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P42451 (SUMT_SYNE7) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uroporphyrinogen-III C-methyltransferase

Short name=Urogen III methylase
EC=2.1.1.107
Alternative name(s):
SUMT
Uroporphyrinogen III methylase
Short name=UROM
Gene names
Name:cobA
Ordered Locus Names:Synpcc7942_0271
OrganismSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) [Complete proteome] [HAMAP]
Taxonomic identifier1140 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus

Protein attributes

Sequence length243 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin.

Catalytic activity

S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.

S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.

Pathway

Cofactor biosynthesis; adenosylcobalamin biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1.

Porphyrin-containing compound metabolism; siroheme biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1.

Sequence similarities

Belongs to the precorrin methyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 243243Uroporphyrinogen-III C-methyltransferase
PRO_0000150374

Sequences

Sequence LengthMass (Da)Tools
P42451 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 9E11AA90724A9870

FASTA24326,463
        10         20         30         40         50         60 
MTGKVYLVGA GPGDPEYLTL QAQQCLQSAE VLIYDALIDP RILDLVPANC DRIAVGKRGG 

        70         80         90        100        110        120 
AESTPQATIN QLLVEHCQQG RKVIRLKSGD PFVFGRAASE LDALERSGCD YAVLPGLSTA 

       130        140        150        160        170        180 
LAAPLLAGIP ITDPVLSRGF AVYTVHEPDA LNWEALAQLE TLILLMGSRH LLTIGHELIR 

       190        200        210        220        230        240 
HGRSPDSPVA LIQWAGHPQQ TVLESSLSRM AQQWGDQPLS PCVIVIGEVV RLRKYWAHYR 


YDG 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterisation of genes for tetrapyrrole biosynthesis from the cyanobacterium Anacystis nidulans R2."
Jones M.C., Jenkins J.M., Smith A.G., Howe C.J.
Plant Mol. Biol. 24:435-448(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7942.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X70966 Genomic DNA. Translation: CAA50302.1.
CP000100 Genomic DNA. Translation: ABB56303.1.
RefSeqYP_171952.1. NC_006576.1.
YP_399290.1. NC_007604.1.

3D structure databases

ProteinModelPortalP42451.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING1140.Synpcc7942_0271.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB56303; ABB56303; Synpcc7942_0271.
GeneID3198695.
3773833.
KEGGsyc:syc1242_c.
syf:Synpcc7942_0271.
PATRIC23785607. VBISynElo51371_0349.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0007.
HOGENOMHOG000290519.
KOK02303.
OrthoDBEOG6BGNXZ.
ProtClustDBCLSK743708.

Enzyme and pathway databases

BioCycSYNEL:SYNPCC7942_0271-MONOMER.
UniPathwayUPA00148; UER00211.
UPA00262; UER00211.

Family and domain databases

Gene3D3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
InterProIPR000878. 4pyrrol_Mease.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR006366. CobA/CysG_C.
IPR003043. Uropor_MeTrfase_CS.
[Graphical view]
PfamPF00590. TP_methylase. 1 hit.
[Graphical view]
SUPFAMSSF53790. SSF53790. 1 hit.
TIGRFAMsTIGR01469. cobA_cysG_Cterm. 1 hit.
PROSITEPS00839. SUMT_1. 1 hit.
PS00840. SUMT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSUMT_SYNE7
AccessionPrimary (citable) accession number: P42451
Secondary accession number(s): Q31RL6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways