Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P42452 (HEM4_SYNE7) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uroporphyrinogen-III synthase

Short name=UROS
EC=4.2.1.75
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene names
Name:hemD
Ordered Locus Names:Synpcc7942_0272
OrganismSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) [Complete proteome] [HAMAP]
Taxonomic identifier1140 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus

Protein attributes

Sequence length264 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III By similarity.

Catalytic activity

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.

Sequence similarities

Belongs to the uroporphyrinogen-III synthase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotoporphyrinogen IX biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionuroporphyrinogen-III synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 264264Uroporphyrinogen-III synthase
PRO_0000135247

Sequences

Sequence LengthMass (Da)Tools
P42452 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 0BAB84E9F86E80FA

FASTA26428,196
        10         20         30         40         50         60 
MAEQPLIGKT ILTTRAAGQS SPFAAQLRAA GAAVIEMPTL EIGPPSSWLP LDEAIAAIAD 

        70         80         90        100        110        120 
FDWLILASAN AVEAVQQRLA AQQKSWSDVP CAIAVVGQKT AQVLAAQGGK ADYIPPEFIA 

       130        140        150        160        170        180 
ESLVEHFPQP VAGQRLLFPR VETGGREQIT QALQSQGAIV VEVPAYESRC PSQIPDDALI 

       190        200        210        220        230        240 
ALRQAHLNLI SFTSSKTVRN FCQLMASNLG VDWSARISGV AIASIGPQTS ITCQELLGRV 

       250        260 
EVEAQEYTLD GLLLAIEQWA RQTT 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterisation of genes for tetrapyrrole biosynthesis from the cyanobacterium Anacystis nidulans R2."
Jones M.C., Jenkins J.M., Smith A.G., Howe C.J.
Plant Mol. Biol. 24:435-448(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7942.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X70966 Genomic DNA. Translation: CAA50303.1.
CP000100 Genomic DNA. Translation: ABB56304.1.
RefSeqYP_171951.1. NC_006576.1.
YP_399291.1. NC_007604.1.

3D structure databases

ProteinModelPortalP42452.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING1140.Synpcc7942_0272.

Protocols and materials databases

DNASU3773834.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB56304; ABB56304; Synpcc7942_0272.
GeneID3199499.
3773834.
KEGGsyc:syc1241_c.
syf:Synpcc7942_0272.
PATRIC23785609. VBISynElo51371_0350.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1587.
HOGENOMHOG000247992.
KOK01719.
OrthoDBEOG6BGNXZ.

Enzyme and pathway databases

BioCycSYNEL:SYNPCC7942_0272-MONOMER.
UniPathwayUPA00251; UER00320.

Family and domain databases

InterProIPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view]
PfamPF02602. HEM4. 1 hit.
[Graphical view]
SUPFAMSSF69618. SSF69618. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHEM4_SYNE7
AccessionPrimary (citable) accession number: P42452
Secondary accession number(s): Q31RL5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways