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P42437

- NASF_BACSU

UniProt

P42437 - NASF_BACSU

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Protein

Uroporphyrinogen-III C-methyltransferase

Gene

nasF

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.
S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.

GO - Molecular functioni

  1. precorrin-2 dehydrogenase activity Source: InterPro
  2. uroporphyrin-III C-methyltransferase activity Source: UniProtKB-EC
  3. uroporphyrinogen-III synthase activity Source: InterPro

GO - Biological processi

  1. porphyrin-containing compound biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciBSUB:BSU03280-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uroporphyrinogen-III C-methyltransferase (EC:2.1.1.107)
Short name:
Urogen III methylase
Alternative name(s):
SUMT
Uroporphyrinogen III methylase
Short name:
UROM
Gene namesi
Name:nasF
Synonyms:nasBE
Ordered Locus Names:BSU03280
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU03280. [Micado]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483Uroporphyrinogen-III C-methyltransferasePRO_0000150384Add
BLAST

Proteomic databases

PaxDbiP42437.

Expressioni

Inductioni

Positively regulated by TnrA under nitrogen-limited conditions.2 Publications

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU03280.

Structurei

3D structure databases

ProteinModelPortaliP42437.
SMRiP42437. Positions 1-250.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the precorrin methyltransferase family.Curated

Phylogenomic databases

eggNOGiCOG1587.
HOGENOMiHOG000290968.
InParanoidiP42437.
KOiK13542.
OMAiWKERKPL.
OrthoDBiEOG6BGNXZ.
PhylomeDBiP42437.

Family and domain databases

Gene3Di3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
InterProiIPR000878. 4pyrrol_Mease.
IPR003754. 4pyrrol_synth_uPrphyn_synth.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR006366. CobA/CysG_C.
IPR003043. Uropor_MeTrfase_CS.
[Graphical view]
PfamiPF02602. HEM4. 1 hit.
PF00590. TP_methylase. 1 hit.
[Graphical view]
SUPFAMiSSF53790. SSF53790. 1 hit.
SSF69618. SSF69618. 1 hit.
TIGRFAMsiTIGR01469. cobA_cysG_Cterm. 1 hit.
PROSITEiPS00839. SUMT_1. 1 hit.
PS00840. SUMT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42437-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIMKNGIVYF VGAGPGDPGL LTIKGKQALK EADVILYDRL ANPKLLEFAS
60 70 80 90 100
PDCQFIYCGK LPNRHFMKQK EINALLVEKA LNGLTVVRLK GGDPSVFGRV
110 120 130 140 150
GEEADALHEH GIRYEMVPGI TSGIAAPLYA GIPVTHRDFA SSFAMITAHD
160 170 180 190 200
KSLKGTPNLD WEGLARSVQT LVFYMGVKNL SYICQQLISY GKSPSVPVIV
210 220 230 240 250
IQWGTWGRQR SVKGTLENIQ QKVQEHQITN PAIIVIGDIV NFQTHSWFES
260 270 280 290 300
KPLIGRHLMV VTHGEDEDPL ADKLRDSGAD LIEWPKWRTE NMPVNEEILR
310 320 330 340 350
KIGTFEDVFF TSRRAVCEFF RALASQKIDI RQLTAKLSAA SEQAKTELEK
360 370 380 390 400
RGFLVTAIQP DSEKRLVVGS RHAVENMQKH ESCSFYITHE NVIDDRFTHM
410 420 430 440 450
IQRTISESPL HMVICPNKLS VQQLINGGEQ IGILPEPSAS RPPIVCIGDD
460 470 480
SAAGIYGFTA VQEQDELLAF IHNQHAEKKL LHT
Length:483
Mass (Da):53,869
Last modified:November 1, 1995 - v1
Checksum:i49752620FA96B74C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30689 Genomic DNA. Translation: BAA06356.1.
D50453 Genomic DNA. Translation: BAA08962.1.
AL009126 Genomic DNA. Translation: CAB12122.1.
PIRiI40031.
RefSeqiNP_388210.1. NC_000964.3.
WP_003234641.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB12122; CAB12122; BSU03280.
GeneIDi938324.
KEGGibsu:BSU03280.
PATRICi18972215. VBIBacSub10457_0336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D30689 Genomic DNA. Translation: BAA06356.1 .
D50453 Genomic DNA. Translation: BAA08962.1 .
AL009126 Genomic DNA. Translation: CAB12122.1 .
PIRi I40031.
RefSeqi NP_388210.1. NC_000964.3.
WP_003234641.1. NC_000964.3.

3D structure databases

ProteinModelPortali P42437.
SMRi P42437. Positions 1-250.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU03280.

Proteomic databases

PaxDbi P42437.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB12122 ; CAB12122 ; BSU03280 .
GeneIDi 938324.
KEGGi bsu:BSU03280.
PATRICi 18972215. VBIBacSub10457_0336.

Organism-specific databases

GenoListi BSU03280. [Micado ]

Phylogenomic databases

eggNOGi COG1587.
HOGENOMi HOG000290968.
InParanoidi P42437.
KOi K13542.
OMAi WKERKPL.
OrthoDBi EOG6BGNXZ.
PhylomeDBi P42437.

Enzyme and pathway databases

BioCyci BSUB:BSU03280-MONOMER.

Family and domain databases

Gene3Di 3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
InterProi IPR000878. 4pyrrol_Mease.
IPR003754. 4pyrrol_synth_uPrphyn_synth.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR006366. CobA/CysG_C.
IPR003043. Uropor_MeTrfase_CS.
[Graphical view ]
Pfami PF02602. HEM4. 1 hit.
PF00590. TP_methylase. 1 hit.
[Graphical view ]
SUPFAMi SSF53790. SSF53790. 1 hit.
SSF69618. SSF69618. 1 hit.
TIGRFAMsi TIGR01469. cobA_cysG_Cterm. 1 hit.
PROSITEi PS00839. SUMT_1. 1 hit.
PS00840. SUMT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nasB operon and nasA gene are required for nitrate/nitrite assimilation in Bacillus subtilis."
    Ogawa K., Akagawa E., Yamane K., Sun Z.-W., Lacelle M., Zuber P., Nakano M.M.
    J. Bacteriol. 177:1409-1413(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  2. "The 25 degrees-36 degrees region of the Bacillus subtilis chromosome: determination of the sequence of a 146 kb segment and identification of 113 genes."
    Yamane K., Kumano M., Kurita K.
    Microbiology 142:3047-3056(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  3. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  4. "Purification and in vitro activities of the Bacillus subtilis TnrA transcription factor."
    Wray L.V. Jr., Zalieckas J.M., Fisher S.H.
    J. Mol. Biol. 300:29-40(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY TNRA.
    Strain: 168.
  5. "Identification of additional TnrA-regulated genes of Bacillus subtilis associated with a TnrA box."
    Yoshida K., Yamaguchi H., Kinehara M., Ohki Y.-H., Nakaura Y., Fujita Y.
    Mol. Microbiol. 49:157-165(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION BY TNRA.

Entry informationi

Entry nameiNASF_BACSU
AccessioniPrimary (citable) accession number: P42437
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3