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P42428

- TFDD2_CUPPJ

UniProt

P42428 - TFDD2_CUPPJ

Protein

Chloromuconate cycloisomerase

Gene

tfdDII

Organism
Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (01 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate.

    Cofactori

    Manganese.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei158 – 1581Proton acceptorBy similarity
    Metal bindingi187 – 1871ManganeseBy similarity
    Metal bindingi213 – 2131ManganeseBy similarity
    Metal bindingi238 – 2381ManganeseBy similarity
    Active sitei316 – 3161Proton donorBy similarity

    GO - Molecular functioni

    1. chloromuconate cycloisomerase activity Source: UniProtKB-EC
    2. manganese ion binding Source: InterPro
    3. muconate cycloisomerase activity Source: InterPro

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-KW
    2. cellular amino acid catabolic process Source: InterPro

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciCPIN264198:GIW3-6560-MONOMER.
    MetaCyc:MONOMER-14413.
    UniPathwayiUPA00083.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Chloromuconate cycloisomerase (EC:5.5.1.7)
    Alternative name(s):
    Muconate cycloisomerase II
    Gene namesi
    Name:tfdDII
    Synonyms:tfdD2
    Ordered Locus Names:Reut_D6474
    Encoded oniPlasmid pJP42 Publications
    Plasmid pReut11 Publication
    OrganismiCupriavidus pinatubonensis (strain JMP 134 / LMG 1197) (Ralstonia eutropha (strain JMP 134))
    Taxonomic identifieri264198 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeCupriavidus
    ProteomesiUP000002697: Plasmid pReut1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 372372Chloromuconate cycloisomerasePRO_0000171257Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi264198.Reut_D6474.

    Structurei

    3D structure databases

    ProteinModelPortaliP42428.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG4948.
    HOGENOMiHOG000185904.
    KOiK01860.
    OMAiTIVRIDS.
    OrthoDBiEOG6QG8F7.

    Family and domain databases

    Gene3Di3.20.20.120. 1 hit.
    3.30.390.10. 1 hit.
    InterProiIPR013370. Chloromuconate_cycloisomerase.
    IPR029065. Enolase_C-like.
    IPR029017. Enolase_N_like.
    IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
    IPR013342. Mandelate_racemase_C.
    IPR013341. Mandelate_racemase_N.
    IPR001354. MR_MLE.
    [Graphical view]
    PANTHERiPTHR13794. PTHR13794. 1 hit.
    PfamiPF01188. MR_MLE. 1 hit.
    PF02746. MR_MLE_N. 1 hit.
    [Graphical view]
    SMARTiSM00922. MR_MLE. 1 hit.
    [Graphical view]
    SUPFAMiSSF51604. SSF51604. 1 hit.
    SSF54826. SSF54826. 1 hit.
    TIGRFAMsiTIGR02534. mucon_cyclo. 1 hit.
    PROSITEiPS00908. MR_MLE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P42428-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIVDLPLRRI QQFARLGAKH QSSVLIRLHT KGGIVGIGES ITPCGPWWSG    50
    DSVEAIQATI NHYLAPLVVG EPALDASRIM AKLHGRVAGN AFAKAGIEMA 100
    LLDAVGKIVD APIHVLLGGR FRDRLSVAWP LATGDVNQEV DEAFRMLEAG 150
    KAGAFKLKMG ALPLAQDLRR ALAIAKELEG KASLRVDPNE AWDEPTTMRA 200
    LAPLEAAGVE IIEQPVARWN LDAMARIHRQ ARSMLLIDEG VQSLHDASEV 250
    VKRAAAGLVS LKIMKTGGMR PARAMADIAN AGGMHVYMGT FLETSIGTAA 300
    NMQLAASIES LPYGGEVIGP LLIEEDLCEV PAVYKEHALW LPEGPGLGIR 350
    LDENQVRRFA RASSQRIDRH SA 372
    Length:372
    Mass (Da):40,045
    Last modified:February 1, 2005 - v2
    Checksum:i7D170C1364D04140
    GO

