P42452 (HEM4_SYNE7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uroporphyrinogen-III synthase
Short name=UROS
EC=4.2.1.75

Alternative name(s):
Hydroxymethylbilane hydrolyase [cyclizing]
Uroporphyrinogen-III cosynthase

Gene names

Name:	hemD
Ordered Locus Names:	Synpcc7942_0272

Organism

Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) [Complete proteome] [HAMAP]

Taxonomic identifier

1140 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechococcus › Synechococcus elongatus

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III By similarity.
Catalytic activity	Hydroxymethylbilane = uroporphyrinogen III + H2O.
Pathway	Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
Sequence similarities	Belongs to the uroporphyrinogen-III synthase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	protoporphyrinogen IX biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	uroporphyrinogen-III synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Uroporphyrinogen-III synthase		PRO_0000135247

Sequences

	Sequence		Length	Mass (Da)
	P42452 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 0BAB84E9F86E80FA	FASTA	264	28,196
	10 20 30 40 50 60 MAEQPLIGKT ILTTRAAGQS SPFAAQLRAA GAAVIEMPTL EIGPPSSWLP LDEAIAAIAD 70 80 90 100 110 120 FDWLILASAN AVEAVQQRLA AQQKSWSDVP CAIAVVGQKT AQVLAAQGGK ADYIPPEFIA 130 140 150 160 170 180 ESLVEHFPQP VAGQRLLFPR VETGGREQIT QALQSQGAIV VEVPAYESRC PSQIPDDALI 190 200 210 220 230 240 ALRQAHLNLI SFTSSKTVRN FCQLMASNLG VDWSARISGV AIASIGPQTS ITCQELLGRV 250 260 EVEAQEYTLD GLLLAIEQWA RQTT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterisation of genes for tetrapyrrole biosynthesis from the cyanobacterium Anacystis nidulans R2." Jones M.C., Jenkins J.M., Smith A.G., Howe C.J. Plant Mol. Biol. 24:435-448(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P. Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 7942.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X70966 Genomic DNA. Translation: CAA50303.1. CP000100 Genomic DNA. Translation: ABB56304.1.
RefSeq	YP_171951.1. NC_006576.1. YP_399291.1. NC_007604.1.
3D structure databases
ProteinModelPortal	P42452.
ModBase	Search...
Protein-protein interaction databases
STRING	1140.Synpcc7942_0272.
Protocols and materials databases
DNASU	3773834.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABB56304; ABB56304; Synpcc7942_0272.
GeneID	3199499. 3773834.
KEGG	syc:syc1241_c. syf:Synpcc7942_0272.
PATRIC	23785609. VBISynElo51371_0350.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1587.
HOGENOM	HOG000247992.
KO	K01719.
ProtClustDB	CLSK919085.
Enzyme and pathway databases
BioCyc	SYNEL:SYNPCC7942_0272-MONOMER.
UniPathway	UPA00251; UER00320.
Family and domain databases
InterPro	IPR003754. 4pyrrol_synth_uPrphyn_synth. [Graphical view]
Pfam	PF02602. HEM4. 1 hit. [Graphical view]
SUPFAM	SSF69618. HEM4_synth. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HEM4_SYNE7

Accession

Primary (citable) accession number: P42452
Secondary accession number(s): Q31RL5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 29, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program