Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P42437

- NASF_BACSU

UniProt

P42437 - NASF_BACSU

Protein

Uroporphyrinogen-III C-methyltransferase

Gene

nasF

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1.
    S-adenosyl-L-methionine + precorrin-1 = S-adenosyl-L-homocysteine + precorrin-2.

    GO - Molecular functioni

    1. precorrin-2 dehydrogenase activity Source: InterPro
    2. uroporphyrin-III C-methyltransferase activity Source: UniProtKB-EC
    3. uroporphyrinogen-III synthase activity Source: InterPro

    GO - Biological processi

    1. porphyrin-containing compound biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Porphyrin biosynthesis

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciBSUB:BSU03280-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uroporphyrinogen-III C-methyltransferase (EC:2.1.1.107)
    Short name:
    Urogen III methylase
    Alternative name(s):
    SUMT
    Uroporphyrinogen III methylase
    Short name:
    UROM
    Gene namesi
    Name:nasF
    Synonyms:nasBE
    Ordered Locus Names:BSU03280
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU03280. [Micado]

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 483483Uroporphyrinogen-III C-methyltransferasePRO_0000150384Add
    BLAST

    Proteomic databases

    PaxDbiP42437.

    Expressioni

    Inductioni

    Positively regulated by TnrA under nitrogen-limited conditions.2 Publications

    Interactioni

    Protein-protein interaction databases

    STRINGi224308.BSU03280.

    Structurei

    3D structure databases

    ProteinModelPortaliP42437.
    SMRiP42437. Positions 1-250.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the precorrin methyltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG1587.
    HOGENOMiHOG000290968.
    KOiK13542.
    OMAiWKERKPL.
    OrthoDBiEOG6BGNXZ.
    PhylomeDBiP42437.

    Family and domain databases

    Gene3Di3.30.950.10. 1 hit.
    3.40.1010.10. 1 hit.
    InterProiIPR000878. 4pyrrol_Mease.
    IPR003754. 4pyrrol_synth_uPrphyn_synth.
    IPR014777. 4pyrrole_Mease_sub1.
    IPR014776. 4pyrrole_Mease_sub2.
    IPR006366. CobA/CysG_C.
    IPR003043. Uropor_MeTrfase_CS.
    [Graphical view]
    PfamiPF02602. HEM4. 1 hit.
    PF00590. TP_methylase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53790. SSF53790. 1 hit.
    SSF69618. SSF69618. 1 hit.
    TIGRFAMsiTIGR01469. cobA_cysG_Cterm. 1 hit.
    PROSITEiPS00839. SUMT_1. 1 hit.
    PS00840. SUMT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P42437-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIMKNGIVYF VGAGPGDPGL LTIKGKQALK EADVILYDRL ANPKLLEFAS    50
    PDCQFIYCGK LPNRHFMKQK EINALLVEKA LNGLTVVRLK GGDPSVFGRV 100
    GEEADALHEH GIRYEMVPGI TSGIAAPLYA GIPVTHRDFA SSFAMITAHD 150
    KSLKGTPNLD WEGLARSVQT LVFYMGVKNL SYICQQLISY GKSPSVPVIV 200
    IQWGTWGRQR SVKGTLENIQ QKVQEHQITN PAIIVIGDIV NFQTHSWFES 250
    KPLIGRHLMV VTHGEDEDPL ADKLRDSGAD LIEWPKWRTE NMPVNEEILR 300
    KIGTFEDVFF TSRRAVCEFF RALASQKIDI RQLTAKLSAA SEQAKTELEK 350
    RGFLVTAIQP DSEKRLVVGS RHAVENMQKH ESCSFYITHE NVIDDRFTHM 400
    IQRTISESPL HMVICPNKLS VQQLINGGEQ IGILPEPSAS RPPIVCIGDD 450
    SAAGIYGFTA VQEQDELLAF IHNQHAEKKL LHT 483
    Length:483
    Mass (Da):53,869
    Last modified:November 1, 1995 - v1
    Checksum:i49752620FA96B74C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D30689 Genomic DNA. Translation: BAA06356.1.
    D50453 Genomic DNA. Translation: BAA08962.1.
    AL009126 Genomic DNA. Translation: CAB12122.1.
    PIRiI40031.
    RefSeqiNP_388210.1. NC_000964.3.
    WP_003234641.1. NC_000964.3.

