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P42437 (NASF_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uroporphyrinogen-III C-methyltransferase

Short name=Urogen III methylase
EC=2.1.1.107
Alternative name(s):
SUMT
Uroporphyrinogen III methylase
Short name=UROM
Gene names
Name:nasF
Synonyms:nasBE
Ordered Locus Names:BSU03280
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length483 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.

S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.

Induction

Positively regulated by TnrA under nitrogen-limited conditions. Ref.4 Ref.5

Sequence similarities

Belongs to the precorrin methyltransferase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 483483Uroporphyrinogen-III C-methyltransferase
PRO_0000150384

Sequences

Sequence LengthMass (Da)Tools
P42437 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 49752620FA96B74C

FASTA48353,869
        10         20         30         40         50         60 
MIMKNGIVYF VGAGPGDPGL LTIKGKQALK EADVILYDRL ANPKLLEFAS PDCQFIYCGK 

        70         80         90        100        110        120 
LPNRHFMKQK EINALLVEKA LNGLTVVRLK GGDPSVFGRV GEEADALHEH GIRYEMVPGI 

       130        140        150        160        170        180 
TSGIAAPLYA GIPVTHRDFA SSFAMITAHD KSLKGTPNLD WEGLARSVQT LVFYMGVKNL 

       190        200        210        220        230        240 
SYICQQLISY GKSPSVPVIV IQWGTWGRQR SVKGTLENIQ QKVQEHQITN PAIIVIGDIV 

       250        260        270        280        290        300 
NFQTHSWFES KPLIGRHLMV VTHGEDEDPL ADKLRDSGAD LIEWPKWRTE NMPVNEEILR 

       310        320        330        340        350        360 
KIGTFEDVFF TSRRAVCEFF RALASQKIDI RQLTAKLSAA SEQAKTELEK RGFLVTAIQP 

       370        380        390        400        410        420 
DSEKRLVVGS RHAVENMQKH ESCSFYITHE NVIDDRFTHM IQRTISESPL HMVICPNKLS 

       430        440        450        460        470        480 
VQQLINGGEQ IGILPEPSAS RPPIVCIGDD SAAGIYGFTA VQEQDELLAF IHNQHAEKKL 


LHT 

« Hide

References

« Hide 'large scale' references
[1]"The nasB operon and nasA gene are required for nitrate/nitrite assimilation in Bacillus subtilis."
Ogawa K., Akagawa E., Yamane K., Sun Z.-W., Lacelle M., Zuber P., Nakano M.M.
J. Bacteriol. 177:1409-1413(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[2]"The 25 degrees-36 degrees region of the Bacillus subtilis chromosome: determination of the sequence of a 146 kb segment and identification of 113 genes."
Yamane K., Kumano M., Kurita K.
Microbiology 142:3047-3056(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[3]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[4]"Purification and in vitro activities of the Bacillus subtilis TnrA transcription factor."
Wray L.V. Jr., Zalieckas J.M., Fisher S.H.
J. Mol. Biol. 300:29-40(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION BY TNRA.
Strain: 168.
[5]"Identification of additional TnrA-regulated genes of Bacillus subtilis associated with a TnrA box."
Yoshida K., Yamaguchi H., Kinehara M., Ohki Y.-H., Nakaura Y., Fujita Y.
Mol. Microbiol. 49:157-165(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION BY TNRA.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D30689 Genomic DNA. Translation: BAA06356.1.
D50453 Genomic DNA. Translation: BAA08962.1.
AL009126 Genomic DNA. Translation: CAB12122.1.
PIRI40031.
RefSeqNP_388210.1. NC_000964.3.

3D structure databases

ProteinModelPortalP42437.
SMRP42437. Positions 1-250.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING224308.BSU03280.

Proteomic databases

PaxDbP42437.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB12122; CAB12122; BSU03280.
GeneID938324.
KEGGbsu:BSU03280.
PATRIC18972215. VBIBacSub10457_0336.

Organism-specific databases

GenoListBSU03280. [Micado]

Phylogenomic databases

eggNOGCOG1587.
HOGENOMHOG000290968.
KOK13542.
OMAWKERKPL.
OrthoDBEOG6BGNXZ.
PhylomeDBP42437.

Enzyme and pathway databases

BioCycBSUB:BSU03280-MONOMER.

Family and domain databases

Gene3D3.30.950.10. 1 hit.
3.40.1010.10. 1 hit.
InterProIPR000878. 4pyrrol_Mease.
IPR003754. 4pyrrol_synth_uPrphyn_synth.
IPR014777. 4pyrrole_Mease_sub1.
IPR014776. 4pyrrole_Mease_sub2.
IPR006366. CobA/CysG_C.
IPR003043. Uropor_MeTrfase_CS.
[Graphical view]
PfamPF02602. HEM4. 1 hit.
PF00590. TP_methylase. 1 hit.
[Graphical view]
SUPFAMSSF53790. SSF53790. 1 hit.
SSF69618. SSF69618. 1 hit.
TIGRFAMsTIGR01469. cobA_cysG_Cterm. 1 hit.
PROSITEPS00839. SUMT_1. 1 hit.
PS00840. SUMT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNASF_BACSU
AccessionPrimary (citable) accession number: P42437
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList