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P42439

- EFTU_CORGL

UniProt

P42439 - EFTU_CORGL

Protein

Elongation factor Tu

Gene

tuf

Organism
Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi19 – 268GTPUniRule annotation
    Nucleotide bindingi83 – 875GTPUniRule annotation
    Nucleotide bindingi138 – 1414GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: UniProtKB-HAMAP
    3. translation elongation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Elongation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongation factor TuUniRule annotation
    Short name:
    EF-TuUniRule annotation
    Gene namesi
    Name:tufUniRule annotation
    Ordered Locus Names:Cgl0497, cg0587
    OrganismiCorynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025)
    Taxonomic identifieri196627 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
    ProteomesiUP000000582: Chromosome, UP000001009: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 396396Elongation factor TuPRO_0000091316Add
    BLAST

    Proteomic databases

    PRIDEiP42439.

    2D gel databases

    World-2DPAGE0001:P42439.

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi196627.cg0587.

    Structurei

    3D structure databases

    ProteinModelPortaliP42439.
    SMRiP42439. Positions 2-395.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 205196tr-type GAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni19 – 268G1By similarity
    Regioni62 – 665G2By similarity
    Regioni83 – 864G3By similarity
    Regioni138 – 1414G4By similarity
    Regioni175 – 1773G5By similarity

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0050.
    HOGENOMiHOG000229290.
    KOiK02358.
    OMAiGDHATFG.
    OrthoDBiEOG6R5C6X.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00118_B. EF_Tu_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004541. Transl_elong_EFTu/EF1A_bac/org.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view]
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SUPFAMiSSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS00301. G_TR_1. 1 hit.
    PS51722. G_TR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P42439-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKAKFERTK PHVNIGTIGH VDHGKTTTTA AITKVLADTY PELNEAFAFD    50
    SIDKAPEEKE RGITINISHV EYQTEKRHYA HVDAPGHADY IKNMITGAAQ 100
    MDGAILVVAA TDGPMPQTRE HVLLARQVGV PYILVALNKC DMVEDEEIIE 150
    LVEMEVRELL AEQDYDEEAP IVHISALKAL EGDEKWGKQI LELMQACDDN 200
    IPDPVRETDK PFLMPIEDIF TITGRGTVVT GRVERGTLNV NDDVDIIGIK 250
    EKSTSTTVTG IEMFRKLLDS AEAGDNCGLL LRGIKREDVE RGQVIVKPGA 300
    YTPHTEFEGS VYVLSKDEGG RHTPFFDNYR PQFYFRTTDV TGVVKLPEGT 350
    EMVMPGDNVD MSVTLIQPVA MDEGLRFAIR EGSRTVGAGR VTKIIK 396
    Length:396
    Mass (Da):43,852
    Last modified:November 1, 1995 - v1
    Checksum:iF46333EC113AB5FD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77034 Genomic DNA. Translation: CAA54323.1.
    BA000036 Genomic DNA. Translation: BAB97890.1.
    BX927149 Genomic DNA. Translation: CAF19210.1.
    RefSeqiNP_599741.1. NC_003450.3.
    WP_011013696.1. NC_006958.1.
    YP_224796.1. NC_006958.1.

    Genome annotation databases

    EnsemblBacteriaiBAB97890; BAB97890; BAB97890.
    CAF19210; CAF19210; cg0587.
    GeneIDi1021503.
    KEGGicgb:cg0587.
    cgl:NCgl0480.
    PATRICi21493060. VBICorGlu203724_0496.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77034 Genomic DNA. Translation: CAA54323.1 .
    BA000036 Genomic DNA. Translation: BAB97890.1 .
    BX927149 Genomic DNA. Translation: CAF19210.1 .
    RefSeqi NP_599741.1. NC_003450.3.
    WP_011013696.1. NC_006958.1.
    YP_224796.1. NC_006958.1.

    3D structure databases

    ProteinModelPortali P42439.
    SMRi P42439. Positions 2-395.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 196627.cg0587.

    2D gel databases

    World-2DPAGE 0001:P42439.

    Proteomic databases

    PRIDEi P42439.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAB97890 ; BAB97890 ; BAB97890 .
    CAF19210 ; CAF19210 ; cg0587 .
    GeneIDi 1021503.
    KEGGi cgb:cg0587.
    cgl:NCgl0480.
    PATRICi 21493060. VBICorGlu203724_0496.

    Phylogenomic databases

    eggNOGi COG0050.
    HOGENOMi HOG000229290.
    KOi K02358.
    OMAi GDHATFG.
    OrthoDBi EOG6R5C6X.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00118_B. EF_Tu_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004541. Transl_elong_EFTu/EF1A_bac/org.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view ]
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SUPFAMi SSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00485. EF-Tu. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS00301. G_TR_1. 1 hit.
    PS51722. G_TR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Phylogenetic relationships of Bacteria based on comparative sequence analysis of elongation factor Tu and ATP-synthase beta-subunit genes."
      Ludwig W., Neumaier J., Klugbauer N., Brockmann E., Roller C., Klugbauer S., Reetz K., Schachtner I., Ludvigsen A., Bachleitner M., Fischer U., Schleifer K.H.
      Antonie Van Leeuwenhoek 64:285-305(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 13059 / LMG 3658 / NCIB 10332 / AS019 / 613.
    2. "The Corynebacterium glutamicum genome: features and impacts on biotechnological processes."
      Ikeda M., Nakagawa S.
      Appl. Microbiol. Biotechnol. 62:99-109(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025.

    Entry informationi

    Entry nameiEFTU_CORGL
    AccessioniPrimary (citable) accession number: P42439
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3