    Genome annotation databases

    EnsemblBacteriaiCAB12122; CAB12122; BSU03280.
    GeneIDi938324.
    KEGGibsu:BSU03280.
    PATRICi18972215. VBIBacSub10457_0336.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D30689 Genomic DNA. Translation: BAA06356.1 .
    D50453 Genomic DNA. Translation: BAA08962.1 .
    AL009126 Genomic DNA. Translation: CAB12122.1 .
    PIRi I40031.
    RefSeqi NP_388210.1. NC_000964.3.
    WP_003234641.1. NC_000964.3.

    3D structure databases

    ProteinModelPortali P42437.
    SMRi P42437. Positions 1-250.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 224308.BSU03280.

    Proteomic databases

    PaxDbi P42437.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB12122 ; CAB12122 ; BSU03280 .
    GeneIDi 938324.
    KEGGi bsu:BSU03280.
    PATRICi 18972215. VBIBacSub10457_0336.

    Organism-specific databases

    GenoListi BSU03280. [Micado ]

    Phylogenomic databases

    eggNOGi COG1587.
    HOGENOMi HOG000290968.
    KOi K13542.
    OMAi WKERKPL.
    OrthoDBi EOG6BGNXZ.
    PhylomeDBi P42437.

    Enzyme and pathway databases

    BioCyci BSUB:BSU03280-MONOMER.

    Family and domain databases

    Gene3Di 3.30.950.10. 1 hit.
    3.40.1010.10. 1 hit.
    InterProi IPR000878. 4pyrrol_Mease.
    IPR003754. 4pyrrol_synth_uPrphyn_synth.
    IPR014777. 4pyrrole_Mease_sub1.
    IPR014776. 4pyrrole_Mease_sub2.
    IPR006366. CobA/CysG_C.
    IPR003043. Uropor_MeTrfase_CS.
    [Graphical view ]
    Pfami PF02602. HEM4. 1 hit.
    PF00590. TP_methylase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53790. SSF53790. 1 hit.
    SSF69618. SSF69618. 1 hit.
    TIGRFAMsi TIGR01469. cobA_cysG_Cterm. 1 hit.
    PROSITEi PS00839. SUMT_1. 1 hit.
    PS00840. SUMT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nasB operon and nasA gene are required for nitrate/nitrite assimilation in Bacillus subtilis."
      Ogawa K., Akagawa E., Yamane K., Sun Z.-W., Lacelle M., Zuber P., Nakano M.M.
      J. Bacteriol. 177:1409-1413(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168.
    2. "The 25 degrees-36 degrees region of the Bacillus subtilis chromosome: determination of the sequence of a 146 kb segment and identification of 113 genes."
      Yamane K., Kumano M., Kurita K.
      Microbiology 142:3047-3056(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168.
    3. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.
    4. "Purification and in vitro activities of the Bacillus subtilis TnrA transcription factor."
      Wray L.V. Jr., Zalieckas J.M., Fisher S.H.
      J. Mol. Biol. 300:29-40(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY TNRA.
      Strain: 168.
    5. "Identification of additional TnrA-regulated genes of Bacillus subtilis associated with a TnrA box."
      Yoshida K., Yamaguchi H., Kinehara M., Ohki Y.-H., Nakaura Y., Fujita Y.
      Mol. Microbiol. 49:157-165(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION BY TNRA.

    Entry informationi

    Entry nameiNASF_BACSU
    AccessioniPrimary (citable) accession number: P42437
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3