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Protein

Uroporphyrinogen-III synthase

Gene

hemD

Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.By similarity

Catalytic activityi

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathwayi

GO - Molecular functioni

  1. uroporphyrinogen-III synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Porphyrin biosynthesis

Enzyme and pathway databases

BioCyciSYNEL:SYNPCC7942_0272-MONOMER.
UniPathwayiUPA00251; UER00320.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen-III synthase (EC:4.2.1.75)
Short name:
UROS
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene namesi
Name:hemD
Ordered Locus Names:Synpcc7942_0272
OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Taxonomic identifieri1140 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000002717 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Uroporphyrinogen-III synthasePRO_0000135247Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi1140.Synpcc7942_0272.

Structurei

3D structure databases

ProteinModelPortaliP42452.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1587.
HOGENOMiHOG000247992.
KOiK01719.
OrthoDBiEOG6BGNXZ.

Family and domain databases

InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view]
PfamiPF02602. HEM4. 1 hit.
[Graphical view]
SUPFAMiSSF69618. SSF69618. 1 hit.

Sequencei

Sequence statusi: Complete.

P42452-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEQPLIGKT ILTTRAAGQS SPFAAQLRAA GAAVIEMPTL EIGPPSSWLP
60 70 80 90 100
LDEAIAAIAD FDWLILASAN AVEAVQQRLA AQQKSWSDVP CAIAVVGQKT
110 120 130 140 150
AQVLAAQGGK ADYIPPEFIA ESLVEHFPQP VAGQRLLFPR VETGGREQIT
160 170 180 190 200
QALQSQGAIV VEVPAYESRC PSQIPDDALI ALRQAHLNLI SFTSSKTVRN
210 220 230 240 250
FCQLMASNLG VDWSARISGV AIASIGPQTS ITCQELLGRV EVEAQEYTLD
260
GLLLAIEQWA RQTT
Length:264
Mass (Da):28,196
Last modified:October 31, 1995 - v1
Checksum:i0BAB84E9F86E80FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70966 Genomic DNA. Translation: CAA50303.1.
CP000100 Genomic DNA. Translation: ABB56304.1.
RefSeqiYP_171951.1. NC_006576.1.
YP_399291.1. NC_007604.1.

Genome annotation databases

EnsemblBacteriaiABB56304; ABB56304; Synpcc7942_0272.
KEGGisyc:syc1241_c.
syf:Synpcc7942_0272.
PATRICi23785609. VBISynElo51371_0350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70966 Genomic DNA. Translation: CAA50303.1.
CP000100 Genomic DNA. Translation: ABB56304.1.
RefSeqiYP_171951.1. NC_006576.1.
YP_399291.1. NC_007604.1.

3D structure databases

ProteinModelPortaliP42452.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi1140.Synpcc7942_0272.

Protocols and materials databases

DNASUi3773834.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB56304; ABB56304; Synpcc7942_0272.
KEGGisyc:syc1241_c.
syf:Synpcc7942_0272.
PATRICi23785609. VBISynElo51371_0350.

Phylogenomic databases

eggNOGiCOG1587.
HOGENOMiHOG000247992.
KOiK01719.
OrthoDBiEOG6BGNXZ.

Enzyme and pathway databases

UniPathwayiUPA00251; UER00320.
BioCyciSYNEL:SYNPCC7942_0272-MONOMER.

Family and domain databases

InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view]
PfamiPF02602. HEM4. 1 hit.
[Graphical view]
SUPFAMiSSF69618. SSF69618. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterisation of genes for tetrapyrrole biosynthesis from the cyanobacterium Anacystis nidulans R2."
    Jones M.C., Jenkins J.M., Smith A.G., Howe C.J.
    Plant Mol. Biol. 24:435-448(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7942.

Entry informationi

Entry nameiHEM4_SYNE7
AccessioniPrimary (citable) accession number: P42452
Secondary accession number(s): Q31RL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1995
Last sequence update: October 31, 1995
Last modified: March 31, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.