BX927150 Genomic DNA. Translation: CAF19535.1 .
PIRi I40717.
RefSeqi NP_600058.1. NC_003450.3.
WP_011013914.1. NC_006958.1.
YP_225121.1. NC_006958.1.

3D structure databases

ProteinModelPortali P42457.
SMRi P42457. Positions 13-437.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 196627.cg0949.

Proteomic databases

PRIDEi P42457.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAB98222 ; BAB98222 ; BAB98222 .
CAF19535 ; CAF19535 ; cg0949 .
GeneIDi 1018824.
KEGGi cgb:cg0949.
cgl:NCgl0795.
PATRICi 21493706. VBICorGlu203724_0813.

Phylogenomic databases

eggNOGi COG0372.
HOGENOMi HOG000021224.
KOi K01647.
OMAi YSGIIFR.
OrthoDBi EOG6P8TP4.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .
BioCyci CGLU196627:GJDM-824-MONOMER.

Family and domain databases

Gene3Di 1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
IPR010953. Citrate_synthase_typ-I.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PIRSFi PIRSF001369. Citrate_synth. 1 hit.
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
TIGRFAMsi TIGR01798. cit_synth_I. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence, expression and transcriptional analysis of the Corynebacterium glutamicum gltA gene encoding citrate synthase."
    Eikmanns B.J., Thum-Schmitz N., Eggeling L., Luedtke K.U., Sahm H.
    Microbiology 140:1817-1828(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  2. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
    Ikeda M., Nakagawa S.
    Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

Entry informationi

Entry nameiCISY_CORGL
AccessioniPrimary (citable) accession number: P42457
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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