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P42403

- BGLC_BACSU

UniProt

P42403 - BGLC_BACSU

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Protein

Aryl-phospho-beta-D-glucosidase BglC

Gene
bglC, yckE, BSU03410
Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Is able to catalyze the hydrolysis of aryl-phospho-beta-D-glucosides such as 4-methylumbelliferyl-phospho-beta-D-glucopyranoside (MUG-P), phosphoarbutin and phosphosalicin. Is not essential for growth on arbutin and salicin as the sole carbon source.1 Publication

Catalytic activityi

6-phospho-beta-D-glucosyl-(1,4)-D-glucose + H2O = D-glucose + D-glucose 6-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei170 – 1701Proton donor Reviewed prediction
Active sitei378 – 3781Nucleophile By similarity

GO - Molecular functioni

  1. 6-phospho-beta-glucosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

BioCyciBSUB:BSU03410-MONOMER.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
Aryl-phospho-beta-D-glucosidase BglC (EC:3.2.1.86)
Alternative name(s):
6-phospho-beta-glucosidase
Gene namesi
Name:bglC
Synonyms:yckE
Ordered Locus Names:BSU03410
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU03410. [Micado]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 477477Aryl-phospho-beta-D-glucosidase BglCPRO_0000063874Add
BLAST

Proteomic databases

PaxDbiP42403.

Expressioni

Developmental stagei

Expressed at a low and constant level during growth, sporulation, and spore germination.1 Publication

Inductioni

Is not induced by aryl-beta-D-glucosides such as arbutin, salicin or 4-methylumbelliferyl-beta-D-glucopyranoside (MUG). Is not repressed by glucose.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi224308.BSU03410.

Structurei

3D structure databases

ProteinModelPortaliP42403.
SMRiP42403. Positions 5-473.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2723.
HOGENOMiHOG000088631.
KOiK01223.
OMAiENGACDN.
OrthoDBiEOG60658J.
PhylomeDBiP42403.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
InterProiIPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42403-1 [UniParc]FASTAAdd to Basket

« Hide

MIHQHPESFP KHFLWGSASA AYQIEGAWNE DGKGPSVWDV FTKIPGKTFK    50
GTNGEIAVDH YHRFKEDVAL MAEMGLKAYR FSVSWPRVFP KGKGEINEAG 100
LAFYDSLIDE LLSHHIEPVL TLYHWDLPQA LMDEYGGFES RNIIEDFNHY 150
CITLYKRFGD RVKYWVTLNE QNYNFNHGFI TAMHPPGVKD RKRFYEANHI 200
AFLANAKAIE SFREYVPEGK IGPSFAYSPA YPLSSHPEDI LAFENAEEFT 250
NNWWLDMYCW GTYPQIPFRC LEKQGWAPTI EAGDMDLLAK GKPDFVGVNY 300
YQTITYERNP LDGVSEGKMN TTGQKGTNQE TGIPGVFKTK KNPHLTTSNW 350
DWTIDPIGLR IGLRRITSRY QLPVFITENG LGEFDKVEDG TVQDDYRIDY 400
LRSHLEQCRQ AISDGVDLIG YCSWSFTDLL SWLNGYQKRY GFVYVNRDEE 450
STSDLKRLKK KSFYWYQDVI KTNGESL 477
Length:477
Mass (Da):55,140
Last modified:November 1, 1995 - v1
Checksum:i64045E7E4C1A10E4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D30762 Genomic DNA. Translation: BAA06429.1.
D50453 Genomic DNA. Translation: BAA08975.1.
AL009126 Genomic DNA. Translation: CAB12135.1.
M21672 Genomic DNA. No translation available.
PIRiG69760.
RefSeqiNP_388223.1. NC_000964.3.
WP_003246242.1. NZ_CM000487.1.

Genome annotation databases

EnsemblBacteriaiCAB12135; CAB12135; BSU03410.
GeneIDi938317.
KEGGibsu:BSU03410.
PATRICi18972245. VBIBacSub10457_0351.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D30762 Genomic DNA. Translation: BAA06429.1 .
D50453 Genomic DNA. Translation: BAA08975.1 .
AL009126 Genomic DNA. Translation: CAB12135.1 .
M21672 Genomic DNA. No translation available.
PIRi G69760.
RefSeqi NP_388223.1. NC_000964.3.
WP_003246242.1. NZ_CM000487.1.

3D structure databases

ProteinModelPortali P42403.
SMRi P42403. Positions 5-473.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 224308.BSU03410.

Protein family/group databases

CAZyi GH1. Glycoside Hydrolase Family 1.

Proteomic databases

PaxDbi P42403.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB12135 ; CAB12135 ; BSU03410 .
GeneIDi 938317.
KEGGi bsu:BSU03410.
PATRICi 18972245. VBIBacSub10457_0351.

Organism-specific databases

GenoListi BSU03410. [Micado ]

Phylogenomic databases

eggNOGi COG2723.
HOGENOMi HOG000088631.
KOi K01223.
OMAi ENGACDN.
OrthoDBi EOG60658J.
PhylomeDBi P42403.

Enzyme and pathway databases

BioCyci BSUB:BSU03410-MONOMER.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
InterProi IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10353. PTHR10353. 1 hit.
Pfami PF00232. Glyco_hydro_1. 1 hit.
[Graphical view ]
PRINTSi PR00131. GLHYDRLASE1.
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A 10 kb nucleotide sequence at the 5' flanking region (32 degrees) of srfAA of the Bacillus subtilis chromosome."
    Fujishima Y., Yamane K.
    Microbiology 141:277-279(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  2. "The 25 degrees-36 degrees region of the Bacillus subtilis chromosome: determination of the sequence of a 146 kb segment and identification of 113 genes."
    Yamane K., Kumano M., Kurita K.
    Microbiology 142:3047-3056(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  3. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  4. "Transformation in Bacillus subtilis: involvement of the 17-kilodalton DNA-entry nuclease and the competence-specific 18-kilodalton protein."
    Vosman B., Kuiken G., Kooistra J., Venema G.
    J. Bacteriol. 170:3703-3710(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 461-477.
  5. "Identification of aryl-phospho-beta-D-glucosidases in Bacillus subtilis."
    Setlow B., Cabrera-Hernandez A., Cabrera-Martinez R.M., Setlow P.
    Arch. Microbiol. 181:60-67(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION AS AN ARYL-PHOSPHO-BETA-D-GLUCOSIDASE, DEVELOPMENTAL STAGE, INDUCTION, GENE NAME.
    Strain: 168 / PS832.

Entry informationi

Entry nameiBGLC_BACSU
AccessioniPrimary (citable) accession number: P42403
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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