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Protein

RsbT antagonist protein RsbS

Gene

rsbS

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Negative regulator of sigma-B activity. Non-phosphorylated RsbS binds to RsbT, preventing its association with RsbU. Requires any one of RsbRA, RsbRB, RsbRC or RsbRD to sequester RsbT. When RsbS and the RsbR paralog(s) are phosphorylated, they release RsbT, which can then bind and activate RsbU.3 Publications

Enzyme and pathway databases

BioCyciBSUB:BSU04680-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
RsbT antagonist protein RsbS
Alternative name(s):
Stressosome protein RsbS
Gene namesi
Name:rsbS
Synonyms:ycxS
Ordered Locus Names:BSU04680
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi59S → A: Loss of phosphorylation and loss of the ability to respond to salt stress. Interacts strongly with RsbT. 2 Publications1
Mutagenesisi59S → D: Loss of interaction with RsbT. 2 Publications1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000974711 – 121RsbT antagonist protein RsbSAdd BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei59Phosphoserine3 Publications1

Post-translational modificationi

Phosphorylated by RsbT. Dephosphorylated by RsbX.3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP42410.

PTM databases

iPTMnetiP42410.

Interactioni

Subunit structurei

Interacts with RsbRA, RsbRB in the stressosome. The stressosome probably also contains RsbRC and RsbRD.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
rsbTP424112EBI-5247936,EBI-5247957

Protein-protein interaction databases

DIPiDIP-382N.
IntActiP42410. 3 interactors.
STRINGi224308.Bsubs1_010100002648.

Structurei

3D structure databases

ProteinModelPortaliP42410.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 115STASPROSITE-ProRule annotationAdd BLAST112

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105FUA. Bacteria.
COG1366. LUCA.
HOGENOMiHOG000269818.
InParanoidiP42410.
KOiK17762.
OMAiMSNLMGA.
PhylomeDBiP42410.

Family and domain databases

Gene3Di3.30.750.24. 1 hit.
InterProiIPR002645. STAS_dom.
[Graphical view]
PfamiPF01740. STAS. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 1 hit.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42410-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRHPKIPILK LYNCLLVSIQ WELDDQTALT FQEDLLNKIY ETGANGVVID
60 70 80 90 100
LTSVDMIDSF IAKVLGDVIT MSKLMGAKVV LTGIQPAVAV TLIELGIALE
110 120
EIETALDLEQ GLETLKRELG E
Length:121
Mass (Da):13,311
Last modified:November 1, 1995 - v1
Checksum:i64BF3EF7D4A81CDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35574 Genomic DNA. Translation: AAA85081.1.
AB001488 Genomic DNA. Translation: BAA19305.1.
AL009126 Genomic DNA. Translation: CAB12275.1.
PIRiF69701.
RefSeqiNP_388349.1. NC_000964.3.
WP_003225190.1. NZ_JNCM01000031.1.

Genome annotation databases

EnsemblBacteriaiCAB12275; CAB12275; BSU04680.
GeneIDi11241771.
938157.
KEGGibsu:BSU04680.
PATRICi18972520. VBIBacSub10457_0488.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35574 Genomic DNA. Translation: AAA85081.1.
AB001488 Genomic DNA. Translation: BAA19305.1.
AL009126 Genomic DNA. Translation: CAB12275.1.
PIRiF69701.
RefSeqiNP_388349.1. NC_000964.3.
WP_003225190.1. NZ_JNCM01000031.1.

3D structure databases

ProteinModelPortaliP42410.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-382N.
IntActiP42410. 3 interactors.
STRINGi224308.Bsubs1_010100002648.

PTM databases

iPTMnetiP42410.

Proteomic databases

PaxDbiP42410.

Protocols and materials databases

DNASUi938157.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12275; CAB12275; BSU04680.
GeneIDi11241771.
938157.
KEGGibsu:BSU04680.
PATRICi18972520. VBIBacSub10457_0488.

Phylogenomic databases

eggNOGiENOG4105FUA. Bacteria.
COG1366. LUCA.
HOGENOMiHOG000269818.
InParanoidiP42410.
KOiK17762.
OMAiMSNLMGA.
PhylomeDBiP42410.

Enzyme and pathway databases

BioCyciBSUB:BSU04680-MONOMER.

Family and domain databases

Gene3Di3.30.750.24. 1 hit.
InterProiIPR002645. STAS_dom.
[Graphical view]
PfamiPF01740. STAS. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 1 hit.
PROSITEiPS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRSBS_BACSU
AccessioniPrimary (citable) accession number: P42410
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 5, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.