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P42451

- SUMT_SYNE7

UniProt

P42451 - SUMT_SYNE7

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Protein

Uroporphyrinogen-III C-methyltransferase

Gene

cobA

Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin.

Catalytic activityi

S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.
S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.

Pathwayi

GO - Molecular functioni

  1. precorrin-2 dehydrogenase activity Source: InterPro
  2. uroporphyrin-III C-methyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. cobalamin biosynthetic process Source: UniProtKB-UniPathway
  2. siroheme biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Cobalamin biosynthesis, Porphyrin biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciSYNEL:SYNPCC7942_0271-MONOMER.
UniPathwayiUPA00148; UER00211.
UPA00262; UER00211.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen-III C-methyltransferase (EC:2.1.1.107)
Short name:
Urogen III methylase
Alternative name(s):
SUMT
Uroporphyrinogen III methylase
Short name:
UROM
Gene namesi
Name:cobA
Ordered Locus Names:Synpcc7942_0271
OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Taxonomic identifieri1140 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000002717: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Uroporphyrinogen-III C-methyltransferasePRO_0000150374Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi1140.Synpcc7942_0271.

Structurei

3D structure databases

ProteinModelPortaliP42451.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the precorrin methyltransferase family.Curated

Phylogenomic databases

eggNOGiCOG0007.
HOGENOMiHOG000290519.
KOiK02303.
OrthoDBiEOG6BGNXZ.

Family and domain databases

Gene3Di3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
InterProiIPR000878. 4pyrrol_Mease.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR006366. CobA/CysG_C.
IPR003043. Uropor_MeTrfase_CS.
[Graphical view]
PfamiPF00590. TP_methylase. 1 hit.
[Graphical view]
SUPFAMiSSF53790. SSF53790. 1 hit.
TIGRFAMsiTIGR01469. cobA_cysG_Cterm. 1 hit.
PROSITEiPS00839. SUMT_1. 1 hit.
PS00840. SUMT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42451-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTGKVYLVGA GPGDPEYLTL QAQQCLQSAE VLIYDALIDP RILDLVPANC
60 70 80 90 100
DRIAVGKRGG AESTPQATIN QLLVEHCQQG RKVIRLKSGD PFVFGRAASE
110 120 130 140 150
LDALERSGCD YAVLPGLSTA LAAPLLAGIP ITDPVLSRGF AVYTVHEPDA
160 170 180 190 200
LNWEALAQLE TLILLMGSRH LLTIGHELIR HGRSPDSPVA LIQWAGHPQQ
210 220 230 240
TVLESSLSRM AQQWGDQPLS PCVIVIGEVV RLRKYWAHYR YDG
Length:243
Mass (Da):26,463
Last modified:November 1, 1995 - v1
Checksum:i9E11AA90724A9870
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70966 Genomic DNA. Translation: CAA50302.1.
CP000100 Genomic DNA. Translation: ABB56303.1.
RefSeqiYP_171952.1. NC_006576.1.
YP_399290.1. NC_007604.1.

Genome annotation databases

EnsemblBacteriaiABB56303; ABB56303; Synpcc7942_0271.
GeneIDi3198695.
3773833.
KEGGisyc:syc1242_c.
syf:Synpcc7942_0271.
PATRICi23785607. VBISynElo51371_0349.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X70966 Genomic DNA. Translation: CAA50302.1 .
CP000100 Genomic DNA. Translation: ABB56303.1 .
RefSeqi YP_171952.1. NC_006576.1.
YP_399290.1. NC_007604.1.

3D structure databases

ProteinModelPortali P42451.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 1140.Synpcc7942_0271.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABB56303 ; ABB56303 ; Synpcc7942_0271 .
GeneIDi 3198695.
3773833.
KEGGi syc:syc1242_c.
syf:Synpcc7942_0271.
PATRICi 23785607. VBISynElo51371_0349.

Phylogenomic databases

eggNOGi COG0007.
HOGENOMi HOG000290519.
KOi K02303.
OrthoDBi EOG6BGNXZ.

Enzyme and pathway databases

UniPathwayi UPA00148 ; UER00211 .
UPA00262 ; UER00211 .
BioCyci SYNEL:SYNPCC7942_0271-MONOMER.

Family and domain databases

Gene3Di 3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
InterProi IPR000878. 4pyrrol_Mease.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR006366. CobA/CysG_C.
IPR003043. Uropor_MeTrfase_CS.
[Graphical view ]
Pfami PF00590. TP_methylase. 1 hit.
[Graphical view ]
SUPFAMi SSF53790. SSF53790. 1 hit.
TIGRFAMsi TIGR01469. cobA_cysG_Cterm. 1 hit.
PROSITEi PS00839. SUMT_1. 1 hit.
PS00840. SUMT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterisation of genes for tetrapyrrole biosynthesis from the cyanobacterium Anacystis nidulans R2."
    Jones M.C., Jenkins J.M., Smith A.G., Howe C.J.
    Plant Mol. Biol. 24:435-448(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7942.

Entry informationi

Entry nameiSUMT_SYNE7
AccessioniPrimary (citable) accession number: P42451
Secondary accession number(s): Q31RL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3