P42423 (YXDL_BACSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ABC transporter ATP-binding protein YxdL

Gene names

Name:	yxdL
Ordered Locus Names:	BSU39640
ORF Names:	B65F

Organism

Bacillus subtilis (strain 168) [Reference proteome] [HAMAP]

Taxonomic identifier

224308 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus subtilis group › Bacillus subtilis › Bacillus subtilis subsp. subtilis

Protein attributes

Sequence length	257 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Part of the ABC transporter complex YxdLM which could be involved in peptide resistance. Responsible for energy coupling to the transport system Probable. Ref.5 Ref.6
Subunit structure	The complex is composed of two ATP-binding proteins (YxdL) and two transmembrane proteins (YxdM) Probable.
Induction	Transcriptionally regulated by YxdJ. Induced by the antibacterial protein LL-37, probably via YxdJ. Ref.5 Ref.6
Sequence similarities	Belongs to the ABC transporter superfamily. Contains 1 ABC transporter domain.

Ontologies

Keywords
Biological process	Transport
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 257	257	ABC transporter ATP-binding protein YxdL		PRO_0000093150
Regions
	Domain	5 – 243	239	ABC transporter
	Nucleotide binding	40 – 47	8	ATP Potential
Experimental info
	Sequence conflict	219 – 220	2	GE → VV in BAA03302. Ref.1
	Sequence conflict	219 – 220	2	GE → VV in BAA08315. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P42423 [UniParc]. Last modified July 28, 2009. Version 2. Checksum: 828B01E9ECD9F133	FASTA	257	28,710
	10 20 30 40 50 60 MANMLEVKHI NKTYKGQVSY QALKQISFSI EEGEFTAVMG PSGSGKTTLL NIISTIDRPD 70 80 90 100 110 120 SGDILINGEN PHRLKRTKLA HFRRKQLGFV FQDFNLLDTL TIGENIMLPL TLEKEAPSVM 130 140 150 160 170 180 EEKLHGIAAK LGIENLLNKR TFEVSGGQRQ RAAIARAVIH KPSLILADEP TGNLDSKATK 190 200 210 220 230 240 DVMETLQSLN RDDHVTALMV THDPVSASYC RRVIFIKDGE LFNEIYRGEN RQVFYEQILD 250 VLSMLGGNAN DLSSVRL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and nucleotide sequencing of a 15 kb region of the Bacillus subtilis genome containing the iol operon." Yoshida K., Sano H., Miwa Y., Ogasawara N., Fujita Y. Microbiology 140:2289-2298(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168 / BGSC1A1.
[2]	"Cloning and sequencing of a 23-kb region of the Bacillus subtilis genome between the iol and hut operons." Yoshida K., Fujimyra M., Yanai N., Fujita Y. DNA Res. 2:295-301(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168 / BGSC1A1.
[3]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A. Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.
[4]	"From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later." Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A. Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION TO 219-220.
[5]	"Characterization of the Bacillus subtilis YxdJ response regulator as the inducer of expression for the cognate ABC transporter YxdLM." Joseph P., Guiseppi A., Sorokin A., Denizot F. Microbiology 150:2609-2617(2004) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION, POSSIBLE FUNCTION. Strain: 168.
[6]	"Cationic antimicrobial peptides elicit a complex stress response in Bacillus subtilis that involves ECF-type sigma factors and two-component signal transduction systems." Pietiaeinen M., Gardemeister M., Mecklin M., Leskelae S., Sarvas M., Kontinen V.P. Microbiology 151:1577-1592(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION BY LL-37, POSSIBLE FUNCTION. Strain: 168.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D14399 Genomic DNA. Translation: BAA03302.1. D45912 Genomic DNA. Translation: BAA08315.1. AL009126 Genomic DNA. Translation: CAB16000.2.
PIR	A70074.
RefSeq	NP_391843.2. NC_000964.3.
3D structure databases
ProteinModelPortal	P42423.
SMR	P42423. Positions 4-247.
ModBase	Search...
Protein-protein interaction databases
STRING	224308.BSU39640.
Protein family/group databases
TCDB	3.A.1.134.6. ATP-binding cassette (ABC) superfamily.
Proteomic databases
PaxDb	P42423.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAB16000; CAB16000; BSU39640.
GeneID	937596.
KEGG	bsu:BSU39640.
PATRIC	18979992. VBIBacSub10457_4158.
Organism-specific databases
GenoList	BSU39640.
Phylogenomic databases
eggNOG	COG1136.
KO	K11635.
ProtClustDB	CLSK888170.
Enzyme and pathway databases
BioCyc	BSUB:BSU39640-MONOMER.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. [Graphical view]
Pfam	PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. 1 hit. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YXDL_BACSU

Accession

Primary (citable) accession number: P42423

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	July 28, 2009
Last modified:	May 1, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program