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P42428

- TFDD2_CUPPJ

UniProt

P42428 - TFDD2_CUPPJ

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Protein
Chloromuconate cycloisomerase
Gene
tfdDII, tfdD2, Reut_D6474
Organism
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate.

Cofactori

Manganese By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei158 – 1581Proton acceptor By similarity
Metal bindingi187 – 1871Manganese By similarity
Metal bindingi213 – 2131Manganese By similarity
Metal bindingi238 – 2381Manganese By similarity
Active sitei316 – 3161Proton donor By similarity

GO - Molecular functioni

  1. chloromuconate cycloisomerase activity Source: UniProtKB-EC
  2. manganese ion binding Source: InterPro
  3. muconate cycloisomerase activity Source: InterPro

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-KW
  2. cellular amino acid catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciCPIN264198:GIW3-6560-MONOMER.
MetaCyc:MONOMER-14413.
UniPathwayiUPA00083.

Names & Taxonomyi

Protein namesi
Recommended name:
Chloromuconate cycloisomerase (EC:5.5.1.7)
Alternative name(s):
Muconate cycloisomerase II
Gene namesi
Name:tfdDII
Synonyms:tfdD2
Ordered Locus Names:Reut_D6474
Encoded oniPlasmid pJP42 Publications
Plasmid pReut11 Publication
OrganismiCupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Taxonomic identifieri264198 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
ProteomesiUP000002697: Plasmid pReut1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Chloromuconate cycloisomerase
PRO_0000171257Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi264198.Reut_D6474.

Structurei

3D structure databases

ProteinModelPortaliP42428.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4948.
HOGENOMiHOG000185904.
KOiK01860.
OMAiTIVRIDS.
OrthoDBiEOG6QG8F7.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
InterProiIPR013370. Chloromuconate_cycloisomerase.
IPR029065. Enolase_C-like.
IPR029017. Enolase_N_like.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N.
IPR001354. MR_MLE.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 1 hit.
PfamiPF01188. MR_MLE. 1 hit.
PF02746. MR_MLE_N. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
TIGRFAMsiTIGR02534. mucon_cyclo. 1 hit.
PROSITEiPS00908. MR_MLE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42428-1 [UniParc]FASTAAdd to Basket

« Hide

MIVDLPLRRI QQFARLGAKH QSSVLIRLHT KGGIVGIGES ITPCGPWWSG    50
DSVEAIQATI NHYLAPLVVG EPALDASRIM AKLHGRVAGN AFAKAGIEMA 100
LLDAVGKIVD APIHVLLGGR FRDRLSVAWP LATGDVNQEV DEAFRMLEAG 150
KAGAFKLKMG ALPLAQDLRR ALAIAKELEG KASLRVDPNE AWDEPTTMRA 200
LAPLEAAGVE IIEQPVARWN LDAMARIHRQ ARSMLLIDEG VQSLHDASEV 250
VKRAAAGLVS LKIMKTGGMR PARAMADIAN AGGMHVYMGT FLETSIGTAA 300
NMQLAASIES LPYGGEVIGP LLIEEDLCEV PAVYKEHALW LPEGPGLGIR 350
LDENQVRRFA RASSQRIDRH SA 372
Length:372
Mass (Da):40,045
Last modified:February 1, 2005 - v2
Checksum:i7D170C1364D04140
GO

Sequence cautioni

The sequence AAA65064.1 differs from that shown. Reason: Frameshift at positions 82 and 132.
The sequence AAZ65772.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 651A → G in AAA65064. 1 Publication
Sequence conflicti93 – 931A → D1 Publication
Sequence conflicti178 – 20124LEGKA…TMRAL → TRGQDEPAPSIPTKRGTSRP RCGT in AAA65064. 1 Publication
Add
BLAST
Sequence conflicti208 – 2114GVEI → AWKF in AAA65064. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY365053 Genomic DNA. Translation: AAR31047.1.
CP000093 Genomic DNA. Translation: AAZ65772.1. Different initiation.
M98445 Genomic DNA. Translation: AAA65064.1. Frameshift.
RefSeqiYP_293629.1. NC_007337.1.

Genome annotation databases

EnsemblBacteriaiAAZ65772; AAZ65772; Reut_D6474.
GeneIDi3607898.
KEGGireu:Reut_D6474.
PATRICi20225328. VBIRalEut24049_0543.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY365053 Genomic DNA. Translation: AAR31047.1 .
CP000093 Genomic DNA. Translation: AAZ65772.1 . Different initiation.
M98445 Genomic DNA. Translation: AAA65064.1 . Frameshift.
RefSeqi YP_293629.1. NC_007337.1.

3D structure databases

ProteinModelPortali P42428.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 264198.Reut_D6474.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAZ65772 ; AAZ65772 ; Reut_D6474 .
GeneIDi 3607898.
KEGGi reu:Reut_D6474.
PATRICi 20225328. VBIRalEut24049_0543.

Phylogenomic databases

eggNOGi COG4948.
HOGENOMi HOG000185904.
KOi K01860.
OMAi TIVRIDS.
OrthoDBi EOG6QG8F7.

Enzyme and pathway databases

UniPathwayi UPA00083 .
BioCyci CPIN264198:GIW3-6560-MONOMER.
MetaCyc:MONOMER-14413.

Family and domain databases

Gene3Di 3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
InterProi IPR013370. Chloromuconate_cycloisomerase.
IPR029065. Enolase_C-like.
IPR029017. Enolase_N_like.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N.
IPR001354. MR_MLE.
[Graphical view ]
PANTHERi PTHR13794. PTHR13794. 1 hit.
Pfami PF01188. MR_MLE. 1 hit.
PF02746. MR_MLE_N. 1 hit.
[Graphical view ]
SMARTi SM00922. MR_MLE. 1 hit.
[Graphical view ]
SUPFAMi SSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
TIGRFAMsi TIGR02534. mucon_cyclo. 1 hit.
PROSITEi PS00908. MR_MLE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic organization of the catabolic plasmid pJP4 from Ralstonia eutropha JMP134 (pJP4) reveals mechanisms of adaptation to chloroaromatic pollutants and evolution of specialized chloroaromatic degradation pathways."
    Trefault N., De la Iglesia R., Molina A.M., Manzano M., Ledger T., Perez-Pantoja D., Sanchez M.A., Stuardo M., Gonzalez B.
    Environ. Microbiol. 6:655-668(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Plasmid: pJP4
  2. "Complete sequence of plasmid 1 of Ralstonia eutropha JMP134."
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JMP134 / LMG 1197.
    Plasmid: pReut1
  3. "Analysis of duplicated gene sequences associated with tfdR and tfdS in Alcaligenes eutrophus JMP134."
    Matrubutham U., Harker A.R.
    J. Bacteriol. 176:2348-2353(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-234.
    Plasmid: pJP4

Entry informationi

Entry nameiTFDD2_CUPPJ
AccessioniPrimary (citable) accession number: P42428
Secondary accession number(s): Q46M58, Q6UP90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: February 1, 2005
Last modified: June 11, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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