    Sequence cautioni

    The sequence AAA65064.1 differs from that shown. Reason: Frameshift at positions 82 and 132.
    The sequence AAZ65772.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti65 – 651A → G in AAA65064. (PubMed:8157603)Curated
    Sequence conflicti93 – 931A → D(PubMed:8157603)Curated
    Sequence conflicti178 – 20124LEGKA…TMRAL → TRGQDEPAPSIPTKRGTSRP RCGT in AAA65064. (PubMed:8157603)CuratedAdd
    BLAST
    Sequence conflicti208 – 2114GVEI → AWKF in AAA65064. (PubMed:8157603)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY365053 Genomic DNA. Translation: AAR31047.1.
    CP000093 Genomic DNA. Translation: AAZ65772.1. Different initiation.
    M98445 Genomic DNA. Translation: AAA65064.1. Frameshift.
    RefSeqiYP_293629.1. NC_007337.1.

    Genome annotation databases

    EnsemblBacteriaiAAZ65772; AAZ65772; Reut_D6474.
    GeneIDi3607898.
    KEGGireu:Reut_D6474.
    PATRICi20225328. VBIRalEut24049_0543.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY365053 Genomic DNA. Translation: AAR31047.1 .
    CP000093 Genomic DNA. Translation: AAZ65772.1 . Different initiation.
    M98445 Genomic DNA. Translation: AAA65064.1 . Frameshift.
    RefSeqi YP_293629.1. NC_007337.1.

    3D structure databases

    ProteinModelPortali P42428.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 264198.Reut_D6474.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAZ65772 ; AAZ65772 ; Reut_D6474 .
    GeneIDi 3607898.
    KEGGi reu:Reut_D6474.
    PATRICi 20225328. VBIRalEut24049_0543.

    Phylogenomic databases

    eggNOGi COG4948.
    HOGENOMi HOG000185904.
    KOi K01860.
    OMAi TIVRIDS.
    OrthoDBi EOG6QG8F7.

    Enzyme and pathway databases

    UniPathwayi UPA00083 .
    BioCyci CPIN264198:GIW3-6560-MONOMER.
    MetaCyc:MONOMER-14413.

    Family and domain databases

    Gene3Di 3.20.20.120. 1 hit.
    3.30.390.10. 1 hit.
    InterProi IPR013370. Chloromuconate_cycloisomerase.
    IPR029065. Enolase_C-like.
    IPR029017. Enolase_N_like.
    IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
    IPR013342. Mandelate_racemase_C.
    IPR013341. Mandelate_racemase_N.
    IPR001354. MR_MLE.
    [Graphical view ]
    PANTHERi PTHR13794. PTHR13794. 1 hit.
    Pfami PF01188. MR_MLE. 1 hit.
    PF02746. MR_MLE_N. 1 hit.
    [Graphical view ]
    SMARTi SM00922. MR_MLE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51604. SSF51604. 1 hit.
    SSF54826. SSF54826. 1 hit.
    TIGRFAMsi TIGR02534. mucon_cyclo. 1 hit.
    PROSITEi PS00908. MR_MLE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetic organization of the catabolic plasmid pJP4 from Ralstonia eutropha JMP134 (pJP4) reveals mechanisms of adaptation to chloroaromatic pollutants and evolution of specialized chloroaromatic degradation pathways."
      Trefault N., De la Iglesia R., Molina A.M., Manzano M., Ledger T., Perez-Pantoja D., Sanchez M.A., Stuardo M., Gonzalez B.
      Environ. Microbiol. 6:655-668(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Plasmid: pJP4
    2. "Complete sequence of plasmid 1 of Ralstonia eutropha JMP134."
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.
      Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JMP134 / LMG 1197.
      Plasmid: pReut1
    3. "Analysis of duplicated gene sequences associated with tfdR and tfdS in Alcaligenes eutrophus JMP134."
      Matrubutham U., Harker A.R.
      J. Bacteriol. 176:2348-2353(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-234.
      Plasmid: pJP4

    Entry informationi

    Entry nameiTFDD2_CUPPJ
    AccessioniPrimary (citable) accession number: P42428
    Secondary accession number(s): Q46M58, Q6UP90
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: February 1, 2005
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Plasmid

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3