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Protein

Chloromuconate cycloisomerase

Gene

tfdDII

Organism
Cupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

(2R)-2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate.

Cofactori

Mn2+By similarity

Pathwayi: 3-chlorocatechol degradation

This protein is involved in the pathway 3-chlorocatechol degradation, which is part of Aromatic compound metabolism.
View all proteins of this organism that are known to be involved in the pathway 3-chlorocatechol degradation and in Aromatic compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei158Proton acceptorBy similarity1
Metal bindingi187ManganeseBy similarity1
Metal bindingi213ManganeseBy similarity1
Metal bindingi238ManganeseBy similarity1
Active sitei316Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processAromatic hydrocarbons catabolism
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14413
UniPathwayiUPA00083

Names & Taxonomyi

Protein namesi
Recommended name:
Chloromuconate cycloisomerase (EC:5.5.1.7)
Alternative name(s):
Muconate cycloisomerase II
Gene namesi
Name:tfdDII
Synonyms:tfdD2
Ordered Locus Names:Reut_D6474
Encoded oniPlasmid pJP42 Publications
Plasmid pPJ41 Publication
OrganismiCupriavidus necator (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Taxonomic identifieri264198 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
Proteomesi
  • UP000002697 Componenti: Plasmid pPJ4

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001712571 – 372Chloromuconate cycloisomeraseAdd BLAST372

Proteomic databases

PRIDEiP42428

Structurei

3D structure databases

ProteinModelPortaliP42428
SMRiP42428
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000185904
KOiK01860
OMAiIGTAANM
OrthoDBiPOG091H04PO

Family and domain databases

CDDicd03318 MLE, 1 hit
Gene3Di3.20.20.120, 1 hit
3.30.390.10, 2 hits
InterProiView protein in InterPro
IPR013370 Chloromuconate_cycloisomerase
IPR036849 Enolase-like_C_sf
IPR029017 Enolase-like_N
IPR034390 Enolase-like_superfamily
IPR029065 Enolase_C-like
IPR018110 Mandel_Rmase/mucon_lact_enz_CS
IPR013342 Mandelate_racemase_C
IPR013341 Mandelate_racemase_N_dom
PfamiView protein in Pfam
PF13378 MR_MLE_C, 1 hit
PF02746 MR_MLE_N, 1 hit
SFLDiSFLDG01258 (chloro)muconate_cycloisomeras, 1 hit
SFLDS00001 Enolase, 1 hit
SMARTiView protein in SMART
SM00922 MR_MLE, 1 hit
SUPFAMiSSF51604 SSF51604, 1 hit
TIGRFAMsiTIGR02534 mucon_cyclo, 1 hit
PROSITEiView protein in PROSITE
PS00908 MR_MLE_1, 1 hit

Sequencei

Sequence statusi: Complete.

P42428-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVDLPLRRI QQFARLGAKH QSSVLIRLHT KGGIVGIGES ITPCGPWWSG
60 70 80 90 100
DSVEAIQATI NHYLAPLVVG EPALDASRIM AKLHGRVAGN AFAKAGIEMA
110 120 130 140 150
LLDAVGKIVD APIHVLLGGR FRDRLSVAWP LATGDVNQEV DEAFRMLEAG
160 170 180 190 200
KAGAFKLKMG ALPLAQDLRR ALAIAKELEG KASLRVDPNE AWDEPTTMRA
210 220 230 240 250
LAPLEAAGVE IIEQPVARWN LDAMARIHRQ ARSMLLIDEG VQSLHDASEV
260 270 280 290 300
VKRAAAGLVS LKIMKTGGMR PARAMADIAN AGGMHVYMGT FLETSIGTAA
310 320 330 340 350
NMQLAASIES LPYGGEVIGP LLIEEDLCEV PAVYKEHALW LPEGPGLGIR
360 370
LDENQVRRFA RASSQRIDRH SA
Length:372
Mass (Da):40,045
Last modified:February 1, 2005 - v2
Checksum:i7D170C1364D04140
GO

Sequence cautioni

The sequence AAA65064 differs from that shown. Reason: Frameshift at positions 82 and 132.Curated
The sequence AAZ65772 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65A → G in AAA65064 (PubMed:8157603).Curated1
Sequence conflicti93A → D (PubMed:8157603).Curated1
Sequence conflicti178 – 201LEGKA…TMRAL → TRGQDEPAPSIPTKRGTSRP RCGT in AAA65064 (PubMed:8157603).CuratedAdd BLAST24
Sequence conflicti208 – 211GVEI → AWKF in AAA65064 (PubMed:8157603).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY365053 Genomic DNA Translation: AAR31047.1
CP000093 Genomic DNA Translation: AAZ65772.1 Different initiation.
M98445 Genomic DNA Translation: AAA65064.1 Frameshift.

Genome annotation databases

EnsemblBacteriaiAAZ65772; AAZ65772; Reut_D6474
KEGGireu:Reut_D6474

Similar proteinsi

Entry informationi

Entry nameiTFDD2_CUPNJ
AccessioniPrimary (citable) accession number: P42428
Secondary accession number(s): Q46M58, Q6UP90
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: February 1, 2005
Last modified: May 23, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

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