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P42452

- HEM4_SYNE7

UniProt

P42452 - HEM4_SYNE7

Protein

Uroporphyrinogen-III synthase

Gene

hemD

Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.By similarity

    Catalytic activityi

    Hydroxymethylbilane = uroporphyrinogen III + H2O.

    Pathwayi

    GO - Molecular functioni

    1. uroporphyrinogen-III synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Enzyme and pathway databases

    BioCyciSYNEL:SYNPCC7942_0272-MONOMER.
    UniPathwayiUPA00251; UER00320.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uroporphyrinogen-III synthase (EC:4.2.1.75)
    Short name:
    UROS
    Alternative name(s):
    Hydroxymethylbilane hydrolyase [cyclizing]
    Uroporphyrinogen-III cosynthase
    Gene namesi
    Name:hemD
    Ordered Locus Names:Synpcc7942_0272
    OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
    Taxonomic identifieri1140 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
    ProteomesiUP000002717: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 264264Uroporphyrinogen-III synthasePRO_0000135247Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi1140.Synpcc7942_0272.

    Structurei

    3D structure databases

    ProteinModelPortaliP42452.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1587.
    HOGENOMiHOG000247992.
    KOiK01719.
    OrthoDBiEOG6BGNXZ.

    Family and domain databases

    InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
    [Graphical view]
    PfamiPF02602. HEM4. 1 hit.
    [Graphical view]
    SUPFAMiSSF69618. SSF69618. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P42452-1 [UniParc]FASTAAdd to Basket

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    MAEQPLIGKT ILTTRAAGQS SPFAAQLRAA GAAVIEMPTL EIGPPSSWLP    50
    LDEAIAAIAD FDWLILASAN AVEAVQQRLA AQQKSWSDVP CAIAVVGQKT 100
    AQVLAAQGGK ADYIPPEFIA ESLVEHFPQP VAGQRLLFPR VETGGREQIT 150
    QALQSQGAIV VEVPAYESRC PSQIPDDALI ALRQAHLNLI SFTSSKTVRN 200
    FCQLMASNLG VDWSARISGV AIASIGPQTS ITCQELLGRV EVEAQEYTLD 250
    GLLLAIEQWA RQTT 264
    Length:264
    Mass (Da):28,196
    Last modified:November 1, 1995 - v1
    Checksum:i0BAB84E9F86E80FA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70966 Genomic DNA. Translation: CAA50303.1.
    CP000100 Genomic DNA. Translation: ABB56304.1.
    RefSeqiYP_171951.1. NC_006576.1.
    YP_399291.1. NC_007604.1.

    Genome annotation databases

    EnsemblBacteriaiABB56304; ABB56304; Synpcc7942_0272.
    GeneIDi3199499.
    3773834.
    KEGGisyc:syc1241_c.
    syf:Synpcc7942_0272.
    PATRICi23785609. VBISynElo51371_0350.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X70966 Genomic DNA. Translation: CAA50303.1 .
    CP000100 Genomic DNA. Translation: ABB56304.1 .
    RefSeqi YP_171951.1. NC_006576.1.
    YP_399291.1. NC_007604.1.

    3D structure databases

    ProteinModelPortali P42452.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 1140.Synpcc7942_0272.

    Protocols and materials databases

    DNASUi 3773834.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABB56304 ; ABB56304 ; Synpcc7942_0272 .
    GeneIDi 3199499.
    3773834.
    KEGGi syc:syc1241_c.
    syf:Synpcc7942_0272.
    PATRICi 23785609. VBISynElo51371_0350.

    Phylogenomic databases

    eggNOGi COG1587.
    HOGENOMi HOG000247992.
    KOi K01719.
    OrthoDBi EOG6BGNXZ.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00320 .
    BioCyci SYNEL:SYNPCC7942_0272-MONOMER.

    Family and domain databases

    InterProi IPR003754. 4pyrrol_synth_uPrphyn_synth.
    [Graphical view ]
    Pfami PF02602. HEM4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF69618. SSF69618. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterisation of genes for tetrapyrrole biosynthesis from the cyanobacterium Anacystis nidulans R2."
      Jones M.C., Jenkins J.M., Smith A.G., Howe C.J.
      Plant Mol. Biol. 24:435-448(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 7942.

    Entry informationi

    Entry nameiHEM4_SYNE7
    AccessioniPrimary (citable) accession number: P42452
    Secondary accession number(s): Q31RL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3