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P42452

- HEM4_SYNE7

UniProt

P42452 - HEM4_SYNE7

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Protein

Uroporphyrinogen-III synthase

Gene
hemD, Synpcc7942_0272
Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III By similarity.

Catalytic activityi

Hydroxymethylbilane = uroporphyrinogen III + H2O.

Pathwayi

GO - Molecular functioni

  1. uroporphyrinogen-III synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Porphyrin biosynthesis

Enzyme and pathway databases

BioCyciSYNEL:SYNPCC7942_0272-MONOMER.
UniPathwayiUPA00251; UER00320.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen-III synthase (EC:4.2.1.75)
Short name:
UROS
Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase
Gene namesi
Name:hemD
Ordered Locus Names:Synpcc7942_0272
OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Taxonomic identifieri1140 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000002717: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Uroporphyrinogen-III synthasePRO_0000135247Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi1140.Synpcc7942_0272.

Structurei

3D structure databases

ProteinModelPortaliP42452.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1587.
HOGENOMiHOG000247992.
KOiK01719.
OrthoDBiEOG6BGNXZ.

Family and domain databases

InterProiIPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view]
PfamiPF02602. HEM4. 1 hit.
[Graphical view]
SUPFAMiSSF69618. SSF69618. 1 hit.

Sequencei

Sequence statusi: Complete.

P42452-1 [UniParc]FASTAAdd to Basket

« Hide

MAEQPLIGKT ILTTRAAGQS SPFAAQLRAA GAAVIEMPTL EIGPPSSWLP    50
LDEAIAAIAD FDWLILASAN AVEAVQQRLA AQQKSWSDVP CAIAVVGQKT 100
AQVLAAQGGK ADYIPPEFIA ESLVEHFPQP VAGQRLLFPR VETGGREQIT 150
QALQSQGAIV VEVPAYESRC PSQIPDDALI ALRQAHLNLI SFTSSKTVRN 200
FCQLMASNLG VDWSARISGV AIASIGPQTS ITCQELLGRV EVEAQEYTLD 250
GLLLAIEQWA RQTT 264
Length:264
Mass (Da):28,196
Last modified:November 1, 1995 - v1
Checksum:i0BAB84E9F86E80FA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70966 Genomic DNA. Translation: CAA50303.1.
CP000100 Genomic DNA. Translation: ABB56304.1.
RefSeqiYP_171951.1. NC_006576.1.
YP_399291.1. NC_007604.1.

Genome annotation databases

EnsemblBacteriaiABB56304; ABB56304; Synpcc7942_0272.
GeneIDi3199499.
3773834.
KEGGisyc:syc1241_c.
syf:Synpcc7942_0272.
PATRICi23785609. VBISynElo51371_0350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70966 Genomic DNA. Translation: CAA50303.1 .
CP000100 Genomic DNA. Translation: ABB56304.1 .
RefSeqi YP_171951.1. NC_006576.1.
YP_399291.1. NC_007604.1.

3D structure databases

ProteinModelPortali P42452.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 1140.Synpcc7942_0272.

Protocols and materials databases

DNASUi 3773834.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB56304 ; ABB56304 ; Synpcc7942_0272 .
GeneIDi 3199499.
3773834.
KEGGi syc:syc1241_c.
syf:Synpcc7942_0272.
PATRICi 23785609. VBISynElo51371_0350.

Phylogenomic databases

eggNOGi COG1587.
HOGENOMi HOG000247992.
KOi K01719.
OrthoDBi EOG6BGNXZ.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00320 .
BioCyci SYNEL:SYNPCC7942_0272-MONOMER.

Family and domain databases

InterProi IPR003754. 4pyrrol_synth_uPrphyn_synth.
[Graphical view ]
Pfami PF02602. HEM4. 1 hit.
[Graphical view ]
SUPFAMi SSF69618. SSF69618. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterisation of genes for tetrapyrrole biosynthesis from the cyanobacterium Anacystis nidulans R2."
    Jones M.C., Jenkins J.M., Smith A.G., Howe C.J.
    Plant Mol. Biol. 24:435-448(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7942.

Entry informationi

Entry nameiHEM4_SYNE7
AccessioniPrimary (citable) accession number: P42452
Secondary accession number(s): Q31RL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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